NO171994C - Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner - Google Patents

Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner

Info

Publication number: NO171994C
Authority: NO; Norway
Prior art keywords: 17alfa; estradien; 11beta; oner; 17beta
Prior art date: 1985-02-07

Application number

NO860425A

Other languages

English (en)

Norwegian (no)

Other versions

NO860425L (no

NO171994B (no

Inventor

Guenter Neef

Sybille Beier

Walter Elger

David Henderson

Eckard Ottow

Ralph Rohde

Rudolf Wiechert

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-07

Filing date

1986-02-06

Publication date

1993-05-26

1985-02-07 Priority claimed from DE19853504421 external-priority patent/DE3504421A1/de

1985-07-29 Priority claimed from DE19853527517 external-priority patent/DE3527517A1/de

1986-02-06 Application filed by Schering Ag filed Critical Schering Ag

1986-08-08 Publication of NO860425L publication Critical patent/NO860425L/no

1986-10-21 Priority to NO864209A priority Critical patent/NO170285C/no

1993-02-15 Publication of NO171994B publication Critical patent/NO171994B/no

1993-05-26 Publication of NO171994C publication Critical patent/NO171994C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO860425A 1985-02-07 1986-02-06 Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner NO171994C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO864209A NO170285C (no)	1985-02-07	1986-10-21	13-alkyl-llbeta-fenyl-gonaner, og antikonsepsjonsmiddel inneholdende disse

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19853504421 DE3504421A1 (de)	1985-02-07	1985-02-07	Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
DE19853527517 DE3527517A1 (de)	1985-07-29	1985-07-29	11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate

Publications (3)

Publication Number	Publication Date
NO860425L NO860425L (no)	1986-08-08
NO171994B NO171994B (no)	1993-02-15
NO171994C true NO171994C (no)	1993-05-26

Family

ID=25829248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO860425A NO171994C (no)	1985-02-07	1986-02-06	Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner

Country Status (16)

Country	Link
US (1)	US5089635A (pt)
EP (1)	EP0190759B1 (pt)
CN (1)	CN1033753C (pt)
AU (1)	AU580843B2 (pt)
CA (1)	CA1310630C (pt)
DE (1)	DE3665307D1 (pt)
DK (1)	DK161709C (pt)
ES (1)	ES8701778A1 (pt)
FI (1)	FI85377C (pt)
GR (1)	GR860342B (pt)
HU (1)	HU194904B (pt)
IE (1)	IE58149B1 (pt)
IL (1)	IL77762A (pt)
NO (1)	NO171994C (pt)
NZ (1)	NZ214998A (pt)
PT (1)	PT81969B (pt)

Families Citing this family (44)

