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NO20050885L - Ny fremgangsmate for syntesen av 1,3-dihydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre - Google Patents

Ny fremgangsmate for syntesen av 1,3-dihydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre

Info

Publication number
NO20050885L
NO20050885L NO20050885A NO20050885A NO20050885L NO 20050885 L NO20050885 L NO 20050885L NO 20050885 A NO20050885 A NO 20050885A NO 20050885 A NO20050885 A NO 20050885A NO 20050885 L NO20050885 L NO 20050885L
Authority
NO
Norway
Prior art keywords
benzazepin
dihydro
synthesis
compounds
new process
Prior art date
Application number
NO20050885A
Other languages
English (en)
Other versions
NO329438B1 (no
NO20050885D0 (no
Inventor
Jean-Pierre Lecouve
Daniel Brigot
Jean-Michel Lerestif
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20050885D0 publication Critical patent/NO20050885D0/no
Publication of NO20050885L publication Critical patent/NO20050885L/no
Publication of NO329438B1 publication Critical patent/NO329438B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20050885A 2004-04-13 2005-02-18 Ny fremgangsmate for syntesen av 1,3-dihydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre NO329438B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0403829A FR2868776B1 (fr) 2004-04-13 2004-04-13 Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (3)

Publication Number Publication Date
NO20050885D0 NO20050885D0 (no) 2005-02-18
NO20050885L true NO20050885L (no) 2005-10-14
NO329438B1 NO329438B1 (no) 2010-10-18

Family

ID=34941960

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050885A NO329438B1 (no) 2004-04-13 2005-02-18 Ny fremgangsmate for syntesen av 1,3-dihydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre

Country Status (32)

Country Link
US (1) US7074920B2 (no)
EP (1) EP1589014B1 (no)
JP (2) JP4511970B2 (no)
KR (1) KR100636500B1 (no)
CN (1) CN1332951C (no)
AR (1) AR047686A1 (no)
AT (1) ATE375339T1 (no)
AU (1) AU2005200860B2 (no)
BR (1) BRPI0500478B8 (no)
CA (1) CA2496721C (no)
CY (1) CY1107101T1 (no)
DE (1) DE602005002776T2 (no)
DK (1) DK1589014T3 (no)
EA (1) EA007744B1 (no)
ES (1) ES2294652T3 (no)
FR (1) FR2868776B1 (no)
GE (1) GEP20074137B (no)
HR (1) HRP20070503T3 (no)
MA (1) MA27599A1 (no)
ME (1) ME01402B (no)
MX (1) MXPA05003695A (no)
MY (1) MY141223A (no)
NO (1) NO329438B1 (no)
NZ (1) NZ538327A (no)
PL (1) PL1589014T3 (no)
PT (1) PT1589014E (no)
RS (1) RS50546B (no)
SG (1) SG116573A1 (no)
SI (1) SI1589014T1 (no)
UA (1) UA81772C2 (no)
WO (1) WO2005111026A1 (no)
ZA (1) ZA200501467B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP2162438A4 (en) 2007-05-30 2011-07-06 Ind Swift Lab Ltd PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND CORRESPONDING POLYMORPHIDE
CN102264689B (zh) 2008-12-22 2014-12-31 新梅斯托克尔卡公司 制备伊伐布雷定的方法
SI23290A (sl) 2010-02-12 2011-08-31 Krka D.D., Novo Mesto Nove oblike ivabradin hidroklorida
FR2956401B1 (fr) * 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3519735A1 (de) * 1985-06-01 1986-12-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JP2568416B2 (ja) * 1986-11-04 1997-01-08 大塚製薬株式会社 ヒドロフルオレン誘導体
JPH0495078A (ja) * 1990-08-08 1992-03-27 Nippon Shoji Kk ピリミドン誘導体の製造法、そのための中間体
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
TW279860B (no) * 1993-11-12 1996-07-01 Ciba Geigy Ag
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Also Published As

Publication number Publication date
EP1589014A1 (fr) 2005-10-26
AU2005200860B2 (en) 2010-08-05
DE602005002776T2 (de) 2008-08-28
BRPI0500478A (pt) 2005-11-16
NZ538327A (en) 2005-11-25
NO329438B1 (no) 2010-10-18
MY141223A (en) 2010-03-31
SI1589014T1 (sl) 2008-02-29
HRP20070503T3 (en) 2007-12-31
BRPI0500478B8 (pt) 2021-05-25
ZA200501467B (en) 2005-11-30
FR2868776B1 (fr) 2008-04-18
CN1683342A (zh) 2005-10-19
CN1332951C (zh) 2007-08-22
EA200500237A1 (ru) 2005-10-27
BRPI0500478B1 (pt) 2019-04-02
CA2496721C (fr) 2010-09-07
CA2496721A1 (fr) 2005-10-13
UA81772C2 (uk) 2008-02-11
FR2868776A1 (fr) 2005-10-14
DK1589014T3 (da) 2008-02-25
SG116573A1 (en) 2005-11-28
NO20050885D0 (no) 2005-02-18
ME01402B (me) 2010-05-07
MXPA05003695A (es) 2006-01-24
AU2005200860A1 (en) 2005-10-27
HK1079776A1 (en) 2006-04-13
US7074920B2 (en) 2006-07-11
WO2005111026A1 (fr) 2005-11-24
KR20060042120A (ko) 2006-05-12
AR047686A1 (es) 2006-02-01
RS50546B (sr) 2010-05-07
EA007744B1 (ru) 2006-12-29
EP1589014B1 (fr) 2007-10-10
MA27599A1 (fr) 2005-11-01
JP2005298479A (ja) 2005-10-27
US20050227962A1 (en) 2005-10-13
JP2010043096A (ja) 2010-02-25
JP4511970B2 (ja) 2010-07-28
DE602005002776D1 (de) 2007-11-22
CY1107101T1 (el) 2012-10-24
ES2294652T3 (es) 2008-04-01
KR100636500B1 (ko) 2006-10-18
PL1589014T3 (pl) 2008-01-31
ATE375339T1 (de) 2007-10-15
PT1589014E (pt) 2007-12-13
GEP20074137B (en) 2007-06-25

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