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NO175981C - Analogous Process for Preparation of Pyrimidine Nucleosides and Intermediates Used Therein - Google Patents

Analogous Process for Preparation of Pyrimidine Nucleosides and Intermediates Used Therein

Info

Publication number
NO175981C
NO175981C NO905300A NO905300A NO175981C NO 175981 C NO175981 C NO 175981C NO 905300 A NO905300 A NO 905300A NO 905300 A NO905300 A NO 905300A NO 175981 C NO175981 C NO 175981C
Authority
NO
Norway
Prior art keywords
compounds
chem
preparation
intermediates used
analogous process
Prior art date
Application number
NO905300A
Other languages
Norwegian (no)
Other versions
NO175981B (en
NO905300D0 (en
NO905300L (en
Inventor
Karl Nils Gunnar Johansson
Hans C G Malmberg
Rolf Noreen
S Christer Sahlberg
Daniel D Sohn
Salo Gronowitz
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of NO905300D0 publication Critical patent/NO905300D0/en
Publication of NO905300L publication Critical patent/NO905300L/en
Publication of NO175981B publication Critical patent/NO175981B/en
Publication of NO175981C publication Critical patent/NO175981C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compounds of the formula <CHEM> wherein R<1> is OH, NH2; R<2> is a heteroaromatic or aromatic substituent as defined in claim 1; R<3> is H, OH, F, OCH3; R<4> is H, F, OH or an ether or ester residue thereof, OCH3, CN, C IDENTICAL CH, N3; R<5> is OH or an ether or ester residue thereof including mono-, di- and triphosphate esters; <CHEM> wherein n is O or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic and/or prophylactic treatment of virus infections such as AIDS. Compounds of the formula <CHEM> wherein R<1> and R<2> are as defined above, are new precursor compounds.
NO905300A 1988-06-10 1990-12-07 Analogous Process for Preparation of Pyrimidine Nucleosides and Intermediates Used Therein NO175981C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8802173A SE8802173D0 (en) 1988-06-10 1988-06-10 PYRIMIDINE DERIVATIVES
PCT/SE1989/000322 WO1989012061A1 (en) 1988-06-10 1989-06-07 Pyrimidine nucleosides and intermediates

Publications (4)

Publication Number Publication Date
NO905300D0 NO905300D0 (en) 1990-12-07
NO905300L NO905300L (en) 1991-02-06
NO175981B NO175981B (en) 1994-10-03
NO175981C true NO175981C (en) 1995-01-11

Family

ID=20372582

Family Applications (1)

Application Number Title Priority Date Filing Date
NO905300A NO175981C (en) 1988-06-10 1990-12-07 Analogous Process for Preparation of Pyrimidine Nucleosides and Intermediates Used Therein

Country Status (20)

Country Link
US (2) US5440040A (en)
EP (2) EP0357571B1 (en)
JP (1) JP2851094B2 (en)
KR (1) KR900701815A (en)
AT (1) ATE136308T1 (en)
AU (1) AU637574B2 (en)
CA (1) CA1339313C (en)
DE (1) DE68926137T2 (en)
DK (1) DK291890A (en)
ES (1) ES2087090T3 (en)
FI (1) FI94643C (en)
GR (1) GR3020212T3 (en)
HU (1) HU211736B (en)
IE (1) IE62914B1 (en)
MY (1) MY109743A (en)
NO (1) NO175981C (en)
PH (1) PH27219A (en)
PT (1) PT90803B (en)
SE (1) SE8802173D0 (en)
WO (1) WO1989012061A1 (en)

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Also Published As

Publication number Publication date
CA1339313C (en) 1997-08-19
PT90803A (en) 1989-12-29
SE8802173D0 (en) 1988-06-10
FI94643B (en) 1995-06-30
FI906053A0 (en) 1990-12-07
JP2851094B2 (en) 1999-01-27
NO175981B (en) 1994-10-03
HU211736B (en) 1995-12-28
NO905300D0 (en) 1990-12-07
US5440040A (en) 1995-08-08
PH27219A (en) 1993-05-04
JPH03504969A (en) 1991-10-31
DE68926137D1 (en) 1996-05-09
ES2087090T3 (en) 1996-07-16
AU637574B2 (en) 1993-06-03
AU3750489A (en) 1990-01-05
DK291890A (en) 1991-02-07
HU894340D0 (en) 1991-08-28
HUT57230A (en) 1991-11-28
MY109743A (en) 1997-05-31
PT90803B (en) 1994-10-31
IE62914B1 (en) 1995-03-08
EP0357571A3 (en) 1990-06-13
US5576429A (en) 1996-11-19
IE891816L (en) 1989-12-10
DK291890D0 (en) 1990-12-07
KR900701815A (en) 1990-12-04
EP0691333A2 (en) 1996-01-10
DE68926137T2 (en) 1996-11-14
EP0357571B1 (en) 1996-04-03
NO905300L (en) 1991-02-06
EP0691333A3 (en) 1996-02-14
FI94643C (en) 1995-10-10
ATE136308T1 (en) 1996-04-15
GR3020212T3 (en) 1996-09-30
WO1989012061A1 (en) 1989-12-14
EP0357571A2 (en) 1990-03-07

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