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NO20044779L - Tri-substituerte heteroarylforbindelser samt fremstilling og anvendelse derav - Google Patents

Tri-substituerte heteroarylforbindelser samt fremstilling og anvendelse derav

Info

Publication number
NO20044779L
NO20044779L NO20044779A NO20044779A NO20044779L NO 20044779 L NO20044779 L NO 20044779L NO 20044779 A NO20044779 A NO 20044779A NO 20044779 A NO20044779 A NO 20044779A NO 20044779 L NO20044779 L NO 20044779L
Authority
NO
Norway
Prior art keywords
tri
preparation
substituted heteroaryl
heteroaryl compounds
alk
Prior art date
Application number
NO20044779A
Other languages
English (en)
Norwegian (no)
Inventor
Zhongli Zheng
Russell C Petter
Wen-Cherng Lee
Lihong Sun
Feng Shan
Claudio Chuaqui
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of NO20044779L publication Critical patent/NO20044779L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20044779A 2002-04-04 2004-11-03 Tri-substituerte heteroarylforbindelser samt fremstilling og anvendelse derav NO20044779L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36979302P 2002-04-04 2002-04-04
PCT/US2003/010440 WO2003087304A2 (fr) 2002-04-04 2003-04-04 Hetero-aryles tri-substitues et procedes de fabrication

Publications (1)

Publication Number Publication Date
NO20044779L true NO20044779L (no) 2005-01-04

Family

ID=29250467

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044779A NO20044779L (no) 2002-04-04 2004-11-03 Tri-substituerte heteroarylforbindelser samt fremstilling og anvendelse derav

Country Status (19)

