NO20040500L - 1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister - Google Patents

1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister

Info

Publication number: NO20040500L
Authority: NO; Norway
Prior art keywords: receptor antagonists; gonadotropin; releasing hormone; trions; triazine
Prior art date: 2001-08-02

Application number

NO20040500A

Other languages

English (en)

Norwegian (no)

Inventor

Chen Chen

Zhiqiang Guo

Fabio C Tucci

Dongpei Wu

Collin Regan

Original Assignee

Neurocrine Biosciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-02

Filing date

2004-01-29

Publication date

2004-03-08

2004-01-29 Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc

2004-03-08 Publication of NO20040500L publication Critical patent/NO20040500L/no

Links

229940127445 Gonadotropin Releasing Hormone Receptor Antagonists Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 1
102000008238 LHRH Receptors Human genes 0.000 abstract 1
108010021290 LHRH Receptors Proteins 0.000 abstract 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
239000003163 gonadal steroid hormone Substances 0.000 abstract 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 1
229940035638 gonadotropin-releasing hormone Drugs 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C07D251/34—Cyanuric or isocyanuric esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Obesity (AREA)
Pregnancy & Childbirth (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20040500A 2001-08-02 2004-01-29 1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister NO20040500L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31001801P	2001-08-02	2001-08-02
PCT/US2002/024451 WO2003011839A1 (fr)	2001-08-02	2002-08-02	1,3,5-triazine-2,4,6-triones, preparation et utilisation de ces derniers en tant qu'antagonistes du recepteur de la gonadoliberine

Publications (1)

Publication Number	Publication Date
NO20040500L true NO20040500L (no)	2004-03-08

Family

ID=23200637

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20040500A NO20040500L (no)	2001-08-02	2004-01-29	1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister

Country Status (12)

Country	Link
US (2)	US6677340B2 (fr)
EP (1)	EP1412338B1 (fr)
JP (1)	JP4328617B2 (fr)
KR (1)	KR20040030892A (fr)
AT (1)	ATE316078T1 (fr)
AU (1)	AU2002324586B2 (fr)
CA (1)	CA2455833A1 (fr)
DE (1)	DE60208803T2 (fr)
ES (1)	ES2256522T3 (fr)
MX (1)	MXPA04000984A (fr)
NO (1)	NO20040500L (fr)
WO (1)	WO2003011839A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002324586B2 (en) *	2001-08-02	2008-04-24	Neurocrine Biosciences, Inc.	1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
PT1646389E (pt)	2003-07-07	2008-12-19	Neurocrine Biosciences Inc	Derivados de pirimidina-2,4-diona utilizados como antagonistas do receptor da hormona libertadora de gonadotropina
MXPA06000300A (es)	2003-07-07	2006-03-28	Neurocrine Biosciences Inc	Derivados de pirimidina-2,4-diona como antagonistas del receptor de la hormona de liberacion de gonadotropina.
ES2387495T3 (es)	2003-07-07	2012-09-25	Neurocrine Biosciences, Inc.	Arilpirimidinas útiles en el tratamiento de trastornos relacionados con las hormonas sexuales, tales como endometriosis, cáncer de próstata y similares
DE102004033902A1 (de)	2004-07-14	2006-02-16	Zentaris Gmbh	Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
GB0622472D0 (en) *	2006-11-10	2006-12-20	Addex Pharmaceuticals Sa	Novel heterocyclic derivatives
WO2008124614A1 (fr)	2007-04-06	2008-10-16	Neurocrine Biosciences, Inc.	Antagonistes des récepteurs de l'hormone libérant la gonadotropine et procédés s'y rapportant
ES2534573T3 (es)	2007-04-06	2015-04-24	Neurocrine Biosciences, Inc.	Antagonistas del receptor de la hormona liberadora de gonadotropina y métodos relacionados con los mismos
EP2095818A1 (fr)	2008-02-29	2009-09-02	AEterna Zentaris GmbH	Utilisation d'antagonistes LHRH dans des doses n'impliquant pas de castration
TW201130854A (en)	2009-12-22	2011-09-16	Bayer Schering Pharma Ag	Pyridinone derivatives and pharmaceutical compositions thereof
WO2012175514A1 (fr)	2011-06-21	2012-12-27	Bayer Intellectual Property Gmbh	Dérivés de pyridinone et compositions pharmaceutiques les contenant
PT3759088T (pt)	2018-02-26	2023-04-10	AlzeCure Pharma AB	Derivados de triazina para tratar doenças relacionadas com neurotrofinas
GB201810669D0 (en) *	2018-06-28	2018-08-15	Stiftelsen Alzecure	New compounds
GB201810668D0 (en)	2018-06-28	2018-08-15	Stiftelsen Alzecure	New compounds

