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NO20050929L - Fremgangsmater for fremstilling, isolering og rensing av epotilon B og rontgen krystallstrukturer av eptilon B - Google Patents

Fremgangsmater for fremstilling, isolering og rensing av epotilon B og rontgen krystallstrukturer av eptilon B

Info

Publication number
NO20050929L
NO20050929L NO20050929A NO20050929A NO20050929L NO 20050929 L NO20050929 L NO 20050929L NO 20050929 A NO20050929 A NO 20050929A NO 20050929 A NO20050929 A NO 20050929A NO 20050929 L NO20050929 L NO 20050929L
Authority
NO
Norway
Prior art keywords
isolation
purification
eptilon
epotilon
preparation
Prior art date
Application number
NO20050929A
Other languages
English (en)
Other versions
NO334167B1 (no
Inventor
Daniel Benigni
Robert Stankavage
Shu-Jen Chiang
Hsing Hou
Bruce Eagan
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20050929L publication Critical patent/NO20050929L/no
Publication of NO334167B1 publication Critical patent/NO334167B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Foreliggende oppfinnelse vedrører forbedrede fremgangsmåter for produksjon, isolasjon og rensing av epotilon B. Disse fremgangsmåtene innbefatter for eksempel en fermenteringsprosess for produksjon av epotilon B, isolering via adsorpsjon til en harpiks, og påfølgende rensing.
NO20050929A 2002-09-23 2005-02-21 Fremgangsmåter for isolering og rensing av epotilon B. NO334167B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41299402P 2002-09-23 2002-09-23
PCT/US2003/029628 WO2004026254A2 (en) 2002-09-23 2003-09-22 Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b

Publications (2)

Publication Number Publication Date
NO20050929L true NO20050929L (no) 2005-04-08
NO334167B1 NO334167B1 (no) 2013-12-23

Family

ID=32030950

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050929A NO334167B1 (no) 2002-09-23 2005-02-21 Fremgangsmåter for isolering og rensing av epotilon B.

Country Status (22)

Country Link
US (4) US7172884B2 (no)
EP (3) EP2287168B1 (no)
JP (2) JP4523843B2 (no)
KR (2) KR101406635B1 (no)
CN (2) CN101050445B (no)
AU (1) AU2003275068B2 (no)
BR (1) BRPI0314133A8 (no)
CA (3) CA2695720C (no)
CO (1) CO5540384A2 (no)
ES (2) ES2405753T3 (no)
GE (1) GEP20074017B (no)
HR (1) HRP20050278A2 (no)
IL (2) IL166868A (no)
IS (1) IS7768A (no)
MX (1) MXPA05003006A (no)
NO (1) NO334167B1 (no)
PL (1) PL375902A1 (no)
RS (1) RS20050235A (no)
RU (1) RU2368661C2 (no)
TW (1) TWI291464B (no)
WO (1) WO2004026254A2 (no)
ZA (1) ZA200501680B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1367057E (pt) * 1996-11-18 2008-12-04 Biotechnolog Forschung Gmbh Epotilonas e e f
CA2273083C (en) * 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6780620B1 (en) 1998-12-23 2004-08-24 Bristol-Myers Squibb Company Microbial transformation method for the preparation of an epothilone
US6518421B1 (en) 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
MXPA03007394A (es) 2001-02-20 2003-12-04 Bristol Myers Squibb Co Tratamiento de tumores refractarios mediante uso de derivados de epotilona.
DK1767535T3 (da) 2002-08-23 2010-04-12 Sloan Kettering Inst Cancer Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP2287168B1 (en) * 2002-09-23 2013-02-13 Bristol-Myers Squibb Company Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
US20050171167A1 (en) * 2003-11-04 2005-08-04 Haby Thomas A. Process and formulation containing epothilones and analogs thereof
US20090004277A1 (en) * 2004-05-18 2009-01-01 Franchini Miriam K Nanoparticle dispersion containing lactam compound
JP2008536479A (ja) 2005-02-11 2008-09-11 ユニバーシティ オブ サザン カリフォルニア ジスルフィド架橋を有するタンパク質の発現法
CA2645278A1 (en) * 2006-04-05 2007-10-25 Novartis Ag Combinations of therapeutic agents for treating cancer
US8008256B2 (en) * 2006-05-01 2011-08-30 University Of Southern California Combination therapy for treatment of cancer
MX2009001635A (es) * 2006-08-16 2009-02-23 Novartis Ag Forma de cristal de epotilona b y su uso en composiciones farmaceuticas.
JP5180321B2 (ja) * 2008-02-01 2013-04-10 浙江海正薬業股▲ふん▼有限公司 エポチロンの分離及び精製方法
CN104116736A (zh) 2008-04-24 2014-10-29 百时美施贵宝公司 埃坡霉素D在治疗包括阿尔茨海默病的τ相关疾病中的用途
WO2010056901A2 (en) 2008-11-13 2010-05-20 University Of Southern California Method of expressing proteins with disulfide bridges with enhanced yields and activity
KR101372563B1 (ko) 2011-12-26 2014-03-14 주식회사 삼양바이오팜 에포틸론 함유물질로부터 에포틸론 ａ와 ｂ의 추출 및 정제 방법
CN103183681B (zh) * 2013-03-06 2016-01-13 浙江海正药业股份有限公司 伊沙匹隆的新晶型及其制备方法
US20160185792A1 (en) * 2013-08-19 2016-06-30 Sandoz Ag Method for the purification of epothilones via crystallization
EP3036240A1 (en) * 2013-08-19 2016-06-29 Sandoz AG Method for the purifiction of epothilones via crystallization
CN104046579B (zh) * 2014-05-16 2016-09-21 虞龙 一株埃博霉素高产菌及其在发酵产埃博霉素中的应用
CN106905338B (zh) * 2017-03-07 2020-06-23 鲁南制药集团股份有限公司 一种埃博霉素b的提纯方法
CN106834377B (zh) * 2017-03-07 2020-05-05 鲁南制药集团股份有限公司 一种生产埃博霉素b的方法
CN107827943B (zh) * 2017-11-28 2022-06-10 绍兴厚普生物科技有限责任公司 一种从发酵液中提取胞嘧啶核苷的方法
CN110964029B (zh) * 2019-12-19 2020-11-03 鲁南制药集团股份有限公司 一种埃博霉素b发酵液的预处理方法
KR102440644B1 (ko) * 2020-05-28 2022-09-05 공주대학교 산학협력단 파클리탁셀 정제 시 가스 버블을 이용한 분별침전방법
CN112409369B (zh) * 2020-11-30 2023-03-28 湖北宏中药业股份有限公司 一种埃博霉素b的高效提取纯化方法
CN112457320A (zh) * 2020-11-30 2021-03-09 湖北宏中药业股份有限公司 一种提高伊沙匹隆合成反应速率的方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE879605C (de) 1951-08-05 1953-06-15 Leitz Ernst Gmbh Optisches Instrument mit gekuppeltem Objektiv- und Kondensor-Wechsler
EP0216731B1 (de) * 1985-09-13 1990-03-14 Gesellschaft für Biotechnologische Forschung mbH (GBF) Makrozyklische Antibiotika
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
DE19639456A1 (de) 1996-09-25 1998-03-26 Biotechnolog Forschung Gmbh Epothilon-Derivate, Herstellung und Mittel
DE19542986A1 (de) 1995-11-17 1997-05-22 Biotechnolog Forschung Gmbh Epothilon-Derivate und deren Verwendung
EP1186606B2 (de) 1995-11-17 2011-09-07 Gesellschaft für Biotechnologische Forschung mbH (GBF) Epothilon-Derivate, ihre Herstellung und Verwendung
DE19645361A1 (de) 1996-08-30 1998-04-30 Ciba Geigy Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II
NZ334821A (en) 1996-08-30 2000-12-22 Novartis Ag Method for producing epothilones
DE19636343C1 (de) 1996-08-30 1997-10-23 Schering Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B
DE19645362A1 (de) 1996-10-28 1998-04-30 Ciba Geigy Ag Verfahren zur Herstellung von Epothilon A und B und Derivaten
PT1367057E (pt) * 1996-11-18 2008-12-04 Biotechnolog Forschung Gmbh Epotilonas e e f
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6204388B1 (en) * 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2273083C (en) * 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6380394B1 (en) 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
DE19701758A1 (de) 1997-01-20 1998-07-23 Wessjohann Ludgar A Dr Epothilone-Synthesebausteine
CN1128803C (zh) 1997-02-25 2003-11-26 生物技术研究有限公司(Gbf) 环氧噻嗪酮b－n－氧化物及其制备方法
DE19713970B4 (de) 1997-04-04 2006-08-31 R&D-Biopharmaceuticals Gmbh Epothilone-Synthesebausteine II - Prenylderivate
WO1998047891A1 (de) 1997-04-18 1998-10-29 Studiengesellschaft Kohle Mbh Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium
DE19821954A1 (de) 1997-05-15 1998-11-19 Biotechnolog Forschung Gmbh Verfahren zur Herstellung eines Epothilon-Derivats
DE19720312A1 (de) 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
DE19726627A1 (de) 1997-06-17 1998-12-24 Schering Ag Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
PT1001951E (pt) 1997-07-16 2003-02-28 Schering Ag Derivados de tiazolo, processo para a sua preparacao e utilizacao
ES2290993T3 (es) 1997-08-09 2008-02-16 Bayer Schering Pharma Aktiengesellschaft Nuevos derivados de epotilona, proceso para su produccion y su utilizacion farmaceutica.
US6365749B1 (en) 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6320045B1 (en) * 1997-12-04 2001-11-20 Bristol-Myers Squibb Company Process for the reduction of oxiranyl epothilones to olefinic epothilones
PL201329B1 (pl) 1998-02-05 2009-03-31 Novartis Ag Preparat farmaceutyczny w postaci koncentratu infuzyjnego
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
NZ506742A (en) 1998-02-25 2003-09-26 Sloan Kettering Inst Cancer Synthesis of desoxyepothilones and hydroxy acid derivative intermediates
FR2776071B1 (fr) * 1998-03-13 2000-05-26 Eastman Kodak Co Dispositif de mesure automatique de la concentration d'un agent developpateur
US6399638B1 (en) 1998-04-21 2002-06-04 Bristol-Myers Squibb Company 12,13-modified epothilone derivatives
AU5036999A (en) 1998-06-30 2000-01-17 Schering Aktiengesellschaft Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use
NZ511722A (en) 1998-11-20 2004-05-28 Kosan Biosciences Inc Recombinant methods and materials for producing epothilone and epothilone derivatives
DE69910831T2 (de) 1998-12-22 2004-07-15 Novartis Ag Epothilonderivate und ihre verwendung als antitumormittel
EP1140928A4 (en) 1998-12-23 2002-10-02 Bristol Myers Squibb Co MICROBIAL CONVERSION METHOD FOR PRODUCING AN EPOTHILONE
CN1209360C (zh) 1999-02-18 2005-07-06 舍林股份公司 16－卤－依泊昔酮衍生物、其制备方法及其医药用途
KR100685336B1 (ko) 1999-02-22 2007-02-23 게젤샤프트 퓌어 비오테크놀로기쉐 포르슝 엠베하(게베에프) Ｃ-21 변형 에포틸론
US6211412B1 (en) * 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones
AR023792A1 (es) 1999-04-30 2002-09-04 Bayer Schering Pharma Ag Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
CN1142163C (zh) * 2002-02-07 2004-03-17 山东大学 一种从粘细菌发酵液中分离提纯埃博霉素的方法
TW200303202A (en) * 2002-02-15 2003-09-01 Bristol Myers Squibb Co Method of preparation of 21-amino epothilone derivatives
EP2287168B1 (en) * 2002-09-23 2013-02-13 Bristol-Myers Squibb Company Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B

Also Published As

Publication number Publication date
EP2287168A3 (en) 2011-03-16
CA2695720A1 (en) 2004-04-01
US20060135474A1 (en) 2006-06-22
PL375902A1 (en) 2005-12-12
WO2004026254A2 (en) 2004-04-01
TWI291464B (en) 2007-12-21
EP2280014A3 (en) 2011-08-03
HRP20050278A2 (en) 2005-10-31
EP2280014A2 (en) 2011-02-02
CN101050445A (zh) 2007-10-10
US20070122891A1 (en) 2007-05-31
JP2010011873A (ja) 2010-01-21
CA2499600C (en) 2012-08-21
CA2695720C (en) 2013-04-02
JP5193983B2 (ja) 2013-05-08
CN1705662A (zh) 2005-12-07
US7767432B2 (en) 2010-08-03
WO2004026254A3 (en) 2004-05-27
CO5540384A2 (es) 2005-07-29
JP4523843B2 (ja) 2010-08-11
EP1542998A4 (en) 2007-01-31
HK1113387A1 (en) 2008-10-03
IS7768A (is) 2005-03-22
BRPI0314133A8 (pt) 2017-09-19
RU2368661C2 (ru) 2009-09-27
KR20050053681A (ko) 2005-06-08
EP2287168B1 (en) 2013-02-13
RS20050235A (sr) 2007-06-04
KR101406635B1 (ko) 2014-06-11
CN1705662B (zh) 2011-07-06
IL166868A (en) 2012-12-31
USRE42191E1 (en) 2011-03-01
JP2006500031A (ja) 2006-01-05
ES2439995T3 (es) 2014-01-27
BR0314133A (pt) 2005-07-12
GEP20074017B (en) 2007-01-10
IL222455A0 (en) 2012-12-02
ZA200501680B (en) 2006-05-31
EP2280014B1 (en) 2013-10-23
US20040132146A1 (en) 2004-07-08
EP2287168A2 (en) 2011-02-23
NO334167B1 (no) 2013-12-23
CA2695671A1 (en) 2004-04-01
ES2405753T3 (es) 2013-06-03
CN101050445B (zh) 2011-08-10
AU2003275068B2 (en) 2009-09-17
TW200409773A (en) 2004-06-16
CA2499600A1 (en) 2004-04-01
KR20120080649A (ko) 2012-07-17
MXPA05003006A (es) 2005-06-22
RU2005112443A (ru) 2005-10-27
AU2003275068A1 (en) 2004-04-08
US7241899B2 (en) 2007-07-10
US7172884B2 (en) 2007-02-06
EP1542998A2 (en) 2005-06-22

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