MX9606531A - Compuestos farmaceuticos. - Google Patents
Compuestos farmaceuticos.Info
- Publication number
- MX9606531A MX9606531A MX9606531A MX9606531A MX9606531A MX 9606531 A MX9606531 A MX 9606531A MX 9606531 A MX9606531 A MX 9606531A MX 9606531 A MX9606531 A MX 9606531A MX 9606531 A MX9606531 A MX 9606531A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- pharmaceutical compounds
- coor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229920001577 copolymer Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Un compuesto farmacéutico de la formula (Ver Formula) en el cual R1 y R2 son cada uno hidrogeno, alquilo de 1 a 4 átomos de carbono, alcoxi de 1 a 4átomos de carbono, HO-C1-4alquilo, C1-4alcoxi-C1-4alquilo, alquiltio de 1 a 4 átomos de carbono, halo, Ph, PhCR'R"= en donde Ph es fenilo opcionalmente substituido y R' y R" son cada uno hidrogeno o alquilo de 1 a 4 átomos de carbono, o R1 y R2 junto con el átomo de carbono, al cual están unidos forman un grupo cicloalquilo de 3 a 6 átomos de carbono, >C=0, >C=NOR' en donde R' es hidrogeno o alquilo de 1 a 4 átomos de carbono. R3, R4 y R5 son cada uno hidrogeno, halo, nitro, alquilo de 1 a 4 átomos de carbono, alcoxi de 1 a 4 átomos de carbono, alquiltio de 1 a 4 átomos de carbono, C1-4-alquilo-CO-, C1-4alquilo-S(O)m- en donde m es 0, 1 o 2, R'R"N-SO2-, COOR', -CONR'R", -NR'R", -N(OR')COOR", -COR', NHSO2R', en donde R' y R" son cada uno hidrogeno o alquilo de 1 a 4 átomos de carbono, R6 y R7 son cada uno hidrogeno o alquilo de 1 a 4 átomos de carbono y n es 1 a 6, X es oxigeno o azufre, W es (Ver Formula) en donde p es 4 a 7, y q y r son cada uno 1 a 3, Y es >CO o -CH(OH)-, y Z es fenilo opcionalmente substituido o heteroarilo opcionalmente substituido; y sales y ésteres de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9525963.6 | 1995-12-19 | ||
| GB9525963A GB2308362A (en) | 1995-12-19 | 1995-12-19 | Pharmaceutical indole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MXPA96006531A MXPA96006531A (es) | 1997-06-01 |
| MX9606531A true MX9606531A (es) | 1997-06-28 |
Family
ID=10785702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9606531A MX9606531A (es) | 1995-12-19 | 1996-12-17 | Compuestos farmaceuticos. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5773448A (es) |
| EP (1) | EP0780388B1 (es) |
| JP (1) | JPH09202784A (es) |
| KR (1) | KR970042503A (es) |
| CN (1) | CN1157822A (es) |
| AR (1) | AR010205A1 (es) |
| AT (1) | ATE204273T1 (es) |
| AU (1) | AU720711B2 (es) |
| BR (1) | BR9606066A (es) |
| CA (1) | CA2193039C (es) |
| CZ (1) | CZ372296A3 (es) |
| DE (1) | DE69614491T2 (es) |
| DK (1) | DK0780388T3 (es) |
| ES (1) | ES2159693T3 (es) |
| GB (1) | GB2308362A (es) |
| HU (1) | HUP9603498A3 (es) |
| IL (1) | IL119844A (es) |
| MX (1) | MX9606531A (es) |
| NO (1) | NO307512B1 (es) |
| NZ (1) | NZ299959A (es) |
| PE (1) | PE26198A1 (es) |
| PL (1) | PL317526A1 (es) |
| PT (1) | PT780388E (es) |
| SG (1) | SG47206A1 (es) |
| TR (1) | TR199601018A1 (es) |
| YU (1) | YU67096A (es) |
| ZA (1) | ZA9610589B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9810886D0 (en) * | 1998-05-13 | 1998-07-22 | Lilly Industries Ltd | Pharmaceutical compounds |
| GB2362826A (en) * | 2000-06-02 | 2001-12-05 | Lilly Co Eli | A pharmaceutical composition comprising a serotonin transport inhibitor and a serotonin recptor antagonist |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| US20170121385A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| CN106928122A (zh) * | 2017-03-07 | 2017-07-07 | 贵州大学 | 3‑烷氧基季碳氧化吲哚及其制备方法 |
| CN116947676A (zh) * | 2023-07-12 | 2023-10-27 | 新疆大学 | α-羟基酰胺或3,3-二取代氧化吲哚类化合物的合成方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4035369A (en) * | 1975-10-08 | 1977-07-12 | Janssen Pharmaceutica N.V. | 1-Benzazolylalkyl-4-substituted-piperidines |
| US4432978A (en) * | 1979-07-30 | 1984-02-21 | Pfizer Inc. | Hexahydro-trans-pyridoindole |
| US4254127A (en) * | 1980-04-03 | 1981-03-03 | Janssen Pharmaceutica, N.V. | 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives |
| FR2523964B1 (fr) * | 1982-03-23 | 1985-09-27 | Sanofi Sa | Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation |
| IL69132A (en) * | 1982-07-14 | 1986-02-28 | Roussel Uclaf | Benzo-and naphtho-thiopyranopyrimidinones,their preparation and pharmaceutical compositions containing them |
| US4658038A (en) * | 1982-10-07 | 1987-04-14 | Research Foundation For Mental Hygiene, Inc. | N-acylated 5-hydroxytryptophan amide derivatives |
| US4608374A (en) * | 1983-11-07 | 1986-08-26 | Hoechst-Roussel Pharmaceuticals Inc. | 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents |
| GB8332704D0 (en) * | 1983-12-07 | 1984-01-11 | Pfizer Ltd | Growth promotants for animals |
| DE3563964D1 (en) * | 1984-10-16 | 1988-09-01 | Synthelabo | Piperidine derivatives, their preparation and their therapeutical application |
| US4789676A (en) * | 1986-03-05 | 1988-12-06 | Merrell Dow Pharmaceuticals Inc. | Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives, usefull as anxiolytic agents |
| EP0351283A1 (fr) * | 1988-07-12 | 1990-01-17 | Synthelabo | Dérivés de [(pipéridinyl-4) méthyl]-2 dihydro-2,3 1H-isoindole et tétrahydro-2,3,4,5 1H-benzazépines, leur préparation et leur application en thérapeutique |
| FR2634207B1 (fr) * | 1988-07-12 | 1990-09-07 | Synthelabo | Derives de ((piperidinyl-4)methyl) benzazepines, leur preparation et leur application en therapeutique |
| FR2635524B1 (fr) * | 1988-08-19 | 1992-04-24 | Adir | Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US5068234A (en) * | 1990-02-26 | 1991-11-26 | Sterling Drug Inc. | 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles |
| GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
| TW203049B (es) * | 1990-04-13 | 1993-04-01 | Yamanouchi Pharma Co Ltd | |
| FR2661177A1 (fr) * | 1990-04-23 | 1991-10-25 | Rhone Poulenc Sante | Derives du naphtosultame antagonistes de la serotonine, leur preparation et les medicaments les contenant. |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| FR2679561A1 (fr) * | 1991-07-26 | 1993-01-29 | Schneider Marc | Nouveaux derives de l'(indolyl-1) alkylamine substituee par une chaine presentant des groupements carbonyles conjugues a un noyau aromatique. |
| SE9103752D0 (sv) | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
| TW218875B (es) * | 1992-03-09 | 1994-01-11 | Takeda Pharm Industry Co Ltd | |
