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NO20001198L - Pyrrolopyrrolondervater som inhibitorer av nøytrofil elastase - Google Patents

Pyrrolopyrrolondervater som inhibitorer av nøytrofil elastase

Info

Publication number
NO20001198L
NO20001198L NO20001198A NO20001198A NO20001198L NO 20001198 L NO20001198 L NO 20001198L NO 20001198 A NO20001198 A NO 20001198A NO 20001198 A NO20001198 A NO 20001198A NO 20001198 L NO20001198 L NO 20001198L
Authority
NO
Norway
Prior art keywords
pyrrolopyrrole
subunits
inhibitors
neutrophil elastase
elastase
Prior art date
Application number
NO20001198A
Other languages
English (en)
Other versions
NO20001198D0 (no
Inventor
Geoffrey Duke Edward Clarke
Michael Dennis Dowle
Harry Finch
Lee Andrew Harrison
Graham George Adam Inglis
Martin Redpath Johnson
Simon John Fawcett Macdonald
Pritom Shah
Robin Andrew Smith
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en
Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en
Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en
Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20001198D0 publication Critical patent/NO20001198D0/no
Publication of NO20001198L publication Critical patent/NO20001198L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Det er beskrevet forbindelser med formel (I) R4R3N(CH2)n-Hetx r <" hvor R1, R2 og R3 er som definert i beskrivelsen. Forbindelser med formel (l) er nyttige, bl.a. ved behandling av inflammatoriske lidelser i luftveiene.
NO20001198A 1997-09-09 2000-03-08 Pyrrolopyrrolondervater som inhibitorer av nøytrofil elastase NO20001198L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9719183.7A GB9719183D0 (en) 1997-09-09 1997-09-09 Compounds
GBGB9719189.4A GB9719189D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GBGB9719290.0A GB9719290D0 (en) 1997-09-10 1997-09-10 Compounds
GBGB9803611.4A GB9803611D0 (en) 1998-02-21 1998-02-21 Compounds
PCT/EP1998/005609 WO1999012933A2 (en) 1997-09-09 1998-09-07 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (2)

Publication Number Publication Date
NO20001198D0 NO20001198D0 (no) 2000-03-08
NO20001198L true NO20001198L (no) 2000-05-08

Family

ID=27451698

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001198A NO20001198L (no) 1997-09-09 2000-03-08 Pyrrolopyrrolondervater som inhibitorer av nøytrofil elastase

Country Status (24)

Country Link
EP (1) EP1003748A2 (no)
JP (1) JP2001515904A (no)
KR (1) KR20010023766A (no)
CN (1) CN1278820A (no)
AP (1) AP2000001761A0 (no)
AR (1) AR017072A1 (no)
AU (1) AU9741298A (no)
BR (1) BR9812062A (no)
CA (1) CA2303176A1 (no)
CO (1) CO4970719A1 (no)
EA (1) EA200000204A1 (no)
EE (1) EE200000138A (no)
HU (1) HUP0004644A3 (no)
ID (1) ID24452A (no)
IL (1) IL134791A0 (no)
IS (1) IS5391A (no)
MA (1) MA26543A1 (no)
NO (1) NO20001198L (no)
NZ (1) NZ503130A (no)
PE (1) PE107899A1 (no)
PL (1) PL339176A1 (no)
SK (1) SK3192000A3 (no)
TR (1) TR200000907T2 (no)
WO (1) WO1999012933A2 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
EP1771432B1 (en) 2004-03-31 2010-12-08 Janssen Pharmaceutica NV Non-imidazole heterocyclic compounds as histamine h3 receptor modulators
DE102004024772A1 (de) * 2004-05-17 2005-12-22 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
JP4853759B2 (ja) * 2004-05-27 2012-01-11 日本農薬株式会社 置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
EP1819681B1 (en) 2004-11-23 2009-08-12 Warner-Lambert Company LLC 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
CA2657956C (en) 2006-05-04 2015-01-06 Argenta Discovery Limited Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
WO2009060206A1 (en) * 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) * 2010-02-26 2011-09-01 The University Of Hong Kong Compositions and methods for treating chronic respiratory inflammation
WO2021053058A1 (en) 2019-09-17 2021-03-25 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
DK4106757T3 (da) 2020-04-16 2023-10-23 Mereo Biopharma 4 Ltd Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel
US20240382472A1 (en) 2021-10-20 2024-11-21 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
EA001437B1 (ru) * 1996-03-28 2001-02-26 Глаксо Груп Лимитед Производные пирролопирролона в качестве ингибиторов нейтрофильной эластазы

Also Published As

Publication number Publication date
EE200000138A (et) 2001-02-15
AP2000001761A0 (en) 2000-03-31
BR9812062A (pt) 2000-09-26
NO20001198D0 (no) 2000-03-08
HUP0004644A3 (en) 2002-01-28
ID24452A (id) 2000-07-20
SK3192000A3 (en) 2001-03-12
WO1999012933A3 (en) 1999-05-27
KR20010023766A (ko) 2001-03-26
CN1278820A (zh) 2001-01-03
IL134791A0 (en) 2001-04-30
AU9741298A (en) 1999-03-29
MA26543A1 (fr) 2004-12-20
NZ503130A (en) 2001-08-31
IS5391A (is) 2000-02-29
AR017072A1 (es) 2001-08-22
PE107899A1 (es) 1999-11-17
CO4970719A1 (es) 2000-11-07
CA2303176A1 (en) 1999-03-18
TR200000907T2 (tr) 2000-11-21
WO1999012933A2 (en) 1999-03-18
PL339176A1 (en) 2000-12-04
HUP0004644A2 (hu) 2001-09-28
EP1003748A2 (en) 2000-05-31
EA200000204A1 (ru) 2000-10-30
JP2001515904A (ja) 2001-09-25

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Legal Events

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