[go: up one dir, main page]

MY103801A - Dideoxydidehydrocarbocyclic nucleosides - Google Patents

Dideoxydidehydrocarbocyclic nucleosides

Info

Publication number
MY103801A
MY103801A MYPI89000064A MYPI19890064A MY103801A MY 103801 A MY103801 A MY 103801A MY PI89000064 A MYPI89000064 A MY PI89000064A MY PI19890064 A MYPI19890064 A MY PI19890064A MY 103801 A MY103801 A MY 103801A
Authority
MY
Malaysia
Prior art keywords
dideoxydidehydrocarbocyclic
nucleosides
compounds
nrr1
formula
Prior art date
Application number
MYPI89000064A
Inventor
Vince Robert
Hua Mei
Leslie Myers Peter
Storer Richard
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/146,252 external-priority patent/US4916224A/en
Priority claimed from GB888821011A external-priority patent/GB8821011D0/en
Priority claimed from US07/278,652 external-priority patent/US4931559A/en
Application filed by Univ Minnesota filed Critical Univ Minnesota
Publication of MY103801A publication Critical patent/MY103801A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

DISCLOSED ARE COMPOUNDS OF FORMULA (FORMULA 1) WHEREIN X IS NRR1, SR OR OR HALOGEN; Z IS H, OR2 OR NRR1; R, R1, R2 ARE H, C1- 4 ALKYL OR ARYL AND PHARMACEUTICALLY ACCEPTABLE DERIVATIVES THEREOF. ALSO DISCLOSED ARE USE OF THE COMPOUNDS AS ANTIVIRAL AND ANTI- TUMOUR AGENTS, PHARMACEUTICAL FORMULATIONS, METHODS FOR THE PREPARATION OF THE COMPOUNDS AND INTERMEDIATES THERETO.
MYPI89000064A 1988-01-20 1989-01-19 Dideoxydidehydrocarbocyclic nucleosides MY103801A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/146,252 US4916224A (en) 1988-01-20 1988-01-20 Dideoxycarbocyclic nucleosides
GB888821011A GB8821011D0 (en) 1988-09-07 1988-09-07 Chemical compounds
US07/278,652 US4931559A (en) 1988-01-20 1988-12-05 Optically-active isomers of dideoxycarbocyclic nucleosides

Publications (1)

Publication Number Publication Date
MY103801A true MY103801A (en) 1993-09-30

Family

ID=27264063

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI89000064A MY103801A (en) 1988-01-20 1989-01-19 Dideoxydidehydrocarbocyclic nucleosides

Country Status (29)

Country Link
JP (1) JP2793825B2 (en)
KR (1) KR0127137B1 (en)
AT (1) AT397801B (en)
AU (2) AU626278B2 (en)
BE (1) BE1003815A4 (en)
CA (1) CA1339896C (en)
CH (1) CH679152A5 (en)
DE (1) DE3901502C2 (en)
DK (1) DK175131B1 (en)
ES (1) ES2010091A6 (en)
FI (1) FI93546C (en)
FR (1) FR2626002B1 (en)
GB (1) GB2217320B (en)
GR (1) GR890100033A (en)
HU (1) HU203755B (en)
IE (1) IE62275B1 (en)
IL (1) IL88999A (en)
IT (1) IT1229531B (en)
LU (1) LU87437A1 (en)
MY (1) MY103801A (en)
NL (1) NL8900122A (en)
NO (1) NO169123C (en)
NZ (1) NZ227663A (en)
OA (1) OA09031A (en)
PL (1) PL163814B1 (en)
PT (1) PT89482B (en)
RU (1) RU2114846C1 (en)
SE (1) SE505213C2 (en)
YU (1) YU47791B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1215339B (en) * 1987-01-14 1990-02-08 Co Pharma Corp Srl PROCEDURE FOR THE PREPARATION OF 9- (HYDROXIALCHIL) -IPOXANTINE
US5631370A (en) 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir
EP0479822B1 (en) * 1989-06-27 1999-08-18 The Wellcome Foundation Limited Therapeutic nucleosides
GB8916477D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916478D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916480D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916479D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5241069A (en) * 1990-04-06 1993-08-31 Glaxo Inc. Carbonate intermediates for the synthesis of purine substituted cyclopentene derivatives
US5144034A (en) * 1990-04-06 1992-09-01 Glaxo Inc. Process for the synthesis of cyclopentene derivatives of purines
US5126452A (en) * 1990-04-06 1992-06-30 Glaxo Inc. Synthesis of purine substituted cyclopentene derivatives
US5057630A (en) * 1990-04-06 1991-10-15 Glaxo Inc. Synthesis of cyclopentene derivatives
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
JPH09509397A (en) * 1993-11-12 1997-09-22 メレルファーマス−ティカルズ インコーポレイテッド 6-oxo-nucleosides useful as immunosuppressants
GB9721780D0 (en) * 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
KR100606625B1 (en) 1998-10-30 2006-07-28 론자 아게 Method for preparing 4-[(2 ', 5'-diamino-6'-halopyrimidin-4'-yl) amino] -cyclopent-2-enylmethanol
EP1124805B1 (en) * 1998-10-30 2003-05-21 Lonza AG Method for producing 4-[(2',5'- diamino-6'- halopyrimidine- 4'-yl)amino]- cyclopent- 2-enylmethanols
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB9903091D0 (en) * 1999-02-12 1999-03-31 Glaxo Group Ltd Therapeutic nucleoside compound
AR039540A1 (en) * 2002-05-13 2005-02-23 Tibotec Pharm Ltd MICROBICIDE COMPOUNDS WITH PIRIMIDINE OR TRIAZINE CONTENT
EP3831836B1 (en) 2018-07-27 2023-09-06 FUJIFILM Corporation Cyclobutyl purine derivative or salt thereof
JP7104154B2 (en) 2018-07-27 2022-07-20 富士フイルム株式会社 Cyclopentenylpurine derivative or salt thereof
JP2023519882A (en) 2020-03-27 2023-05-15 ソム、イノベーション、バイオテック、ソシエダッド、アノニマ Compounds useful for treating synucleinopathies

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268672A (en) * 1977-02-09 1981-05-19 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
JPS62177234A (en) * 1986-01-30 1987-08-04 Mitsubishi Heavy Ind Ltd Production device of carbon fiber by centrifugal spinning
IN164556B (en) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.

Also Published As

Publication number Publication date
FR2626002A1 (en) 1989-07-21
OA09031A (en) 1991-03-31
AU2867189A (en) 1989-07-20
RU2114846C1 (en) 1998-07-10
NO169123C (en) 1992-05-13
IL88999A (en) 1994-12-29
NO890253L (en) 1989-07-21
AU637015B2 (en) 1993-05-13
PL277261A1 (en) 1989-09-18
DE3901502A1 (en) 1989-07-27
NL8900122A (en) 1989-08-16
LU87437A1 (en) 1989-08-30
FI93546B (en) 1995-01-13
HU203755B (en) 1991-09-30
FI890286A0 (en) 1989-01-19
IL88999A0 (en) 1989-08-15
JPH02196788A (en) 1990-08-03
KR890011902A (en) 1989-08-23
AU626278B2 (en) 1992-07-30
DK23489A (en) 1989-07-21
PL163814B1 (en) 1994-05-31
DK175131B1 (en) 2004-06-14
SE8900192D0 (en) 1989-01-19
SE8900192L (en) 1989-07-21
BE1003815A4 (en) 1992-06-23
FR2626002B1 (en) 1994-01-28
FI890286L (en) 1989-07-21
GB2217320B (en) 1992-04-08
AT397801B (en) 1994-07-25
SE505213C2 (en) 1997-07-14
IT8947546A0 (en) 1989-01-19
CH679152A5 (en) 1991-12-31
CA1339896C (en) 1998-06-02
KR0127137B1 (en) 1997-12-29
IE890153L (en) 1989-07-20
HUT48887A (en) 1989-07-28
IT1229531B (en) 1991-09-04
NO890253D0 (en) 1989-01-19
YU12389A (en) 1991-10-31
IE62275B1 (en) 1995-01-25
PT89482A (en) 1989-10-04
PT89482B (en) 1994-02-28
NO169123B (en) 1992-02-03
ATA10689A (en) 1993-11-15
GB2217320A (en) 1989-10-25
DK23489D0 (en) 1989-01-19
YU47791B (en) 1996-01-09
JP2793825B2 (en) 1998-09-03
AU1018092A (en) 1992-03-12
GR890100033A (en) 1994-03-31
DE3901502C2 (en) 2002-06-13
GB8901187D0 (en) 1989-03-15
FI93546C (en) 1995-04-25
NZ227663A (en) 1990-09-26
ES2010091A6 (en) 1989-10-16

Similar Documents

Publication Publication Date Title
MY103801A (en) Dideoxydidehydrocarbocyclic nucleosides
GR3002866T3 (en) Morpholinoethylester of mycophenolic acid and derivatives thereof, their preparation and use in pharmaceutical compositions
CA2009637A1 (en) Substituted-1,3-oxathiolanes with antiviral properties
MY102986A (en) Benzo (5,6) cycloheptapyridines, compositions and methods of use
IL99755A0 (en) Hydroxymethyl(methylenecyclopentyl)purines and pyrimidines and pharmaceutical compositions containing the same
GR3023219T3 (en) Pyrazolopyridine compounds and processes for preparation thereof
DK0471236T3 (en) Imidazopyridine derivatives and their use
RU92004364A (en) DIDESOXIDIDE HYDROCARBOCYCLIC NUCLEOSIDES
MY105523A (en) Substituted-1,3-oxathiolanes with antiviral properties.
DE68903226D1 (en) DIDEOXYDIDEHYDROCARBOCYCLIC NUCLEOSIDES.
IL76175A0 (en) Tricyclic oxindole derivatives and pharmaceutical compositions containing them
FI881816A0 (en) NYA BICYCLISKA FOERENINGAR, FOERFARANE FOER DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE PHARMACEUTICAL BLANDNINGAR.
ES2046641T3 (en) ANTITUMORAL COMPOSITION.
NZ222741A (en) Pharmaceutical compositions containing an interferon and a purine derivative
DK0408044T3 (en) Anti-inflammatory and / or antiallergic preparation comprising glutathione derivatives
DK283984A (en) BENZODIAZEPINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
EP0272596A3 (en) Theophyllinemethyldithiolan and theophyllinemethyldithianyl derivates, a method for their preparation and pharmaceutical compositions in which they are included
HUT39147A (en) Process for preparing phenoxy-propanol-acethylene derivatives and pharmaceutical compositions containing such compounds
OA06527A (en) Preparation of hydroxylated derivatives of isopropylamine pyrimidine (mineral base sequence).
GR3007498T3 (en)
DE3883434D1 (en) Mitomycin analogs, processes for their preparation and pharmaceutical preparations.
ES2027507A6 (en) Selenophen derivatives, a preparation process of the same and therapeutical compositions containing them
NZ216741A (en) 6-oxo-1,6-dihydropyridazines and pharmaceutical compositions
ES8507520A1 (en) Intermediates for clavulanic-acid derivatives.
GR1000138B (en) New derivatives of rivofurane acid