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MXPA03005940A - Perfluorocicloaminas terciarias como una base para emulsiones de transporte de gas y proceso para preparar las mismas. - Google Patents

Perfluorocicloaminas terciarias como una base para emulsiones de transporte de gas y proceso para preparar las mismas.

Info

Publication number
MXPA03005940A
MXPA03005940A MXPA03005940A MXPA03005940A MXPA03005940A MX PA03005940 A MXPA03005940 A MX PA03005940A MX PA03005940 A MXPA03005940 A MX PA03005940A MX PA03005940 A MXPA03005940 A MX PA03005940A MX PA03005940 A MXPA03005940 A MX PA03005940A
Authority
MX
Mexico
Prior art keywords
emulsions
tpfca
mixture
see formula
tertiary
Prior art date
Application number
MXPA03005940A
Other languages
English (en)
Inventor
Lvovich Gervits Lev
Original Assignee
Otkrytoe Aktsionernoe Obschest
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otkrytoe Aktsionernoe Obschest filed Critical Otkrytoe Aktsionernoe Obschest
Publication of MXPA03005940A publication Critical patent/MXPA03005940A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/37—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/27—Halogenation
    • C25B3/28—Fluorination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Electrochemistry (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Cardiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Perfluorocicloaminas terciarias (TPFCA) de la formula general (I) (ver formula I) donde n = 1 o 2, m = 2 o 3, X es (ver formula) o en donde n = 2 X es (ver formula) como la base para emulsiones de transporte de gas. Las TPFCA comprenden un grupo de compuestos que estan cercanos en sus propiedades fisicoquimicas a la perfluoro-N-(4-metil-ciclohexil)-piperidina, particularmente en la temperatura critica de disolucion en hexano, y que se usan en una mezcla, que forman varios compuestos con caracteristicas gradualmente variables. Debido a esto, se puede lograr una mayor homogeneidad de la fase de fluorocarburo en las emulsiones y llega a ser posible mejorar la estabilidad de las particulas de la emulsion estabilizadas por un copolimero de bloques de oxido de etileno-oxido de propileno, con la ausencia de toxicidad para animales grandes, se prepara una mezcla de TPFCA Por fluoracion electroquimica de n-piperidinoheptafluorotolueno en fluoruro de hidrogeno anhidro. El uso de esta mezcla de TPFCA en lugar de la perfluoro-N-(4-metil-ciclohexil)-piperidina individual simplifica y acelera el proceso para preparar compuestos organicos perfluorados, lo hace mas barato y proporciona condiciones para la aplicacion mas amplia de emulsiones de transporte de gas basadas en las misma.
MXPA03005940A 2000-12-29 2000-12-29 Perfluorocicloaminas terciarias como una base para emulsiones de transporte de gas y proceso para preparar las mismas. MXPA03005940A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2000/000547 WO2002053525A1 (en) 2000-12-29 2000-12-29 Perfluoronated cycle-containing tertiary amines used as a basis for gas-conveying emulsions and device for the production thereof

Publications (1)

Publication Number Publication Date
MXPA03005940A true MXPA03005940A (es) 2004-05-04

Family

ID=20129588

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03005940A MXPA03005940A (es) 2000-12-29 2000-12-29 Perfluorocicloaminas terciarias como una base para emulsiones de transporte de gas y proceso para preparar las mismas.

Country Status (9)

Country Link
US (1) US6878826B2 (es)
EP (1) EP1354868A4 (es)
JP (1) JP2004517119A (es)
KR (1) KR20030076593A (es)
CN (1) CN1241901C (es)
CA (1) CA2433580A1 (es)
MX (1) MXPA03005940A (es)
RU (1) RU2263662C2 (es)
WO (1) WO2002053525A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6602844B2 (en) * 2000-08-11 2003-08-05 Showa Denko Kabushiki Kaisha Perfluorocyclicamine, constant boiling composition and process for producing the same
RU2686491C1 (ru) * 2018-10-17 2019-04-29 Общество с ограниченной ответственностью "ГалоПолимер Кирово-Чепецк" Способ получения перфторированных циклосодержащих третичных аминов

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2631151A (en) * 1950-05-12 1953-03-10 Minnesota Mining & Mfg Perfluoro n-alkyl piperidines
DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
CA1132417A (en) 1979-01-29 1982-09-28 Gary L. Casey Electromagnetic fuel injector
US5214214A (en) * 1981-09-08 1993-05-25 The Green Cross Corporation Perfluoro branched alkyl ethers and emulsions
JPS5939870A (ja) * 1982-08-30 1984-03-05 Green Cross Corp:The フルオロカ−ボン乳化製剤
US4534978A (en) * 1982-12-28 1985-08-13 The Green Cross Corporation Perfluorocycloamines
JPS63198651A (ja) * 1987-02-13 1988-08-17 Daikin Ind Ltd トリパ−フルオロアルキルアミンおよびその製法
DE4019061A1 (de) * 1989-08-30 1991-03-07 Kali Chemie Ag Verfahren zur herstellung perfluorierter heterocyclischer verbindungen und nach diesem verfahren hergestellte verbindungen
GB9017390D0 (en) * 1990-08-08 1990-09-19 Norgine Ltd Improvements in or relating to propylamine derivatives
GB9108222D0 (en) * 1991-04-17 1991-06-05 Ici Plc Composition and method
ATE145330T1 (de) * 1991-09-06 1996-12-15 Mcneilab Inc Zusammensetzungen, die tramadol und irgendein kodein, oxykoden oder hydrokoden enthalten, und deren verwendung
RU2088217C1 (ru) * 1993-05-07 1997-08-27 Институт биофизики клетки РАН Эмульсия перфторорганических соединений с газотранспортными свойствами
US5877351A (en) * 1997-12-24 1999-03-02 Wyckoff Chemical Company, Inc. Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts
WO2002034297A2 (en) * 2000-10-24 2002-05-02 Visys Ag Endoscopic vascular visualisation, diagnostic and/or surgical procedure

Also Published As

Publication number Publication date
US20040054184A1 (en) 2004-03-18
CN1489573A (zh) 2004-04-14
CA2433580A1 (en) 2002-07-11
RU2003123103A (ru) 2005-02-20
EP1354868A4 (en) 2004-09-29
CN1241901C (zh) 2006-02-15
EP1354868A1 (en) 2003-10-22
US6878826B2 (en) 2005-04-12
WO2002053525A1 (en) 2002-07-11
RU2263662C2 (ru) 2005-11-10
KR20030076593A (ko) 2003-09-26
JP2004517119A (ja) 2004-06-10

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