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MX2024008100A - Lactamas funcionalizadas novedosas como moduladores del receptor 7 de 5-hidroxitriptamina y su metodo de uso. - Google Patents

Lactamas funcionalizadas novedosas como moduladores del receptor 7 de 5-hidroxitriptamina y su metodo de uso.

Info

Publication number
MX2024008100A
MX2024008100A MX2024008100A MX2024008100A MX2024008100A MX 2024008100 A MX2024008100 A MX 2024008100A MX 2024008100 A MX2024008100 A MX 2024008100A MX 2024008100 A MX2024008100 A MX 2024008100A MX 2024008100 A MX2024008100 A MX 2024008100A
Authority
MX
Mexico
Prior art keywords
modulators
hydroxytryptamine receptor
novel functionalized
group
lactams
Prior art date
Application number
MX2024008100A
Other languages
English (en)
Inventor
Daniel J Canney
Benjamin E Blass
Kevin M Blattner
Douglas A Pippin
Original Assignee
Univ Temple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple filed Critical Univ Temple
Publication of MX2024008100A publication Critical patent/MX2024008100A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
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  • Reproductive Health (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Las composiciones farmacéuticas de la invención comprenden derivados de lactamas funcionalizadas que tienen una acción modificadora de la enfermedad en el tratamiento de enfermedades asociadas con la desregulación de la actividad del receptor 7 d e 5-hidroxitriptamina.
MX2024008100A 2018-05-11 2020-11-10 Lactamas funcionalizadas novedosas como moduladores del receptor 7 de 5-hidroxitriptamina y su metodo de uso. MX2024008100A (es)

Applications Claiming Priority (1)

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US201862670116P 2018-05-11 2018-05-11

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MX2024008100A true MX2024008100A (es) 2024-07-15

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MX2020012030A MX2020012030A (es) 2018-05-11 2019-05-10 Lactamas funcionalizadas novedosas como moduladores del receptor 7 de 5-hidroxitriptamina y su método de uso.
MX2024008100A MX2024008100A (es) 2018-05-11 2020-11-10 Lactamas funcionalizadas novedosas como moduladores del receptor 7 de 5-hidroxitriptamina y su metodo de uso.

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US (1) US20220306629A1 (es)
EP (1) EP3790859A1 (es)
JP (3) JP7429652B2 (es)
KR (1) KR20210020182A (es)
CN (2) CN112437768B (es)
AU (2) AU2019267846B2 (es)
BR (1) BR112020023072A2 (es)
CA (1) CA3110799A1 (es)
EA (1) EA202092328A1 (es)
IL (1) IL317778A (es)
MA (1) MA52567A (es)
MX (2) MX2020012030A (es)
TW (2) TWI856012B (es)
WO (1) WO2019217890A1 (es)

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WO2014164756A1 (en) 2013-03-11 2014-10-09 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
US10544117B2 (en) 2014-09-10 2020-01-28 Temple University—Of the Commonwealth System of Higher Education 5-hydroxytryptamine receptor 7 activity modulators and their method of use
CA3043319A1 (en) 2016-11-15 2018-05-24 Temple University-Of The Commonwealth System Of Higher Education Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
US11220505B2 (en) 2017-03-21 2022-01-11 Temple University-Of The Commonwealth System Of Higher Education 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
MA49019A (fr) 2017-03-21 2020-02-05 Univ Temple Nouveaux modulateurs du récepteur sigma 2 et leur procédé d'utilisation
GB201809295D0 (en) 2018-06-06 2018-07-25 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
US20230002383A1 (en) * 2019-11-13 2023-01-05 Temple University-Of The Commonwealth System Of Higher Education Novel functionalized lactams as modulators of the 5-hydroxytryptamine receptor 7 and their method of use

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