MXPA06000774A - E3-nitro-pirazolo[1,5-a]pirimidinas 7-sustituidas y composiciones y metodos relacionados. - Google Patents
E3-nitro-pirazolo[1,5-a]pirimidinas 7-sustituidas y composiciones y metodos relacionados.Info
- Publication number
- MXPA06000774A MXPA06000774A MXPA06000774A MXPA06000774A MXPA06000774A MX PA06000774 A MXPA06000774 A MX PA06000774A MX PA06000774 A MXPA06000774 A MX PA06000774A MX PA06000774 A MXPA06000774 A MX PA06000774A MX PA06000774 A MXPA06000774 A MX PA06000774A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazolo
- pyrimidines
- nitro
- substituted
- compounds
- Prior art date
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 2
- 108091008681 GABAA receptors Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000006806 disease prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se refiere a compuestos de la Formula (I), en donde R1 es como se define en las reivindicaciones. Los compuestos tienen afinidad especifica para el receptor GABAA y por tanto son utiles en el tratamiento y prevencion de enfermedades moduladas por a1- y a2GABAA.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200301747A ES2222814B1 (es) | 2003-07-24 | 2003-07-24 | 3-nitro-pirazolo(1,5-a)pirimidinas 7-sustituidas y composiciones y metodos relacionados. |
| ES200401696A ES2245893B1 (es) | 2003-07-24 | 2004-07-12 | Mejoras en el objeto de la patente de invencion n.p200301747 que se refiere a "3-nitro-pirazolo(1,5-a)pirimidinas 7-sustituidas y composiciones y metodos relacionados". |
| PCT/EP2004/008207 WO2005014596A1 (en) | 2003-07-24 | 2004-07-22 | 7-substituted 3-nitro-pyrazolo `1,5-a! pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06000774A true MXPA06000774A (es) | 2006-04-18 |
Family
ID=34137683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA06000774A MXPA06000774A (es) | 2003-07-24 | 2004-07-22 | E3-nitro-pirazolo[1,5-a]pirimidinas 7-sustituidas y composiciones y metodos relacionados. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070043064A1 (es) |
| EP (1) | EP1648896B1 (es) |
| JP (1) | JP2006528607A (es) |
| KR (1) | KR20060030907A (es) |
| AT (1) | ATE386040T1 (es) |
| AU (1) | AU2004263277A1 (es) |
| BR (1) | BRPI0412837A (es) |
| CA (1) | CA2532431A1 (es) |
| DE (1) | DE602004011780D1 (es) |
| HR (1) | HRP20060008A2 (es) |
| MX (1) | MXPA06000774A (es) |
| NO (1) | NO20060586L (es) |
| TW (1) | TWI252851B (es) |
| UY (1) | UY28439A1 (es) |
| WO (1) | WO2005014596A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005108401A1 (en) * | 2004-04-29 | 2005-11-17 | Dov Pharmaceutical, Inc. | 2-pyridinyl[7-(substituted-pyridin-4-yl) pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
| EP1884516A1 (en) * | 2006-08-04 | 2008-02-06 | Ferrer Internacional, S.A. | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions |
| GB201223308D0 (en) | 2012-12-21 | 2013-02-06 | Univ Sunderland | Enzyme inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792533A (fr) * | 1971-12-09 | 1973-06-08 | Int Chem & Nuclear Corp | Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation |
| US4626538A (en) * | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
| EP0264773A1 (en) * | 1986-10-16 | 1988-04-27 | American Cyanamid Company | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines |
| DE4333705C2 (de) * | 1993-10-02 | 2003-10-30 | Guenter Ege | Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen |
| US5538977A (en) * | 1995-03-17 | 1996-07-23 | American Cyanamid Company | 3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines |
| AU4203500A (en) * | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines as crf antagonists |
| US6399621B1 (en) * | 1999-08-10 | 2002-06-04 | American Cyanamid Company | N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
| DE10153344A1 (de) * | 2001-10-29 | 2003-05-15 | Gruenenthal Gmbh | Verwendung von substituierten Pyrazolopyrimidinen als Liganden von Nucleosid-Transport-Proteinen und/oder von Purinorezeptoren |
-
2004
- 2004-07-15 TW TW093121112A patent/TWI252851B/zh not_active IP Right Cessation
- 2004-07-22 AT AT04741222T patent/ATE386040T1/de not_active IP Right Cessation
- 2004-07-22 HR HR20060008A patent/HRP20060008A2/xx not_active Application Discontinuation
- 2004-07-22 AU AU2004263277A patent/AU2004263277A1/en not_active Abandoned
- 2004-07-22 CA CA002532431A patent/CA2532431A1/en not_active Abandoned
- 2004-07-22 EP EP04741222A patent/EP1648896B1/en not_active Expired - Lifetime
- 2004-07-22 BR BRPI0412837-0A patent/BRPI0412837A/pt not_active IP Right Cessation
- 2004-07-22 JP JP2006520795A patent/JP2006528607A/ja not_active Abandoned
- 2004-07-22 WO PCT/EP2004/008207 patent/WO2005014596A1/en not_active Ceased
- 2004-07-22 DE DE602004011780T patent/DE602004011780D1/de not_active Expired - Lifetime
- 2004-07-22 US US10/563,104 patent/US20070043064A1/en not_active Abandoned
- 2004-07-22 MX MXPA06000774A patent/MXPA06000774A/es not_active Application Discontinuation
- 2004-07-22 KR KR1020067001168A patent/KR20060030907A/ko not_active Ceased
- 2004-07-26 UY UY28439A patent/UY28439A1/es unknown
-
2006
- 2006-02-06 NO NO20060586A patent/NO20060586L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006528607A (ja) | 2006-12-21 |
| UY28439A1 (es) | 2004-11-08 |
| TWI252851B (en) | 2006-04-11 |
| NO20060586L (no) | 2006-02-06 |
| TW200504074A (en) | 2005-02-01 |
| ATE386040T1 (de) | 2008-03-15 |
| AU2004263277A1 (en) | 2005-02-17 |
| DE602004011780D1 (de) | 2008-03-27 |
| BRPI0412837A (pt) | 2006-09-26 |
| CA2532431A1 (en) | 2005-02-17 |
| WO2005014596A1 (en) | 2005-02-17 |
| EP1648896A1 (en) | 2006-04-26 |
| HRP20060008A2 (en) | 2006-07-31 |
| EP1648896B1 (en) | 2008-02-13 |
| KR20060030907A (ko) | 2006-04-11 |
| US20070043064A1 (en) | 2007-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |