[go: up one dir, main page]

MXPA06002939A - 6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer. - Google Patents

6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer.

Info

Publication number
MXPA06002939A
MXPA06002939A MXPA06002939A MXPA06002939A MXPA06002939A MX PA06002939 A MXPA06002939 A MX PA06002939A MX PA06002939 A MXPA06002939 A MX PA06002939A MX PA06002939 A MXPA06002939 A MX PA06002939A MX PA06002939 A MXPA06002939 A MX PA06002939A
Authority
MX
Mexico
Prior art keywords
mammal
compounds
pharmaceutically acceptable
acceptable salts
pyrimidines
Prior art date
Application number
MXPA06002939A
Other languages
English (en)
Inventor
Nan Zhang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA06002939A publication Critical patent/MXPA06002939A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invencion se relaciona con ciertas 6-aril-7-haloimidazo[1,2-a]pirimidinas o sales farmaceuticamente aceptables de las mismas y composiciones que contienen a dichos compuestos o sales farmaceuticamente aceptables de los mismos, en donde los compuestos son agentes contra el cancer utiles para el tratamiento de cancer en mamiferos al promover la polimerizacion de los microtubulos. Esta invencion se relaciona adicionalmente con un metodo para tratar o inhibir el crecimiento de celulas tumorales cancerosas y enfermedades relacionadas en un mamifero y proporciona ademas un metodo para el tratamiento o prevencion de tumores cancerosos que expresan resistencia a medicamentos multiples (MDR) o que son resistentes debido a MDR, en un mamifero en necesidad del mismo, metodo el cual comprende administrar al mamifero una cantidad eficaz de los compuestos o sales farmaceuticamente aceptables de los mismos.
MXPA06002939A 2003-09-24 2004-09-17 6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer. MXPA06002939A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
PCT/US2004/030595 WO2005030218A1 (en) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent

Publications (1)

Publication Number Publication Date
MXPA06002939A true MXPA06002939A (es) 2006-05-31

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06002939A MXPA06002939A (es) 2003-09-24 2004-09-17 6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer.

Country Status (14)

Country Link
US (2) US7285555B2 (es)
EP (1) EP1684763B1 (es)
JP (1) JP4695595B2 (es)
CN (1) CN100486580C (es)
AT (1) ATE398452T1 (es)
AU (1) AU2004275728A1 (es)
BR (1) BRPI0414778A (es)
CA (1) CA2537520A1 (es)
DE (1) DE602004014525D1 (es)
DK (1) DK1684763T3 (es)
ES (1) ES2308256T3 (es)
MX (1) MXPA06002939A (es)
PL (1) PL1684763T3 (es)
WO (1) WO2005030218A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1140022B8 (en) * 1998-12-18 2008-10-15 Hadasit Medical Research Services & Development Ltd. Method of administering a compound to multi-drug resistant cells
DK1973545T3 (da) 2005-12-23 2013-02-25 Ariad Pharma Inc Bicykliske heteroarylforbindelser
JP2010515669A (ja) * 2007-01-08 2010-05-13 ビーエーエスエフ ソシエタス・ヨーロピア 有害な植物病原菌類を防除するためのアゾロピリミジンの使用
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224044B (es) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
TW258648B (es) 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
ATE231485T1 (de) 1997-03-18 2003-02-15 Basf Ag Verfahren zur herstellung von arylmalonaten
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
IL137617A0 (en) 1998-02-11 2001-07-24 American Cyanamid Co Fungicidal 7-akyl-triazolopyrimidines
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
ES2244183T3 (es) 1998-03-23 2005-12-01 Basf Aktiengesellschaft 6-(2-halo-4-alcoxifenil)-triazolpirimidinas fungicidas.
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6156925A (en) 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
ES2203021T3 (es) 1998-09-25 2004-04-01 Basf Aktiengesellschaft Mezclas fungicidas.
BR9913922A (pt) 1998-09-25 2002-04-23 Basf Ag Concentrado de suspensão (cs) estável não aquosa, processo para a preparação do mesmo, e, método para o controle de pestes em um local que compreende a diluição de cs
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
BR0112038A (pt) * 2000-06-30 2003-04-01 Wyeth Corp Triazolopirimidinas substituìdas como agentes anticâncer
KR100765025B1 (ko) 2000-08-25 2007-10-09 바스프 악티엔게젤샤프트 살진균 제제
AU2001223629A1 (en) 2000-12-06 2002-06-18 Basf Aktiengesellschaft Fungicidal 6-(trifluoromethyl-phenyl)-triazolopyrimidines
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
CZ295558B6 (cs) 2001-04-11 2005-08-17 Basf Aktiengesellschaft 5-Halogen-6-fenyl-7-fluoralkylamino-triazolopyrimidiny, způsob jejich přípravy a prostředek pro potírání fytopatogenních hub
DE60220296T2 (de) 2001-09-04 2008-01-17 Sumitomo Chemical Co., Ltd. IMIDAZO(1,2-a)PYRIMIDINE UND DIESE ENTHALTENDE FUNGIZIDZUSAMMENSETZUNGEN
AU2003211651A1 (en) * 2002-04-19 2003-11-03 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO(1,2-a)PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Also Published As

Publication number Publication date
ATE398452T1 (de) 2008-07-15
PL1684763T3 (pl) 2008-11-28
US7915266B2 (en) 2011-03-29
ES2308256T3 (es) 2008-12-01
CN1856311A (zh) 2006-11-01
CA2537520A1 (en) 2005-04-07
CN100486580C (zh) 2009-05-13
US20080255157A1 (en) 2008-10-16
US20050065167A1 (en) 2005-03-24
WO2005030218A1 (en) 2005-04-07
US7285555B2 (en) 2007-10-23
BRPI0414778A (pt) 2006-11-21
EP1684763A1 (en) 2006-08-02
DK1684763T3 (da) 2008-09-01
JP4695595B2 (ja) 2011-06-08
DE602004014525D1 (de) 2008-07-31
EP1684763B1 (en) 2008-06-18
JP2007506745A (ja) 2007-03-22
AU2004275728A1 (en) 2005-04-07

Similar Documents

Publication Publication Date Title
EP4548918A3 (en) Tricyclic compounds as inhibitors of kras
TW200512198A (en) 5-arylpyrimidines as anticancer agents
MXPA05012155A (es) Metodos y composiciones que utilizan compuestos inmunomoduladores para el tratamiento y manejo de canceres y otras enfermedades.
IL244727A0 (en) Methods and preparations using immunomodulatory compounds for the treatment and management of cancer and other diseases
TW200500355A (en) Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
WO2004111192A3 (en) Targeted delivery to legumain-expressing cells
SG166775A1 (en) Combinations and modes of administration of therapeutic agents and combination therapy
PT1765362E (pt) Composições e métodos para o tratamento de doenças neovasculares
MXPA02011913A (es) Triazolopirimidinas sustituidas como agentes anticancer.
TW200512211A (en) 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents
PL342614A1 (en) Anticarcinogenic drugs
TNSN07294A1 (en) Treatment of metastasized tumors
EP1177791A3 (en) Use of glycogen phosphorylase inhibitors to inhibit tumor growth
PL1732926T3 (pl) Inhibitory kinezyn motorycznych
MXPA06002939A (es) 6-aril-7-haloimidazo[1,2-a]pirimidinas como agentes contra el cancer.
TW200501946A (en) Pharmaceutical composition for the treatment of schizophrenia in a patient with overweight
WO2007075465A8 (en) Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
DE502004007950D1 (en) Antitumor wirksame 2-substituierte d-homoestra-1,3,5(10)-trien-3-yl sulfamate
TW200727904A (en) Method of administration for 5-(2-chlorophenyl)-1,2-dihydro-7-fluoro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine

Legal Events

Date Code Title Description
FG Grant or registration