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NO20034470L - Anvendelse av pyrazolin-derivater ved fremstilling av et medikament for forebygging og/eller behandling av proliferasjonssykdommer - Google Patents

Anvendelse av pyrazolin-derivater ved fremstilling av et medikament for forebygging og/eller behandling av proliferasjonssykdommer

Info

Publication number
NO20034470L
NO20034470L NO20034470A NO20034470A NO20034470L NO 20034470 L NO20034470 L NO 20034470L NO 20034470 A NO20034470 A NO 20034470A NO 20034470 A NO20034470 A NO 20034470A NO 20034470 L NO20034470 L NO 20034470L
Authority
NO
Norway
Prior art keywords
methyl
hydrogen
trifluoromethyl
fluorine
aminosulphonyl
Prior art date
Application number
NO20034470A
Other languages
English (en)
Norwegian (no)
Other versions
NO20034470D0 (no
Inventor
Maria Rosa Cuberes-Altisent
Juana Maria Berrocal-Romero
Maria Montser Contijoch-Llobet
Jordi Frigola-Constansa
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of NO20034470D0 publication Critical patent/NO20034470D0/no
Publication of NO20034470L publication Critical patent/NO20034470L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20034470A 2001-04-06 2003-10-06 Anvendelse av pyrazolin-derivater ved fremstilling av et medikament for forebygging og/eller behandling av proliferasjonssykdommer NO20034470L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200100818A ES2174757B1 (es) 2001-04-06 2001-04-06 Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares.
PCT/ES2002/000137 WO2002080909A1 (fr) 2001-04-06 2002-03-21 Utilisation de derives de pyrazolines dans l'elaboration d'un medicament pour la prevention et/ou le traitement de maladies proliferatives cellulaires

Publications (2)

Publication Number Publication Date
NO20034470D0 NO20034470D0 (no) 2003-10-06
NO20034470L true NO20034470L (no) 2003-12-05

Family

ID=8497370

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20034470A NO20034470L (no) 2001-04-06 2003-10-06 Anvendelse av pyrazolin-derivater ved fremstilling av et medikament for forebygging og/eller behandling av proliferasjonssykdommer

Country Status (26)

Country Link
US (1) US20040034082A1 (fr)
EP (2) EP1384477B1 (fr)
JP (1) JP4451599B2 (fr)
KR (1) KR20040025912A (fr)
CN (2) CN1299682C (fr)
AT (1) ATE326966T1 (fr)
AU (1) AU2002246152B2 (fr)
BR (1) BR0208805A (fr)
CA (1) CA2442974C (fr)
CY (1) CY1105523T1 (fr)
DE (1) DE60211681T2 (fr)
DK (1) DK1384477T3 (fr)
ES (2) ES2174757B1 (fr)
HU (1) HUP0400918A3 (fr)
IL (1) IL158269A0 (fr)
IS (1) IS6973A (fr)
MA (1) MA27019A1 (fr)
MX (1) MXPA03009124A (fr)
NO (1) NO20034470L (fr)
NZ (1) NZ529304A (fr)
PL (1) PL365220A1 (fr)
PT (1) PT1384477E (fr)
RU (1) RU2305545C2 (fr)
UA (1) UA75402C2 (fr)
WO (1) WO2002080909A1 (fr)
ZA (1) ZA200308626B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2238923B1 (es) * 2004-02-16 2006-11-01 Laboratorios Del Dr. Esteve, S.A. Nuevos derivados pirazolinicos sustituidos.
EP1718618A1 (fr) * 2004-02-16 2006-11-08 Laboratorios del Dr. Esteve S.A. Interfaces homme-machine (ihm) actionnables par le pouce pour dispositifs electroniques portatifs, dispositifs electroniques portatifs comprenant ces interfaces et procedes d'utilisation correspondants
US7998996B2 (en) 2004-02-17 2011-08-16 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds for reducing triglycerides in blood
EP1637522A1 (fr) * 2004-09-16 2006-03-22 Laboratorios Del Dr. Esteve, S.A. Composés de pyrazolines substituées pour réduire des triglycerides dans le sang
TW200533657A (en) * 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
KR20060135815A (ko) * 2004-02-17 2006-12-29 라보라토리오스 델 드라. 에스테브.에스.에이. 혈중 트리글리세리드를 감소시키기 위한 치환된 피라졸린화합물
EP1749526A1 (fr) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Utilisation des derivés de la pyrazoline pour le traitement des troubles alimentaires, comme l'obesité ou le syndrome métabolique chez les patients diabetiques
ES2326725B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos alimentarios, que incluyen la obesidad o el sindrome metabolico en pacientes con diabetes desarrollada.
WO2007009700A2 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Utilisation de composes pyrazoliniques substitues pour le traitement de parametres des lipides du syndrome metabolique
WO2007009703A2 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Nouvelles formulations de composes de pyraoline substitues
ES2327203B1 (es) * 2005-07-15 2010-06-07 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos relacionados con la coagulacion.
EP1743892A1 (fr) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Composés pyrazoline substitués, leur préparation et utilisation comme médicaments
EP1746090A1 (fr) * 2005-07-15 2007-01-24 Laboratorios del Dr. Esteve S.A. Composés de pyrazolines substituées ayant une stereochimie predeterminèe pour réduire des triglycerides dans le sang
WO2007009701A2 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Utilisation de composes pyrazoliniques substitues pour traiter des facteurs de risque cardiovasculaires imputables a des troubles du metabolisme ou de l'alimentation
EP1743636A1 (fr) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Combinaison d'une pyrazoline substituée avec un agent utilisé contre les dérangements alimentaires
WO2007009699A2 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Utilisation de composes pyrazoliniques substitues et de leurs derives contre des affections associees au systeme des cannabinoides
EP1849776A1 (fr) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Dérivés de la pyrazoline azépane- ou azocane-substituées, leur préparation et utilisation comme médicaments
EP1743889A1 (fr) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Composés de pyrazolines substituées ayant une stereochimie predeterminèe pour réduire des triglycerides dans le sang
ES2319074B1 (es) * 2005-07-15 2009-12-03 Laboratorios Del Dr. Esteve, S.A. Combinacion de principios activos.
EP1743642A1 (fr) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Utilisation de composés à base de pyrazoline pour le traitement des maladies associées avec le système cannabinoïde
EP1743639A1 (fr) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Utilisation des derivés de la pyrazoline pour le traitement des troubles liées à la coagulation
EP1849784A1 (fr) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Dérivés de la pyrazoline Indoline-substituée, leur préparation and utilisation comme médicaments
WO2007009702A2 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Composes de pyrazoline substitues, leur preparation et leur utilisation comme medicaments
WO2007009693A1 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr.Esteve, S.A Combinaison d'un compose pyrazolinique substitue et medicament utilise pour des troubles en lien avec les aliments
ES2334967B1 (es) * 2005-07-15 2010-10-21 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre.
EP1743643A1 (fr) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Nouvelles formulations de composés à base de pyrazoline
EP1743637A1 (fr) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Utilisation des derivés du pyrazole seuls ou en combinaison pour le traitement du syndrome métabolique
EP1749525A1 (fr) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Combination de pyrazoline substitués et de médicaments contre la dépendance
EP1749527A1 (fr) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Utilisation des derivés du pyrazole pour le traitement du syndrome métabolique
WO2007009712A1 (fr) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Composes de pyrazoline a substitution d'indoline, leur preparation et utilisation comme medicaments
EP1743890A1 (fr) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Dérivés 4,5-dihydro-1H-pyrazole, leur, préparation et utilisation comme médicaments.
US7897589B2 (en) 2005-07-15 2011-03-01 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
KR101457637B1 (ko) * 2012-10-24 2014-11-20 건국대학교 산학협력단 디히드로피라졸카르보티오아미드 유도체 및 그 제법 및 그 유도체를 포함하는 항암제 조성물
CN103664785A (zh) * 2013-11-04 2014-03-26 南京大学 一类新颖的二氢吡唑磺胺衍生物的合成及在抗癌药物中的应用
WO2023043778A1 (fr) * 2021-09-14 2023-03-23 Maverick Gold (Nv), Llc Procédés et systèmes de titrage et d'échange de réserves alternatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013643A1 (fr) * 1992-12-17 1994-06-23 Pfizer Inc. Pyrazoles et pyrazolopyrimidines presentant une activite d'antagonistes du facteur de liberation de la cortitrophine
ATE233245T1 (de) * 1993-11-30 2003-03-15 Searle & Co Substituierte pyrazolyl-benzolsulfonamide und ihre verwendung als cyclooxygenaseii inhibitoren
US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5972986A (en) * 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
ES2137138B1 (es) * 1998-05-29 2000-09-16 Esteve Labor Dr Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
JP2003501464A (ja) * 1999-06-16 2003-01-14 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション シクロオキシゲナーゼ−２の阻害剤としての１−（４−スルファミルアリール）−３−置換−５−アリール−２−ピラゾリン

Also Published As

Publication number Publication date
ES2174757B1 (es) 2003-11-01
HUP0400918A2 (hu) 2004-07-28
ZA200308626B (en) 2004-11-05
MA27019A1 (fr) 2004-12-20
MXPA03009124A (es) 2005-04-11
PT1384477E (pt) 2006-09-29
WO2002080909A1 (fr) 2002-10-17
RU2305545C2 (ru) 2007-09-10
HK1067311A1 (en) 2005-04-08
PL365220A1 (en) 2004-12-27
NZ529304A (en) 2006-02-24
RU2003132457A (ru) 2005-04-10
UA75402C2 (en) 2006-04-17
CN1299682C (zh) 2007-02-14
EP1384477B1 (fr) 2006-05-24
IS6973A (is) 2003-10-03
BR0208805A (pt) 2004-07-13
EP1516621A2 (fr) 2005-03-23
JP2004525166A (ja) 2004-08-19
IL158269A0 (en) 2004-05-12
CN1509171A (zh) 2004-06-30
ATE326966T1 (de) 2006-06-15
CN1698602A (zh) 2005-11-23
DE60211681T2 (de) 2007-05-16
EP1516621A3 (fr) 2005-05-04
CA2442974A1 (fr) 2002-10-17
ES2174757A1 (es) 2002-11-01
DK1384477T3 (da) 2006-08-21
HUP0400918A3 (en) 2004-10-28
CA2442974C (fr) 2010-02-23
KR20040025912A (ko) 2004-03-26
DE60211681D1 (de) 2006-06-29
NO20034470D0 (no) 2003-10-06
US20040034082A1 (en) 2004-02-19
AU2002246152B2 (en) 2007-05-31
CY1105523T1 (el) 2010-07-28
EP1384477A1 (fr) 2004-01-28
ES2264723T3 (es) 2007-01-16
JP4451599B2 (ja) 2010-04-14

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