| TW226019B (es) * | 1992-03-23 | 1994-07-01 | Sankyo Co | |
| EP0572235A3 (en) * | 1992-05-28 | 1994-06-01 | Tanabe Seiyaku Co | Beta-carboline derivatives with anticholecystoquinine activity |
| EP0669830A4 (en) * | 1992-11-06 | 1997-02-26 | Merck & Co Inc | SUBSTITUTED DIPEPTIDE ANALOGS, WHICH SUPPORT THE RELEASE OF GROWTH HORMONE. |
| HUT72076A (en) * | 1992-12-11 | 1996-03-28 | Merck & Co Inc | Process for preparing spiro piperidines and homologs which promote release of growth hormone and pharmaceutical compositions containing them |
| US5578593A (en) * | 1992-12-11 | 1996-11-26 | Merck & Co., Inc. | Spiro piperidines and homologs promote release of growth hormone |
| UA45962C2 (uk) * | 1993-12-23 | 2002-05-15 | Ново Нордіск А/С | Похідні пептидів, фармацевтична композиція,спосіб стимулювання секреції гормону росту з гіпофізу |
| ES2153469T3 (es) * | 1993-12-23 | 2001-03-01 | Novo Nordisk As | Compuestos con propiedades para liberar la hormona del crecimiento. |
| GB9418326D0 (en) * | 1994-09-12 | 1994-11-02 | Lilly Industries Ltd | Pharmaceutical compounds |
| ES2204932T3 (es) * | 1994-09-12 | 2004-05-01 | Eli Lilly And Company Limited | Moduladores serotonergicos. |
| US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
-
1995
- 1995-12-19 GB GB9525963A patent/GB2308362A/en not_active Withdrawn
-
1996
- 1996-12-16 PE PE1996000916A patent/PE26198A1/es not_active Application Discontinuation
- 1996-12-16 CA CA002193039A patent/CA2193039C/en not_active Expired - Fee Related
- 1996-12-17 DE DE69614491T patent/DE69614491T2/de not_active Expired - Fee Related
- 1996-12-17 NZ NZ299959A patent/NZ299959A/en unknown
- 1996-12-17 YU YU67096A patent/YU67096A/sh unknown
- 1996-12-17 PL PL96317526A patent/PL317526A1/xx unknown
- 1996-12-17 IL IL11984496A patent/IL119844A/xx not_active IP Right Cessation
- 1996-12-17 ZA ZA9610589A patent/ZA9610589B/xx unknown
- 1996-12-17 EP EP96309200A patent/EP0780388B1/en not_active Expired - Lifetime
- 1996-12-17 DK DK96309200T patent/DK0780388T3/da active
- 1996-12-17 ES ES96309200T patent/ES2159693T3/es not_active Expired - Lifetime
- 1996-12-17 AR ARP960105722A patent/AR010205A1/es not_active Application Discontinuation
- 1996-12-17 SG SG1996011771A patent/SG47206A1/en unknown
- 1996-12-17 AT AT96309200T patent/ATE204273T1/de not_active IP Right Cessation
- 1996-12-17 MX MX9606531A patent/MX9606531A/es unknown
- 1996-12-17 TR TR96/01018A patent/TR199601018A1/xx unknown
- 1996-12-17 PT PT96309200T patent/PT780388E/pt unknown
- 1996-12-18 NO NO965448A patent/NO307512B1/no not_active IP Right Cessation
- 1996-12-18 HU HU9603498A patent/HUP9603498A3/hu unknown
- 1996-12-18 KR KR1019960067182A patent/KR970042503A/ko not_active Withdrawn
- 1996-12-18 JP JP8337819A patent/JPH09202784A/ja active Pending
- 1996-12-18 BR BR9606066A patent/BR9606066A/pt not_active Application Discontinuation
- 1996-12-18 CN CN96117941A patent/CN1157822A/zh active Pending
- 1996-12-18 CZ CZ963722A patent/CZ372296A3/cs unknown
- 1996-12-19 AU AU75460/96A patent/AU720711B2/en not_active Ceased
-
1997
- 1997-04-14 US US08/833,239 patent/US5773448A/en not_active Expired - Fee Related
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