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AU580843B2 (en) *	1985-02-07	1989-02-02	Schering Aktiengesellschaft	11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
GB8513723D0 (en) *	1985-05-31	1985-07-03	Erba Farmitalia	11-beta substituted steroids
ATE69820T1 (de) *	1987-04-24	1991-12-15	Akzo Nv	11-arylestranderivate und 11-arylpregnanderivate.
AU625450B2 (en) *	1987-07-16	1992-07-09	Schering Aktiengesellschaft Berlin Und Bergkamen	11beta-phenyl-4,9,15-estratrienes, their manufacture, and pharmaceutical preparations containing them
DE3723788A1 (de) *	1987-07-16	1989-01-26	Schering Ag	11(beta)-phenyl-4,9,15-estratriene, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3878198T2 (de) *	1987-12-12	1993-06-24	Akzo Nv	11-arylsteroid-derivate.
DE3822770A1 (de) *	1988-07-01	1990-01-04	Schering Ag	13-alkyl-11ss-phenylgonane
FR2643638B1 (fr) *	1989-02-24	1991-06-14	Roussel Uclaf	Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2665901B2 (fr) *	1989-02-24	1994-07-29	Roussel Uclaf	Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments.
US5364847A (en) *	1989-03-10	1994-11-15	Endorecherche	Inhibitors of sex steroid biosynthesis and methods for their production and use
US5372996A (en) *	1989-03-10	1994-12-13	Endorecherche, Inc.	Method of treatment of androgen-related diseases
GR1001164B (el) *	1989-07-07	1993-05-24	Endorecherche Inc	Παραγωγα αρρενογονου ορμονης προς χρησιν εις την αναστολην δραστηριοτητος της στεροειδους ορμονης φυλου
AU5851690A (en) *	1989-07-07	1991-02-06	Endorecherche Inc.	Method of treatment of androgen-related diseases
JP3202224B2 (ja) *	1989-08-04	2001-08-27	シエーリングアクチエンゲゼルシヤフト	１１β―アリール―ゴナ―４，９―ジエン―３―オン、その製造方法及びそれを含有する調剤学的調製剤
DE4042007A1 (de) *	1990-12-22	1992-06-25	Schering Ag	6,7-modifizierte-11(beta)-aryl-4-estrene
DK0471612T3 (da) *	1990-08-14	1999-02-22	Hoechst Marion Roussel Inc	Nye 19-nor steroider med carbonkæde omfattende en amidgruppe i 11-beta-stillingen, fremgangsmåde til deres fremstilling, de
US5407928A (en) *	1990-08-15	1995-04-18	Schering Aktiengesellschaft	11β-aryl-gona-4,9-dien-3-ones
FR2688004A1 (fr) *	1992-02-27	1993-09-03	Roussel Uclaf	Nouveaux sterouides comportant en position 17 un radical methylene lactone, leur procede et des intermediaires de preparation, leur application comme medicaments.
HUT71514A (en) *	1992-05-21	1995-12-28	Endorecherche Inc	Inhibitors of testosterone 5 alfa-reductase activity and pharmaceutical compositions containing the same
DE4332283A1 (de) *	1993-09-20	1995-04-13	Jenapharm Gmbh	Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332284C2 (de) *	1993-09-20	1997-05-28	Jenapharm Gmbh	11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5780220A (en) *	1994-05-19	1998-07-14	Trustees Of The University Of Pennsylvania	Methods and compositions for inhibiting HIV replication
US5639598A (en) *	1994-05-19	1997-06-17	The Trustees Of The University Of Pennsylvania	Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5576310A (en) *	1994-09-20	1996-11-19	Jenapharm Gmbh	11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
US5521166A (en) *	1994-12-19	1996-05-28	Ortho Pharmaceitical Corporation	Antiprogestin cyclophasic hormonal regimen
ZA9510926B (en)	1994-12-23	1996-07-03	Schering Ag	Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
US6900193B1 (en) *	1996-05-01	2005-05-31	The United States Of America As Represented By The Department Of Health And Human Services	Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
JP4260886B2 (ja)	1996-05-01	2009-04-30	アメリカ合衆国	新規の抗プロゲステロンとしての２１―置換プロゲステロン誘導体
IL122740A (en) *	1997-01-15	2003-09-17	Akzo Nobel Nv	16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
US6090798A (en) *	1997-12-19	2000-07-18	Alcon Laboratories, Inc.	Treatment of GLC1A glaucoma with glucocorticoid antagonists
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en)	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) *	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
EP1285927A3 (de) *	2001-08-16	2005-06-29	Schering Aktiengesellschaft	Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
DE10236405A1 (de) *	2002-08-02	2004-02-19	Schering Ag	Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
DE102009034367A1 (de) *	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
EP2576582B1 (en)	2010-05-26	2019-09-18	Corcept Therapeutics, Inc.	Treatment of muscular dystrophy
AU2016226451B2 (en)	2015-03-02	2019-12-19	Corcept Therapeutics, Inc.	Use of glucocorticoid receptor antagonist and somatostatin analogues to treat ACTH-secreting tumors
ES2906778T3 (es)	2015-03-30	2022-04-20	Corcept Therapeutics Inc	Uso de antagonistas del receptor de glucocorticoides en combinación con glucocorticoides para tratar la insuficiencia suprarrenal
AU2016305092B2 (en)	2015-08-13	2022-01-27	Corcept Therapeutics, Inc.	Method for differentially diagnosing ACTH-dependent Cushing's syndrome
EP3405101B1 (en)	2016-01-19	2020-12-23	Corcept Therapeutics, Inc.	Differential diagnosis of ectopic cushing's syndrome
SG11201908790PA (en)	2017-03-31	2019-10-30	Corcept Therapeutics Inc	Glucocorticoid receptor modulators to treat cervical cancer
EP3641780B1 (en)	2017-06-20	2025-09-10	Corcept Therapeutics Incorporated	Treatment of neuroepithelial tumors using selective glucocorticoid receptor modulators
JP2024500748A (ja)	2020-12-18	2024-01-10	インスティルバイオ（ユーケイ）リミテッド	腫瘍浸潤リンパ球の処理

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Publication number	Priority date	Publication date	Assignee	Title
FR2377418A1 (fr) *	1977-01-13	1978-08-11	Roussel Uclaf	Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) *	1982-03-01	1986-02-14	Roussel Uclaf	Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
DE3231827A1 (de) *	1982-08-24	1984-03-01	Schering AG, 1000 Berlin und 4709 Bergkamen	11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2573657B1 (fr) *	1984-11-29	1989-05-12	Roussel Uclaf	Produit comprenant une substance antiprogestomimetique et une substance uterotonique
AU580843B2 (en) *	1985-02-07	1989-02-02	Schering Aktiengesellschaft	11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them

1986
- 1986-01-31 AU AU52913/86A patent/AU580843B2/en not_active Ceased
- 1986-01-31 NZ NZ214998A patent/NZ214998A/xx unknown
- 1986-02-02 IL IL77762A patent/IL77762A/xx not_active IP Right Cessation
- 1986-02-03 CN CN86100994A patent/CN1033753C/zh not_active Expired - Lifetime
- 1986-02-04 ES ES551625A patent/ES8701778A1/es not_active Expired
- 1986-02-05 GR GR860342A patent/GR860342B/el unknown
- 1986-02-05 DK DK056086A patent/DK161709C/da not_active IP Right Cessation
- 1986-02-05 PT PT81969A patent/PT81969B/pt not_active IP Right Cessation
- 1986-02-06 HU HU86499A patent/HU194904B/hu not_active IP Right Cessation
- 1986-02-06 IE IE33486A patent/IE58149B1/en not_active IP Right Cessation
- 1986-02-06 NO NO860425A patent/NO171994C/no not_active IP Right Cessation
- 1986-02-06 CA CA000501252A patent/CA1310630C/en not_active Expired - Lifetime
- 1986-02-06 EP EP86101548A patent/EP0190759B1/de not_active Expired
- 1986-02-06 DE DE8686101548T patent/DE3665307D1/de not_active Expired
- 1986-02-07 FI FI860559A patent/FI85377C/fi not_active IP Right Cessation
- 1986-02-07 US US06/827,050 patent/US5089635A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0190759B1 (de)	1989-08-30
CA1310630C (en)	1992-11-24
IE58149B1 (en)	1993-07-14
US5089635A (en)	1992-02-18
ES8701778A1 (es)	1986-12-16
DK161709C (da)	1992-01-13
DK56086D0 (da)	1986-02-05
FI860559L (fi)	1986-08-08
PT81969A (de)	1986-03-01
ES551625A0 (es)	1986-12-16
CN1033753C (zh)	1997-01-08
AU580843B2 (en)	1989-02-02
FI860559A0 (fi)	1986-02-07
EP0190759A3 (en)	1986-11-20
NO860425L (no)	1986-08-08
DE3665307D1 (en)	1989-10-05
CN86100994A (zh)	1986-10-08
FI85377C (fi)	1992-04-10
EP0190759A2 (de)	1986-08-13
NZ214998A (en)	1989-06-28
HUT40453A (en)	1986-12-28
AU5291386A (en)	1986-08-14
HU194904B (en)	1988-03-28
DK161709B (da)	1991-08-05
IE860334L (en)	1986-08-07
FI85377B (fi)	1991-12-31
PT81969B (pt)	1988-03-03
IL77762A (en)	1992-08-18
GR860342B (en)	1986-06-03
NO171994B (no)	1993-02-15
DK56086A (da)	1986-08-08

Publication	Publication Date	Title
NO171994C (no)	1993-05-26	Fremgangsmaate for fremstilling av dihydroxylerte 11beta-(4-acetylfenyl)-17beta-hydroxy-17alfa-(1-propynyl)-4,9-estradien-3-oner
DK162371C (da)	1992-03-23	Loefteindretning til handikappede
NO903920L (no)	1986-09-15	Fremgangsmaate for fremstilling av en isomerblanding.
NO865013D0 (no)	1986-12-11	Fremgangsmaate for fremstilling av antibaktercelle kinolon-derivater.
NO864879L (no)	1987-06-09	Fremgangsmaate for fremstilling av terapeutisk aktive tiazolforbindelser.
NO165143C (no)	1991-01-09	Fremgangsmaate til fremstilling av hydrokloridet av fenyl-1-dietylaminokarbonyl-1-aminometyl-2-cyklopropan (z).
NO861486L (no)	1986-10-20	Fremgangsmaate til fremstilling av fluorerte benzyltriazolforbindelser.
NO864108L (no)	1987-04-23	Fremgangsmaate for fremstilling av nye flavon-derivater.
NO863251D0 (no)	1986-08-12	Fremgangsmaate for fremstilling av sphingosinderivater.
NO862942D0 (no)	1986-07-22	Fremgangsmaate for fremstilling av kalsiumfluorsilikat.
NO864515D0 (no)	1986-11-12	Fremgangsmaate for fremstilling av heterocyliske oxazoloner
NO860429L (no)	1986-08-11	Fremgangsmaate for fremstilling av imidazolyl-indol-derivater.
NO863389L (no)	1987-02-25	Fremgangsmaate til fremstilling av substituerte toluidiner.
NO163010C (no)	1990-03-21	Fremgangsmaate for fremstilling av n-sulfamyl-3-(2-guanidino-thiazolo-4-yl-methylthio)-propionamid.
NO862270D0 (no)	1986-06-06	Fremgangsmaate for fremstilling av nye isatinforbindelser.
NO863343L (no)	1987-02-23	Fremgangsmaate for fremstilling av gem-dihalo-1,8-diamino-4-aza-octaner.
NO864446D0 (no)	1986-11-07	Fremgangsmaate til fremstilling av en oksydisk katalysatorforloeper.
NO164543C (no)	1990-10-17	Fremgangsmaate til fremstilling av n7-amidino substituerte mitomycin c-derivater.
NO864121D0 (no)	1986-10-16	Fremgangsmaate til fremstilling av polyvinylklorid.
NO863769D0 (no)	1986-09-22	Fremgangsmaate for fremstilling av 4-hydroksy-2-oksopyrrolin-1-yl-acetamid.
FI863883A0 (fi)	1986-09-25	Anordning foer tillslutning av flaskhals.
NO864087D0 (no)	1986-10-14	Fremgangsmaate for fremstilling av aroylthiazoloner.
NO862493L (no)	1986-12-22	Fremgangsmaate for fremstilling av 2-halonicergolinderivater.
NO863045D0 (no)	1986-07-28	Fremgangsmaate for fremstilling av alkyl-2-karboalkoksy-3,4-dialkoksybenzenkarbamater.
FI864790A0 (fi)	1986-11-25	Foerfarande foer framstaellning av 5-klor- och 5-brom-2-hydroxinikotinsyror.

Legal Events

Date	Code	Title	Description
2004-12-20	MM1K	Lapsed by not paying the annual fees