Country Link
US (1) US7612094B2 (fr)
EP (1) EP1499308A4 (fr)
JP (1) JP2005527590A (fr)
KR (1) KR20040094908A (fr)
CN (1) CN100448868C (fr)
AR (1) AR039241A1 (fr)
AU (1) AU2003228446B2 (fr)
CA (1) CA2480860A1 (fr)
EA (1) EA010418B1 (fr)
IL (1) IL164295A0 (fr)
IS (1) IS7475A (fr)
MX (1) MXPA04009546A (fr)
NO (1) NO20044779L (fr)
NZ (1) NZ536202A (fr)
PL (1) PL373502A1 (fr)
RS (1) RS95904A (fr)
UA (1) UA81624C2 (fr)
WO (1) WO2003087304A2 (fr)
ZA (1) ZA200407902B (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039241A1 (es) 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
GB0217787D0 (en) * 2002-07-31 2002-09-11 Glaxo Group Ltd C ompounds
AP2005003262A0 (en) 2002-09-18 2005-03-31 Pfizer Prod Inc Novel isothiazole and isoxazole compounds as tranforming growth factor (TGF) inhibitors.
HRP20050251A2 (en) 2002-09-18 2005-10-31 Pfizer Products Inc. Triazole derivatives as transforming growth factor (tfg) inhibitors
ES2325687T3 (es) 2002-09-18 2009-09-14 Pfizer Products Inc. Compuestos de imidazol novedosos como inhibidores del factor de crecimiento transformante (tgf).
WO2004026863A1 (fr) 2002-09-18 2004-04-01 Pfizer Products Inc. Nouveaux composes de triazole et d'oxazole, inhibiteurs du facteur de croissance transformant
DE60330362D1 (de) 2002-09-18 2010-01-14 Pfizer Prod Inc Neue pyrazol-verbindungen als hemmer des transformierenden wachstumsfaktors (tgf)
PA8595001A1 (es) 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
EP1708712A1 (fr) * 2003-12-24 2006-10-11 Scios, Inc. Traitement de gliomas malignes avec des inhibiteurs de tgf-beta
NZ549003A (en) * 2004-03-05 2009-07-31 Taisho Pharmaceutical Co Ltd Thiazole derivative as an ALK5 inhibitor
US20080319012A1 (en) 2004-04-21 2008-12-25 In2Gen Co., Ltd. 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
EP1786802A1 (fr) * 2004-08-31 2007-05-23 Biogen Idec MA, Inc. Pyrimidinylimidazoles utilises comme inhibiteurs de tgf-beta
EP1798229A4 (fr) * 2004-09-07 2009-07-29 Sankyo Co Derive de biphenyle substitue
MX2007003623A (es) 2004-09-24 2007-09-11 Johnson & Johnson Compuestos sulfonamida.
JP2008516962A (ja) * 2004-10-15 2008-05-22 バイオジェン・アイデック・エムエイ・インコーポレイテッド 血管傷害を治療する方法
GB0510141D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
EP1973914A2 (fr) 2005-12-22 2008-10-01 Biogen Idec MA Inc. Modulateurs du facteur de croissance transformant
ES2647472T3 (es) 2006-10-03 2017-12-21 Genzyme Corporation Anticuerpos contra TGF-BETA para uso en el tratamiento de lactantes con riesgo de desarrollar displasia broncopulmonar
WO2009009059A1 (fr) * 2007-07-09 2009-01-15 Biogen Idec Ma Inc. Composés spiro en tant qu'antagonistes du tgf-bêta
US8138168B1 (en) 2007-09-26 2012-03-20 Takeda Pharmaceutical Company Limited Renin inhibitors
US8865732B2 (en) 2008-03-21 2014-10-21 Novartis Ag Heterocyclic compounds and uses thereof
US8129394B2 (en) * 2008-03-21 2012-03-06 Novartis Ag Heteroaryl-substituted imidazole compounds and uses thereof
CL2009000904A1 (es) 2008-04-21 2010-04-30 Shionogi & Co Compuestos derivados de ciclohexil sulfonamidas que tienen actividad antagonista en el receptor npy y5, composicion farmaceutica y formulacion farmaceutica que los comprende.
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
US20100087486A1 (en) * 2008-05-30 2010-04-08 Hiroshi Nakamura Methods for using tgf-b receptor inhibitors or activin-like kinase (alk) 5 inhibitors a-83-01 and sb-431542 to treat eye disease and wound healing conditions
WO2010011917A1 (fr) * 2008-07-25 2010-01-28 Glaxosmithkline Llc Inhibiteurs doubles de seh et 11β-hsd1
US20100267731A1 (en) * 2009-04-17 2010-10-21 Summa Health Systems, LLC Use of transforming growth factor-b receptor inhibitors to suppress ocular scarring
US8080568B1 (en) 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
USRE47141E1 (en) 2010-06-29 2018-11-27 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
US8513222B2 (en) 2010-06-29 2013-08-20 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
US8871744B2 (en) 2010-07-21 2014-10-28 B & G Partyers, LLC Compounds and methods for selectively targeting tumor-associated mucins
CA2841252C (fr) 2011-07-13 2019-02-26 Sk Chemicals Co., Ltd. 2-pyridylimidazoles substitues utilises comme inhibiteurs d'alk5 et/ou d'alk4
US20140308275A1 (en) 2011-07-27 2014-10-16 Inserm (Institut National De La Sante Et De La Recherche Medicale Methods for diagnosing and treating myhre syndrome
IN2014DN03049A (fr) 2011-10-26 2015-05-15 Seattle Childrens Res Inst
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
JP6433974B2 (ja) 2013-03-14 2018-12-05 トレロ ファーマシューティカルズ, インコーポレイテッド Jak2およびalk2阻害剤およびその使用方法
ES2848710T3 (es) 2014-02-07 2021-08-11 Tamogatott Kutatocsoportok Irodaja Nuevo uso de compuestos agonistas del receptor sigma-1
US10842794B2 (en) 2014-02-07 2020-11-24 Támogatott Kutatócsoportok Irodája Use of Sigma-1 receptor agonist compounds
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
EP3515446B1 (fr) 2016-09-19 2023-12-20 Novartis AG Combinaisons thérapeutiques comprenant un inhibiteur de raf et un inhibiteur d'erk
CN110494166B (zh) 2017-05-02 2022-11-08 诺华股份有限公司 组合疗法
WO2019195278A1 (fr) * 2018-04-02 2019-10-10 Silverback Therapeutics, Inc. Inhibiteurs d'alk5, conjugués et leurs utilisations
AU2019310590A1 (en) 2018-07-26 2021-01-14 Sumitomo Pharma Oncology, Inc. Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
CN113330012A (zh) * 2019-01-22 2021-08-31 比西切姆有限公司 作为alk4/5抑制剂的稠环杂芳基化合物
JP2022527972A (ja) 2019-04-02 2022-06-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 前悪性病変を有する患者において癌を予測及び予防する方法
KR102881316B1 (ko) 2019-05-13 2025-11-05 노파르티스 아게 암 치료를 위한 raf 억제제로서의 n-(3-(2-(2-하이드록시에톡시)-6-모르폴리노피리딘-4-일)-4-메틸페닐)-2 (트리플루오로메틸)이소니코틴아미드의 새로운 결정질 형태
WO2021142086A1 (fr) 2020-01-08 2021-07-15 Synthis Therapeutics, Inc. Conjugués inhibiteurs d'alk5 et leurs utilisations
WO2022013311A1 (fr) 2020-07-15 2022-01-20 Chiesi Farmaceutici S.P.A. Dérivés de pyrido-oxazine en tant qu'inhibiteurs d'alk5
FI4182308T3 (fi) 2020-07-15 2024-12-07 Chiesi Farm Spa Pyridatsinyyliaminojohdannaisia alk5-estäjinä
US20240190891A1 (en) 2020-07-15 2024-06-13 Chiesi Farmaceutici S.P.A. Pyrido oxazine amino derivatives as alk5 inhibitors
WO2022136221A1 (fr) 2020-12-23 2022-06-30 Chiesi Farmaceutici S.P.A. Dérivés de pyrido-oxazine utilisés comme inhibiteurs d'alk5
CN112759592A (zh) * 2021-02-01 2021-05-07 无锡鸣鹭医药科技有限公司 一种6-碘[1,2,3]三唑并[1,5-a]吡啶的合成方法
CN114105975A (zh) * 2021-02-25 2022-03-01 无锡海伦生物科技有限公司 一种[1,2,4]三氮唑[1,5-a]吡啶-6-甲醛的合成方法
CN118201915A (zh) 2021-09-21 2024-06-14 奇斯药制品公司 作为alk5抑制剂的哒嗪基氨基衍生物
WO2023208986A1 (fr) 2022-04-27 2023-11-02 Chiesi Farmaceutici S.P.A. Dérivés d'imidazole en tant qu'inhibiteurs d'alk5
WO2024111626A1 (fr) * 2022-11-25 2024-05-30 カルナバイオサイエンス株式会社 Nouveau dérivé de thiazole
WO2024258967A1 (fr) 2023-06-13 2024-12-19 Synthis Therapeutics, Inc. Anticorps anti-cd5 et leurs utilisations

Family Cites Families (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940486A (en) 1971-05-10 1976-02-24 Ciba-Geigy Corporation Imidazole derivatives in the treatment of pain
DE3029376A1 (de) 1980-07-31 1982-03-18 Nepera Chemical Co. Inc., Harriman, N.Y. Verfahren zur herstellung von 2,4,5-tris-pyridylimidazolen
US4302464A (en) 1980-10-16 1981-11-24 Pfizer Inc. Imidazolylpyridine therapeutic agents
JPH01181187U (fr) 1988-06-13 1989-12-27
ATE131335T1 (de) 1988-09-16 1995-12-15 Philips Electronics Nv Hochauflösungs-fersehsystem.
JPH02216969A (ja) 1989-02-16 1990-08-29 Nec Corp ファクシミリ端末
WO1992016527A1 (fr) * 1991-03-22 1992-10-01 Nippon Soda Co., Ltd. Derive de pyridine substitue en position 2, sa production, et bactericide d'agrohorticulture
MX9300141A (es) 1992-01-13 1994-07-29 Smithkline Beecham Corp Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
US5656644A (en) 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
DK64592D0 (da) * 1992-05-14 1992-05-14 Carlbiotech Ltd As Peptider til terapeutisk behandling
US5593991A (en) 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
US5670527A (en) 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
IL110296A (en) 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
US5593992A (en) 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
WO1995003297A1 (fr) 1993-07-21 1995-02-02 Smithkline Beecham Corporation Imidazoles actives contre les maladies transmises par la cytokine
US5559137A (en) 1994-05-16 1996-09-24 Smithkline Beecham Corp. Compounds
GB9423460D0 (en) 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
AU4301096A (en) 1994-12-13 1996-07-03 F. Hoffmann-La Roche Ag Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase
JP3734180B2 (ja) 1994-12-28 2006-01-11 エーザイ株式会社 新規ピラゾール誘導体
US5514505A (en) 1995-05-15 1996-05-07 Xerox Corporation Method for obtaining improved image contrast in migration imaging members
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
US5739143A (en) 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
IL118544A (en) 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
EP0846699A1 (fr) 1995-06-29 1998-06-10 Fujisawa Pharmaceutical Co., Ltd. Substance wf16616, procede de production et utilisation
US5792778A (en) 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
US5837719A (en) 1995-08-10 1998-11-17 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
US6083949A (en) 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US5717100A (en) 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
GB2306108A (en) 1995-10-13 1997-04-30 Merck & Co Inc Treatment of Raf-mediated cancers with imidazole derivatives
AU7529096A (en) 1995-10-31 1997-05-22 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use
AU7482396A (en) 1995-10-31 1997-05-22 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use
ZA9610687B (en) 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
US6046208A (en) 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
ZA97175B (en) 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
TR199801361T2 (xx) 1996-01-11 1998-10-21 Smithkline Beecham Corporation Yeni ikameli imidazol bile�imleri.
JP2000504013A (ja) 1996-02-01 2000-04-04 スミスクライン・ビーチャム・コーポレイション エンドセリンレセプターアンタゴニスト
EP1005343A1 (fr) 1996-03-08 2000-06-07 Smithkline Beecham Corporation Utilisations de composes csaid?tm en tant qu'inhibiteurs de l'angiogenese
WO1997033883A1 (fr) 1996-03-13 1997-09-18 Smithkline Beecham Corporation Nouveaux composes de pyrimidine utiles dans le traitement de maladies a mediation cytokine
JP2000507545A (ja) 1996-03-25 2000-06-20 スミスクライン・ビーチャム・コーポレイション Cns損傷についての新規な治療
EP0889888A4 (fr) 1996-03-25 2003-01-08 Smithkline Beecham Corp Nouveau traitement des lesions du systeme nerveux central
DE19613172A1 (de) 1996-04-02 1997-10-09 Bayer Ag Verwendung von substituierten Aryl-imidazolen
US5883105A (en) 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5872136A (en) 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US6080870A (en) 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5854265A (en) 1996-04-03 1998-12-29 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5939557A (en) 1996-04-03 1999-08-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5880140A (en) 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
ATE294174T1 (de) 1996-06-10 2005-05-15 Merck & Co Inc Substituierte imidazole mit cytokinin- inhibirender wirkung
US5854264A (en) 1996-07-24 1998-12-29 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1998022457A1 (fr) 1996-11-19 1998-05-28 Amgen Inc. Agents anti-inflammatoires a base de pyrrole condense a substitution aryle et heteroaryle
US6096753A (en) 1996-12-05 2000-08-01 Amgen Inc. Substituted pyrimidinone and pyridone compounds and methods of use
US6410729B1 (en) 1996-12-05 2002-06-25 Amgen Inc. Substituted pyrimidine compounds and methods of use
ZA9711092B (en) 1996-12-11 1999-07-22 Smithkline Beecham Corp Novel compounds.
US5939439A (en) 1996-12-30 1999-08-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
PT1028954E (pt) 1997-04-24 2003-11-28 Ortho Mcneil Pharm Inc Imidazoles substituidos uteis no tratamento de doencas inflamatorias
CA2288741A1 (fr) 1997-05-22 1998-11-26 G.D. Searle And Co. Pyrazoles 3(5)-heteroaryl substituees utilisees comme inhibiteurs de kinase p38
US6087496A (en) 1998-05-22 2000-07-11 G. D. Searle & Co. Substituted pyrazoles suitable as p38 kinase inhibitors
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
AU7726898A (en) 1997-05-22 1998-12-11 G.D. Searle & Co. Pyrazole derivatives as p38 kinase inhibitors
BR9810007B1 (pt) 1997-06-12 2010-04-06 compostos, e, derivados da resina de merrifield.
EP1023066A4 (fr) 1997-06-13 2001-05-23 Smithkline Beecham Corp Nouveaux composes de pyrazole et de pyrazoline substitues
US6610695B1 (en) 1997-06-19 2003-08-26 Smithkline Beecham Corporation Aryloxy substituted pyrimidine imidazole compounds
IL133766A0 (en) 1997-06-30 2001-04-30 Ortho Mcneil Pharm Inc 2-substituted imidazoles useful in the treatment of inflammatory diseases
GB9713726D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
WO1999003480A1 (fr) 1997-07-17 1999-01-28 William Harvey Research Limited Utilisation d'adenosine tri- ou tetra-phosphates et de leurs analogues dans le traitement de l'infarctus cerebral
AU9449398A (en) 1997-10-10 1999-05-03 Imperial College Innovations Ltd. Use of csaidtm compounds for the management of uterine contractions
JP2001526230A (ja) 1997-12-19 2001-12-18 スミスクライン・ビーチャム・コーポレイション ヘテロアリール置換イミダゾール化合物、その医薬組成物および使用
GB9809869D0 (en) 1998-05-09 1998-07-08 Medical Res Council Inhibition of protein kinases
WO1999061437A1 (fr) 1998-05-22 1999-12-02 Smithkline Beecham Corporation Nouveaux composes d'imidazole a substitution alkyle en position 2
WO2000001688A1 (fr) 1998-07-02 2000-01-13 Sankyo Company, Limited Composes heteroaryle a cinq elements
ES2221426T3 (es) 1998-08-20 2004-12-16 Smithkline Beecham Corporation Nuevos compuestos de triazol sustituidos.
WO2000023444A1 (fr) 1998-10-21 2000-04-27 Abbott Laboratories Composes de 4-aminopyrido[2,3-d]pyrimidine a disubstitution 5,7
WO2000026209A1 (fr) 1998-11-03 2000-05-11 Novartis Ag 4-phenyl-5-pyrimidinyl-imidazoles anti-inflammatoires
WO2000025791A1 (fr) 1998-11-04 2000-05-11 Smithkline Beecham Corporation Pyrazines substitues pyridin-4-yle ou pyrimidin-4-yle
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
US6288089B1 (en) 1998-12-21 2001-09-11 Michael Zawada Use of kinase inhibitors for treating neurodegenerative diseases
ATE301116T1 (de) 1998-12-25 2005-08-15 Teikoku Hormone Mfg Co Ltd Aminopyrazol derivate
AU4327600A (en) 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Aryl sulfonyls as factor xa inhibitors
WO2000061576A1 (fr) * 1999-04-09 2000-10-19 Smithkline Beecham Corporation Triarylimidazoles
CO5170501A1 (es) 1999-04-14 2002-06-27 Novartis Ag AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO
JP4627944B2 (ja) 1999-06-03 2011-02-09 あすか製薬株式会社 置換ピラゾール化合物
JP2003503456A (ja) 1999-07-02 2003-01-28 スチュアート エイ. リプトン 神経傷害またはアポトーシスを軽減する方法
WO2001022965A1 (fr) 1999-09-28 2001-04-05 Merck & Co., Inc. Imizadoles substitues a activite inhibitrice de la cytokine
ES2228629T3 (es) 1999-11-22 2005-04-16 Smithkline Beecham Plc Derivados de imidazol y su uso como inhibidores de raf-quinasa.
US20030109428A1 (en) 1999-12-01 2003-06-12 John Bertin Novel molecules of the card-related protein family and uses thereof
ATE299881T1 (de) 1999-12-21 2005-08-15 Sugen Inc 4-substituierte 7-aza-indolin-2-one und ihre anwendung als protein kinase inhibitoren
AR029803A1 (es) 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
AU2001235838A1 (en) 2000-03-06 2001-09-17 Smithkline Beecham Plc Imidazol derivatives as raf kinase inhibitors
GB0007405D0 (en) 2000-03-27 2000-05-17 Smithkline Beecham Corp Compounds
GB0011092D0 (en) 2000-05-08 2000-06-28 Black James Foundation Gastrin and cholecystokinin receptor ligands (III)
AU2001266611A1 (en) 2000-06-01 2001-12-11 Merck & Co., Inc. Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors
AU2001268711A1 (en) 2000-06-23 2002-01-08 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
WO2002000651A2 (fr) 2000-06-27 2002-01-03 Bristol-Myers Squibb Pharma Company Inhibiteurs du facteur xa
PE20020506A1 (es) 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
GB0021726D0 (en) 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
EP1318992B1 (fr) 2000-09-21 2005-07-27 Smithkline Beecham Plc Derives d'imidazole en tant qu'inhibiteurs de la raf kinase
US6755497B2 (en) * 2000-09-26 2004-06-29 Canon Kabushiki Kaisha Ink-jet printing apparatus, control method thereof, and data processing apparatus and method
JP2002114780A (ja) * 2000-10-11 2002-04-16 Taisho Pharmaceut Co Ltd 4−(3−インドリル)イミダゾール誘導体
CA2426337A1 (fr) 2000-10-18 2002-04-25 Ortho-Mcneil Pharmaceutical, Inc. Imidazoles substitues utilises dans le traitement de maladies inflammatoires
US6630325B1 (en) 2000-10-19 2003-10-07 Maine Medical Center Research Institute Compositions, methods and kits relating to remodel
GB0027987D0 (en) 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
AU2002225730A1 (en) 2000-11-16 2002-05-27 Smith Kline Beecham Corporation Compounds
ES2289004T3 (es) 2000-11-20 2008-02-01 Smithkline Beecham Corporation Nuevos compuestos.
GB0100762D0 (en) * 2001-01-11 2001-02-21 Smithkline Beecham Plc Novel use
GB0102672D0 (en) 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
GB0102665D0 (en) 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
WO2002066462A1 (fr) 2001-02-02 2002-08-29 Glaxo Group Limited Derives pyrazole contre la surexpression du facteur
GB0102668D0 (en) 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
EP1363904A1 (fr) 2001-02-02 2003-11-26 Glaxo Group Limited Pyrazoles utilises comme inhibiteurs du tgf
GB0102673D0 (en) 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
ITMI20010821A1 (it) 2001-04-17 2002-10-17 Gienne Pharma S P A Impiego di composti derivati dallo spirolattone per inibire l'azione pro-fibrigenetica delle cellule stellate epatiche e delle cellule musco
DE60227794D1 (de) 2001-04-26 2008-09-04 Eisai R&D Man Co Ltd Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon
CA2445568A1 (fr) 2001-04-27 2002-11-07 Vertex Pharmaceuticals Incorporated Derives triazole inhibiteurs des kinases et leurs utilisations
US6787555B2 (en) 2001-04-30 2004-09-07 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
US6727364B2 (en) 2001-04-30 2004-04-27 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
JP2005022972A (ja) 2001-05-16 2005-01-27 Teikoku Hormone Mfg Co Ltd 4−(4−ピリダジニル)ピラゾール誘導体
CA2452865A1 (fr) * 2001-06-07 2002-12-12 Skinmedica, Inc. Milieu de culture cellulaire conditionne et utilisations de ce milieu
US7300442B2 (en) * 2001-07-11 2007-11-27 Daniel Cherfas Method of destroying formations in a body
WO2003015781A1 (fr) 2001-08-15 2003-02-27 Sankyo Company, Limited Nouvelles compositions pharmaceutiques antidiabetiques
GB0127433D0 (en) 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
AU2002357740A1 (en) 2001-12-11 2003-06-23 Smithkline Beecham Corporation Pyrazolo-pyridine derivatives as antiherpes agents
AR039241A1 (es) 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
ATE384053T1 (de) 2002-04-26 2008-02-15 Lilly Co Eli Triazolderivate als tachykininrezeptor- antagonisten
WO2003097615A1 (fr) 2002-05-17 2003-11-27 Scios, Inc. Traitement de troubles de fibro-proliferation au moyen d'inhibiteur de tgf-$g(b)
GB0215844D0 (en) 2002-07-09 2002-08-14 Novartis Ag Organic compounds
GB0217783D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Compounds
JP2005539000A (ja) 2002-07-31 2005-12-22 スミスクライン・ビーチャム・コーポレイション Alk5阻害剤としての2−フェニルピリジン−4−イル誘導体
GB0217780D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Compounds
GB0217786D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Compounds
HRP20050251A2 (en) 2002-09-18 2005-10-31 Pfizer Products Inc. Triazole derivatives as transforming growth factor (tfg) inhibitors
WO2004026863A1 (fr) 2002-09-18 2004-04-01 Pfizer Products Inc. Nouveaux composes de triazole et d'oxazole, inhibiteurs du facteur de croissance transformant
ES2325687T3 (es) 2002-09-18 2009-09-14 Pfizer Products Inc. Compuestos de imidazol novedosos como inhibidores del factor de crecimiento transformante (tgf).
ES2396606T3 (es) 2002-09-25 2013-02-22 Ube Industries, Ltd. Compuestos de pirazol
UA80571C2 (en) 2002-11-22 2007-10-10 Lilly Co Eli Quinolinyl-pyrrolopyrazoles
AU2003300099A1 (en) 2003-01-02 2004-07-29 Millennium Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR INHIBITING TGF-Beta
WO2004065392A1 (fr) 2003-01-24 2004-08-05 Smithkline Beecham Corporation Pyridines et pyrimidines condensees et leur utilisation en tant que ligands du recepteur alk-5
GB0313914D0 (en) 2003-06-16 2003-07-23 Smithkline Beecham Corp Compounds
GB0313915D0 (en) 2003-06-16 2003-07-23 Smithkline Beecham Corp Compounds

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EP1499308A2 (fr) 2005-01-26
EP1499308A4 (fr) 2006-05-24
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AU2003228446B2 (en) 2009-08-06
UA81624C2 (ru) 2008-01-25
US7612094B2 (en) 2009-11-03
CN1658866A (zh) 2005-08-24
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JP2005527590A (ja) 2005-09-15
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IL164295A0 (en) 2005-12-18
US20060063809A1 (en) 2006-03-23
CA2480860A1 (fr) 2003-10-23
AU2003228446A1 (en) 2003-10-27
KR20040094908A (ko) 2004-11-10
WO2003087304A2 (fr) 2003-10-23
EA010418B1 (ru) 2008-08-29
IS7475A (is) 2004-09-28
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AR039241A1 (es) 2005-02-16

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