NO20016341L - Inhibitorer for integrinet <alfa>v<beta>6 - Google Patents
Inhibitorer for integrinet <alfa>v<beta>6Info
- Publication number
- NO20016341L NO20016341L NO20016341A NO20016341A NO20016341L NO 20016341 L NO20016341 L NO 20016341L NO 20016341 A NO20016341 A NO 20016341A NO 20016341 A NO20016341 A NO 20016341A NO 20016341 L NO20016341 L NO 20016341L
- Authority
- NO
- Norway
- Prior art keywords
- asp
- leu
- arg
- xer
- phe
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000006495 integrins Human genes 0.000 title abstract 2
- 108010044426 integrins Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Oppfinnelsen vedrører nye peptider med formel (I) : Ac-Arg-X^Asp-X^X^XXNH, som er biologisk aktive som ligander for integrinet ctvP, hvor: Ac er acetyl; Xer Ser, Gly, Thr, Asp, Arg, Val, Tyr, His ellerla;er Leu, Ile, Nie, Val eller Phe;er Asp, Glu, Lys, Phe, Aib, Nal, Gly, Ala, Bgl eller Phg; Xer Gly, Ala, Ser, PAla eller co-Abu; Xer Leu, Ile,ie, Val eller Phe; og Xer Arg, Har, Lys, Leu, Orn, Phe, Ala, Tyr, Gly, Ser eller Asp, hvorved de ovenfor nevnte amino-syrer kan være derivatiserte. Amino-syreradikalene er bundet til hverandre på en peptidlignende måte via a-amino-gruppene og a-karboksygruppene. Så vel de dekstrodreiende former og de levo-dreiende former av de optisk aktive aminosyreradikaler som saltene av peptidene er omfattet. Ac-Arg-Thr-Asp-Leu-Asp-Ser-Leu-Arg-NHer utelukket. Peptidene ifølge oppfinnelsen kan også anvendes som effektive inhibitorer for-integrinreseptoren, og således for behandling av forskjellige sykdommer og patologiske funn.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19929410A DE19929410A1 (de) | 1999-06-26 | 1999-06-26 | Inhibitoren des Integrins avß6 |
| PCT/EP2000/005404 WO2001000660A1 (de) | 1999-06-26 | 2000-06-13 | INHIBITOREN DES INTEGRINS αv$(g)b¿6? |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20016341D0 NO20016341D0 (no) | 2001-12-21 |
| NO20016341L true NO20016341L (no) | 2002-02-25 |
Family
ID=7912712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20016341A NO20016341L (no) | 1999-06-26 | 2001-12-21 | Inhibitorer for integrinet <alfa>v<beta>6 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1189930A1 (no) |
| JP (1) | JP2003503422A (no) |
| KR (1) | KR20020015704A (no) |
| CN (1) | CN1358195A (no) |
| AR (1) | AR024472A1 (no) |
| AU (1) | AU771099B2 (no) |
| BR (1) | BR0011954A (no) |
| CA (1) | CA2377224A1 (no) |
| CZ (1) | CZ20014484A3 (no) |
| DE (1) | DE19929410A1 (no) |
| HU (1) | HUP0201729A3 (no) |
| MX (1) | MXPA01013247A (no) |
| NO (1) | NO20016341L (no) |
| PL (1) | PL352374A1 (no) |
| SK (1) | SK18722001A3 (no) |
| WO (1) | WO2001000660A1 (no) |
| ZA (1) | ZA200200673B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| RU2005127668A (ru) * | 2003-02-06 | 2006-01-27 | Мерк Патент ГмбХ (DE) | Пептидные сульфонамиды |
| GB0520068D0 (en) * | 2005-10-03 | 2005-11-09 | Cancer Res Technology | av peptide ligand |
| JP5362563B2 (ja) | 2006-08-03 | 2013-12-11 | アストラゼネカ・アクチエボラーグ | αＶβ６に対する抗体およびその使用 |
| CN109952376B (zh) | 2016-11-01 | 2023-09-05 | 箭头药业股份有限公司 | αvβ6整联蛋白配体及其应用 |
| IL274300B2 (en) | 2017-11-01 | 2024-09-01 | Arrowhead Pharmaceuticals Inc | Alpha v beta 6 integrin ligands, compositions comprising same and uses thereof |
| KR20230167082A (ko) | 2021-04-08 | 2023-12-07 | 애로우헤드 파마슈티컬스 인코포레이티드 | 진행성 당화 최종 산물에 대한 수용체의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2029392A (en) * | 1991-05-14 | 1992-12-30 | Board Of Regents Of The University Of Oklahoma, The | Peptide inhibitors of inflammation |
| PT996460E (pt) * | 1997-08-08 | 2005-04-29 | Univ California | Tratamento da fibrose renal com anticorpos contra integrina alfa-v-beta 6 |
| JP2002533064A (ja) * | 1998-12-19 | 2002-10-08 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | インテグリンαｖβ６阻害剤 |
-
1999
- 1999-06-26 DE DE19929410A patent/DE19929410A1/de not_active Withdrawn
-
2000
- 2000-06-13 WO PCT/EP2000/005404 patent/WO2001000660A1/de not_active Ceased
- 2000-06-13 BR BR0011954-7A patent/BR0011954A/pt not_active IP Right Cessation
- 2000-06-13 KR KR1020017016580A patent/KR20020015704A/ko not_active Withdrawn
- 2000-06-13 SK SK1872-2001A patent/SK18722001A3/sk unknown
- 2000-06-13 CN CN00809493A patent/CN1358195A/zh active Pending
- 2000-06-13 CZ CZ20014484A patent/CZ20014484A3/cs unknown
- 2000-06-13 JP JP2001507066A patent/JP2003503422A/ja active Pending
- 2000-06-13 PL PL00352374A patent/PL352374A1/xx unknown
- 2000-06-13 AU AU62630/00A patent/AU771099B2/en not_active Ceased
- 2000-06-13 HU HU0201729A patent/HUP0201729A3/hu unknown
- 2000-06-13 MX MXPA01013247A patent/MXPA01013247A/es unknown
- 2000-06-13 EP EP00949177A patent/EP1189930A1/de not_active Withdrawn
- 2000-06-13 CA CA002377224A patent/CA2377224A1/en not_active Abandoned
- 2000-06-23 AR ARP000103177A patent/AR024472A1/es not_active Application Discontinuation
-
2001
- 2001-12-21 NO NO20016341A patent/NO20016341L/no not_active Application Discontinuation
-
2002
- 2002-01-24 ZA ZA200200673A patent/ZA200200673B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001000660A1 (de) | 2001-01-04 |
| KR20020015704A (ko) | 2002-02-28 |
| DE19929410A1 (de) | 2000-12-28 |
| AU771099B2 (en) | 2004-03-11 |
| MXPA01013247A (es) | 2002-07-02 |
| SK18722001A3 (sk) | 2002-05-09 |
| CA2377224A1 (en) | 2001-01-04 |
| HUP0201729A3 (en) | 2005-01-28 |
| CN1358195A (zh) | 2002-07-10 |
| ZA200200673B (en) | 2003-04-24 |
| JP2003503422A (ja) | 2003-01-28 |
| AU6263000A (en) | 2001-01-31 |
| PL352374A1 (en) | 2003-08-25 |
| NO20016341D0 (no) | 2001-12-21 |
| CZ20014484A3 (cs) | 2002-04-17 |
| BR0011954A (pt) | 2002-05-07 |
| HUP0201729A2 (en) | 2002-08-28 |
| EP1189930A1 (de) | 2002-03-27 |
| AR024472A1 (es) | 2002-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |