NO20003671L - 4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister - Google Patents

4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister

Info

Publication number: NO20003671L
Authority: NO; Norway
Prior art keywords: benzimidazolinyl; keto; receptor agonists; piperidine compounds; aryl
Prior art date: 1998-01-19

Application number

NO20003671A

Other languages

English (en)

Norwegian (no)

Other versions

NO20003671D0 (no

Inventor

Fumitaka Ito

Hiroshi Kondo

Hirohide Noguchi

Yoriko Ohashi

Tatsuya Yamagishi

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-19

Filing date

2000-07-18

Publication date

2000-09-18

2000-07-18 Application filed by Pfizer filed Critical Pfizer

2000-07-18 Publication of NO20003671D0 publication Critical patent/NO20003671D0/no

2000-09-18 Publication of NO20003671L publication Critical patent/NO20003671L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

NO20003671A 1998-01-19 2000-07-18 4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister NO20003671L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB9800069		1998-01-19
PCT/IB1999/000012 WO1999036421A1 (fr)	1998-01-19	1999-01-08	Composes de 4-(2-ceto-1-benzimidazolinyl)piperidine, utiles comme agonistes du recepteur orl1

Publications (2)

Publication Number	Publication Date
NO20003671D0 NO20003671D0 (no)	2000-07-18
NO20003671L true NO20003671L (no)	2000-09-18

Family

ID=11004651

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20003671A NO20003671L (no)	1998-01-19	2000-07-18	4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister

Country Status (30)

Country	Link
US (1)	US6423725B1 (fr)
EP (1)	EP1049689B1 (fr)
JP (1)	JP3342478B2 (fr)
CN (1)	CN1288464A (fr)
AP (1)	AP9901442A0 (fr)
AR (1)	AR014421A1 (fr)
AT (1)	ATE219772T1 (fr)
AU (1)	AU1679099A (fr)
BG (1)	BG104670A (fr)
BR (1)	BR9907104A (fr)
CA (1)	CA2317462C (fr)
CO (1)	CO4990962A1 (fr)
DE (1)	DE69901934T2 (fr)
DK (1)	DK1049689T3 (fr)
EA (1)	EA200000683A1 (fr)
ES (1)	ES2175925T3 (fr)
GT (1)	GT199900008A (fr)
IL (1)	IL137149A0 (fr)
IS (1)	IS5539A (fr)
MA (1)	MA26598A1 (fr)
NO (1)	NO20003671L (fr)
OA (1)	OA11445A (fr)
PA (1)	PA8467101A1 (fr)
PE (1)	PE20000166A1 (fr)
PL (1)	PL342046A1 (fr)
PT (1)	PT1049689E (fr)
TN (1)	TNSN99006A1 (fr)
TR (1)	TR200002090T2 (fr)
WO (1)	WO1999036421A1 (fr)
ZA (1)	ZA99314B (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6262066B1 (en)	1998-07-27	2001-07-17	Schering Corporation	High affinity ligands for nociceptin receptor ORL-1
ES2237047T3 (es) *	1998-10-23	2005-07-16	Pfizer Inc.	Compuestos de 1,3,8-triazaespiro(4,5)decanona como agonistas del receptor orl1.
AU1185300A (en) *	1998-11-20	2000-06-13	Banyu Pharmaceutical Co., Ltd.	2-oxoimidazole derivatives
SE9903544D0 (sv)	1999-10-01	1999-10-01	Astra Pharma Prod	Novel compounds
US6699880B1 (en)	1999-10-13	2004-03-02	Banyu Pharmaceutical Co., Ltd.	Substituted imidazolidinone derivatives
HK1049799A1 (zh)	1999-12-06	2003-05-30	Euro-Celtique, S.A.	具有类鸦片受体亲和力的三级氨基化合物
US6686370B2 (en)	1999-12-06	2004-02-03	Euro-Celtique S.A.	Triazospiro compounds having nociceptin receptor affinity
AU1816901A (en) *	1999-12-06	2001-06-12	Euro-Celtique S.A.	Benzimidazole compounds having nociceptin receptor affinity
GB2359078A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB2359081A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active thiazolopyrimidines
GB2359551A (en)	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en)	2000-03-10	2000-05-03	Astrazeneca Uk Ltd	Chemical compounds
SE0003828D0 (sv)	2000-10-20	2000-10-20	Astrazeneca Ab	Novel compounds
WO2002040019A1 (fr) *	2000-11-15	2002-05-23	Banyu Pharmaceutical Co.,Ltd.	Derives benzimidazoles
SE0101322D0 (sv)	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
EP1385515B1 (fr)	2001-04-18	2008-08-06	Euro-Celtique S.A.	Composes de spiropyrazole
CN100441182C (zh)	2001-04-18	2008-12-10	欧罗赛铁克股份有限公司	伤害感受肽化合物
ATE413175T1 (de)	2001-04-18	2008-11-15	Euro Celtique Sa	Spiroinden- und spiroindan-verbindungen
EP1598338B9 (fr) *	2001-04-18	2009-11-18	Euro-Celtique S.A.	Derivés de la 1-(4-piperidinyl)-1,3-dihydro-2h-indole-2-one et composés similaires pour l'utilisation comme analogues du nociceptin et ligands du orl1 pour le traitement de la douleur
SI1975164T1 (sl) *	2001-04-18	2010-05-31	Euro Celtique Sa	Oktahidrobenzimidazolonske spojine kot analgetiki
DE10123163A1 (de) *	2001-05-09	2003-01-16	Gruenenthal Gmbh	Substituierte Cyclohexan-1,4-diaminderivate
JP3896309B2 (ja)	2001-07-09	2007-03-22	ファイザー株式会社	プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
EP1491212B1 (fr) *	2002-03-29	2012-08-08	Mitsubishi Tanabe Pharma Corporation	Remede contre les troubles du sommeil
JP2005289816A (ja)	2002-05-14	2005-10-20	Banyu Pharmaceut Co Ltd	ベンズイミダゾール誘導体
GB0221828D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
ATE457299T1 (de)	2002-11-12	2010-02-15	Gruenenthal Gmbh	4-hydroxymethyl-1-aryl-cyclohexylamin-derivativ
AR045939A1 (es)	2003-09-25	2005-11-16	Solvay Pharm Bv	Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
AR045843A1 (es) *	2003-10-03	2005-11-16	Solvay Pharm Bv	Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
GB0328243D0 (en)	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
AR054816A1 (es) *	2005-07-13	2007-07-18	Banyu Pharma Co Ltd	Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
US7300947B2 (en) *	2005-07-13	2007-11-27	Banyu Pharmaceutical Co., Ltd.	N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
WO2007061862A2 (fr) *	2005-11-18	2007-05-31	Janssen Pharmaceutica N.V.	2-ceto-oxazoles en tant que modulateurs d'amide d'acide gras hydrolase
JP2009525269A (ja)	2006-01-30	2009-07-09	ユーロ−セルティークエス．エイ．	カルシウムチャネルブロッカーとしての環状尿素化合物
GB0605784D0 (en) *	2006-03-22	2006-05-03	Glaxo Group Ltd	Compounds
GB0605786D0 (en) *	2006-03-22	2006-05-03	Glaxo Group Ltd	Compounds
US8207201B2 (en)	2006-10-16	2012-06-26	Mitsubishi Tanabe Pharma Corporation	Agent for prophylaxis or treatment of alcohol dependence or drug dependence
MX2009007644A (es) *	2007-01-16	2009-07-27	Purdue Pharma Lp	Compuestos de piperidina heterociclicos sustituidos y usos de los mismos.
BRPI0808025A2 (pt) *	2007-03-01	2014-06-24	Mitsubishi Tanabe Pharma Corp	Composto de benzimidazol e uso farmacêutico do mesmo
KR20120102172A (ko)	2007-08-31	2012-09-17	시오노기세이야쿠가부시키가이샤	치환-퀴녹살린-형 피페리딘 화합물 및 그의 용도
US8119661B2 (en)	2007-09-11	2012-02-21	Astrazeneca Ab	Piperidine derivatives and their use as muscarinic receptor modulators
TW201016675A (en)	2008-09-16	2010-05-01	Mitsubishi Tanabe Pharma Corp	Crystalline benzoimidazole compound and salt thereof
JP2013532149A (ja) *	2010-06-17	2013-08-15	ノバルティスアーゲー	ピペリジニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体
US9656994B2 (en)	2013-03-22	2017-05-23	The Scripps Research Institute	Substituted benzimidazoles as nociceptin receptor modulators
CA3044950A1 (fr) *	2016-11-28	2018-05-31	Mitsubishi Tanabe Pharma Corporation	Medicament pour le traitement de la dependance a la cocaine ou pour la prevention de la recidive de celle-ci
CN111615513A (zh) *	2018-01-19	2020-09-01	爱杜西亚药品有限公司	C5a受体调节剂
CN116496270B (zh) *	2022-01-27	2024-09-24	四川大学华西医院	一类4-氨基哌啶衍生物及其制备方法和用途
TW202527948A (zh) *	2024-01-05	2025-07-16	大陸商宜昌人福藥業有限責任公司	一種環己基取代呱啶衍生物、包含其的藥物組合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3161645A (en) *	1962-12-18	1964-12-15	Res Lab Dr C Janssen N V	1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en)	1964-05-06	1967-05-09	Janssen Pharmaceutica Nv	Derivatives of benzimidazolinyl piperidine
JPS58180481A (ja) *	1982-04-15	1983-10-21	Kyowa Hakko Kogyo Co Ltd	新規なピペリジン誘導体
AT388731B (de) *	1987-12-15	1989-08-25	Gerot Pharmazeutika	Neue derivate von benzimidazol, ihre herstellung und verwendung
AU7478396A (en)	1995-10-31	1997-05-22	Merck & Co., Inc.	Muscarine agonists
ZA9610745B (en) *	1995-12-22	1997-06-24	Warner Lambert Co	4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
US6180649B1 (en)	1996-04-19	2001-01-30	Nerosearch A/S	1-(4-piperidyl)-benzimidazoles having neurotrophic activity
CN1258294A (zh)	1997-05-30	2000-06-28	万有制药株式会社	2－氧代咪唑衍生物

1999
- 1999-01-08 US US09/403,408 patent/US6423725B1/en not_active Expired - Fee Related
- 1999-01-08 AT AT99900012T patent/ATE219772T1/de not_active IP Right Cessation
- 1999-01-08 TR TR2000/02090T patent/TR200002090T2/xx unknown
- 1999-01-08 BR BR9907104-5A patent/BR9907104A/pt not_active Application Discontinuation
- 1999-01-08 CA CA002317462A patent/CA2317462C/fr not_active Expired - Fee Related
- 1999-01-08 ES ES99900012T patent/ES2175925T3/es not_active Expired - Lifetime
- 1999-01-08 JP JP2000540137A patent/JP3342478B2/ja not_active Expired - Fee Related
- 1999-01-08 AU AU16790/99A patent/AU1679099A/en not_active Abandoned
- 1999-01-08 PL PL99342046A patent/PL342046A1/xx not_active Application Discontinuation
- 1999-01-08 EP EP99900012A patent/EP1049689B1/fr not_active Expired - Lifetime
- 1999-01-08 WO PCT/IB1999/000012 patent/WO1999036421A1/fr not_active Application Discontinuation
- 1999-01-08 PT PT99900012T patent/PT1049689E/pt unknown
- 1999-01-08 CN CN99802227A patent/CN1288464A/zh active Pending
- 1999-01-08 IL IL13714999A patent/IL137149A0/xx unknown
- 1999-01-08 EA EA200000683A patent/EA200000683A1/ru unknown
- 1999-01-08 DK DK99900012T patent/DK1049689T3/da active
- 1999-01-08 DE DE69901934T patent/DE69901934T2/de not_active Expired - Fee Related
- 1999-01-14 AP APAP/P/1999/001442A patent/AP9901442A0/en unknown
- 1999-01-15 PA PA19998467101A patent/PA8467101A1/es unknown
- 1999-01-15 MA MA25432A patent/MA26598A1/fr unknown
- 1999-01-15 TN TNTNSN99006A patent/TNSN99006A1/fr unknown
- 1999-01-18 AR ARP990100184A patent/AR014421A1/es unknown
- 1999-01-18 PE PE1999000041A patent/PE20000166A1/es not_active Application Discontinuation
- 1999-01-18 ZA ZA9900314A patent/ZA99314B/xx unknown
- 1999-01-19 GT GT199900008A patent/GT199900008A/es unknown
- 1999-01-19 CO CO99002592A patent/CO4990962A1/es unknown
2000
- 2000-06-16 IS IS5539A patent/IS5539A/is unknown
- 2000-07-07 OA OA1200000203A patent/OA11445A/en unknown
- 2000-07-18 NO NO20003671A patent/NO20003671L/no not_active Application Discontinuation
- 2000-08-07 BG BG104670A patent/BG104670A/xx unknown

