MX336946B - Heterociclos novedosos. - Google Patents
Heterociclos novedosos.Info
- Publication number
- MX336946B MX336946B MX2010008414A MX2010008414A MX336946B MX 336946 B MX336946 B MX 336946B MX 2010008414 A MX2010008414 A MX 2010008414A MX 2010008414 A MX2010008414 A MX 2010008414A MX 336946 B MX336946 B MX 336946B
- Authority
- MX
- Mexico
- Prior art keywords
- useful
- compounds
- diseases
- disease
- pde4
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 206010040070 Septic Shock Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 abstract 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 abstract 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 abstract 1
- 206010006895 Cachexia Diseases 0.000 abstract 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010012442 Dermatitis contact Diseases 0.000 abstract 1
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 1
- 201000005569 Gout Diseases 0.000 abstract 1
- 206010018634 Gouty Arthritis Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000034578 Multiple myelomas Diseases 0.000 abstract 1
- 206010028289 Muscle atrophy Diseases 0.000 abstract 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 abstract 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 208000027520 Somatoform disease Diseases 0.000 abstract 1
- 206010044248 Toxic shock syndrome Diseases 0.000 abstract 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 230000036783 anaphylactic response Effects 0.000 abstract 1
- 208000003455 anaphylaxis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000019664 bone resorption disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 208000010247 contact dermatitis Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 208000027753 pain disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
Abstract
Se describen nuevos compuestos heterocíclicos de la fórmula general (I), sus derivados, análogos, formas tautoméricas, estereoisómeros, polimorfos, hidratos, solvatos, sales farmacéuticamente aceptables, composiciones farmacéuticas, metabolitos y profármacos del mismo. Estos compuestos son útiles en el tratamiento de enfermedades inmunológicas, inflamación, trastorno por dolor, artritis reumatoide; osteoporosis; mieloma múltiple; uveítis;, leucemia mielógena aguda y crónica; aterosclerosis; cáncer; caquexia; daño isquémico inducido por la destrucción de las células; destrucción de las células beta del páncreas; osteoartritis; espondilitis reumatoide; artritis gotosa; enfermedad inflamatoria intestinal; SDRA; psoriasis; enfermedad de Crohn; rinitis alérgica; colitis ulcerosa; anafilaxis; dermatitis de contacto; degeneración muscular; asma; EPOC, enfermedades de la resorción ósea; esclerosis múltiple; sepsis, shock séptico; síndrome del shock tóxico y fiebre. En concreto estos compuestos son útiles como inhibidores de la PDE4 y son útiles para el tratamiento de enfermedades mediadas PDE4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN271CH2008 | 2008-02-01 | ||
| PCT/IB2009/000157 WO2009095773A2 (en) | 2008-02-01 | 2009-01-30 | Novel heterocycles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2010008414A MX2010008414A (es) | 2010-12-15 |
| MX336946B true MX336946B (es) | 2016-02-08 |
Family
ID=40913343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010008414A MX336946B (es) | 2008-02-01 | 2009-01-30 | Heterociclos novedosos. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8420653B2 (es) |
| EP (1) | EP2245017A4 (es) |
| JP (1) | JP5704924B2 (es) |
| KR (1) | KR101595506B1 (es) |
| CN (1) | CN101965338B (es) |
| AU (1) | AU2009208712B2 (es) |
| BR (1) | BRPI0912029A2 (es) |
| CA (1) | CA2715069C (es) |
| IL (1) | IL207298A (es) |
| MX (1) | MX336946B (es) |
| NZ (1) | NZ587153A (es) |
| RU (1) | RU2572616C2 (es) |
| SG (1) | SG10201406210PA (es) |
| WO (1) | WO2009095773A2 (es) |
| ZA (1) | ZA201005986B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ305457B6 (cs) | 2011-02-28 | 2015-09-30 | Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. | Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití |
| AR090880A1 (es) * | 2012-04-30 | 2014-12-10 | Janssen R & D Ireland | Derivados de pirimidina |
| IL257743B (en) | 2015-09-17 | 2022-08-01 | Marvin J Miller | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
| AU2023406476A1 (en) | 2022-12-02 | 2025-06-05 | Neumora Therapeutics, Inc. | Methods of treating neurological disorders |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4698340A (en) * | 1984-07-19 | 1987-10-06 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine derivatives, processes for preparation thereof and composition containing the same |
| US5166137A (en) | 1991-03-27 | 1992-11-24 | Nobipols Forskningsstiftelse | Guluronic acid polymers and use of same for inhibition of cytokine production |
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| TW200614993A (en) * | 2004-06-11 | 2006-05-16 | Akzo Nobel Nv | 4-phenyl-pyrimidine-2-carbonitrile derivatives |
| US7863446B2 (en) * | 2006-01-19 | 2011-01-04 | Orchid Research Laboratories Limited | Heterocycles |
| AU2006335967B2 (en) * | 2006-01-19 | 2012-01-19 | Orchid Chemicals & Pharmaceuticals Limited | Novel heterocycles |
-
2009
- 2009-01-30 SG SG10201406210PA patent/SG10201406210PA/en unknown
- 2009-01-30 AU AU2009208712A patent/AU2009208712B2/en not_active Ceased
- 2009-01-30 CA CA2715069A patent/CA2715069C/en not_active Expired - Fee Related
- 2009-01-30 BR BRPI0912029-7A patent/BRPI0912029A2/pt not_active Application Discontinuation
- 2009-01-30 WO PCT/IB2009/000157 patent/WO2009095773A2/en not_active Ceased
- 2009-01-30 JP JP2010544807A patent/JP5704924B2/ja not_active Expired - Fee Related
- 2009-01-30 MX MX2010008414A patent/MX336946B/es active IP Right Grant
- 2009-01-30 US US12/863,796 patent/US8420653B2/en not_active Expired - Fee Related
- 2009-01-30 RU RU2010136707/04A patent/RU2572616C2/ru not_active IP Right Cessation
- 2009-01-30 CN CN200980107230.5A patent/CN101965338B/zh not_active Expired - Fee Related
- 2009-01-30 KR KR1020107019451A patent/KR101595506B1/ko not_active Expired - Fee Related
- 2009-01-30 EP EP09706532A patent/EP2245017A4/en not_active Withdrawn
- 2009-01-30 NZ NZ587153A patent/NZ587153A/xx not_active IP Right Cessation
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2010
- 2010-07-29 IL IL207298A patent/IL207298A/en active IP Right Grant
- 2010-08-23 ZA ZA2010/05986A patent/ZA201005986B/en unknown
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0912029A2 (pt) | 2020-06-30 |
| WO2009095773A3 (en) | 2010-04-22 |
| EP2245017A2 (en) | 2010-11-03 |
| WO2009095773A8 (en) | 2010-01-07 |
| AU2009208712A1 (en) | 2009-08-06 |
| JP5704924B2 (ja) | 2015-04-22 |
| IL207298A0 (en) | 2010-12-30 |
| KR20100131443A (ko) | 2010-12-15 |
| WO2009095773A2 (en) | 2009-08-06 |
| US20100329998A1 (en) | 2010-12-30 |
| IL207298A (en) | 2017-08-31 |
| CA2715069C (en) | 2016-06-07 |
| NZ587153A (en) | 2012-10-26 |
| JP2011510967A (ja) | 2011-04-07 |
| SG10201406210PA (en) | 2014-11-27 |
| US8828999B2 (en) | 2014-09-09 |
| EP2245017A4 (en) | 2011-12-28 |
| CN101965338B (zh) | 2014-09-17 |
| US20130172350A1 (en) | 2013-07-04 |
| KR101595506B1 (ko) | 2016-02-18 |
| US8420653B2 (en) | 2013-04-16 |
| ZA201005986B (en) | 2011-04-28 |
| RU2572616C2 (ru) | 2016-01-20 |
| RU2010136707A (ru) | 2012-03-10 |
| AU2009208712B2 (en) | 2013-03-14 |
| CA2715069A1 (en) | 2009-08-06 |
| CN101965338A (zh) | 2011-02-02 |
| MX2010008414A (es) | 2010-12-15 |
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