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MX379555B - Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo. - Google Patents

Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo.

Info

Publication number
MX379555B
MX379555B MX2018013336A MX2018013336A MX379555B MX 379555 B MX379555 B MX 379555B MX 2018013336 A MX2018013336 A MX 2018013336A MX 2018013336 A MX2018013336 A MX 2018013336A MX 379555 B MX379555 B MX 379555B
Authority
MX
Mexico
Prior art keywords
sup
hydroxyalkyl
phenyl
producing
triazole
Prior art date
Application number
MX2018013336A
Other languages
English (en)
Other versions
MX2018013336A (es
Inventor
Chantal Fürstner
Frank Süssmeier
Hans-Christian Militzer
Heiko Schirmer
Kersten Matthias Gericke
Marie- Pierre COLLIN-KRÖPELIN
Philipp Rubenbauer
Thomas Neubauer
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MX2018013336A publication Critical patent/MX2018013336A/es
Publication of MX379555B publication Critical patent/MX379555B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente solicitud se refiere a un procedimiento novedoso y mejorado para la preparación de derivados de 5-(hidroxialquilo)-1-fenilo-1,2,4-triazol de la fórmula (I) (ver Fórmula) (I) en la que R1A y R1B se seleccionan independientemente del grupo que consiste en hidrógeno, flúor, cloro, metilo, monofluormetilo, difluormetilo, trifluormetilo, etilo, metoxi, difluormetoxi y trifluormetoxi, nuevas fases previas para su preparación y la preparación y el uso de la modificación cristalina I de (5-(4-clorofenil)-2-({1-(3-clorofenil)-5-[(1S)-1-hidroxietil]-1H-1,2,4-triazol-3-ilo}metilo)-4-[(2S)-3,3,3-trifluor-2-hidroxipropil]-2,4-dihidro-3H-1,2,4-triazol-3-ona de la fórmula (l-A-1).
MX2018013336A 2016-05-03 2017-05-02 Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo. MX379555B (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP16168165 2016-05-03
EP16168172 2016-05-03
EP16168163 2016-05-03
EP16168169 2016-05-03
EP16168166 2016-05-03
EP17160086 2017-03-09
PCT/EP2017/060367 WO2017191104A1 (de) 2016-05-03 2017-05-02 Verfahren zur herstellung von 5-hydroxyalkyl-substituierten 1-phenyl-1,2,4-triazolderivativen

Publications (2)

Publication Number Publication Date
MX2018013336A MX2018013336A (es) 2019-05-09
MX379555B true MX379555B (es) 2025-03-11

Family

ID=58633014

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020010365A MX391356B (es) 2016-05-03 2017-05-02 Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo
MX2018013336A MX379555B (es) 2016-05-03 2017-05-02 Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020010365A MX391356B (es) 2016-05-03 2017-05-02 Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo

Country Status (18)

Country Link
US (2) US10703742B2 (es)
EP (1) EP3452467A1 (es)
JP (2) JP6921863B2 (es)
KR (1) KR20190003536A (es)
CN (2) CN113105403A (es)
AU (2) AU2017259872B2 (es)
BR (1) BR112018072528A2 (es)
CA (1) CA3022789A1 (es)
CL (1) CL2018003107A1 (es)
CO (1) CO2018011948A2 (es)
IL (1) IL262534B (es)
MX (2) MX391356B (es)
PE (1) PE20190202A1 (es)
RU (1) RU2742885C2 (es)
SG (1) SG11201809672YA (es)
TW (1) TWI755393B (es)
UY (1) UY37222A (es)
WO (1) WO2017191104A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10800746B2 (en) * 2016-05-03 2020-10-13 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
UY37222A (es) * 2016-05-03 2017-11-30 Bayer Pharma AG PROCEDIMIENTO PARA LA PREPARACIÓN DE DERIVADOS DE 1-FENILO-1,2,4-TRIAZOL SUSTITUIDOS POR 5-HIdroxIalQUILO
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183384B2 (en) * 2006-05-25 2012-05-22 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
US20110237528A1 (en) * 2008-09-19 2011-09-29 Institute For Oneworld Health Compositions and methods comprising imidazole and triazole derivatives
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
CU24162B1 (es) * 2010-02-27 2016-03-31 Bayer Ip Gmbh Derivados 5-aril-1,2,4-triazolona ligada a bisarilo sustituidos
DK2847183T3 (en) * 2012-05-08 2017-10-02 Bayer Pharma AG PROCEDURE FOR MAKING TRIAZOL COMPOUNDS
SG11201703199UA (en) 2014-11-03 2017-05-30 Bayer Pharma AG Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
US10800746B2 (en) * 2016-05-03 2020-10-13 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
UY37222A (es) * 2016-05-03 2017-11-30 Bayer Pharma AG PROCEDIMIENTO PARA LA PREPARACIÓN DE DERIVADOS DE 1-FENILO-1,2,4-TRIAZOL SUSTITUIDOS POR 5-HIdroxIalQUILO
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof

Also Published As

Publication number Publication date
CN113105403A (zh) 2021-07-13
PE20190202A1 (es) 2019-02-05
IL262534A (en) 2018-12-31
UY37222A (es) 2017-11-30
AU2017259872B2 (en) 2021-06-24
IL262534B (en) 2021-04-29
US20190144431A1 (en) 2019-05-16
SG11201809672YA (en) 2018-11-29
TW201815782A (zh) 2018-05-01
JP6921863B2 (ja) 2021-08-18
MX2018013336A (es) 2019-05-09
TWI755393B (zh) 2022-02-21
MX391356B (es) 2025-03-19
JP2019514948A (ja) 2019-06-06
MX2020010365A (es) 2022-04-06
CA3022789A1 (en) 2017-11-09
KR20190003536A (ko) 2019-01-09
CL2018003107A1 (es) 2019-02-22
AU2021236502A1 (en) 2021-10-21
EP3452467A1 (de) 2019-03-13
BR112018072528A2 (pt) 2019-03-26
CN109071500A (zh) 2018-12-21
US20200299271A1 (en) 2020-09-24
AU2017259872A1 (en) 2018-11-22
RU2018142264A (ru) 2020-06-03
RU2742885C2 (ru) 2021-02-11
US10703742B2 (en) 2020-07-07
CN109071500B (zh) 2021-05-18
JP2021143193A (ja) 2021-09-24
RU2018142264A3 (es) 2020-08-19
CO2018011948A2 (es) 2018-11-22
WO2017191104A1 (de) 2017-11-09

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