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NO20016071L - Fremgangsmåte for stabilisering av proteiner i komplekse blandinger i löpet av deres lagring i vandige opplösningsmidler - Google Patents

Fremgangsmåte for stabilisering av proteiner i komplekse blandinger i löpet av deres lagring i vandige opplösningsmidler

Info

Publication number
NO20016071L
NO20016071L NO20016071A NO20016071A NO20016071L NO 20016071 L NO20016071 L NO 20016071L NO 20016071 A NO20016071 A NO 20016071A NO 20016071 A NO20016071 A NO 20016071A NO 20016071 L NO20016071 L NO 20016071L
Authority
NO
Norway
Prior art keywords
course
storage
aqueous solvents
complex mixtures
stabilizing proteins
Prior art date
Application number
NO20016071A
Other languages
English (en)
Other versions
NO329429B1 (no
NO20016071D0 (no
Inventor
Franz-Josef Rubroeder
Reinhold Keller
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20016071D0 publication Critical patent/NO20016071D0/no
Publication of NO20016071L publication Critical patent/NO20016071L/no
Publication of NO329429B1 publication Critical patent/NO329429B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Foreliggende oppfinnelse angår en fremgangsmåte for lagring av proteiner i et vandig oppløsningsmiddel. Tilsats av cystein forsinker reduksjon av den virksomme konsentrasjonen av proteinet. Fremgangsmåten egner seg for anvendelse ved produksjon av proteiner i mikroorganismer.
NO20016071A 1999-07-02 2001-12-12 Fremgangsmate for lagring av insulin i et vandig opplosningsmiddel. NO329429B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19930676A DE19930676B4 (de) 1999-07-02 1999-07-02 Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
PCT/EP2000/005666 WO2001002435A1 (de) 1999-07-02 2000-06-20 Verfahren zur stabilisierung von proteinen in komplexen mischungen bei deren lagerung in wässrigen lösungsmitteln

Publications (3)

Publication Number Publication Date
NO20016071D0 NO20016071D0 (no) 2001-12-12
NO20016071L true NO20016071L (no) 2001-12-12
NO329429B1 NO329429B1 (no) 2010-10-18

Family

ID=7913515

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20016071A NO329429B1 (no) 1999-07-02 2001-12-12 Fremgangsmate for lagring av insulin i et vandig opplosningsmiddel.

Country Status (25)

Country Link
US (3) US6339061B1 (no)
EP (1) EP1196447B1 (no)
JP (1) JP4555525B2 (no)
KR (1) KR100754235B1 (no)
CN (1) CN1220703C (no)
AR (1) AR024621A1 (no)
AT (1) ATE423137T1 (no)
AU (1) AU768443B2 (no)
BR (1) BRPI0012150B8 (no)
CA (1) CA2377794C (no)
CY (1) CY1109050T1 (no)
DE (2) DE19930676B4 (no)
DK (1) DK1196447T3 (no)
ES (1) ES2321373T3 (no)
HK (1) HK1047115B (no)
HU (1) HU228936B1 (no)
IL (2) IL147250A0 (no)
MX (1) MXPA01012836A (no)
NO (1) NO329429B1 (no)
NZ (1) NZ516372A (no)
PL (1) PL200145B1 (no)
PT (1) PT1196447E (no)
SI (1) SI1196447T1 (no)
WO (1) WO2001002435A1 (no)
ZA (1) ZA200110507B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10224111A1 (de) * 2002-05-29 2003-12-18 November Ag Molekulare Medizin Verfahren zum Assemblieren von Untereinheiten zu Kapsoiden
US20060201877A1 (en) * 2005-03-10 2006-09-14 Baldridge John W Septic system cleaning
US8116073B2 (en) * 2010-01-26 2012-02-14 Amtek System Co., Ltd. Display structure of slip-cover-hinge electronic device
CN108404194A (zh) * 2018-04-20 2018-08-17 朱清 一种快速止血纱布的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4371523A (en) * 1980-12-29 1983-02-01 The Regents Of The University Of California Reducing the aggregation of insulin in solution
FI78616C (fi) * 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
EP0158487B1 (en) * 1984-04-09 1991-08-28 Takeda Chemical Industries, Ltd. Stable composition of interleukin-2
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
US4937085A (en) * 1986-08-15 1990-06-26 Agra-Research, Inc. Discoloration preventing food preservative and method
GB8806893D0 (en) * 1988-03-23 1988-04-27 Unilever Plc Cosmetic composition
KR900003362A (ko) * 1988-08-24 1990-03-26 전학제 유전공학기법을 이용한 인체 인슈린 유사체의 제조방법
JPH0341033A (ja) * 1989-07-07 1991-02-21 Kyowa Hakko Kogyo Co Ltd 安定なモチリン類含有製剤
GR1005153B (el) 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
US5227293A (en) 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
IL139335A (en) * 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
US6165981A (en) * 1995-03-07 2000-12-26 Dade Behring Inc. Stabilizing solutions for proteins and peptides
US5780431A (en) * 1996-09-20 1998-07-14 Neurobiological Technologies, Inc. Pharmaceutical formulations of corticotropin releasing factor having improved stability in liquid form
DE19735711C2 (de) * 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken

Also Published As

Publication number Publication date
HK1047115A1 (en) 2003-02-07
CN1220703C (zh) 2005-09-28
BRPI0012150B8 (pt) 2021-05-25
PL353160A1 (en) 2003-10-20
BR0012150A (pt) 2002-05-21
US20020058623A1 (en) 2002-05-16
HK1047115B (zh) 2006-02-24
SI1196447T1 (sl) 2009-08-31
NZ516372A (en) 2004-03-26
KR100754235B1 (ko) 2007-09-03
DE19930676A1 (de) 2001-01-18
AU5816400A (en) 2001-01-22
JP2003504313A (ja) 2003-02-04
CA2377794A1 (en) 2001-01-11
US6339061B1 (en) 2002-01-15
ATE423137T1 (de) 2009-03-15
IL147250A (en) 2010-02-17
EP1196447A1 (de) 2002-04-17
PT1196447E (pt) 2009-04-20
WO2001002435A1 (de) 2001-01-11
ES2321373T3 (es) 2009-06-05
KR20020026515A (ko) 2002-04-10
DK1196447T3 (da) 2009-06-15
NO329429B1 (no) 2010-10-18
EP1196447B1 (de) 2009-02-18
NO20016071D0 (no) 2001-12-12
HUP0202264A2 (en) 2002-10-28
PL200145B1 (pl) 2008-12-31
MXPA01012836A (es) 2002-07-30
JP4555525B2 (ja) 2010-10-06
CA2377794C (en) 2011-12-06
DE50015562D1 (de) 2009-04-02
HUP0202264A3 (en) 2005-01-28
AR024621A1 (es) 2002-10-16
BRPI0012150B1 (pt) 2016-06-14
DE19930676B4 (de) 2006-01-19
US6734164B2 (en) 2004-05-11
US20040230038A1 (en) 2004-11-18
CY1109050T1 (el) 2014-07-02
AU768443B2 (en) 2003-12-11
CN1357008A (zh) 2002-07-03
US7514403B2 (en) 2009-04-07
IL147250A0 (en) 2002-08-14
HU228936B1 (en) 2013-06-28
ZA200110507B (en) 2002-07-24

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