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EP0828731A1 (fr)	1995-06-01	1998-03-18	Takeda Chemical Industries, Ltd.	DIAZEPINES TRICYCLIQUES UTILES COMME ANTAGONISTES DE RECEPTEURS DE GnRH
CZ146196A3 (en) *	1995-06-02	1997-05-14	American Cyanamid Co	1-(3-heterocyclylphenyl)-s-triazin-2,4,6-oxo or thiotriones and herbicidal agent based thereon
AU7333496A (en)	1995-10-19	1997-05-07	Takeda Chemical Industries Ltd.	Quinoline derivatives as gnrh antagonists
CN1063446C (zh)	1995-10-19	2001-03-21	武田药品工业株式会社	作为促性腺激素释放激素拮抗剂的噻吩并吡啶衍生物
EA000829B1 (ru)	1995-12-14	2000-04-24	Мерк Энд Ко., Инк.	Антагонисты гонадотропин-высвобождающего фактора
JP3230818B2 (ja)	1995-12-14	2001-11-19	メルクエンドカンパニーインコーポレーテッド	ゴナドトロピン放出ホルモン拮抗剤
EA000828B1 (ru)	1995-12-14	2000-04-24	Мерк Энд Ко., Инк.	Антагонисты гонадотропин-высвобождающего фактора
US5849764A (en)	1995-12-14	1998-12-15	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
US5780437A (en)	1995-12-14	1998-07-14	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
EP0868178A4 (fr)	1995-12-14	2000-03-29	Merck & Co Inc	Antagonistes de la gonadoliberine
EP0901489A1 (fr) *	1996-05-20	1999-03-17	Merck & Co., Inc.	Antagonistes de la gonadoliberine
EP0918522A4 (fr)	1996-05-20	1999-08-18	Merck & Co Inc	Antagonistes de la gonadoliberine
CA2254768A1 (fr)	1996-05-20	1997-11-27	Jinlong Jiang	Antagonistes de la gonadoliberine
AU712019B2 (en)	1996-05-20	1999-10-28	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
EP0986557A4 (fr)	1997-06-05	2001-03-14	Merck & Co Inc	Antagonistes de la gonadoliberine
WO1998055119A1 (fr)	1997-06-05	1998-12-10	Merck & Co., Inc.	Antagonistes de l'hormone de liberation de la gonadotrophine
WO1998055116A1 (fr)	1997-06-05	1998-12-10	Merck & Co., Inc.	Antagonistes de gonadoliberine
AU729752B2 (en)	1997-06-05	2001-02-08	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
US6313301B1 (en)	1997-08-13	2001-11-06	Takeda Chemical Industries, Ltd.	Thienopyridine derivatives, their intermediates and production thereof
CN1277612A (zh)	1997-12-26	2000-12-20	武田药品工业株式会社	含氮杂环化合物及其制备方法和用途
TWI225863B (en)	1999-03-24	2005-01-01	Takeda Chemical Industries Ltd	Thienopyrimidine compounds, their production and use
DE60022769T2 (de)	1999-10-15	2006-07-06	Neurocrine Biosciences, Inc., San Diego	Gonadotropin freisetzenden hormon rezeptor antagonisten und ihre verwandten verwendungen
AU2002324586B2 (en) *	2001-08-02	2008-04-24	Neurocrine Biosciences, Inc.	1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists

2002
- 2002-08-01 AU AU2002324586A patent/AU2002324586B2/en not_active Expired - Fee Related
- 2002-08-02 CA CA002455833A patent/CA2455833A1/fr not_active Abandoned
- 2002-08-02 KR KR10-2004-7001492A patent/KR20040030892A/ko not_active Withdrawn
- 2002-08-02 JP JP2003517031A patent/JP4328617B2/ja not_active Expired - Fee Related
- 2002-08-02 US US10/211,955 patent/US6677340B2/en not_active Expired - Lifetime
- 2002-08-02 EP EP02759239A patent/EP1412338B1/fr not_active Expired - Lifetime
- 2002-08-02 DE DE60208803T patent/DE60208803T2/de not_active Expired - Lifetime
- 2002-08-02 MX MXPA04000984A patent/MXPA04000984A/es not_active Application Discontinuation
- 2002-08-02 AT AT02759239T patent/ATE316078T1/de not_active IP Right Cessation
- 2002-08-02 WO PCT/US2002/024451 patent/WO2003011839A1/fr not_active Ceased
- 2002-08-02 ES ES02759239T patent/ES2256522T3/es not_active Expired - Lifetime
2003
- 2003-11-10 US US10/705,723 patent/US20040162290A1/en not_active Abandoned
2004
- 2004-01-29 NO NO20040500A patent/NO20040500L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20040162290A1 (en)	2004-08-19
ES2256522T3 (es)	2006-07-16
MXPA04000984A (es)	2005-02-17
US6677340B2 (en)	2004-01-13
KR20040030892A (ko)	2004-04-09
CA2455833A1 (fr)	2003-02-13
EP1412338A1 (fr)	2004-04-28
JP2005501055A (ja)	2005-01-13
DE60208803D1 (de)	2006-04-06
AU2002324586B2 (en)	2008-04-24
DE60208803T2 (de)	2006-08-31
ATE316078T1 (de)	2006-02-15
JP4328617B2 (ja)	2009-09-09
WO2003011839A1 (fr)	2003-02-13
US20030130282A1 (en)	2003-07-10
EP1412338B1 (fr)	2006-01-18

Publication	Publication Date	Title
DK1255738T3 (da)	2012-06-25	Gonadotropin-frigivende hormonreceptor-antagonister og fremgangsmåder relateret dertil
DK1646389T3 (da)	2009-01-05	Pyrimidin-2,4-dionderivater som gonadotropinfrigörende hormonreceptorantagonister
DE60022769D1 (de)	2006-02-02	Gonadotropin freisetzenden hormon rezeptor antagonisten und ihre verwandten verwendungen
NO20040500L (no)	2004-03-08	1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister
EA200600188A1 (ru)	2006-08-25	Производные пиримидин-2,4-диона и их применение в качестве антагонистов рецепторов гонадолиберина
ZA200104396B (en)	2002-11-29	Compositions and methods for stimulating gastrointestinal motility.
IL157254A0 (en)	2004-02-19	N-substituted nonaryl-heterocyclic nmda/mr2b antagonists
WO2003011293A3 (fr)	2003-04-17	Antagonistes du recepteur de l'hormone liberant la gonadotropine et procedes associes
MXPA03007837A (es)	2004-03-16	Composiciones para suministrar bisfosfonatos.
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MXPA04010625A (es)	2004-12-13	Antagonista de receptor de taquicinina.
IL142893A0 (en)	2002-04-21	Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same
MXPA03010766A (es)	2005-03-07	Nuevos compuestos y composiciones como inhibicores de las catepsinas.
MXPA01008993A (es)	2004-11-10	Tratamiento de combinacion para depresion y ansiedad.
ATE384066T1 (de)	2008-02-15	Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
DK1684763T3 (da)	2008-09-01	6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel
ES2173027A2 (es)	2002-10-01	Uso de nucleotidos en el tratamiento del glaucoma y la hipertension ocular.

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Date	Code	Title	Description
2006-03-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application