MXPA05000527A - Secuencias nucleotidas que codifican a las deshidrogenasas de fosfoglicerato desregularizadas de bacterias corineformes y procedimiento para la produccion de l-serina. - Google Patents
Secuencias nucleotidas que codifican a las deshidrogenasas de fosfoglicerato desregularizadas de bacterias corineformes y procedimiento para la produccion de l-serina.Info
- Publication number
- MXPA05000527A MXPA05000527A MXPA05000527A MXPA05000527A MXPA05000527A MX PA05000527 A MXPA05000527 A MX PA05000527A MX PA05000527 A MXPA05000527 A MX PA05000527A MX PA05000527 A MXPA05000527 A MX PA05000527A MX PA05000527 A MXPA05000527 A MX PA05000527A
- Authority
- MX
- Mexico
- Prior art keywords
- serine
- producing
- nucleotide sequences
- coryneform bacteria
- phosphoglycerate
- Prior art date
Links
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 title abstract 7
- 241000186031 Corynebacteriaceae Species 0.000 title abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 108010038555 Phosphoglycerate dehydrogenase Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 102100037579 D-3-phosphoglycerate dehydrogenase Human genes 0.000 title 1
- 230000002074 deregulated effect Effects 0.000 title 1
- 229960001153 serine Drugs 0.000 abstract 3
- 229940024606 amino acid Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01095—Phosphoglycerate dehydrogenase (1.1.1.95)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La invencion se refiere a secuencias de nucleotidos de bacterias corineformes que codifican a las proteinas que participan en la biosintesis de la L-serina asi como a un procedimiento para la produccion de L-serina. Por medio de la delecion de cuando menos 79 aminoacidos en la terminal C de la secuencia serA tipo silvestre puede producirse una dihidrogenasa de 3-fosfoglicerato que tiene una reducida retroinhibicion por L-serina frente a la secuencia de tipo silvestre.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10231297A DE10231297A1 (de) | 2002-07-10 | 2002-07-10 | Nukleotidsequenzen coryneformer Bakterien codierend für an der Biosynthese von L-Serin beteiligte Proteine sowie Verfahren zur Herstellung von L-Serin |
| PCT/DE2003/002290 WO2004007705A1 (de) | 2002-07-10 | 2003-07-08 | Nukleotidsequenzen codierend für deregulierte phosphoglycerat-dehydrogenasen coryneformer bakterien sowie verfahren zur herstellung von l-serin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05000527A true MXPA05000527A (es) | 2005-09-30 |
Family
ID=30009893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05000527A MXPA05000527A (es) | 2002-07-10 | 2003-07-08 | Secuencias nucleotidas que codifican a las deshidrogenasas de fosfoglicerato desregularizadas de bacterias corineformes y procedimiento para la produccion de l-serina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7732176B2 (es) |
| EP (1) | EP1520013B1 (es) |
| JP (1) | JP2006524032A (es) |
| KR (1) | KR20060015439A (es) |
| AT (1) | ATE479745T1 (es) |
| BR (1) | BR0312374A (es) |
| DE (2) | DE10231297A1 (es) |
| DK (1) | DK1520013T3 (es) |
| MX (1) | MXPA05000527A (es) |
| WO (1) | WO2004007705A1 (es) |
| ZA (1) | ZA200501158B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007144018A1 (en) * | 2006-06-12 | 2007-12-21 | Metabolic Explorer | Ethanolamine production by fermentation |
| WO2013126721A1 (en) | 2012-02-23 | 2013-08-29 | Massachusetts Institute Of Technology | Engineering microbes and metabolic pathways for the production of ethylene glycol |
| CN114134185B (zh) * | 2021-10-30 | 2024-06-21 | 新泰市佳禾生物科技有限公司 | 一种发酵生产l-丝氨酸的方法 |
| KR20250084931A (ko) * | 2022-10-20 | 2025-06-11 | 시스바이오 에이피에스 | L-세린을 생산하는 유전자 변형 숙주 세포 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3078312B2 (ja) * | 1990-11-22 | 2000-08-21 | 協和醗酵工業株式会社 | 物質の製造法 |
| DE4232468A1 (de) | 1992-09-28 | 1994-03-31 | Consortium Elektrochem Ind | Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung |
| JP3997631B2 (ja) * | 1998-01-12 | 2007-10-24 | 味の素株式会社 | 発酵法によるｌ−セリンの製造法 |
| JP4066543B2 (ja) * | 1998-01-12 | 2008-03-26 | 味の素株式会社 | 発酵法によるｌ−セリンの製造法 |
-
2002
- 2002-07-10 DE DE10231297A patent/DE10231297A1/de not_active Withdrawn
-
2003
- 2003-07-08 WO PCT/DE2003/002290 patent/WO2004007705A1/de not_active Ceased
- 2003-07-08 EP EP03763598A patent/EP1520013B1/de not_active Expired - Lifetime
- 2003-07-08 BR BR0312374-0A patent/BR0312374A/pt not_active Application Discontinuation
- 2003-07-08 DK DK03763598.4T patent/DK1520013T3/da active
- 2003-07-08 AT AT03763598T patent/ATE479745T1/de active
- 2003-07-08 JP JP2004520314A patent/JP2006524032A/ja active Pending
- 2003-07-08 DE DE50313042T patent/DE50313042D1/de not_active Expired - Lifetime
- 2003-07-08 KR KR1020057000470A patent/KR20060015439A/ko not_active Ceased
- 2003-07-08 US US10/520,999 patent/US7732176B2/en not_active Expired - Fee Related
- 2003-07-08 MX MXPA05000527A patent/MXPA05000527A/es not_active Application Discontinuation
-
2005
- 2005-02-09 ZA ZA200501158A patent/ZA200501158B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004007705A1 (de) | 2004-01-22 |
| US7732176B2 (en) | 2010-06-08 |
| DE50313042D1 (de) | 2010-10-14 |
| US20060106207A1 (en) | 2006-05-18 |
| EP1520013A1 (de) | 2005-04-06 |
| DE10231297A1 (de) | 2004-02-05 |
| DK1520013T3 (da) | 2010-12-20 |
| JP2006524032A (ja) | 2006-10-26 |
| EP1520013B1 (de) | 2010-09-01 |
| KR20060015439A (ko) | 2006-02-17 |
| ZA200501158B (en) | 2007-04-25 |
| WO2004007705A9 (de) | 2005-03-31 |
| ATE479745T1 (de) | 2010-09-15 |
| BR0312374A (pt) | 2005-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |