NO20020467L - Purinderivatinhibitorer av tyrosinproteinkinase syk - Google Patents

Purinderivatinhibitorer av tyrosinproteinkinase syk

Info

Publication number: NO20020467L
Authority: NO; Norway
Prior art keywords: ill; protein kinase; purine derivative; tyrosine protein; derivative inhibitors
Prior art date: 1999-07-30

Application number

NO20020467A

Other languages

English (en)

Other versions

NO20020467D0 (no

Inventor

Stephen Paul Collingwood

Judy Hayler

Darren Mark Le Grand

Henri Mattes

Keith Allan Menear

Clive Victor Walker

Xiao-Ling Cockcroft

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-30

Filing date

2002-01-29

Publication date

2002-03-20

2002-01-29 Application filed by Novartis Ag filed Critical Novartis Ag

2002-01-29 Publication of NO20020467D0 publication Critical patent/NO20020467D0/no

2002-03-20 Publication of NO20020467L publication Critical patent/NO20020467L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20020467A 1999-07-30 2002-01-29 Purinderivatinhibitorer av tyrosinproteinkinase syk NO20020467L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9918035.8A GB9918035D0 (en)	1999-07-30	1999-07-30	Organic compounds
PCT/EP2000/007311 WO2001009134A1 (en)	1999-07-30	2000-07-28	Purine derivatives inhibitors of tyrosine protein kinase syk

Publications (2)

Publication Number	Publication Date
NO20020467D0 NO20020467D0 (no)	2002-01-29
NO20020467L true NO20020467L (no)	2002-03-20

Family

ID=10858317

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20020467A NO20020467L (no)	1999-07-30	2002-01-29	Purinderivatinhibitorer av tyrosinproteinkinase syk

Country Status (33)

Country	Link
US (1)	US6589950B1 (no)
EP (1)	EP1200435B1 (no)
JP (2)	JP2003506375A (no)
KR (1)	KR100485289B1 (no)
CN (1)	CN1213047C (no)
AR (1)	AR029175A1 (no)
AT (1)	ATE251160T1 (no)
AU (1)	AU767349B2 (no)
BR (1)	BR0012888A (no)
CA (1)	CA2379560C (no)
CO (1)	CO5180626A1 (no)
CZ (1)	CZ2002299A3 (no)
DE (1)	DE60005684T2 (no)
DK (1)	DK1200435T3 (no)
EC (1)	ECSP003589A (no)
ES (1)	ES2208395T3 (no)
GB (1)	GB9918035D0 (no)
HK (1)	HK1046679A1 (no)
HU (1)	HUP0201935A3 (no)
IL (1)	IL147455A0 (no)
MX (1)	MXPA02001102A (no)
MY (1)	MY126862A (no)
NO (1)	NO20020467L (no)
NZ (1)	NZ516667A (no)
PE (1)	PE20010543A1 (no)
PL (1)	PL354477A1 (no)
PT (1)	PT1200435E (no)
RU (1)	RU2248977C2 (no)
SK (1)	SK285730B6 (no)
TR (1)	TR200200234T2 (no)
TW (2)	TWI255268B (no)
WO (1)	WO2001009134A1 (no)
ZA (1)	ZA200200783B (no)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1941501A (en) *	1999-11-30	2001-06-12	Parker Hughes Institute	Syk localized at centrosome
FR2802091A1 (fr) *	1999-12-08	2001-06-15	Oreal	Compositions pour la teinture des fibres keratiniques contenant des derives de paraphenylenediamine a groupement azetidinyle
JP2004509876A (ja)	2000-09-20	2004-04-02	メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング	４−アミノ−キナゾリン
EP1343782B1 (en) *	2000-12-21	2009-05-06	SmithKline Beecham Corporation	Pyrimidineamines as angiogenesis modulators
GB0101686D0 (en) *	2001-01-23	2001-03-07	Cancer Res Campaign Tech	Cyclin dependent kinase inhibitors
US7829566B2 (en)	2001-09-17	2010-11-09	Werner Mederski	4-amino-quinazolines
AU2002342051B2 (en) *	2001-10-12	2009-06-11	Irm Llc	Kinase inhibitor scaffolds and methods for their preparation
US20030158195A1 (en)	2001-12-21	2003-08-21	Cywin Charles L.	1,6 naphthyridines useful as inhibitors of SYK kinase
CA2472619A1 (en) *	2002-01-10	2003-07-24	Bayer Corporation	Fused pyrimidine derivates as rho-kinase inhibitors
US6924290B2 (en)	2002-01-23	2005-08-02	Bayer Pharmaceuticals Corporation	Rho-kinase inhibitors
US6943172B2 (en)	2002-01-23	2005-09-13	Bayer Pharmaceuticals Corporation	Rho-kinase inhibitors
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
OA12790A (en) *	2002-03-13	2006-07-10	Janssen Pharmaceutica Nv	New inhibitors of histone deacetylase.
CN1305850C (zh)	2002-03-13	2007-03-21	詹森药业有限公司	作为组蛋白脱乙酰酶新颖抑制剂的磺酰基氨基衍生物
US6897307B2 (en)	2002-03-28	2005-05-24	Novartis Ag	Process for preparing 2,6-diaminopurine derivatives
US6855724B2 (en)	2002-04-08	2005-02-15	Agouron Pharmaceuticals, Inc.	Tropane derivatives useful in therapy
IL165286A0 (en) *	2002-06-17	2005-12-18	Smithkline Beecham Corp	Chemical process
CA2492911A1 (en) *	2002-07-19	2004-01-29	Memory Pharmaceuticals Corporation	6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
CN103169708B (zh)	2002-07-29	2018-02-02	里格尔药品股份有限公司	用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法
EP1444982A1 (de) *	2003-02-06	2004-08-11	Merckle Gmbh	Verwendung von Purinderivaten als selektive Kinase-Inhibitoren
US7122542B2 (en)	2003-07-30	2006-10-17	Rigel Pharmaceuticals, Inc.	Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
AU2004264419B2 (en) *	2003-08-15	2009-01-15	Irm Llc	6-substituted anilino purines as RTK inhibitors
KR20060121878A (ko) *	2003-09-25	2006-11-29	얀센 파마슈티카 엔.브이.	Ｈｉｖ를 저해하는 퓨린 유도체
JP2007510671A (ja) *	2003-11-06	2007-04-26	セルジーン・コーポレーション	アスベスト関連疾患および障害の治療および管理のための、ｊｎｋ阻害剤の使用方法およびそれを含む組成物
ES2398239T3 (es)	2003-11-10	2013-03-14	The Scripps Research Institute	Composiciones y procedimientos para inducir la desdiferenciación celular
GB0407723D0 (en) *	2004-04-05	2004-05-12	Novartis Ag	Organic compounds
US8057815B2 (en) *	2004-04-19	2011-11-15	Portola Pharmaceuticals, Inc.	Methods of treatment with Syk inhibitors
WO2005118543A1 (ja) *	2004-06-03	2005-12-15	Ono Pharmaceutical Co., Ltd.	キナーゼ阻害薬およびその用途
US7439246B2 (en)	2004-06-28	2008-10-21	Bristol-Myers Squibb Company	Fused heterocyclic kinase inhibitors
US20050288290A1 (en) *	2004-06-28	2005-12-29	Borzilleri Robert M	Fused heterocyclic kinase inhibitors
JP2008508303A (ja)	2004-07-27	2008-03-21	エスジーエックスファーマシューティカルズ、インコーポレイテッド	ピロロ−ピリジンキナーゼモジュレーター
EP1778687A2 (en)	2004-07-27	2007-05-02	SGX Pharmaceuticals, Inc.	Fused ring heterocycle kinase modulators
US7361764B2 (en) *	2004-07-27	2008-04-22	Sgx Pharmaceuticals, Inc.	Pyrrolo-pyridine kinase modulators
US7626021B2 (en) *	2004-07-27	2009-12-01	Sgx Pharmaceuticals, Inc.	Fused ring heterocycle kinase modulators
US7709645B2 (en) *	2004-07-27	2010-05-04	Sgx Pharmaceuticals, Inc.	Pyrrolo-pyridine kinase modulators
WO2006010750A1 (en)	2004-07-28	2006-02-02	Janssen Pharmaceutica N.V.	Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
CA2579007A1 (en) *	2004-09-10	2006-03-16	Altana Pharma Ag	Ciclesonide and syk inhibitor combination and methods of use thereof
ATE540035T1 (de)	2004-11-24	2012-01-15	Rigel Pharmaceuticals Inc	Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
CN100526315C (zh) *	2005-06-16	2009-08-12	浙江医药股份有限公司新昌制药厂	N2-喹啉或异喹啉取代的嘌呤衍生物及其制备方法和其用途
US20080004295A1 (en) *	2005-10-13	2008-01-03	Gore Paul M	Novel compounds
US7803806B2 (en) *	2005-11-03	2010-09-28	Sgx Pharmaceuticals, Inc.	Pyrimidinyl-thiophene kinase modulators
WO2007070872A1 (en)	2005-12-15	2007-06-21	Rigel Pharmaceuticals, Inc.	Kinase inhibitors and their uses
US8114876B2 (en)	2006-01-19	2012-02-14	Janssen Pharmaceutica N.V.	Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
WO2007082882A1 (en) *	2006-01-19	2007-07-26	Janssen Pharmaceutica N.V.	Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
JP5225104B2 (ja) *	2006-01-19	2013-07-03	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	新しい、ヒストンデアセチラーゼのインヒビターとしてのアミノフェニル誘導体
EP2001480A4 (en) *	2006-03-31	2011-06-15	Abbott Lab	Indazole CONNECTIONS
PL2084162T3 (pl)	2006-10-23	2013-01-31	Sgx Pharmaceuticals Inc	Bicykliczne triazole jako modulatory kinaz białkowych
US20080139531A1 (en) *	2006-12-04	2008-06-12	Alcon Manufacturing Ltd.	Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
RS53588B1 (sr)	2006-12-08	2015-02-27	Irm Llc	Jedinjenja i kompozicije kao inhibitori protein kinaza
BRPI0720264B1 (pt) *	2006-12-08	2022-03-03	Novartis Ag	Compostos e composições como inibidores de proteína cinase
KR20090103897A (ko)	2006-12-28	2009-10-01	다이쇼 세이야꾸 가부시끼가이샤	피라졸로피리미딘 화합물
EP2134723B1 (en)	2007-03-07	2017-07-12	Boehringer Ingelheim International GmbH	2,6 diamino-9h-purine derivatives and their use in the treatment of proliferative diseases
JP2010524858A (ja)	2007-04-10	2010-07-22	エスジーエックスファーマシューティカルズ、インコーポレイテッド	縮合環複素環キナーゼ調節因子
CN101289449A (zh) *	2007-04-20	2008-10-22	浙江医药股份有限公司新昌制药厂	2,6-二含氮取代的嘌呤衍生物及其制备方法和应用
WO2008135232A1 (en) *	2007-05-02	2008-11-13	Riccardo Cortese	Use and compositions of purine derivatives for the treatment of proliferative disorders
WO2008144767A1 (en) *	2007-05-21	2008-11-27	Sgx Pharmaceuticals, Inc.	Heterocyclic kinase modulators
TW200908968A (en) *	2007-05-29	2009-03-01	Sgx Pharmaceuticals Inc	Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
WO2009026107A1 (en) *	2007-08-17	2009-02-26	Portola Pharmaceuticals, Inc.	Protein kinase inhibitors
