MXPA03011199A - Derivados de pirazol como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana (vih). - Google Patents
Derivados de pirazol como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana (vih).Info
- Publication number
- MXPA03011199A MXPA03011199A MXPA03011199A MXPA03011199A MXPA03011199A MX PA03011199 A MXPA03011199 A MX PA03011199A MX PA03011199 A MXPA03011199 A MX PA03011199A MX PA03011199 A MXPA03011199 A MX PA03011199A MX PA03011199 A MXPA03011199 A MX PA03011199A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- reverse transcriptase
- pyrazole derivatives
- formula
- transcriptase inhibitors
- Prior art date
Links
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 title abstract 2
- 150000003217 pyrazoles Chemical class 0.000 title abstract 2
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000029812 viral genome replication Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La invencion se refiere a derivados de pirazol novedosos, un procedimiento para su fabricacion, composiciones farmaceuticas y el uso de estos compuestos en medicina. En particular, los compuestos de la formula I son inhibidores de la enzima transcriptasa inversa de virus de inmunodeficiencia humana que se incluye en replicacion viral. Como consecuencia, el compuesto de esta invencion se puede usar ventajosamente como agentes terapeuticos para procedimiento mediado de VIH. La invencion describe compuestos novedosos de la formula I en donde R1, R2, R3 y A son como se definen en la descripcion; eteres de compuestos de la formula I asi como sales farmaceuticamente aceptables del anterior.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0113524.3A GB0113524D0 (en) | 2001-06-04 | 2001-06-04 | Pyrazole derivatives |
| PCT/EP2002/005898 WO2002100853A1 (en) | 2001-06-04 | 2002-05-29 | Pyrazole derivatives as hiv reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03011199A true MXPA03011199A (es) | 2004-02-26 |
Family
ID=9915841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03011199A MXPA03011199A (es) | 2001-06-04 | 2002-05-29 | Derivados de pirazol como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana (vih). |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6538015B1 (es) |
| EP (1) | EP1401826B1 (es) |
| JP (1) | JP4088249B2 (es) |
| KR (1) | KR100627532B1 (es) |
| CN (1) | CN1249052C (es) |
| AT (1) | ATE357439T1 (es) |
| AU (1) | AU2002325221B2 (es) |
| BR (1) | BR0210158A (es) |
| CA (1) | CA2448058C (es) |
| DE (1) | DE60219009T2 (es) |
| DK (1) | DK1401826T3 (es) |
| ES (1) | ES2282446T3 (es) |
| GB (1) | GB0113524D0 (es) |
| MX (1) | MXPA03011199A (es) |
| PT (1) | PT1401826E (es) |
| WO (1) | WO2002100853A1 (es) |
| ZA (1) | ZA200308781B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200423930A (en) * | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| WO2006013948A1 (ja) | 2004-08-04 | 2006-02-09 | Taisho Pharmaceutical Co., Ltd. | トリアゾール誘導体 |
| JP2008526828A (ja) * | 2005-01-06 | 2008-07-24 | ファイザー・リミテッド | 逆転写酵素モジュレーターとしてのイミダゾール誘導体 |
| CN101415691B (zh) | 2006-02-03 | 2011-12-14 | 大正制药株式会社 | 三唑衍生物 |
| JP5218737B2 (ja) | 2006-02-06 | 2013-06-26 | 大正製薬株式会社 | スフィンゴシン−１−リン酸結合阻害物質 |
| CN101501002B (zh) | 2006-08-16 | 2012-06-27 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
| WO2009000663A1 (en) | 2007-06-22 | 2008-12-31 | F. Hoffmann-La Roche Ag | Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors |
| RU2468009C2 (ru) | 2007-08-01 | 2012-11-27 | Тайсо Фармасьютикал Ко., Лтд. | Ингибитор связывания s1p1 |
| BRPI0821349A2 (pt) | 2007-12-21 | 2019-09-24 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| DE102008015033A1 (de) * | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| EP2295038B1 (en) * | 2009-09-11 | 2013-05-29 | AiCuris GmbH & Co. KG | Solid dispersion comprising an anti-HIV agent |
| CN102906073B (zh) * | 2010-05-20 | 2015-11-25 | 拜耳知识产权有限责任公司 | 1-烷基-3-二氟甲基-5-羟基吡唑的制备方法 |
| AU2011277426B2 (en) | 2010-07-15 | 2015-04-23 | Sumitomo Pharma Co., Ltd. | Pyrazole compound |
| US9695127B2 (en) | 2012-11-08 | 2017-07-04 | University of Pittsburgh—of the Commonwealth System of Higher Education | Compounds for treating HIV and methods for using the compounds |
| US9925190B2 (en) | 2015-02-16 | 2018-03-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecules targeting HIV-1 Nef |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627423A4 (en) | 1992-01-22 | 1995-02-15 | Nissan Chemical Ind Ltd | SUBSTITUTED PYRAZOLE DERIVATIVES AND BACTERICIDES FOR AGRICULTURE AND GARDENING. |
| US6005109A (en) | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| EP0786455B1 (en) | 1994-09-26 | 2003-12-03 | Shionogi & Co., Ltd. | Imidazole derivative |
| US5698495A (en) | 1995-11-15 | 1997-12-16 | Zeneca Limited | Herbicidal substituted pyrazole compounds |
| GB0016787D0 (en) | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| GB0024795D0 (en) * | 2000-10-10 | 2000-11-22 | Hoffmann La Roche | Pyrazole derivatives for the treatment of viral diseases |
-
2001
- 2001-06-04 GB GBGB0113524.3A patent/GB0113524D0/en not_active Ceased
-
2002
- 2002-05-24 US US10/154,585 patent/US6538015B1/en not_active Expired - Fee Related
- 2002-05-29 AU AU2002325221A patent/AU2002325221B2/en not_active Ceased
- 2002-05-29 ES ES02758207T patent/ES2282446T3/es not_active Expired - Lifetime
- 2002-05-29 BR BR0210158-0A patent/BR0210158A/pt not_active IP Right Cessation
- 2002-05-29 CN CNB028111974A patent/CN1249052C/zh not_active Expired - Fee Related
- 2002-05-29 KR KR1020037015833A patent/KR100627532B1/ko not_active Expired - Fee Related
- 2002-05-29 DE DE60219009T patent/DE60219009T2/de not_active Expired - Fee Related
- 2002-05-29 JP JP2003503620A patent/JP4088249B2/ja not_active Expired - Fee Related
- 2002-05-29 DK DK02758207T patent/DK1401826T3/da active
- 2002-05-29 AT AT02758207T patent/ATE357439T1/de not_active IP Right Cessation
- 2002-05-29 EP EP02758207A patent/EP1401826B1/en not_active Expired - Lifetime
- 2002-05-29 CA CA002448058A patent/CA2448058C/en not_active Expired - Fee Related
- 2002-05-29 MX MXPA03011199A patent/MXPA03011199A/es active IP Right Grant
- 2002-05-29 PT PT02758207T patent/PT1401826E/pt unknown
- 2002-05-29 WO PCT/EP2002/005898 patent/WO2002100853A1/en not_active Ceased
-
2003
- 2003-11-11 ZA ZA200308781A patent/ZA200308781B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1401826T3 (da) | 2007-07-30 |
| CN1249052C (zh) | 2006-04-05 |
| KR100627532B1 (ko) | 2006-09-21 |
| PT1401826E (pt) | 2007-06-19 |
| EP1401826B1 (en) | 2007-03-21 |
| ZA200308781B (en) | 2005-02-11 |
| GB0113524D0 (en) | 2001-07-25 |
| EP1401826A1 (en) | 2004-03-31 |
| JP4088249B2 (ja) | 2008-05-21 |
| BR0210158A (pt) | 2004-06-08 |
| ATE357439T1 (de) | 2007-04-15 |
| AU2002325221B2 (en) | 2008-07-31 |
| KR20040003050A (ko) | 2004-01-07 |
| DE60219009D1 (de) | 2007-05-03 |
| CA2448058A1 (en) | 2002-12-19 |
| ES2282446T3 (es) | 2007-10-16 |
| CA2448058C (en) | 2008-12-23 |
| DE60219009T2 (de) | 2007-12-13 |
| JP2004532276A (ja) | 2004-10-21 |
| WO2002100853A1 (en) | 2002-12-19 |
| CN1527829A (zh) | 2004-09-08 |
| US6538015B1 (en) | 2003-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |