MA49019A - Nouveaux modulateurs du récepteur sigma 2 et leur procédé d'utilisation - Google Patents
Nouveaux modulateurs du récepteur sigma 2 et leur procédé d'utilisationInfo
- Publication number
- MA49019A MA49019A MA049019A MA49019A MA49019A MA 49019 A MA49019 A MA 49019A MA 049019 A MA049019 A MA 049019A MA 49019 A MA49019 A MA 49019A MA 49019 A MA49019 A MA 49019A
- Authority
- MA
- Morocco
- Prior art keywords
- new sigma
- receiver modulators
- modulators
- receiver
- sigma
- Prior art date
Links
- 102100037651 AP-2 complex subunit sigma Human genes 0.000 title 1
- 101000806914 Homo sapiens AP-2 complex subunit sigma Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762474277P | 2017-03-21 | 2017-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA49019A true MA49019A (fr) | 2020-02-05 |
Family
ID=63585700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA049019A MA49019A (fr) | 2017-03-21 | 2018-03-15 | Nouveaux modulateurs du récepteur sigma 2 et leur procédé d'utilisation |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10961249B2 (fr) |
| EP (1) | EP3600290B1 (fr) |
| JP (2) | JP7365237B2 (fr) |
| MA (1) | MA49019A (fr) |
| WO (1) | WO2018175188A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014164756A1 (fr) | 2013-03-11 | 2014-10-09 | Temple University Of The Commonwealth System Of Higher Education | Nouveaux modulateurs de l'activité du récepteur 7 de la 5-hydroxytryptamine et leur procédé d'utilisation |
| US10544117B2 (en) | 2014-09-10 | 2020-01-28 | Temple University—Of the Commonwealth System of Higher Education | 5-hydroxytryptamine receptor 7 activity modulators and their method of use |
| CA3043319A1 (fr) | 2016-11-15 | 2018-05-24 | Temple University-Of The Commonwealth System Of Higher Education | Modulateurs du recepteur 7 de 5-hydroxytryptamine et leur proce de d'utilisation |
| US11220505B2 (en) | 2017-03-21 | 2022-01-11 | Temple University-Of The Commonwealth System Of Higher Education | 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents |
| MA49019A (fr) * | 2017-03-21 | 2020-02-05 | Univ Temple | Nouveaux modulateurs du récepteur sigma 2 et leur procédé d'utilisation |
| CN112437768B (zh) * | 2018-05-11 | 2025-06-24 | 英联邦高等教育系统坦普尔大学 | 作为5-羟色胺受体7调节剂的新型官能化内酰胺及其使用方法 |
| GB201809295D0 (en) * | 2018-06-06 | 2018-07-25 | Institute Of Cancer Res Royal Cancer Hospital | Lox inhibitors |
| WO2020239073A1 (fr) * | 2019-05-30 | 2020-12-03 | 中国科学院上海药物研究所 | Composé cyclique fusionné, son procédé de préparation et son utilisation |
| CA3261797A1 (fr) * | 2022-08-11 | 2024-02-15 | Remynd N.V. | Dérivés d'(aza)spiroheptane pour le traitement de troubles neurodégénératifs |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2558211C (fr) * | 2004-03-03 | 2013-09-03 | Chemocentryx, Inc. | Heterocycles d'azote bicycliques et pontes |
| GB0419192D0 (en) * | 2004-08-27 | 2004-09-29 | Merck Sharp & Dohme | Therapeutic agents |
| WO2008063984A2 (fr) * | 2006-11-13 | 2008-05-29 | King Pharmaceuticals Research And Development, Inc. | Modulateurs allostériques du récepteur de l'adénosine a1 |
| US8148408B2 (en) | 2008-05-09 | 2012-04-03 | Abbott Laboratories | Selective substituted pyridine ligands for neuronal nicotinic receptors |
| US8697888B2 (en) * | 2012-01-06 | 2014-04-15 | Vanderbilt University | Substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs as antagonists of muscarinic acetylcholine M1 receptors |
| US9464062B2 (en) | 2012-11-28 | 2016-10-11 | Temple University—Of the Commonwealth System of Higher Education | Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2B activity modulators |
| ES2707323T3 (es) * | 2012-12-07 | 2019-04-03 | Chemocentryx Inc | Diazol lactamas |
| WO2014164756A1 (fr) * | 2013-03-11 | 2014-10-09 | Temple University Of The Commonwealth System Of Higher Education | Nouveaux modulateurs de l'activité du récepteur 7 de la 5-hydroxytryptamine et leur procédé d'utilisation |
| EP2978425B1 (fr) * | 2013-03-27 | 2017-09-27 | Merck Sharp & Dohme Corp. | Inhibiteurs du facteur xia |
| KR20160098506A (ko) * | 2013-12-20 | 2016-08-18 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 통증에 대한 다양한 활성을 갖는 피페라진 유도체 |
| US10544117B2 (en) | 2014-09-10 | 2020-01-28 | Temple University—Of the Commonwealth System of Higher Education | 5-hydroxytryptamine receptor 7 activity modulators and their method of use |
| CR20170118A (es) * | 2014-10-08 | 2017-07-10 | Hoffmann La Roche | Derivados espirodiamina como inhibidores de la aldosterona sintasa |
| TWI698436B (zh) * | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
| WO2016183150A1 (fr) | 2015-05-12 | 2016-11-17 | Temple University-Of The Commonwealth System Of Higher Education | Nouveaux liants des récepteurs sigma 2 et leur procédé d'utilisation |
| CA3043319A1 (fr) | 2016-11-15 | 2018-05-24 | Temple University-Of The Commonwealth System Of Higher Education | Modulateurs du recepteur 7 de 5-hydroxytryptamine et leur proce de d'utilisation |
| MA49019A (fr) | 2017-03-21 | 2020-02-05 | Univ Temple | Nouveaux modulateurs du récepteur sigma 2 et leur procédé d'utilisation |
| US11220505B2 (en) * | 2017-03-21 | 2022-01-11 | Temple University-Of The Commonwealth System Of Higher Education | 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents |
| CN112437768B (zh) | 2018-05-11 | 2025-06-24 | 英联邦高等教育系统坦普尔大学 | 作为5-羟色胺受体7调节剂的新型官能化内酰胺及其使用方法 |
| US20230002383A1 (en) | 2019-11-13 | 2023-01-05 | Temple University-Of The Commonwealth System Of Higher Education | Novel functionalized lactams as modulators of the 5-hydroxytryptamine receptor 7 and their method of use |
| JP2023501576A (ja) | 2019-11-13 | 2023-01-18 | テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクトンおよびその使用方法 |
-
2018
- 2018-03-15 MA MA049019A patent/MA49019A/fr unknown
- 2018-03-15 WO PCT/US2018/022574 patent/WO2018175188A1/fr not_active Ceased
- 2018-03-15 JP JP2019551998A patent/JP7365237B2/ja active Active
- 2018-03-15 EP EP18772377.0A patent/EP3600290B1/fr active Active
- 2018-03-15 US US16/496,073 patent/US10961249B2/en active Active
-
2021
- 2021-01-21 US US17/154,761 patent/US11820774B2/en active Active
-
2023
- 2023-10-06 JP JP2023174368A patent/JP7781122B2/ja active Active
- 2023-10-11 US US18/484,858 patent/US20240300954A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3600290C0 (fr) | 2025-06-04 |
| JP7365237B2 (ja) | 2023-10-19 |
| WO2018175188A1 (fr) | 2018-09-27 |
| US11820774B2 (en) | 2023-11-21 |
| EP3600290B1 (fr) | 2025-06-04 |
| JP2020511506A (ja) | 2020-04-16 |
| EP3600290A4 (fr) | 2020-08-12 |
| JP2023168623A (ja) | 2023-11-24 |
| US20200039985A1 (en) | 2020-02-06 |
| JP7781122B2 (ja) | 2025-12-05 |
| EP3600290A1 (fr) | 2020-02-05 |
| US20210363145A1 (en) | 2021-11-25 |
| US10961249B2 (en) | 2021-03-30 |
| US20240300954A1 (en) | 2024-09-12 |
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