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MX351636B - Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos. - Google Patents

Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos.

Info

Publication number
MX351636B
MX351636B MX2017002458A MX2017002458A MX351636B MX 351636 B MX351636 B MX 351636B MX 2017002458 A MX2017002458 A MX 2017002458A MX 2017002458 A MX2017002458 A MX 2017002458A MX 351636 B MX351636 B MX 351636B
Authority
MX
Mexico
Prior art keywords
methods
benzimidazole derivatives
compositions
parasiticidal compositions
mammal
Prior art date
Application number
MX2017002458A
Other languages
English (en)
Inventor
Q Meng Charles
Original Assignee
Merial Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Ltd filed Critical Merial Ltd
Publication of MX351636B publication Critical patent/MX351636B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composiciones orales, tópicas o inyectables para combatir los parásitos gusanos trematodos hepáticos en mamíferos, que comprenden al menos un agente activo derivado de benzimidazol. La invención también provee un método mejorado para erradicar y controlar las infecciones e infestaciones por parásitos gusanos trematodos hepáticos en un mamífero que comprende administrar las composiciones de la invención al mamífero que lo necesita.
MX2017002458A 2012-04-20 2013-04-18 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos. MX351636B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261635961P 2012-04-20 2012-04-20
PCT/US2013/037193 WO2013158894A1 (en) 2012-04-20 2013-04-18 Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof

Publications (1)

Publication Number Publication Date
MX351636B true MX351636B (es) 2017-10-23

Family

ID=48225136

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2014012713A MX345971B (es) 2012-04-20 2013-04-18 Composiciones parasiticidas que comprenden derivados de benzimidazol, metodos y usos de los mismos.
MX2017012361A MX367536B (es) 2012-04-20 2013-04-18 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos.
MX2017002458A MX351636B (es) 2012-04-20 2013-04-18 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2014012713A MX345971B (es) 2012-04-20 2013-04-18 Composiciones parasiticidas que comprenden derivados de benzimidazol, metodos y usos de los mismos.
MX2017012361A MX367536B (es) 2012-04-20 2013-04-18 Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos.

Country Status (23)

Country Link
US (3) US9000187B2 (es)
EP (3) EP2895465B1 (es)
JP (4) JP6161173B2 (es)
KR (3) KR102160836B1 (es)
CN (4) CN105884693B (es)
AR (1) AR090766A1 (es)
AU (2) AU2013249217B2 (es)
BR (3) BR122015032741B1 (es)
CA (2) CA2870956C (es)
CL (3) CL2014002831A1 (es)
CO (1) CO7151497A2 (es)
EA (1) EA028430B1 (es)
ES (1) ES2703535T3 (es)
IL (3) IL235107A (es)
MX (3) MX345971B (es)
NZ (3) NZ711847A (es)
PH (1) PH12014502345A1 (es)
PT (1) PT2895465T (es)
SG (3) SG11201406730RA (es)
UA (1) UA115981C2 (es)
UY (1) UY34761A (es)
WO (1) WO2013158894A1 (es)
ZA (1) ZA201407605B (es)

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ES2723969T3 (es) * 2014-06-19 2019-09-04 Merial Inc Composiciones parasiticidas que comprenden derivados de indol, procedimientos y usos de las mismas
MX393468B (es) 2016-03-31 2025-03-24 Boehringer Ingelheim Animal Health Usa Inc Etiquetas y sistema para animales con tecnologia simple o dual y metodos para usarlos.
CN106496037A (zh) * 2016-10-20 2017-03-15 上海毕得医药科技有限公司 一种1,4‑二碘‑2‑甲氧基‑5‑硝基苯的合成方法
KR102147235B1 (ko) * 2018-05-18 2020-08-24 연세대학교 산학협력단 발광성, 강유전성 및 압전성을 나타내는 헤테로아릴 화합물 및 이를 포함하는 전자소자
GB201811695D0 (en) * 2018-07-17 2018-08-29 Salvensis Compounds for use in the treatment of fascioliasis
EP4561989A1 (en) * 2022-07-26 2025-06-04 The Board Of Trustees Of The University Of Illinois Compounds and methods for the treatment of diseases associated with parasitic worms

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Also Published As

Publication number Publication date
AR090766A1 (es) 2014-12-03
JP6124321B2 (ja) 2017-05-10
MX2014012713A (es) 2015-01-19
CA3059936A1 (en) 2013-10-24
CL2014002831A1 (es) 2014-12-12
CO7151497A2 (es) 2014-12-29
CN105884693A (zh) 2016-08-24
EA028430B1 (ru) 2017-11-30
CL2018003596A1 (es) 2019-01-25
KR102160889B1 (ko) 2020-09-28
US9695129B2 (en) 2017-07-04
BR122015032742A2 (pt) 2018-12-11
MX345971B (es) 2017-02-28
NZ711847A (en) 2015-11-27
IL235107A (en) 2017-09-28
KR20150002853A (ko) 2015-01-07
NZ701185A (en) 2015-08-28
CN105884693B (zh) 2019-11-01
BR112014026184A2 (pt) 2017-06-27
US20150166485A1 (en) 2015-06-18
IL251177A0 (en) 2017-05-29
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JP2015516977A (ja) 2015-06-18
ES2703535T3 (es) 2019-03-11
EP2895465A1 (en) 2015-07-22
US20130281392A1 (en) 2013-10-24
AU2013249217A1 (en) 2014-11-06
PH12014502345B1 (en) 2014-12-22
SG11201406730RA (en) 2014-11-27
US20160251317A1 (en) 2016-09-01
CN104395295B (zh) 2018-03-06
PH12014502345A1 (en) 2014-12-22
BR122015032742B1 (pt) 2020-04-07
BR112014026184B1 (pt) 2019-04-24
BR122015032741A2 (pt) 2019-08-27
PT2895465T (pt) 2019-01-16
US9000187B2 (en) 2015-04-07
KR102160836B1 (ko) 2020-09-28
JP2016106154A (ja) 2016-06-16
WO2013158894A1 (en) 2013-10-24
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EA201401160A1 (ru) 2015-04-30
UA115981C2 (uk) 2018-01-25
JP6161173B2 (ja) 2017-07-12
EP3453702A2 (en) 2019-03-13
KR20190114002A (ko) 2019-10-08
UY34761A (es) 2013-11-29
SG10201704665QA (en) 2017-07-28
BR122015032741B1 (pt) 2019-11-26
CL2017001239A1 (es) 2017-12-11
KR102114598B1 (ko) 2020-05-25
EP3763706A1 (en) 2021-01-13
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