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MXPA05013631A - Derivado heterociclico de metilsulfona. - Google Patents

Derivado heterociclico de metilsulfona.

Info

Publication number
MXPA05013631A
MXPA05013631A MXPA05013631A MXPA05013631A MXPA05013631A MX PA05013631 A MXPA05013631 A MX PA05013631A MX PA05013631 A MXPA05013631 A MX PA05013631A MX PA05013631 A MXPA05013631 A MX PA05013631A MX PA05013631 A MXPA05013631 A MX PA05013631A
Authority
MX
Mexico
Prior art keywords
optionally substituted
methyl sulfone
sulfone derivative
heterocyclic group
heterocyclic methyl
Prior art date
Application number
MXPA05013631A
Other languages
English (en)
Inventor
Hitoshi Iimori
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of MXPA05013631A publication Critical patent/MXPA05013631A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Se provee un compuestos capaz de inhibir la produccion o secrecion de proteina (-amiloide; un compuesto representado por la formula (1) siguiente: [Formula quimica 1] (ver formula (I) en donde R1 representa un grupo heterociclico que puede tener un sustituyente, R2 representa un grupo hidrocarburo ciclico que puede tener un sustituyente o un grupo heterociclico que puede tener un sustituyente, R3 representa un grupo hidrocarburo ciclico que puede tener un sustituyente o un grupo heterociclico que puede tener un sustituyente, R4 representa un atomo de hidrogeno o un grupo alquilo de C1-6, y X representa -S-, -SO- o -SO2-): un N-oxido o S-oxido del mismo; una sal del mismo; o un solvato del mismo; y un medicamento que contiene cualquiera de los mismos.
MXPA05013631A 2003-06-30 2004-06-29 Derivado heterociclico de metilsulfona. MXPA05013631A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003187796 2003-06-30
JP2004099151 2004-03-30
PCT/JP2004/009132 WO2005000798A1 (ja) 2003-06-30 2004-06-29 複素環メチルスルホン誘導体

Publications (1)

Publication Number Publication Date
MXPA05013631A true MXPA05013631A (es) 2006-02-24

Family

ID=33554493

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05013631A MXPA05013631A (es) 2003-06-30 2004-06-29 Derivado heterociclico de metilsulfona.

Country Status (13)

Country Link
US (1) US7932271B2 (es)
EP (1) EP1640366A4 (es)
JP (1) JP4523914B2 (es)
KR (1) KR20060066057A (es)
AU (1) AU2004251987C1 (es)
CA (1) CA2526487A1 (es)
IL (1) IL172139A0 (es)
MX (1) MXPA05013631A (es)
NO (1) NO20055921L (es)
PL (1) PL379466A1 (es)
RU (1) RU2336270C2 (es)
TW (1) TWI328005B (es)
WO (1) WO2005000798A1 (es)

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GB0108591D0 (en) 2001-04-05 2001-05-23 Merck Sharp & Dohme Therapeutic agents
GB0120347D0 (en) 2001-08-21 2001-10-17 Merck Sharp & Dohme Therapeutic agents
AU2002367147A1 (en) * 2001-12-27 2003-07-15 Daiichi Pharmaceutical Co., Ltd. Beta-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS
GB0223039D0 (en) 2002-10-04 2002-11-13 Merck Sharp & Dohme Therapeutic compounds
EP1640366A4 (en) 2003-06-30 2009-05-13 Daiichi Seiyaku Co HETEROCYCLES METHYLSULFON DERIVATIVE
RU2404968C2 (ru) * 2005-04-08 2010-11-27 Дайити Санкио Компани, Лимитед Пиридилдиметилсульфоновое производное
RU2446158C9 (ru) * 2006-06-22 2012-06-20 Астразенека Аб Замещенные изоиндолы в качестве ингибиторов васе и их применение
JP2008115166A (ja) * 2006-10-10 2008-05-22 Daiichi Sankyo Co Ltd ピリジルフェニルメチルスルホン誘導体
WO2008061795A2 (en) 2006-11-24 2008-05-29 Ac Immune Sa N- (methyl) -1h- pyrazol- 3 -amine, n- (methyl) -pyridin-2-amine and n- (methyl) -thiaz0l-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's
TW200920362A (en) 2007-09-11 2009-05-16 Daiichi Sankyo Co Ltd Alkylsulfone derivatives
US8304434B2 (en) 2007-10-04 2012-11-06 Merck Sharp & Dohme Corp. Substituted aryl sulfone derivatives as calcium channel blockers
EP2311823A1 (en) 2009-10-15 2011-04-20 AC Immune S.A. 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases
UA103272C2 (uk) * 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
US9120752B2 (en) 2010-07-16 2015-09-01 Purdue Pharma, L.P. Pyridine compounds as sodium channel blockers
WO2013136170A1 (en) 2012-03-16 2013-09-19 Purdue Pharma L.P. Substituted pyridines as sodium channel blockers
US9714252B2 (en) 2012-12-20 2017-07-25 Purdue Pharma L.P. Cyclic sulfonamides as sodium channel blockers
US10730866B2 (en) 2014-04-07 2020-08-04 Purdue Pharma L.P. Indole derivatives and use thereof
JP6726299B2 (ja) * 2016-03-30 2020-07-22 株式会社ニコン 硬化性組成物、硬化物、および、光学部材

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Also Published As

Publication number Publication date
RU2336270C2 (ru) 2008-10-20
TWI328005B (en) 2010-08-01
JP4523914B2 (ja) 2010-08-11
NO20055921L (no) 2006-01-24
EP1640366A4 (en) 2009-05-13
AU2004251987A1 (en) 2005-01-06
PL379466A1 (pl) 2006-09-18
EP1640366A1 (en) 2006-03-29
US20060241302A1 (en) 2006-10-26
IL172139A0 (en) 2006-04-10
CA2526487A1 (en) 2005-01-06
HK1090362A1 (zh) 2006-12-22
AU2004251987B8 (en) 2010-07-22
AU2004251987C1 (en) 2010-11-18
JPWO2005000798A1 (ja) 2006-08-03
US7932271B2 (en) 2011-04-26
RU2005141552A (ru) 2006-06-27
WO2005000798A1 (ja) 2005-01-06
TW200523251A (en) 2005-07-16
AU2004251987B2 (en) 2010-07-01
KR20060066057A (ko) 2006-06-15

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