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NO20023009L - Pyrrolidiner som inhiberer CAMP-spesifikk PDE - Google Patents

Pyrrolidiner som inhiberer CAMP-spesifikk PDE

Info

Publication number
NO20023009L
NO20023009L NO20023009A NO20023009A NO20023009L NO 20023009 L NO20023009 L NO 20023009L NO 20023009 A NO20023009 A NO 20023009A NO 20023009 A NO20023009 A NO 20023009A NO 20023009 L NO20023009 L NO 20023009L
Authority
NO
Norway
Prior art keywords
pyrrolidines
specific pde
inhibit camp
camp
inhibit
Prior art date
Application number
NO20023009A
Other languages
English (en)
Norwegian (no)
Other versions
NO20023009D0 (no
Inventor
Timothy J Martins
Kerry W Fowler
Joshua Odingo
Laurence E Burgess
Stephen T Schlachter
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of NO20023009D0 publication Critical patent/NO20023009D0/no
Publication of NO20023009L publication Critical patent/NO20023009L/no

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Cardiology (AREA)
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  • Diabetes (AREA)
  • Dermatology (AREA)
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  • Hematology (AREA)
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  • Psychiatry (AREA)
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NO20023009A 1999-12-23 2002-06-21 Pyrrolidiner som inhiberer CAMP-spesifikk PDE NO20023009L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17202399P 1999-12-23 1999-12-23
PCT/US2000/034116 WO2001047879A1 (fr) 1999-12-23 2000-12-15 Pyrrolidines inhibitrices de la phosphodiesterase specifique d'amp cyclique

Publications (2)

Publication Number Publication Date
NO20023009D0 NO20023009D0 (no) 2002-06-21
NO20023009L true NO20023009L (no) 2002-08-19

Family

ID=22626053

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023009A NO20023009L (no) 1999-12-23 2002-06-21 Pyrrolidiner som inhiberer CAMP-spesifikk PDE

Country Status (16)

Country Link
US (1) US6376489B1 (fr)
EP (1) EP1244619A1 (fr)
JP (1) JP2003519122A (fr)
KR (1) KR20020063601A (fr)
CN (1) CN1246311C (fr)
AU (1) AU778795B2 (fr)
BR (1) BR0016687A (fr)
CA (1) CA2395173A1 (fr)
EA (1) EA007589B1 (fr)
HU (1) HUP0300169A3 (fr)
IL (1) IL150287A0 (fr)
MX (1) MXPA02006206A (fr)
NO (1) NO20023009L (fr)
PL (1) PL355893A1 (fr)
WO (1) WO2001047879A1 (fr)
ZA (1) ZA200205015B (fr)

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US7473691B2 (en) 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
KR20030032035A (ko) 2000-09-15 2003-04-23 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서 유용한 피라졸 화합물
MXPA03005610A (es) 2000-12-21 2003-10-06 Vertex Pharma Compuestos de pirazol utiles como inhibidores de la proteina cinasa.
US20050101000A1 (en) * 2002-12-11 2005-05-12 Isis Pharmaceuticals Inc. Modulation of phosphodiesterase 4B expression
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
KR20050032105A (ko) 2002-08-02 2005-04-06 버텍스 파마슈티칼스 인코포레이티드 Ｇｓｋ-3의 억제제로서 유용한 피라졸 조성물
US7138423B2 (en) * 2004-07-20 2006-11-21 Bristol-Myers Squibb Company Arylpyrrolidine derivatives as NK-1 /SSRI antagonists
CA2620333A1 (fr) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenese par modulation du recepteur muscarinique
EP2258357A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse avec inhibiteur de l'acetylcholinestérase
WO2007047978A2 (fr) 2005-10-21 2007-04-26 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
EP1942879A1 (fr) 2005-10-31 2008-07-16 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
BRPI0619706A2 (pt) 2005-11-03 2011-10-11 Vertex Pharma composto, composição, método para inibir a atividade da proteìna aurora quinase numa amostra biológica, método para tratar um distúrbio proliferativo num paciente, método para tratar cáncer num indivìduo
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
WO2007134077A2 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenèse induite par le récepteur 5ht
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
WO2013106547A1 (fr) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
JO3264B1 (ar) * 2013-03-13 2018-09-16 Lilly Co Eli مركبات ازيتيدينيل أوكسي فينيل بيروليدين
HUE052714T2 (hu) 2014-05-29 2021-05-28 Mitsubishi Tanabe Pharma Corp Új pirrolidin vegyület és alkalmazás melanokortin receptor agonistaként
EP3689861B1 (fr) 2017-09-29 2023-11-08 Mitsubishi Tanabe Pharma Corporation Composé de pyrrolidine optiquement actif et procédé de production de celui-ci
EP3901146A4 (fr) * 2018-12-18 2022-01-19 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Composé phénylpyrrolidine et son utilisation
CN113563246B (zh) * 2020-04-29 2025-01-17 广东东阳光药业股份有限公司 取代的氮杂五元环类衍生物及其在药物中的应用

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CA2143143A1 (fr) 1994-03-08 1995-09-09 Toshihiko Tanaka Derives de la 3-phenylpyrrolidine
DE19601938A1 (de) 1996-01-12 1997-07-17 Schering Ag Neue Phosphodiesteraseinhibitoren
US5908858A (en) * 1996-04-05 1999-06-01 Sankyo Company, Limited 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses

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EA200200591A1 (ru) 2002-12-26
AU2106501A (en) 2001-07-09
NO20023009D0 (no) 2002-06-21
CA2395173A1 (fr) 2001-07-05
HUP0300169A2 (en) 2003-05-28
JP2003519122A (ja) 2003-06-17
EP1244619A1 (fr) 2002-10-02
US6376489B1 (en) 2002-04-23
HUP0300169A3 (en) 2009-03-30
ZA200205015B (en) 2004-04-08
CN1246311C (zh) 2006-03-22
IL150287A0 (en) 2002-12-01
EA007589B1 (ru) 2006-12-29
PL355893A1 (en) 2004-05-31
AU778795B2 (en) 2004-12-23
WO2001047879A1 (fr) 2001-07-05
MXPA02006206A (es) 2004-02-26
CN1434798A (zh) 2003-08-06
KR20020063601A (ko) 2002-08-03
BR0016687A (pt) 2003-02-25

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