[go: up one dir, main page]

MXPA04002009A - Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico. - Google Patents

Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico.

Info

Publication number
MXPA04002009A
MXPA04002009A MXPA04002009A MXPA04002009A MXPA04002009A MX PA04002009 A MXPA04002009 A MX PA04002009A MX PA04002009 A MXPA04002009 A MX PA04002009A MX PA04002009 A MXPA04002009 A MX PA04002009A MX PA04002009 A MXPA04002009 A MX PA04002009A
Authority
MX
Mexico
Prior art keywords
aminoamide
gabapentin
analogue
pharmaceutical composition
analgesic use
Prior art date
Application number
MXPA04002009A
Other languages
English (en)
Inventor
Salvati Patricia
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of MXPA04002009A publication Critical patent/MXPA04002009A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe una composicion farmaceutica que comprende gabapentina o un analogo de la misma (pregabalina o tiagabina) y una a-aminoamida y su uso analgesico. Se observa un efecto sinergistico de las actividades analgesicas respectivas sin incremento concomitante de los efectos secundarios.
MXPA04002009A 2001-09-03 2002-08-09 Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico. MXPA04002009A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01121069 2001-09-03
PCT/EP2002/008910 WO2003020273A2 (en) 2001-09-03 2002-08-09 Pharmaceutical composition comprising gabapentin or an analogue thereof and an $g(a)-aminoamide and its analgesic use

Publications (1)

Publication Number Publication Date
MXPA04002009A true MXPA04002009A (es) 2004-07-08

Family

ID=8178510

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04002009A MXPA04002009A (es) 2001-09-03 2002-08-09 Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico.

Country Status (20)

Country Link
US (2) US8084447B2 (es)
EP (1) EP1423168B1 (es)
JP (1) JP4350508B2 (es)
KR (1) KR100890875B1 (es)
CN (1) CN1274306C (es)
AT (1) ATE317280T1 (es)
AU (1) AU2002333374B2 (es)
BR (1) BRPI0212298B8 (es)
CA (1) CA2459470C (es)
DE (1) DE60209152T2 (es)
DK (1) DK1423168T3 (es)
ES (1) ES2253579T3 (es)
IL (2) IL160523A0 (es)
MX (1) MXPA04002009A (es)
NO (1) NO331298B1 (es)
NZ (1) NZ531586A (es)
PT (1) PT1423168E (es)
RU (1) RU2295337C2 (es)
SI (1) SI1423168T1 (es)
WO (1) WO2003020273A2 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
DK1169060T3 (da) 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
ATE317280T1 (de) 2001-09-03 2006-02-15 Newron Pharm Spa Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
JP2006515327A (ja) * 2003-01-30 2006-05-25 ダイノジェン ファーマシューティカルズ, インコーポレイテッド ナトリウムチャネル調節因子を用いた下部尿路障害を処置するための方法
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
PT1658062E (pt) * 2003-08-25 2010-03-31 Newron Pharm Spa Derivados de alfa-amino amida úteis como agentes antiinflamatórios
EP1533302A1 (en) * 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. Histidine derivatives
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. (할로벤질옥시)벤질아미노-프로판아미드를 포함하는 선택적 나트륨 및/또는 칼슘 채널 조절제로서 유용한 약제학적 조성물
CA2604624A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
CA2619473C (en) 2005-09-19 2012-04-17 Teva Pharmaceutical Industries Ltd. An asymmetric synthesis of (s)-(+)-3-(aminomethyl)-5-methylhexanoic acid
EP1798236A1 (en) * 2005-12-13 2007-06-20 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Process for the preparation of 3-pyridyl-1-hydroxyethylidene-1,1- biphosphonic acid and hydrated forms thereof
NZ567540A (en) * 2005-12-22 2010-07-30 Newron Pharm Spa 2-Phenylethylamino derivatives as calcium and/or sodium channel modulators
EA025326B1 (ru) * 2006-06-19 2016-12-30 Ньюрон Фармасьютикалс С.П.А. Применение сафинамида и ралфинамида высокой степени чистоты для лечения заболеваний и болезненных состояний в условиях, не препятствующих активности цитохромов системы cyp450 и не проявляющих блокирующих свойств в отношении herg канала
AU2008261325B2 (en) 2007-06-15 2012-12-06 Newron Pharmaceuticals S.P.A. Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
CN101896456B (zh) 2007-12-11 2014-10-22 纽朗制药有限公司 具有高纯度的2-[4-(3-或2-氟苄氧基)苄氨基]丙酰胺类的生产方法
WO2010099200A1 (en) 2009-02-24 2010-09-02 Nektar Therapeutics Oligomer-amino acid conjugates
KR101851118B1 (ko) 2010-04-27 2018-04-23 뉴론 파마슈티칼즈 에스. 피. 에이. 랄핀아미드 메탄설포네이트 염들 또는 이들의 r―에난티오머들의 제조 방법
IL281166B2 (en) * 2018-09-04 2025-08-01 Minerva Neurosciences Inc Methods of using a phenoxypropylamine compound to treat pain
IT201900006602A1 (it) * 2019-05-07 2020-11-07 Acraf Composizione farmaceutica per il trattamento del dolore neuropatico

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140748A (en) * 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US3658967A (en) * 1966-06-23 1972-04-25 Ici Ltd Carboxylic acid derivatives for lowering the concentration of triglycerides in the blood
CH480308A (de) * 1966-08-11 1969-10-31 Ciba Geigy Verfahren zur Herstellung von Thiosemicarbazid-Verbindungen
US4049663A (en) * 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4311853A (en) * 1979-02-06 1982-01-19 The Radiochemical Centre Limited Selenium derivatives of thyroxine and tri-iodothyronine
DE3010599A1 (de) 1979-03-22 1980-10-09 Continental Pharma Derivate von glycinamid, deren herstellung und verwendung
US4267354A (en) * 1979-04-25 1981-05-12 E. R. Squibb & Sons, Inc. Substituted amides having antiinflammatory activity and intermediates
IL60201A (en) * 1979-06-01 1984-05-31 Wellcome Found 3-amino-6-(substituted)phenyl-1,2,4-triazine derivatives,their preparation and pharmaceutical compositions containing them
ZA805476B (en) 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
DE3483308D1 (de) * 1983-11-21 1990-10-31 Fujisawa Pharmaceutical Co Semicarbazid-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4839369A (en) 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
GB8714901D0 (en) * 1986-07-23 1987-07-29 Ici Plc Amide derivatives
GB2216515A (en) * 1988-03-04 1989-10-11 Nippon Shinyaku Co Ltd Acylphenol derivatives
US4894476A (en) * 1988-05-02 1990-01-16 Warner-Lambert Company Gabapentin monohydrate and a process for producing the same
FR2639225B1 (fr) * 1988-11-21 1993-05-21 Centre Nat Rech Scient Compositions pharmaceutiques pour la neuroprotection contenant des arylcyclohexylamines
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
DE3928488A1 (de) 1989-08-29 1991-03-07 Standard Elektrik Lorenz Ag Interferometrisches messsystem
US5025035A (en) * 1990-10-12 1991-06-18 Warner-Lambert Company Method of treating depression
EP0525360B1 (en) 1991-07-30 1998-03-25 Korea Research Institute Of Chemical Technology Novel phenylacetamide derivatives and processes for the preparation thereof
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
US5330515A (en) * 1992-06-17 1994-07-19 Cyberonics, Inc. Treatment of pain by vagal afferent stimulation
US5256669A (en) * 1992-08-07 1993-10-26 Aminotek Sciences, Inc. Methods and compositions for treating acute or chronic pain and drug addiction
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
GB9306899D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
GB9306886D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
US5475007A (en) * 1993-05-28 1995-12-12 The Regents Of The University Of California 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof
ZA953078B (en) * 1994-04-28 1996-01-05 Alza Corp Effective therapy for epilepsies
US5482964A (en) * 1994-10-11 1996-01-09 Warner-Lambert Company Substituted phenoxyhydroxypropyl amines as central nervous system agents
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
GB9426102D0 (en) * 1994-12-23 1995-02-22 Merck Sharp & Dohme Pharmacuetical compositions
KR0147963B1 (ko) 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
US5849737A (en) * 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US5741818A (en) 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
US5795864A (en) * 1995-06-27 1998-08-18 Neurex Corporation Stable omega conopetide formulations
GB9515412D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
GB9515411D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa N-(4-substituted-benzyl)-2-aminolactam derivatives
US5688830A (en) * 1996-01-25 1997-11-18 Syntex (U.S.A.) Inc. Treatment of neuropathic pain
US6372792B1 (en) * 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
ATE241351T1 (de) 1996-07-24 2003-06-15 Warner Lambert Co Isobutylgaba und dessen derivate zur schmerzbehandlung
WO1998007447A1 (en) * 1996-08-23 1998-02-26 Algos Pharmaceutical Corporation Anticonvulsant containing composition for treating neuropathic pain
CA2264231A1 (en) 1996-08-29 1998-03-05 Takeda Chemical Industries, Ltd. Cyclic ether compounds as sodium channel modulators
US6290986B1 (en) * 1996-10-24 2001-09-18 Pharmaceutical Applications Associates, Llc Method and composition for transdermal administration of pharmacologic agents
WO1998019674A2 (en) * 1996-11-05 1998-05-14 Head Explorer Aps A method for treating tension-type headache
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
US6207685B1 (en) * 1996-12-06 2001-03-27 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Therapeutic application of a thienycyclohexylamine derivative
FR2756738B1 (fr) 1996-12-06 1999-02-12 Sod Conseils Rech Applic Nouvelle application therapeutique d'un derive de la thienylcyclohexylamine
IL119890A (en) 1996-12-24 2002-03-10 Teva Pharma Gabapentin form iii and preparation of gabapentin form ii
GB9706730D0 (en) 1997-04-03 1997-05-21 Pharmacia & Upjohn Spa 2-[(3-substituted)-5-Isoxazolymethylaminojalkanamid derivatives
KR20010020201A (ko) 1997-04-22 2001-03-15 코센시스 인크 탄소고리 및 헤테로고리 치환된 세미카르바존 및 티오세미카르바존과 그들의 사용 방법
WO1999008670A1 (en) * 1997-08-20 1999-02-25 Guglietta, Antonio Gaba analogs to prevent and treat gastrointestinal damage
DE69832712T2 (de) * 1997-09-08 2006-06-22 Warner-Lambert Company Llc Analgetische zusammensetzung enthaltend antiepileptische arzneistoffe und deren verwendungen
EP2201945B1 (en) * 1997-11-21 2013-03-06 Purdue Neuroscience Company Use of substituted 2-aminoacetamides for treating or ameliorating anxiety
GB9727521D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
GB9727523D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
AU2463099A (en) 1998-01-23 1999-08-09 Warner-Lambert Company Gabapentin and its derivatives for the treatment of muscular and skeletal pain
US5905069A (en) * 1998-01-26 1999-05-18 The General Hospital Corporation Methods of decreasing or preventing pain using spicamycin or derivatives thereof
CA2319484A1 (en) 1998-02-04 1999-08-12 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
GB9804885D0 (en) 1998-03-06 1998-04-29 Merck Sharp & Dohme Therapeutic combination
ES2137137B1 (es) 1998-05-25 2000-08-16 Medichem Sa Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.
PT1093366E (pt) 1998-07-09 2005-02-28 Warner Lambert Co Composicao farmaceutica que contem analogos de gaba e um agente antiviral para o tratamento de herpes zoster
PL345340A1 (en) 1998-07-09 2001-12-17 Warner Lambert Co Compositions comprising gaba analogs and caffeine
US6281211B1 (en) * 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
JP2002538221A (ja) * 1999-03-10 2002-11-12 ワーナー−ランバート・カンパニー 抗てんかん作用を有する化合物を包含する鎮痛組成物およびその使用方法
KR20020015308A (ko) 1999-03-26 2002-02-27 추후보정 아릴 치환된 피라졸, 이미다졸, 옥사졸, 티아졸 및 피롤,및 이의 용도
DK1169060T3 (da) * 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
WO2001007037A1 (en) * 1999-07-22 2001-02-01 University Of Rochester Method of treating symptoms of hormonal variation, including hot flashes
US6326385B1 (en) * 1999-08-04 2001-12-04 Icagen, Inc. Methods for treating or preventing pain
US6113915A (en) * 1999-10-12 2000-09-05 Allergan Sales, Inc. Methods for treating pain
GB9930079D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
EP1297341A2 (en) 2000-06-19 2003-04-02 Merck Frosst Canada Inc. Methods of identifying gaba b? receptor subtype-specific agonists
EP1229332A3 (en) 2001-02-02 2004-07-28 Warner-Lambert Company In vitro assay for testing gabapentinoid activity
ATE317280T1 (de) 2001-09-03 2006-02-15 Newron Pharm Spa Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (en) * 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. (할로벤질옥시)벤질아미노-프로판아미드를 포함하는 선택적 나트륨 및/또는 칼슘 채널 조절제로서 유용한 약제학적 조성물

Also Published As

Publication number Publication date
US8084447B2 (en) 2011-12-27
DE60209152D1 (de) 2006-04-20
JP4350508B2 (ja) 2009-10-21
RU2004110041A (ru) 2005-03-10
US20040248978A1 (en) 2004-12-09
BRPI0212298B1 (pt) 2015-11-03
US20120142777A1 (en) 2012-06-07
JP2005504782A (ja) 2005-02-17
CN1274306C (zh) 2006-09-13
DE60209152T2 (de) 2006-08-03
RU2295337C2 (ru) 2007-03-20
US8710040B2 (en) 2014-04-29
WO2003020273A3 (en) 2003-09-04
EP1423168B1 (en) 2006-02-08
AU2002333374A2 (en) 2003-03-18
CA2459470C (en) 2010-10-12
ATE317280T1 (de) 2006-02-15
BRPI0212298B8 (pt) 2021-05-25
ES2253579T3 (es) 2006-06-01
AU2002333374B2 (en) 2007-03-22
NZ531586A (en) 2005-09-30
DK1423168T3 (da) 2006-05-15
SI1423168T1 (sl) 2006-06-30
KR20040034686A (ko) 2004-04-28
NO20040907L (no) 2004-05-14
BR0212298A (pt) 2004-09-14
IL160523A (en) 2009-02-11
EP1423168A2 (en) 2004-06-02
PT1423168E (pt) 2006-05-31
WO2003020273A2 (en) 2003-03-13
CA2459470A1 (en) 2003-03-13
HK1070305A1 (en) 2005-06-17
IL160523A0 (en) 2004-07-25
KR100890875B1 (ko) 2009-03-31
NO331298B1 (no) 2011-11-21
CN1556720A (zh) 2004-12-22

Similar Documents

Publication Publication Date Title
MXPA04002009A (es) Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico.
ECSP034922A (es) Pirrolopirimidinas
BR0207961A (pt) Combinação de análogos da epotilona e agentes quimioterápicos para o tratamento de doenças proliferativas
BR0207930A (pt) Composições farmacêuticas lìquidas com sabor mascarado
IL158181A0 (en) N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity
DK1296671T3 (da) Gabapentinanaloger til sövnforstyrrelser
ATE409065T1 (de) Inhibitoren der 17 beta- hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten
IL119989A0 (en) Pharmaceutical compositions for oral treatment of multiple sclerosis
DE602004017871D1 (de) Zubereitungen zur behandlung von arthritischen erscheinungen
PT1404304E (pt) Comprimido contendo cetirizina e pseudoefedrina
HUP0302441A2 (hu) Antibiotikus hatású gyógyászati készítmények
BR9911917A (pt) Composições compreendendo análogos de gaba e cafeìna
AU2003292006A1 (en) 3,5,3'-triiodothyronine sulfate as thyromimetic agent and pharmaceutical formulations thereof
BR0213536A (pt) Formulações de xarope de ribavirina
MY129643A (en) Tablet comprising cetirizine and pseudoephedrine
CO5210869A1 (es) Una combinacion sinergetica: gabapentina y pregabalina
PT1368016E (pt) Formas de dosagem parenterica que compreendem uma suspensao de sal de tramadol e sal de diclofenac
HUP0301348A2 (hu) COX-2 inhibitorokat tartalmazó fájdalomcsillapító és gyulladásgátló hatású készítmények és alkalmazásuk
IL155273A0 (en) Pharmaceutical compositions comprising an aplidine compound
AR003293A1 (es) Mezclas fungicidas sinergicas y procedimiento para combatir hongos nocivos y preparacion de dichas mezclas.
YU11904A (sh) Upotreba inhibitora il-18 kod poremećaja preosetljivosti
MXPA05005326A (es) Tableta que comprende efletirizina y pseudoefedrina.
PT1299114E (pt) Composicao farmaceutica de diclofenac com base em vitamina e, papina e hialuronidase
AU2003255429A1 (en) Use of treosulfan and derivatives thereof for treating multiple sclerosis
AU2002253445A8 (en) Synergistic composition of trans-tetracos-15-enoic acid and apocynin and use thereof

Legal Events

Date Code Title Description
FG Grant or registration