FR2929851B1 (fr)	2008-04-09	2012-11-30	Centre Nat Rech Scient	Molecules inhibant une voie metabolique impliquant la proteine tyrosine kinase syk et procede d'identification de ces molecules
US8138339B2 (en)	2008-04-16	2012-03-20	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
PT2323993E (pt)	2008-04-16	2015-10-12	Portola Pharm Inc	2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak
US8258144B2 (en)	2008-04-22	2012-09-04	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
US9273077B2 (en)	2008-05-21	2016-03-01	Ariad Pharmaceuticals, Inc.	Phosphorus derivatives as kinase inhibitors
PT2300013T (pt)	2008-05-21	2017-10-31	Ariad Pharma Inc	Derivados de fósforo como inibidores de cinases
US20100029689A1 (en) *	2008-07-02	2010-02-04	Memory Pharmaceuticals Corporation	Phosphodiesterase 4 inhibitors
WO2010111406A2 (en) *	2009-03-24	2010-09-30	Myriad Pharmaceuticals, Inc.	Compounds and therapeutic uses thereof
MA33926B1 (fr) *	2009-12-17	2013-01-02	Merck Sharp & Dohme	Aminopyrimidines en tant qu'inhibiteurs de la syk
KR101790255B1 (ko) *	2009-12-23	2017-10-26	다케다 야쿠힌 고교 가부시키가이샤	Ｓｙｋ 억제제로서의 융합된 헤테로방향족 피롤리디논
WO2011153553A2 (en)	2010-06-04	2011-12-08	The Regents Of The University Of California	Methods and compositions for kinase inhibition
EP2489663A1 (en)	2011-02-16	2012-08-22	Almirall, S.A.	Compounds as syk kinase inhibitors
EP2704572B1 (en)	2011-05-04	2015-12-30	Ariad Pharmaceuticals, Inc.	Compounds for inhibiting cell proliferation in egfr-driven cancers
JP2014513687A (ja)	2011-05-10	2014-06-05	メルク・シャープ・アンド・ドーム・コーポレーション	Ｓｙｋ阻害薬としてのピリジルアミノピリジン
EP2706853B1 (en)	2011-05-10	2017-06-14	Merck Sharp & Dohme Corp.	Aminopyrimidines as syk inhibitors
EP2706852B1 (en)	2011-05-10	2018-08-22	Merck Sharp & Dohme Corp.	Bipyridylaminopyridines as syk inhibitors
AU2012262021B2 (en) *	2011-06-01	2016-07-28	Janus Biotherapeutics, Inc.	Novel immune system modulators
EP2723739B1 (en)	2011-06-22	2016-08-24	Takeda Pharmaceutical Company Limited	Substituted 6-aza-isoindolin-1-one derivatives
US8987456B2 (en)	2011-10-05	2015-03-24	Merck Sharp & Dohme Corp.	3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
EP2763976B1 (en)	2011-10-05	2016-05-18	Merck Sharp & Dohme Corp.	2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
EP2763974B1 (en)	2011-10-05	2016-09-14	Merck Sharp & Dohme Corp.	Phenyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
US8877760B2 (en)	2011-11-23	2014-11-04	Portola Pharmaceuticals, Inc.	Substituted pyrazine-2-carboxamide kinase inhibitors
AR090650A1 (es) *	2012-04-12	2014-11-26	Alcon Res Ltd	Tratamiento para respuestas inflamatorias inducidas por microbios en el ojo
AU2013204563B2 (en)	2012-05-05	2016-05-19	Takeda Pharmaceutical Company Limited	Compounds for inhibiting cell proliferation in EGFR-driven cancers
EP2863914B1 (en)	2012-06-20	2018-10-03	Merck Sharp & Dohme Corp.	Pyrazolyl derivatives as syk inhibitors
WO2013192128A1 (en)	2012-06-20	2013-12-27	Merck Sharp & Dohme Corp.	Imidazolyl analogs as syk inhibitors
WO2013192098A1 (en)	2012-06-22	2013-12-27	Merck Sharp & Dohme Corp.	SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS
EP2863915B1 (en)	2012-06-22	2017-12-06	Merck Sharp & Dohme Corp.	SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS
WO2014031438A2 (en)	2012-08-20	2014-02-27	Merck Sharp & Dohme Corp.	SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS
WO2014048065A1 (en)	2012-09-28	2014-04-03	Merck Sharp & Dohme Corp.	Triazolyl derivatives as syk inhibitors
US9624210B2 (en)	2012-12-12	2017-04-18	Merck Sharp & Dohme Corp.	Amino-pyrimidine-containing spleen tyrosine kinase (Syk) inhibitors
EP2934525B1 (en)	2012-12-21	2019-05-08	Merck Sharp & Dohme Corp.	Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
US9611283B1 (en)	2013-04-10	2017-04-04	Ariad Pharmaceuticals, Inc.	Methods for inhibiting cell proliferation in ALK-driven cancers
EP2988749B1 (en)	2013-04-26	2019-08-14	Merck Sharp & Dohme Corp.	Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
US9745295B2 (en)	2013-04-26	2017-08-29	Merck Sharp & Dohme Corp.	Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
CN104418858B (zh) *	2013-08-30	2018-12-11	浙江医药股份有限公司新昌制药厂	2,6-二含氮取代的嘌呤衍生物及其制备方法和其药物组合物与应用
EP3082807B1 (en)	2013-12-20	2018-07-04	Merck Sharp & Dohme Corp.	Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
WO2015095445A1 (en)	2013-12-20	2015-06-25	Merck Sharp & Dohme Corp.	Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9670196B2 (en)	2013-12-20	2017-06-06	Merck Sharp & Dohme Corp.	Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors
WO2015138273A1 (en)	2014-03-13	2015-09-17	Merck Sharp & Dohme Corp.	2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
WO2015162518A1 (en)	2014-04-25	2015-10-29	Pfizer Inc.	Heteroaromatic compounds and their use as dopamine d1 ligands
RU2570113C1 (ru) *	2014-12-08	2015-12-10	Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук	N-(2-ацетамидопурин-6-ил)глицин, обладающий противотуберкулезной активностью
US10913744B2 (en)	2015-02-13	2021-02-09	Dana-Farber Cancer Institute, Inc.	LRRK2 inhibitors and methods of making and using the same
RU2018106663A (ru) *	2015-07-24	2019-08-26	Глэксо Груп Лимитед	Лечение витилиго
US10711002B2 (en)	2016-04-21	2020-07-14	The Royal Institution For The Advancement Of Learning/Mcgill University	Purine compounds and method for the treatment of cancer
IL266109B2 (en) *	2016-10-21	2025-05-01	Nimbus Lakshmi Inc	Tyk2 inhibitors and uses thereof
MX2020004155A (es)	2017-10-19	2020-08-03	Bayer Animal Health Gmbh	Uso de pirrolidonas heteroaromaticas fusionadas para el tratamiento y prevencion de enfermedades en animales.
WO2019241896A1 (en) *	2018-06-22	2019-12-26	The Royal Institution For The Advancement Of Learning/Mcgill University	Purine compounds and method for the treatment of cancer
WO2020123675A1 (en) *	2018-12-11	2020-06-18	Duke University	Compositions and methods for the treatment of cancer
AU2020242287A1 (en)	2019-03-21	2021-09-02	INSERM (Institut National de la Santé et de la Recherche Médicale)	A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko)	2019-11-08	2022-07-12	인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔)	키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3529497A1 (de)	1985-08-17	1987-02-26	Boehringer Mannheim Gmbh	N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US5583137A (en) *	1992-02-19	1996-12-10	Pfizer Inc.	Heterocyclic compounds for enhancing antitumor activity
CZ236494A3 (en)	1992-04-03	1994-12-15	Upjohn Co	Pharmaceutically active bicyclic-heterocyclic amines
US5550132A (en)	1994-06-22	1996-08-27	University Of North Carolina	Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines
GB9417249D0 (en) *	1994-08-26	1994-10-19	Wellcome Found	A novel salt
AU7296896A (en) *	1995-11-01	1997-05-22	Novartis Ag	Purine derivatives and processes for their preparation
US5866702A (en)	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2
JP2001516694A (ja)	1997-08-07	2001-10-02	ザリージェンツオブザユニバーシティオブカリフォルニア	プロテインキナーゼ、ｇプロテイン及びポリメラーゼのプリン阻害剤
GB9903762D0 (en) *	1999-02-18	1999-04-14	Novartis Ag	Organic compounds

1999
- 1999-07-30 GB GBGB9918035.8A patent/GB9918035D0/en not_active Ceased
2000
- 2000-07-20 TW TW089114515A patent/TWI255268B/zh not_active IP Right Cessation
- 2000-07-20 TW TW94101835A patent/TWI274754B/zh not_active IP Right Cessation
- 2000-07-25 PE PE2000000744A patent/PE20010543A1/es not_active Application Discontinuation
- 2000-07-26 CO CO00056110A patent/CO5180626A1/es not_active Application Discontinuation
- 2000-07-27 AR ARP000103890A patent/AR029175A1/es unknown
- 2000-07-27 EC EC2000003589A patent/ECSP003589A/es unknown
- 2000-07-28 US US10/048,577 patent/US6589950B1/en not_active Expired - Lifetime
- 2000-07-28 CZ CZ2002299A patent/CZ2002299A3/cs unknown
- 2000-07-28 JP JP2001514337A patent/JP2003506375A/ja not_active Withdrawn
- 2000-07-28 HU HU0201935A patent/HUP0201935A3/hu unknown
- 2000-07-28 CA CA002379560A patent/CA2379560C/en not_active Expired - Fee Related
- 2000-07-28 WO PCT/EP2000/007311 patent/WO2001009134A1/en not_active Ceased
- 2000-07-28 HK HK02107013.6A patent/HK1046679A1/zh unknown
- 2000-07-28 AU AU65677/00A patent/AU767349B2/en not_active Ceased
- 2000-07-28 BR BR0012888-0A patent/BR0012888A/pt not_active Application Discontinuation
- 2000-07-28 DE DE60005684T patent/DE60005684T2/de not_active Expired - Fee Related
- 2000-07-28 IL IL14745500A patent/IL147455A0/xx unknown
- 2000-07-28 ES ES00953112T patent/ES2208395T3/es not_active Expired - Lifetime
- 2000-07-28 TR TR2002/00234T patent/TR200200234T2/xx unknown
- 2000-07-28 KR KR10-2002-7001276A patent/KR100485289B1/ko not_active Expired - Fee Related
- 2000-07-28 EP EP00953112A patent/EP1200435B1/en not_active Expired - Lifetime
- 2000-07-28 CN CNB008110263A patent/CN1213047C/zh not_active Expired - Fee Related
- 2000-07-28 MX MXPA02001102A patent/MXPA02001102A/es active IP Right Grant
- 2000-07-28 DK DK00953112T patent/DK1200435T3/da active
- 2000-07-28 AT AT00953112T patent/ATE251160T1/de not_active IP Right Cessation
- 2000-07-28 MY MYPI20003444 patent/MY126862A/en unknown
- 2000-07-28 NZ NZ516667A patent/NZ516667A/en unknown
- 2000-07-28 RU RU2002103305/04A patent/RU2248977C2/ru not_active IP Right Cessation
- 2000-07-28 PT PT00953112T patent/PT1200435E/pt unknown
- 2000-07-28 SK SK126-2002A patent/SK285730B6/sk not_active IP Right Cessation
- 2000-07-28 PL PL00354477A patent/PL354477A1/xx not_active Application Discontinuation
2002
- 2002-01-29 ZA ZA200200783A patent/ZA200200783B/en unknown
- 2002-01-29 NO NO20020467A patent/NO20020467L/no not_active Application Discontinuation
2007
- 2007-05-16 JP JP2007130684A patent/JP2007217426A/ja active Pending

Also Published As

Publication number	Publication date
DE60005684D1 (de)	2003-11-06
CN1365360A (zh)	2002-08-21
HUP0201935A3 (en)	2005-02-28
EP1200435B1 (en)	2003-10-01
KR20020015394A (ko)	2002-02-27
RU2248977C2 (ru)	2005-03-27
JP2003506375A (ja)	2003-02-18
AU767349B2 (en)	2003-11-06
HUP0201935A2 (hu)	2002-11-28
AU6567700A (en)	2001-02-19
US6589950B1 (en)	2003-07-08
TW200524932A (en)	2005-08-01
ES2208395T3 (es)	2004-06-16
CA2379560C (en)	2009-09-29
ECSP003589A (es)	2002-02-25
NO20020467D0 (no)	2002-01-29
CO5180626A1 (es)	2002-07-30
SK1262002A3 (en)	2002-07-02
PT1200435E (pt)	2004-02-27
IL147455A0 (en)	2002-08-14
ATE251160T1 (de)	2003-10-15
GB9918035D0 (en)	1999-09-29
MY126862A (en)	2006-10-31
WO2001009134A1 (en)	2001-02-08
BR0012888A (pt)	2002-04-09
CN1213047C (zh)	2005-08-03
EP1200435A1 (en)	2002-05-02
TR200200234T2 (tr)	2002-06-21
AR029175A1 (es)	2003-06-18
CZ2002299A3 (cs)	2002-04-17
DK1200435T3 (da)	2004-02-02
SK285730B6 (sk)	2007-07-06
NZ516667A (en)	2004-05-28
HK1046679A1 (zh)	2003-01-24
TWI255268B (en)	2006-05-21
CA2379560A1 (en)	2001-02-08
PL354477A1 (en)	2004-01-26
TWI274754B (en)	2007-03-01
MXPA02001102A (es)	2002-08-20
JP2007217426A (ja)	2007-08-30
ZA200200783B (en)	2003-04-30
KR100485289B1 (ko)	2005-04-27
PE20010543A1 (es)	2001-05-14
DE60005684T2 (de)	2004-07-29

Publication	Publication Date	Title
NO20020467L (no)	2002-03-20	Purinderivatinhibitorer av tyrosinproteinkinase syk
CY2008015I2 (el)	2009-11-04	Δικυκλικες ετepοαρωματικες ενωσεις σαν αναστολεις πρωτεϊνης κινασης τυροσινης
FR13C0003I2 (fr)	2015-11-20	Inhibiteurs cycliques de proteine tyrosine kinase
ATE445613T1 (de)	2009-10-15	Indolylmaleimidderivative als proteinkinase-c- inhibitoren
CY2014034I2 (el)	2016-04-13	Υποκατεστημενες 3-κυανοκινολινες ως αναστολεις κινασων πρωτεϊνης τυροσινης
NO20021820L (no)	2002-05-23	Tyrosinkinaseinhibitorer
EP1161433A4 (en)	2002-05-08	TYROSINE KINASE INHIBITORS
ATE255575T1 (de)	2003-12-15	Substituierte 3-cyanochinoline als protein tyrosine kinase inhibitoren
NO20022864L (no)	2002-08-13	Aminotiazol inhibitorer av syklin uavhengig kinase
ATE430149T1 (de)	2009-05-15	Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren
DE60117568D1 (de)	2006-04-27	Kondensierte pyrazol derivate als protein kinase inhibitoren
NO20021783L (no)	2002-04-16	Alkylamino-substituerte bicykliske nitrogen-heterocykler som inhibitorer for P38-protein-kinase
DE69511253D1 (de)	1999-09-09	Wasserlösliche 3-arylidene-2-oxindole derivate als tyrosine kinase inhibitoren
NO990123D0 (no)	1999-01-12	Bicykliske heteroaromatiske forbindelser som protein-tyrosin-kinase-inhibitorer
NO990124D0 (no)	1999-01-12	Bicykliske heteroaromatiske forbindelser som protein-tyrosin-kinase-inhibitorer
ATE214381T1 (de)	2002-03-15	Thiazole derivate als protein kinase c inhibitoren
ATE205836T1 (de)	2001-10-15	Bicyclische 4-aralkylaminopyrimidin-derivate als tyrosinkinase-inhibitoren

Legal Events

Date	Code	Title	Description
2010-02-15	FC2A	Withdrawal, rejection or dismissal of laid open patent application