Also Published As

Publication number	Publication date
BG104670A (en)	2001-05-31
JP2002509148A (ja)	2002-03-26
ZA99314B (en)	2000-07-18
DE69901934T2 (de)	2002-11-07
PA8467101A1 (es)	2000-09-29
DE69901934D1 (de)	2002-08-01
PT1049689E (pt)	2002-09-30
CA2317462A1 (fr)	1999-07-22
MA26598A1 (fr)	2004-12-20
EP1049689A1 (fr)	2000-11-08
AR014421A1 (es)	2001-02-28
CA2317462C (fr)	2005-09-13
PL342046A1 (en)	2001-05-21
DK1049689T3 (da)	2002-07-22
ES2175925T3 (es)	2002-11-16
AP9901442A0 (en)	1999-03-31
GT199900008A (es)	2000-07-12
ATE219772T1 (de)	2002-07-15
IS5539A (is)	2000-06-16
TR200002090T2 (tr)	2000-11-21
US6423725B1 (en)	2002-07-23
PE20000166A1 (es)	2000-03-07
OA11445A (en)	2004-04-30
JP3342478B2 (ja)	2002-11-11
AU1679099A (en)	1999-08-02
BR9907104A (pt)	2000-10-24
CO4990962A1 (es)	2000-12-26
EP1049689B1 (fr)	2002-06-26
IL137149A0 (en)	2001-07-24
TNSN99006A1 (fr)	2005-11-10
WO1999036421A1 (fr)	1999-07-22
CN1288464A (zh)	2001-03-21
NO20003671D0 (no)	2000-07-18
EA200000683A1 (ru)	2000-12-25

Publication	Publication Date	Title
NO20003671L (no)	2000-09-18	4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister
ES2188095T3 (es)	2003-06-16	Carboxamidas heterociclicas.
NO20032252D0 (no)	2003-05-19	Piperazinylpyrazinforbindelser som agonist eller antagonist av serotonin 5HT-2-reseptor
RS49688B (sr)	2007-12-31	Novi derivat 3-aril-2- hidroksipropionske kiseline (i)
TR199500844A1 (tr)	1996-10-21	Heterosiklik takikininin reseptör antagonistleri.
NL300146I2 (nl)	2004-07-01	Morfolinetachykininereceptorantagonisten.
NO20015365L (no)	2002-01-03	Piperidinderivater som er anvendbare som CCR5-antagonister
TW333527B (en)	1998-06-11	Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them
NO20000722L (no)	2000-02-14	2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater
NO20022232L (no)	2002-05-10	Imidazolforbindelser for anvendelse som inhibitorer for fosfodiesterase VII
NO20001514L (no)	2000-03-23	Vitronectin-reseptor-antagonist
TR200000786T2 (tr)	2000-08-21	Vitronektin reseptör antagonisti
DE69617226D1 (de)	2002-01-03	Piperidinderivate.
NO20021502L (no)	2002-03-26	Kinazolinoner
TR200101654T2 (tr)	2002-03-21	Vitronektin reseptr antagonistleri
DK0896822T3 (da)	2003-06-02	4-aminopyrrol (3,2-d) pyrimidiner som neuropeptide Y receptorantagonister
DK1245564T3 (da)	2006-08-14	Benzamidinderivater
BR0317671A (pt)	2005-11-29	Composto
PE20030063A1 (es)	2003-02-08	Derivados de 1-(3-feniloxipropil) piperidina
EP1264829A4 (fr)	2003-06-18	Composes heterocycliques contenant de l'oxygene
DE69402703D1 (de)	1997-05-22	3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND
SE9404192D0 (sv)	1994-12-02	New process
ES2103675B1 (es)	1998-07-01	Nuevas piperidinas sustituidas.
ATE206125T1 (de)	2001-10-15	Furoindolizine
IS7911A (is)	2005-06-23	Ímídasólafleiður með sækni í alfa 2 viðtakavirkni

Legal Events

Date	Code	Title	Description
2001-01-22	FC2A	Withdrawal, rejection or dismissal of laid open patent application