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MXPA05006420A - Derivados de pirimidina para el tratamiento de crecimiento celular anormal. - Google Patents

Derivados de pirimidina para el tratamiento de crecimiento celular anormal.

Info

Publication number
MXPA05006420A
MXPA05006420A MXPA05006420A MXPA05006420A MXPA05006420A MX PA05006420 A MXPA05006420 A MX PA05006420A MX PA05006420 A MXPA05006420 A MX PA05006420A MX PA05006420 A MXPA05006420 A MX PA05006420A MX PA05006420 A MXPA05006420 A MX PA05006420A
Authority
MX
Mexico
Prior art keywords
cell growth
abnormal cell
treatment
compounds
formula
Prior art date
Application number
MXPA05006420A
Other languages
English (en)
Inventor
John Charles Kath
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MXPA05006420A publication Critical patent/MXPA05006420A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invencion se refiere a compuestos de formula 1 (ver formula 1) y a sales, profarmacos y solvatos farmaceuticamente aceptables delos mismos, en la que R1, R2, R3, R4, R5, n A y B son como se han definido en esta memoria descriptiva. La invencion tambien se refiere a procedimientos de tratamiento de crecimiento celular anormal en mamiferos mediante la administracion de los compuestos de formula 1 y a composiciones farmaceuticas para tratar dichos trastornos, que contienen los compuestos de formula 1. la invencion tambien se refiere a procedimientos de preparacion de los compuestos de formula 1.
MXPA05006420A 2002-12-20 2003-12-17 Derivados de pirimidina para el tratamiento de crecimiento celular anormal. MXPA05006420A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43567002P 2002-12-20 2002-12-20
PCT/IB2003/006055 WO2004056786A2 (en) 2002-12-20 2003-12-17 Pyrimidine derivates for the treatment of abnormal cell growth

Publications (1)

Publication Number Publication Date
MXPA05006420A true MXPA05006420A (es) 2006-03-08

Family

ID=32682276

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05006420A MXPA05006420A (es) 2002-12-20 2003-12-17 Derivados de pirimidina para el tratamiento de crecimiento celular anormal.

Country Status (17)

Country Link
US (1) US20040220177A1 (es)
EP (1) EP1578732A2 (es)
JP (1) JP2006515298A (es)
AR (1) AR042531A1 (es)
AU (1) AU2003288603A1 (es)
BR (1) BR0317435A (es)
CA (1) CA2510848A1 (es)
GT (2) GT200300292A (es)
HN (1) HN2003000422A (es)
MX (1) MXPA05006420A (es)
NL (1) NL1025071C2 (es)
PA (1) PA8593101A1 (es)
PE (1) PE20040934A1 (es)
TW (1) TW200413330A (es)
UA (1) UA80767C2 (es)
UY (1) UY28135A1 (es)
WO (1) WO2004056786A2 (es)

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