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NO20026001L - 3'-promedikamenter av 2'-deoksy-<Beta>-L-nukleosider - Google Patents

3'-promedikamenter av 2'-deoksy-<Beta>-L-nukleosider

Info

Publication number
NO20026001L
NO20026001L NO20026001A NO20026001A NO20026001L NO 20026001 L NO20026001 L NO 20026001L NO 20026001 A NO20026001 A NO 20026001A NO 20026001 A NO20026001 A NO 20026001A NO 20026001 L NO20026001 L NO 20026001L
Authority
NO
Norway
Prior art keywords
nucleosides
deoxy
promoters
beta
compositions
Prior art date
Application number
NO20026001A
Other languages
English (en)
Other versions
NO20026001D0 (no
Inventor
Martin L Bryant
Gilles Gosselin
Jean Louis Imbach
Original Assignee
Univ Montpellier Ii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Montpellier Ii filed Critical Univ Montpellier Ii
Publication of NO20026001D0 publication Critical patent/NO20026001D0/no
Publication of NO20026001L publication Critical patent/NO20026001L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser, preparater og metoder for behandling av en vert infisert med et heptatitt B-virus. Spesielt beskrives forbindelser og preparater av 3" -estere av 2'-deciksy-P-L-nukleosider som kan administreres enten alene eller i kombinasjoner med andre anti-hepatitt B-midler. Forbindelsene og preparatene av 3\ 5'-estere av 2'-deoksy-P-L-nukleosider beskrives som kan administreres enten alene eller med andre anti-hepatitt B-midler.
NO20026001A 2000-06-15 2002-12-13 3'-promedikamenter av 2'-deoksy-<Beta>-L-nukleosider NO20026001L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21210000P 2000-06-15 2000-06-15
PCT/US2001/019147 WO2001096353A2 (en) 2000-06-15 2001-06-15 3'-PRODRUGS OF 2'-DEOXY-β-L-NUCLEOSIDES

Publications (2)

Publication Number Publication Date
NO20026001D0 NO20026001D0 (no) 2002-12-13
NO20026001L true NO20026001L (no) 2003-02-12

Family

ID=22789563

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20026001A NO20026001L (no) 2000-06-15 2002-12-13 3'-promedikamenter av 2'-deoksy-<Beta>-L-nukleosider

Country Status (27)

Country Link
EP (1) EP1296995B1 (no)
JP (1) JP4639032B2 (no)
KR (2) KR20070048277A (no)
CN (3) CN101012259A (no)
AP (1) AP1771A (no)
AR (1) AR035711A1 (no)
AT (1) ATE411332T1 (no)
AU (2) AU6692701A (no)
BR (1) BR0111732A (no)
CA (1) CA2413163C (no)
CZ (1) CZ2003122A3 (no)
DE (1) DE60136181D1 (no)
EA (1) EA005774B1 (no)
ES (1) ES2317912T3 (no)
IL (3) IL153379A0 (no)
MA (1) MA27126A1 (no)
MX (1) MXPA02012443A (no)
MY (1) MY141594A (no)
NO (1) NO20026001L (no)
NZ (2) NZ535246A (no)
OA (1) OA12384A (no)
PE (1) PE20020216A1 (no)
PL (1) PL360404A1 (no)
UY (1) UY26779A1 (no)
WO (1) WO2001096353A2 (no)
YU (1) YU94802A (no)
ZA (2) ZA200300168B (no)

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WO2004002422A2 (en) 2002-06-28 2004-01-08 Idenix (Cayman) Limited 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
KR20050055630A (ko) 2002-06-28 2005-06-13 이데닉스 (케이만) 리미티드 플라비비리다에 감염 치료를 위한 1'-, 2'- 및 3'-변형된뉴클레오시드 유도체
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
TW200500375A (en) * 2002-06-28 2005-01-01 Idenix Cayman Ltd Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
BR0314259A (pt) * 2002-09-13 2005-07-26 Idenix Cayman Ltd ß-l-2'-desoxinucleosìdeos para o tratamento de cepas de hbv resistentes e terapias combinadas
ES2624353T3 (es) 2002-11-15 2017-07-13 Idenix Pharmaceuticals Llc 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
CN101415719A (zh) 2003-03-20 2009-04-22 微生物化学及药品有限公司 生产2’-脱氧-β-L-核苷的方法
CN1812995A (zh) 2003-04-28 2006-08-02 艾登尼科斯（开曼）有限公司 工业化规模的核苷合成
EP4032897B1 (en) 2003-05-30 2025-01-29 Gilead Pharmasset LLC Modified fluorinated nucleoside analogues
MXPA06000162A (es) 2003-06-30 2006-03-21 Idenix Cayman Ltd Sintesis de ?-l-2-desoxinucleosidos.
CN1980657A (zh) 2004-05-05 2007-06-13 耶鲁大学 新颖的抗病毒赛菊宁黄质类似物
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
WO2006031725A2 (en) 2004-09-14 2006-03-23 Pharmasset, Inc. Preparation of 2'­fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US7524831B2 (en) 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
WO2006138507A1 (en) 2005-06-17 2006-12-28 Novartis Ag Use of sanglifehrin in hcv
GB0609178D0 (en) 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
US7897737B2 (en) 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
AU2009257369B2 (en) 2008-06-11 2015-03-26 Agilent Technologies, Inc. Nucleotides and nucleosides and methods for their use in DNA sequencing
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
NZ593647A (en) 2008-12-23 2013-08-30 Gilead Pharmasset Llc Synthesis of purine nucleosides
SG172359A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Nucleoside phosphoramidates
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
EP2552203B1 (en) 2010-04-01 2017-03-22 Idenix Pharmaceuticals LLC. Compounds and pharmaceutical compositions for the treatment of viral infections
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
CN103906759A (zh) 2011-09-12 2014-07-02 埃迪尼克斯医药公司 用于治疗病毒感染的化合物和药物组合物
CN104024269B (zh) 2011-09-13 2017-05-24 激光基因公司 5‑甲氧基，3’‑oh未阻断，可快速光切割的终止核苷酸以及用于核酸测序的方法
CA2840242C (en) 2011-09-16 2019-03-26 Gilead Sciences, Inc. Methods for treating hcv
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
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IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
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WO2000009531A2 (en) * 1998-08-10 2000-02-24 Novirio Pharmaceuticals Limited β-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HEPATITIS B

Also Published As

Publication number Publication date
JP2004533403A (ja) 2004-11-04
AU2001266927B2 (en) 2006-12-14
WO2001096353A3 (en) 2002-04-18
IL153379A (en) 2007-02-11
MXPA02012443A (es) 2004-09-10
EA005774B1 (ru) 2005-06-30
AP1771A (en) 2007-08-23
CN1452627A (zh) 2003-10-29
AU6692701A (en) 2001-12-24
BR0111732A (pt) 2003-06-24
IL153379A0 (en) 2003-07-06
PL360404A1 (en) 2004-09-06
CN101012259A (zh) 2007-08-08
CA2413163C (en) 2008-11-18
MY141594A (en) 2010-05-14
CZ2003122A3 (cs) 2003-06-18
ES2317912T3 (es) 2009-05-01
WO2001096353A2 (en) 2001-12-20
JP4639032B2 (ja) 2011-02-23
UY26779A1 (es) 2001-12-28
PE20020216A1 (es) 2002-04-16
ZA200300168B (en) 2004-07-07
NZ535246A (en) 2006-06-30
CN1900104A (zh) 2007-01-24
EA200300023A1 (ru) 2003-08-28
ATE411332T1 (de) 2008-10-15
IL178864A0 (en) 2007-03-08
CN1295242C (zh) 2007-01-17
MA27126A1 (fr) 2005-01-03
AP2003002713A0 (en) 2003-03-31
DE60136181D1 (de) 2008-11-27
YU94802A (sh) 2006-03-03
KR20070048277A (ko) 2007-05-08
EP1296995A2 (en) 2003-04-02
CA2413163A1 (en) 2001-12-20
ZA200404306B (en) 2005-06-15
KR20030032967A (ko) 2003-04-26
AR035711A1 (es) 2004-07-07
OA12384A (en) 2006-04-17
NO20026001D0 (no) 2002-12-13
EP1296995B1 (en) 2008-10-15
NZ523632A (en) 2005-03-24

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