MXPA04002009A - Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico. - Google Patents
Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico.Info
- Publication number
- MXPA04002009A MXPA04002009A MXPA04002009A MXPA04002009A MXPA04002009A MX PA04002009 A MXPA04002009 A MX PA04002009A MX PA04002009 A MXPA04002009 A MX PA04002009A MX PA04002009 A MXPA04002009 A MX PA04002009A MX PA04002009 A MXPA04002009 A MX PA04002009A
- Authority
- MX
- Mexico
- Prior art keywords
- aminoamide
- gabapentin
- analogue
- pharmaceutical composition
- analgesic use
- Prior art date
Links
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title abstract 4
- 230000000202 analgesic effect Effects 0.000 title abstract 3
- 229960002870 gabapentin Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- PBJUNZJWGZTSKL-MRXNPFEDSA-N tiagabine Chemical compound C1=CSC(C(=CCCN2C[C@@H](CCC2)C(O)=O)C2=C(C=CS2)C)=C1C PBJUNZJWGZTSKL-MRXNPFEDSA-N 0.000 abstract 1
- 229960001918 tiagabine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describe una composicion farmaceutica que comprende gabapentina o un analogo de la misma (pregabalina o tiagabina) y una a-aminoamida y su uso analgesico. Se observa un efecto sinergistico de las actividades analgesicas respectivas sin incremento concomitante de los efectos secundarios.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01121069 | 2001-09-03 | ||
| PCT/EP2002/008910 WO2003020273A2 (en) | 2001-09-03 | 2002-08-09 | Pharmaceutical composition comprising gabapentin or an analogue thereof and an $g(a)-aminoamide and its analgesic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04002009A true MXPA04002009A (es) | 2004-07-08 |
Family
ID=8178510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04002009A MXPA04002009A (es) | 2001-09-03 | 2002-08-09 | Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8084447B2 (es) |
| EP (1) | EP1423168B1 (es) |
| JP (1) | JP4350508B2 (es) |
| KR (1) | KR100890875B1 (es) |
| CN (1) | CN1274306C (es) |
| AT (1) | ATE317280T1 (es) |
| AU (1) | AU2002333374B2 (es) |
| BR (1) | BRPI0212298B8 (es) |
| CA (1) | CA2459470C (es) |
| DE (1) | DE60209152T2 (es) |
| DK (1) | DK1423168T3 (es) |
| ES (1) | ES2253579T3 (es) |
| IL (2) | IL160523A0 (es) |
| MX (1) | MXPA04002009A (es) |
| NO (1) | NO331298B1 (es) |
| NZ (1) | NZ531586A (es) |
| PT (1) | PT1423168E (es) |
| RU (1) | RU2295337C2 (es) |
| SI (1) | SI1423168T1 (es) |
| WO (1) | WO2003020273A2 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| DK1169060T3 (da) | 1999-04-09 | 2006-01-16 | Euro Celtique Sa | Natriumkanalblokkerpræparater og anvendelse deraf |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| ATE317280T1 (de) | 2001-09-03 | 2006-02-15 | Newron Pharm Spa | Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung |
| EP1438956A1 (en) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| JP2006515327A (ja) * | 2003-01-30 | 2006-05-25 | ダイノジェン ファーマシューティカルズ, インコーポレイテッド | ナトリウムチャネル調節因子を用いた下部尿路障害を処置するための方法 |
| US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| PT1658062E (pt) * | 2003-08-25 | 2010-03-31 | Newron Pharm Spa | Derivados de alfa-amino amida úteis como agentes antiinflamatórios |
| EP1533302A1 (en) * | 2003-11-21 | 2005-05-25 | Newron Pharmaceuticals S.p.A. | Histidine derivatives |
| EP1557166A1 (en) * | 2004-01-21 | 2005-07-27 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders |
| KR101277520B1 (ko) * | 2004-09-10 | 2013-06-21 | 뉴론 파마슈티칼즈 에스. 피. 에이. | (할로벤질옥시)벤질아미노-프로판아미드를 포함하는 선택적 나트륨 및/또는 칼슘 채널 조절제로서 유용한 약제학적 조성물 |
| CA2604624A1 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid |
| CN100410242C (zh) * | 2005-06-23 | 2008-08-13 | 江苏恩华药业股份有限公司 | 普瑞巴林中间体及其制备方法 |
