MXPA02000465A - Derivados ciclopeptidicos como inhibidores de la integrina alfav beta6. - Google Patents
Derivados ciclopeptidicos como inhibidores de la integrina alfav beta6.Info
- Publication number
- MXPA02000465A MXPA02000465A MXPA02000465A MXPA02000465A MXPA02000465A MX PA02000465 A MXPA02000465 A MX PA02000465A MX PA02000465 A MXPA02000465 A MX PA02000465A MX PA02000465 A MXPA02000465 A MX PA02000465A MX PA02000465 A MXPA02000465 A MX PA02000465A
- Authority
- MX
- Mexico
- Prior art keywords
- representing
- phe
- peptide derivatives
- inhibitors
- cyclic peptide
- Prior art date
Links
- 108010069514 Cyclic Peptides Proteins 0.000 title 1
- 102000001189 Cyclic Peptides Human genes 0.000 title 1
- 108010040765 Integrin alphaV Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 108010004788 integrin alphavbeta6 Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El invento describe los nuevos derivados peptidicos de formula I, que ejercen un efecto biologico como ligandos de la integrina ?v ?6. Ciclo- (Arg-X1-Asp-X2-X3-X4-X5-X6-R1), caracterizados porque: X1 representa Ser, Gli o Tr, X2 representa Leu, Ile, Nle, Val o Fen, X3 representa Asp, Glu, Lis o Fen, X4 representa Gli, Ala o Ser, X5 representa Leu, Ile, Nle, Val o Fen, X6 representa Arg, Har o Lis, R1 esta ausente o representa uno o varios radicales de acido ?-aminocarboxilico, presentando el/o los radical/es de acido ?- aminocarboxilico una longitud de 500 a 2500 pm, y en donde los aminoacidos mencionados tambien pueden estar derivatizados, e incluyendo tanto las formas D como las formas L de los radicales de aminoacido opticamente activos, y a los solvatos y las sales, aceptables desde el punto de vista fisiologico, de estos compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19933173A DE19933173A1 (de) | 1999-07-15 | 1999-07-15 | Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶ |
| PCT/EP2000/006188 WO2001005810A2 (de) | 1999-07-15 | 2000-07-03 | CYCLISCHE PEPTIDDERIVATE ALS INHIBITOREN DES INTEGRINS αvβ¿6? |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02000465A true MXPA02000465A (es) | 2002-07-30 |
Family
ID=7914891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02000465A MXPA02000465A (es) | 1999-07-15 | 2000-07-03 | Derivados ciclopeptidicos como inhibidores de la integrina alfav beta6. |
Country Status (23)
| Country | Link |
|---|---|
| EP (2) | EP1754714A1 (es) |
| JP (1) | JP2003505395A (es) |
| KR (1) | KR20020010928A (es) |
| CN (1) | CN1361792A (es) |
| AR (1) | AR024742A1 (es) |
| AT (1) | ATE340803T1 (es) |
| AU (1) | AU772782C (es) |
| BR (1) | BR0012418A (es) |
| CA (1) | CA2379022A1 (es) |
| CZ (1) | CZ200226A3 (es) |
| DE (2) | DE19933173A1 (es) |
| DK (1) | DK1196433T3 (es) |
| ES (1) | ES2273703T3 (es) |
| HK (1) | HK1048641A1 (es) |
| HU (1) | HUP0201925A3 (es) |
| MX (1) | MXPA02000465A (es) |
| NO (1) | NO20020176L (es) |
| PL (1) | PL354363A1 (es) |
| PT (1) | PT1196433E (es) |
| SK (1) | SK262002A3 (es) |
| TW (1) | TWI226890B (es) |
| WO (1) | WO2001005810A2 (es) |
| ZA (1) | ZA200201275B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4028386B2 (ja) * | 2001-02-19 | 2007-12-26 | タカラバイオ株式会社 | 環状ペプチド |
| DE10118550A1 (de) * | 2001-04-14 | 2002-10-17 | Merck Patent Gmbh | Liganden des Integrins alpha¶nu¶beta¶6¶ |
| WO2004082629A2 (en) | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| BRPI0414927A (pt) * | 2003-10-01 | 2006-11-07 | Merck Patent Ges Mit Beschaenk | antagonistas de integrina alfavbeta3 e alfavbeta6 como agentes antifibróticos |
| WO2005056575A2 (en) * | 2003-12-03 | 2005-06-23 | The Scripps Research Institute | INTEGRIN αIIbβ3 SPECIFIC ANTIBODIES AND PEPTIDES |
| US7378391B2 (en) | 2004-09-29 | 2008-05-27 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| JP2008514702A (ja) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | 新規シクロスポリン類似体およびそれらの薬学的使用 |
| US7361636B2 (en) | 2004-10-06 | 2008-04-22 | Amr Technology, Inc. | Cyclosporin alkynes and their utility as pharmaceutical agents |
| GB0520068D0 (en) * | 2005-10-03 | 2005-11-09 | Cancer Res Technology | av peptide ligand |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| JP5362563B2 (ja) | 2006-08-03 | 2013-12-11 | アストラゼネカ・アクチエボラーグ | αＶβ６に対する抗体およびその使用 |
| EP2784511A1 (en) | 2013-03-27 | 2014-10-01 | Universität Zürich | Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma |
| SI3350222T1 (sl) * | 2015-09-18 | 2022-01-31 | Technische Universitaet Muenchen | Ligandi za integrin avbeta6, sinteza in uporaba le-teh |
| MA52117A (fr) | 2017-02-28 | 2022-04-06 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
| TW201835078A (zh) | 2017-02-28 | 2018-10-01 | 美商萊築理公司 | αvβ6整合蛋白之抑制劑 |
| WO2018167295A1 (en) | 2017-03-17 | 2018-09-20 | Technische Universität München | LIGANDS FOR INTEGRIN αvβ8, SYNTHESIS AND USES THEREOF |
| GB201706472D0 (en) * | 2017-04-24 | 2017-06-07 | Cancer Res Tech Ltd | Tumour-targeting peptide variants |
| MX2021002181A (es) | 2018-08-29 | 2021-07-15 | Morphic Therapeutic Inc | Inhibicion de la integrina alfa v beta 6. |
| IL296081A (en) * | 2020-03-12 | 2022-11-01 | Univ Muenchen Tech | Cyclic peptides and their conjugates for addressing alpha-v-beta-6 integrin in vivo |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472305A (en) | 1983-05-17 | 1984-09-18 | Sterling Drug Inc. | Hexapeptide amides |
| DE4310643A1 (de) | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| DE19538741A1 (de) | 1995-10-18 | 1997-04-24 | Merck Patent Gmbh | Cyclopeptidderivate |
| BR9916323A (pt) * | 1998-12-19 | 2001-10-30 | Merck Patent Gmbh | Inibidores da integrina alfavbeta6 |
-
1999
- 1999-07-15 DE DE19933173A patent/DE19933173A1/de not_active Withdrawn
-
2000
- 2000-07-03 PL PL00354363A patent/PL354363A1/xx unknown
- 2000-07-03 ES ES00943971T patent/ES2273703T3/es not_active Expired - Lifetime
- 2000-07-03 AU AU58236/00A patent/AU772782C/en not_active Ceased
- 2000-07-03 BR BR0012418-4A patent/BR0012418A/pt not_active Application Discontinuation
- 2000-07-03 WO PCT/EP2000/006188 patent/WO2001005810A2/de not_active Ceased
- 2000-07-03 CN CN00810415A patent/CN1361792A/zh active Pending
- 2000-07-03 MX MXPA02000465A patent/MXPA02000465A/es unknown
- 2000-07-03 SK SK26-2002A patent/SK262002A3/sk unknown
- 2000-07-03 CA CA002379022A patent/CA2379022A1/en not_active Abandoned
- 2000-07-03 KR KR1020017015995A patent/KR20020010928A/ko not_active Withdrawn
- 2000-07-03 DE DE50013525T patent/DE50013525D1/de not_active Expired - Fee Related
- 2000-07-03 EP EP06019918A patent/EP1754714A1/de not_active Withdrawn
- 2000-07-03 JP JP2001511467A patent/JP2003505395A/ja active Pending
- 2000-07-03 AT AT00943971T patent/ATE340803T1/de not_active IP Right Cessation
- 2000-07-03 HU HU0201925A patent/HUP0201925A3/hu unknown
- 2000-07-03 DK DK00943971T patent/DK1196433T3/da active
- 2000-07-03 HK HK03100378.9A patent/HK1048641A1/zh unknown
- 2000-07-03 PT PT00943971T patent/PT1196433E/pt unknown
- 2000-07-03 EP EP00943971A patent/EP1196433B1/de not_active Expired - Lifetime
- 2000-07-03 CZ CZ200226A patent/CZ200226A3/cs unknown
- 2000-07-13 TW TW089113997A patent/TWI226890B/zh not_active IP Right Cessation
- 2000-07-14 AR ARP000103621A patent/AR024742A1/es unknown
-
2002
- 2002-01-14 NO NO20020176A patent/NO20020176L/no unknown
- 2002-02-14 ZA ZA200201275A patent/ZA200201275B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5823600A (en) | 2001-02-05 |
| NO20020176D0 (no) | 2002-01-14 |
| NO20020176L (no) | 2002-01-14 |
| EP1196433B1 (de) | 2006-09-27 |
| EP1196433A2 (de) | 2002-04-17 |
| DE19933173A1 (de) | 2001-01-18 |
| TWI226890B (en) | 2005-01-21 |
| JP2003505395A (ja) | 2003-02-12 |
| HUP0201925A2 (en) | 2002-10-28 |
| PT1196433E (pt) | 2007-01-31 |
| ZA200201275B (en) | 2003-08-22 |
| DK1196433T3 (da) | 2007-02-12 |
| AU772782B2 (en) | 2004-05-06 |
| PL354363A1 (en) | 2004-01-12 |
| CA2379022A1 (en) | 2001-01-25 |
| ES2273703T3 (es) | 2007-05-16 |
| AR024742A1 (es) | 2002-10-23 |
| WO2001005810A2 (de) | 2001-01-25 |
| ATE340803T1 (de) | 2006-10-15 |
| EP1754714A1 (de) | 2007-02-21 |
| WO2001005810A3 (de) | 2001-05-17 |
| BR0012418A (pt) | 2002-03-26 |
| CZ200226A3 (cs) | 2002-04-17 |
| DE50013525D1 (de) | 2006-11-09 |
| KR20020010928A (ko) | 2002-02-06 |
| HK1048641A1 (zh) | 2003-04-11 |
| CN1361792A (zh) | 2002-07-31 |
| AU772782C (en) | 2005-01-27 |
| HUP0201925A3 (en) | 2002-11-28 |
| SK262002A3 (en) | 2002-07-02 |
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