| CA2619473C (en) | 2005-09-19 | 2012-04-17 | Teva Pharmaceutical Industries Ltd. | An asymmetric synthesis of (s)-(+)-3-(aminomethyl)-5-methylhexanoic acid |
| EP1798236A1 (en) * | 2005-12-13 | 2007-06-20 | EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. | Process for the preparation of 3-pyridyl-1-hydroxyethylidene-1,1- biphosphonic acid and hydrated forms thereof |
| NZ567540A (en) * | 2005-12-22 | 2010-07-30 | Newron Pharm Spa | 2-Phenylethylamino derivatives as calcium and/or sodium channel modulators |
| EA025326B1 (ru) * | 2006-06-19 | 2016-12-30 | Ньюрон Фармасьютикалс С.П.А. | Применение сафинамида и ралфинамида высокой степени чистоты для лечения заболеваний и болезненных состояний в условиях, не препятствующих активности цитохромов системы cyp450 и не проявляющих блокирующих свойств в отношении herg канала |
| AU2008261325B2 (en) | 2007-06-15 | 2012-12-06 | Newron Pharmaceuticals S.P.A. | Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators |
| CN101896456B (zh) | 2007-12-11 | 2014-10-22 | 纽朗制药有限公司 | 具有高纯度的2-[4-(3-或2-氟苄氧基)苄氨基]丙酰胺类的生产方法 |
| WO2010099200A1 (en) | 2009-02-24 | 2010-09-02 | Nektar Therapeutics | Oligomer-amino acid conjugates |
| KR101851118B1 (ko) | 2010-04-27 | 2018-04-23 | 뉴론 파마슈티칼즈 에스. 피. 에이. | 랄핀아미드 메탄설포네이트 염들 또는 이들의 r―에난티오머들의 제조 방법 |
| IL281166B2 (en) * | 2018-09-04 | 2025-08-01 | Minerva Neurosciences Inc | Methods of using a phenoxypropylamine compound to treat pain |
| IT201900006602A1 (it) * | 2019-05-07 | 2020-11-07 | Acraf | Composizione farmaceutica per il trattamento del dolore neuropatico |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1140748A (en) * | 1966-06-23 | 1969-01-22 | Ici Ltd | New carboxylic acid derivatives |
| US3658967A (en) * | 1966-06-23 | 1972-04-25 | Ici Ltd | Carboxylic acid derivatives for lowering the concentration of triglycerides in the blood |
| CH480308A (de) * | 1966-08-11 | 1969-10-31 | Ciba Geigy | Verfahren zur Herstellung von Thiosemicarbazid-Verbindungen |
| US4049663A (en) * | 1972-06-06 | 1977-09-20 | Allen & Hanburys Limited | Ethylene diamine derivatives |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4311853A (en) * | 1979-02-06 | 1982-01-19 | The Radiochemical Centre Limited | Selenium derivatives of thyroxine and tri-iodothyronine |
| DE3010599A1 (de) | 1979-03-22 | 1980-10-09 | Continental Pharma | Derivate von glycinamid, deren herstellung und verwendung |
| US4267354A (en) * | 1979-04-25 | 1981-05-12 | E. R. Squibb & Sons, Inc. | Substituted amides having antiinflammatory activity and intermediates |
| IL60201A (en) * | 1979-06-01 | 1984-05-31 | Wellcome Found | 3-amino-6-(substituted)phenyl-1,2,4-triazine derivatives,their preparation and pharmaceutical compositions containing them |
| ZA805476B (en) | 1979-09-26 | 1981-11-25 | Robins Co Inc A H | 2-amino-3-benzoyl-phenylacetamides and cyclic homologues |
| FR2480747A1 (fr) * | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
| DE3483308D1 (de) * | 1983-11-21 | 1990-10-31 | Fujisawa Pharmaceutical Co | Semicarbazid-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
| US4631287A (en) * | 1985-04-16 | 1986-12-23 | Usv Pharmaceutical Corp. | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| US4725619A (en) | 1985-04-16 | 1988-02-16 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| US4839369A (en) | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| GB8714901D0 (en) * | 1986-07-23 | 1987-07-29 | Ici Plc | Amide derivatives |
| GB2216515A (en) * | 1988-03-04 | 1989-10-11 | Nippon Shinyaku Co Ltd | Acylphenol derivatives |
| US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
| FR2639225B1 (fr) * | 1988-11-21 | 1993-05-21 | Centre Nat Rech Scient | Compositions pharmaceutiques pour la neuroprotection contenant des arylcyclohexylamines |
| IL94466A (en) * | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| DE3928488A1 (de) | 1989-08-29 | 1991-03-07 | Standard Elektrik Lorenz Ag | Interferometrisches messsystem |
| US5025035A (en) * | 1990-10-12 | 1991-06-18 | Warner-Lambert Company | Method of treating depression |
| EP0525360B1 (en) | 1991-07-30 | 1998-03-25 | Korea Research Institute Of Chemical Technology | Novel phenylacetamide derivatives and processes for the preparation thereof |
| GB9203483D0 (en) * | 1992-02-19 | 1992-04-08 | Wellcome Found | Anti-inflammatory compounds |
| US5330515A (en) * | 1992-06-17 | 1994-07-19 | Cyberonics, Inc. | Treatment of pain by vagal afferent stimulation |
| US5256669A (en) * | 1992-08-07 | 1993-10-26 | Aminotek Sciences, Inc. | Methods and compositions for treating acute or chronic pain and drug addiction |
| US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
| GB9306899D0 (en) * | 1993-04-01 | 1993-05-26 | Erba Carlo Spa | Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation |
| GB9306886D0 (en) | 1993-04-01 | 1993-05-26 | Erba Carlo Spa | Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation |
| US5475007A (en) * | 1993-05-28 | 1995-12-12 | The Regents Of The University Of California | 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof |
| ZA953078B (en) * | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| US5482964A (en) * | 1994-10-11 | 1996-01-09 | Warner-Lambert Company | Substituted phenoxyhydroxypropyl amines as central nervous system agents |
| US5541204A (en) * | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
| GB9426102D0 (en) * | 1994-12-23 | 1995-02-22 | Merck Sharp & Dohme | Pharmacuetical compositions |
| KR0147963B1 (ko) | 1995-01-10 | 1998-08-17 | 강박광 | 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법 |
| US5849737A (en) * | 1995-04-14 | 1998-12-15 | The Regents Of The University Of California | Compositions and methods for treating pain |
| US5741818A (en) | 1995-06-07 | 1998-04-21 | University Of Saskatchewan | Semicarbazones having CNS activity and pharmaceutical preparations containing same |
| GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
| US5795864A (en) * | 1995-06-27 | 1998-08-18 | Neurex Corporation | Stable omega conopetide formulations |
| GB9515412D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives |
| GB9515411D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | N-(4-substituted-benzyl)-2-aminolactam derivatives |
| US5688830A (en) * | 1996-01-25 | 1997-11-18 | Syntex (U.S.A.) Inc. | Treatment of neuropathic pain |
| US6372792B1 (en) * | 1996-04-26 | 2002-04-16 | Guy Chouinard | Method for treating anxiety, anxiety disorders and insomnia |
| ATE241351T1 (de) | 1996-07-24 | 2003-06-15 | Warner Lambert Co | Isobutylgaba und dessen derivate zur schmerzbehandlung |
| WO1998007447A1 (en) * | 1996-08-23 | 1998-02-26 | Algos Pharmaceutical Corporation | Anticonvulsant containing composition for treating neuropathic pain |
| CA2264231A1 (en) | 1996-08-29 | 1998-03-05 | Takeda Chemical Industries, Ltd. | Cyclic ether compounds as sodium channel modulators |
| US6290986B1 (en) * | 1996-10-24 | 2001-09-18 | Pharmaceutical Applications Associates, Llc | Method and composition for transdermal administration of pharmacologic agents |
| WO1998019674A2 (en) * | 1996-11-05 | 1998-05-14 | Head Explorer Aps | A method for treating tension-type headache |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| US6207685B1 (en) * | 1996-12-06 | 2001-03-27 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Therapeutic application of a thienycyclohexylamine derivative |
| FR2756738B1 (fr) | 1996-12-06 | 1999-02-12 | Sod Conseils Rech Applic | Nouvelle application therapeutique d'un derive de la thienylcyclohexylamine |
| IL119890A (en) | 1996-12-24 | 2002-03-10 | Teva Pharma | Gabapentin form iii and preparation of gabapentin form ii |
| GB9706730D0 (en) | 1997-04-03 | 1997-05-21 | Pharmacia & Upjohn Spa | 2-[(3-substituted)-5-Isoxazolymethylaminojalkanamid derivatives |
| KR20010020201A (ko) | 1997-04-22 | 2001-03-15 | 코센시스 인크 | 탄소고리 및 헤테로고리 치환된 세미카르바존 및 티오세미카르바존과 그들의 사용 방법 |
| WO1999008670A1 (en) * | 1997-08-20 | 1999-02-25 | Guglietta, Antonio | Gaba analogs to prevent and treat gastrointestinal damage |
| DE69832712T2 (de) * | 1997-09-08 | 2006-06-22 | Warner-Lambert Company Llc | Analgetische zusammensetzung enthaltend antiepileptische arzneistoffe und deren verwendungen |
| EP2201945B1 (en) * | 1997-11-21 | 2013-03-06 | Purdue Neuroscience Company | Use of substituted 2-aminoacetamides for treating or ameliorating anxiety |
| GB9727521D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Substituted 2-benzylamino-2-phenyl-acetamide compounds |
| GB9727523D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| AU2463099A (en) | 1998-01-23 | 1999-08-09 | Warner-Lambert Company | Gabapentin and its derivatives for the treatment of muscular and skeletal pain |
| US5905069A (en) * | 1998-01-26 | 1999-05-18 | The General Hospital Corporation | Methods of decreasing or preventing pain using spicamycin or derivatives thereof |
| CA2319484A1 (en) | 1998-02-04 | 1999-08-12 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
| GB9804885D0 (en) | 1998-03-06 | 1998-04-29 | Merck Sharp & Dohme | Therapeutic combination |
| ES2137137B1 (es) | 1998-05-25 | 2000-08-16 | Medichem Sa | Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica. |
| PT1093366E (pt) | 1998-07-09 | 2005-02-28 | Warner Lambert Co | Composicao farmaceutica que contem analogos de gaba e um agente antiviral para o tratamento de herpes zoster |
| PL345340A1 (en) | 1998-07-09 | 2001-12-17 | Warner Lambert Co | Compositions comprising gaba analogs and caffeine |
| US6281211B1 (en) * | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
| JP2002538221A (ja) * | 1999-03-10 | 2002-11-12 | ワーナー−ランバート・カンパニー | 抗てんかん作用を有する化合物を包含する鎮痛組成物およびその使用方法 |
| KR20020015308A (ko) | 1999-03-26 | 2002-02-27 | 추후보정 | 아릴 치환된 피라졸, 이미다졸, 옥사졸, 티아졸 및 피롤,및 이의 용도 |
| DK1169060T3 (da) * | 1999-04-09 | 2006-01-16 | Euro Celtique Sa | Natriumkanalblokkerpræparater og anvendelse deraf |
| WO2001007037A1 (en) * | 1999-07-22 | 2001-02-01 | University Of Rochester | Method of treating symptoms of hormonal variation, including hot flashes |
| US6326385B1 (en) * | 1999-08-04 | 2001-12-04 | Icagen, Inc. | Methods for treating or preventing pain |
| US6113915A (en) * | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
| GB9930079D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
| EP1297341A2 (en) | 2000-06-19 | 2003-04-02 | Merck Frosst Canada Inc. | Methods of identifying gaba b? receptor subtype-specific agonists |
| EP1229332A3 (en) | 2001-02-02 | 2004-07-28 | Warner-Lambert Company | In vitro assay for testing gabapentinoid activity |
| ATE317280T1 (de) | 2001-09-03 | 2006-02-15 | Newron Pharm Spa | Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung |
| EP1438956A1 (en) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| AR044007A1 (es) * | 2003-04-11 | 2005-08-24 | Newron Pharmaceuticals Inc | Metodos para el tratamiento de la enfermedad de parkinson |
| EP1588704A1 (en) * | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
| KR101277520B1 (ko) * | 2004-09-10 | 2013-06-21 | 뉴론 파마슈티칼즈 에스. 피. 에이. | (할로벤질옥시)벤질아미노-프로판아미드를 포함하는 선택적 나트륨 및/또는 칼슘 채널 조절제로서 유용한 약제학적 조성물 |
-
2002
- 2002-08-09 AT AT02797573T patent/ATE317280T1/de active
- 2002-08-09 US US10/487,931 patent/US8084447B2/en not_active Expired - Lifetime
- 2002-08-09 AU AU2002333374A patent/AU2002333374B2/en not_active Expired
- 2002-08-09 MX MXPA04002009A patent/MXPA04002009A/es active IP Right Grant
- 2002-08-09 DE DE60209152T patent/DE60209152T2/de not_active Expired - Lifetime
- 2002-08-09 WO PCT/EP2002/008910 patent/WO2003020273A2/en not_active Ceased
- 2002-08-09 NZ NZ531586A patent/NZ531586A/en not_active IP Right Cessation
- 2002-08-09 CN CNB028185897A patent/CN1274306C/zh not_active Expired - Lifetime
- 2002-08-09 IL IL16052302A patent/IL160523A0/xx active IP Right Grant
- 2002-08-09 JP JP2003524580A patent/JP4350508B2/ja not_active Expired - Lifetime
- 2002-08-09 PT PT02797573T patent/PT1423168E/pt unknown
- 2002-08-09 RU RU2004110041/15A patent/RU2295337C2/ru active
- 2002-08-09 ES ES02797573T patent/ES2253579T3/es not_active Expired - Lifetime
- 2002-08-09 EP EP02797573A patent/EP1423168B1/en not_active Expired - Lifetime
- 2002-08-09 CA CA2459470A patent/CA2459470C/en not_active Expired - Lifetime
- 2002-08-09 KR KR1020047003189A patent/KR100890875B1/ko not_active Expired - Lifetime
- 2002-08-09 BR BRPI0212298A patent/BRPI0212298B8/pt not_active IP Right Cessation
- 2002-08-09 SI SI200230290T patent/SI1423168T1/sl unknown
- 2002-08-09 DK DK02797573T patent/DK1423168T3/da active
-
2004
- 2004-02-23 IL IL160523A patent/IL160523A/en unknown
- 2004-03-02 NO NO20040907A patent/NO331298B1/no not_active IP Right Cessation
-
2011
- 2011-12-07 US US13/313,627 patent/US8710040B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA04002009A (es) | Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico. | |
| ECSP034922A (es) | Pirrolopirimidinas | |
| BR0207961A (pt) | Combinação de análogos da epotilona e agentes quimioterápicos para o tratamento de doenças proliferativas | |
| BR0207930A (pt) | Composições farmacêuticas lìquidas com sabor mascarado | |
| IL158181A0 (en) | N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity | |
| DK1296671T3 (da) | Gabapentinanaloger til sövnforstyrrelser | |
| ATE409065T1 (de) | Inhibitoren der 17 beta- hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten | |
| IL119989A0 (en) | Pharmaceutical compositions for oral treatment of multiple sclerosis | |
| DE602004017871D1 (de) | Zubereitungen zur behandlung von arthritischen erscheinungen | |
| PT1404304E (pt) | Comprimido contendo cetirizina e pseudoefedrina | |
| HUP0302441A2 (hu) | Antibiotikus hatású gyógyászati készítmények | |
| BR9911917A (pt) | Composições compreendendo análogos de gaba e cafeìna | |
| AU2003292006A1 (en) | 3,5,3'-triiodothyronine sulfate as thyromimetic agent and pharmaceutical formulations thereof | |
| BR0213536A (pt) | Formulações de xarope de ribavirina | |
| MY129643A (en) | Tablet comprising cetirizine and pseudoephedrine | |
| CO5210869A1 (es) | Una combinacion sinergetica: gabapentina y pregabalina | |
| PT1368016E (pt) | Formas de dosagem parenterica que compreendem uma suspensao de sal de tramadol e sal de diclofenac | |
| HUP0301348A2 (hu) | COX-2 inhibitorokat tartalmazó fájdalomcsillapító és gyulladásgátló hatású készítmények és alkalmazásuk | |
| IL155273A0 (en) | Pharmaceutical compositions comprising an aplidine compound | |
| AR003293A1 (es) | Mezclas fungicidas sinergicas y procedimiento para combatir hongos nocivos y preparacion de dichas mezclas. | |
| YU11904A (sh) | Upotreba inhibitora il-18 kod poremećaja preosetljivosti | |
| MXPA05005326A (es) | Tableta que comprende efletirizina y pseudoefedrina. | |
| PT1299114E (pt) | Composicao farmaceutica de diclofenac com base em vitamina e, papina e hialuronidase | |
| AU2003255429A1 (en) | Use of treosulfan and derivatives thereof for treating multiple sclerosis | |
| AU2002253445A8 (en) | Synergistic composition of trans-tetracos-15-enoic acid and apocynin and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |