MX2023015504A - Metrica de la relacion se?al a ruido para determinar llamadas de bases de nucleotidos y la calidad de las llamadas de base. - Google Patents
Metrica de la relacion se?al a ruido para determinar llamadas de bases de nucleotidos y la calidad de las llamadas de base.Info
- Publication number
- MX2023015504A MX2023015504A MX2023015504A MX2023015504A MX2023015504A MX 2023015504 A MX2023015504 A MX 2023015504A MX 2023015504 A MX2023015504 A MX 2023015504A MX 2023015504 A MX2023015504 A MX 2023015504A MX 2023015504 A MX2023015504 A MX 2023015504A
- Authority
- MX
- Mexico
- Prior art keywords
- noise
- base
- signal
- generate
- calls
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 238000013442 quality metrics Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Theoretical Computer Science (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Bioethics (AREA)
- Data Mining & Analysis (AREA)
- Software Systems (AREA)
- Public Health (AREA)
- Signal Processing (AREA)
- Evolutionary Computation (AREA)
- Epidemiology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Artificial Intelligence (AREA)
- Databases & Information Systems (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Esta descripción describe métodos, medios no transitorios legibles por computadora y sistemas que pueden generar métricas de la relación señal a ruido para grupos de oligonucleótidos a los que se añaden bases de nucleótidos etiquetadas y utilizar las métricas de la relación señal a ruido para generar llamadas de bases de nucleótidos y determinar la calidad de la llamada de base. Por ejemplo, los sistemas descritos pueden generar las métricas de la relación señal a ruido usando factores de escala y niveles de ruido asociados con señales de luz detectadas a partir de grupos de oligonucleótidos. Los sistemas descritos pueden utilizar las métricas de la relación señal a ruido para generar límites de valores de intensidad para generar llamadas de bases de nucleótidos para las señales de acuerdo con uno o más modelos de distribución de llamadas de base. Además, los sistemas descritos pueden utilizar un umbral para filtrar señales detectadas de los grupos de oligonucleótidos que tienen métricas de la relación señal a ruido bajas. Los sistemas descritos pueden utilizar además las métricas de la relación señal a ruido para generar métricas de calidad para las llamadas de bases de nucleótidos generadas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163216401P | 2021-06-29 | 2021-06-29 | |
| PCT/US2022/072737 WO2023278927A1 (en) | 2021-06-29 | 2022-06-02 | Signal-to-noise-ratio metric for determining nucleotide-base calls and base-call quality |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023015504A true MX2023015504A (es) | 2024-01-22 |
Family
ID=82483142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023015504A MX2023015504A (es) | 2021-06-29 | 2022-06-02 | Metrica de la relacion se?al a ruido para determinar llamadas de bases de nucleotidos y la calidad de las llamadas de base. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220415442A1 (es) |
| EP (1) | EP4364154A1 (es) |
| JP (1) | JP2024527307A (es) |
| KR (1) | KR20240022490A (es) |
| CN (1) | CN117730372A (es) |
| AU (1) | AU2022305321A1 (es) |
| BR (1) | BR112023026615A2 (es) |
| CA (1) | CA3224402A1 (es) |
| IL (1) | IL309308A (es) |
| MX (1) | MX2023015504A (es) |
| WO (1) | WO2023278927A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250210137A1 (en) * | 2023-12-20 | 2025-06-26 | Illumina, Inc. | Directly determining signal-to-noise-ratio metrics for accelerated convergence in determining nucleotide-base calls and base-call quality |
| CN117497055B (zh) * | 2024-01-02 | 2024-03-12 | 北京普译生物科技有限公司 | 神经网络模型训练、碱基测序电信号的片段化方法及装置 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0450060A1 (en) | 1989-10-26 | 1991-10-09 | Sri International | Dna sequencing |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| JP2002503954A (ja) | 1997-04-01 | 2002-02-05 | グラクソ、グループ、リミテッド | 核酸増幅法 |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
| US7001792B2 (en) | 2000-04-24 | 2006-02-21 | Eagle Research & Development, Llc | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
| CN101525660A (zh) | 2000-07-07 | 2009-09-09 | 维西根生物技术公司 | 实时序列测定 |
| EP1354064A2 (en) | 2000-12-01 | 2003-10-22 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| EP3795577A1 (en) | 2002-08-23 | 2021-03-24 | Illumina Cambridge Limited | Modified nucleotides |
| GB0321306D0 (en) | 2003-09-11 | 2003-10-15 | Solexa Ltd | Modified polymerases for improved incorporation of nucleotide analogues |
| EP3175914A1 (en) | 2004-01-07 | 2017-06-07 | Illumina Cambridge Limited | Improvements in or relating to molecular arrays |
| US7315019B2 (en) | 2004-09-17 | 2008-01-01 | Pacific Biosciences Of California, Inc. | Arrays of optical confinements and uses thereof |
| EP1828412B2 (en) | 2004-12-13 | 2019-01-09 | Illumina Cambridge Limited | Improved method of nucleotide detection |
| US8623628B2 (en) | 2005-05-10 | 2014-01-07 | Illumina, Inc. | Polymerases |
| GB0514936D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| EP3722409A1 (en) | 2006-03-31 | 2020-10-14 | Illumina, Inc. | Systems and devices for sequence by synthesis analysis |
| WO2008051530A2 (en) | 2006-10-23 | 2008-05-02 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
| EP4134667B1 (en) | 2006-12-14 | 2025-11-12 | Life Technologies Corporation | Apparatus for measuring analytes using fet arrays |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| CA2859660C (en) | 2011-09-23 | 2021-02-09 | Illumina, Inc. | Methods and compositions for nucleic acid sequencing |
| JP6159391B2 (ja) | 2012-04-03 | 2017-07-05 | イラミーナ インコーポレーテッド | 核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ |
| RS60736B1 (sr) * | 2013-12-03 | 2020-09-30 | Illumina Inc | Postupci i sistemi za analizu podataka sa slika |
| MX2020007904A (es) * | 2018-01-26 | 2020-09-07 | Quantum Si Inc | Llamado de pulso y base habilitado por maquina de aprendizaje para dispositivos de secuenciacion. |
| US11210554B2 (en) * | 2019-03-21 | 2021-12-28 | Illumina, Inc. | Artificial intelligence-based generation of sequencing metadata |
-
2022
- 2022-06-02 CN CN202280043937.XA patent/CN117730372A/zh active Pending
- 2022-06-02 AU AU2022305321A patent/AU2022305321A1/en active Pending
- 2022-06-02 JP JP2023579787A patent/JP2024527307A/ja active Pending
- 2022-06-02 CA CA3224402A patent/CA3224402A1/en active Pending
- 2022-06-02 IL IL309308A patent/IL309308A/en unknown
- 2022-06-02 WO PCT/US2022/072737 patent/WO2023278927A1/en not_active Ceased
- 2022-06-02 US US17/805,138 patent/US20220415442A1/en active Pending
- 2022-06-02 KR KR1020237043195A patent/KR20240022490A/ko active Pending
- 2022-06-02 BR BR112023026615A patent/BR112023026615A2/pt not_active Application Discontinuation
- 2022-06-02 EP EP22740728.5A patent/EP4364154A1/en active Pending
- 2022-06-02 MX MX2023015504A patent/MX2023015504A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL309308A (en) | 2024-02-01 |
| BR112023026615A2 (pt) | 2024-03-05 |
| US20220415442A1 (en) | 2022-12-29 |
| JP2024527307A (ja) | 2024-07-24 |
| CA3224402A1 (en) | 2023-01-05 |
| EP4364154A1 (en) | 2024-05-08 |
| CN117730372A (zh) | 2024-03-19 |
| AU2022305321A1 (en) | 2024-01-18 |
| WO2023278927A1 (en) | 2023-01-05 |
| KR20240022490A (ko) | 2024-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2023015504A (es) | Metrica de la relacion se?al a ruido para determinar llamadas de bases de nucleotidos y la calidad de las llamadas de base. | |
| MX389681B (es) | Eliminacion de ruido para datos de deteccion acustica distribuida. | |
| BR112016029751A2 (pt) | perfil, patamar, nível para o 0-ésimo conjunto de camada de saída em codificação de vídeo | |
| MX2019003650A (es) | Metodo y dispositivo para determinar areas de interes con base en datos de geolocalizacion. | |
| PH12017550091A1 (en) | Systems and methods for order pairing | |
| MX375859B (es) | Aparato, metodo o programa de computadora para generar una descripcion de campo de sonido | |
| PH12019501623A1 (en) | Blockchain-based data processing method and device | |
| MX347233B (es) | Aparato y método para desvanecimiento mejorado de señal para sistemas de codificación de audio conmutados durante el ocultamiento de errores. | |
| MX385727B (es) | Método y aparato para generar una señal de audio filtrada realizando representación de elevación. | |
| GB2556283A (en) | Defect discrimination apparatus, methods, and systems | |
| DE60238602D1 (de) | Verfahren und system zum decodieren von mehrpegelsignalen | |
| Cândido et al. | Conditional reachability of uncertain max plus linear systems | |
| HK1252656A1 (zh) | 通过数据挖掘进行基准测试 | |
| EA201990986A1 (ru) | Способы и системы анализа хроматографических данных | |
| MX385944B (es) | Estimación del ruido de fondo en las señales de audio. | |
| GB2522365A (en) | Method for processing an image | |
| CA3025741C (en) | Heuristic occupancy and non-occupancy detection in a lighting system | |
| MY190143A (en) | Device and method for generating a high-band signal from non-linearly processed sub-ranges | |
| EA201891373A1 (ru) | Система и способ проведения морских геофизических съемок с распределенными сейсмическими источниками | |
| MY181166A (en) | Method, and apparatus for eliminating popping sounds at the beginning of audio, and storage medium | |
| MX2022016356A (es) | Sistema y método de retroalimentación de usuario. | |
| EP2966644A3 (en) | Methods and systems for managing speech recognition in a multi-speech system environment | |
| CN104867497A (zh) | 一种语音降噪方法 | |
| MX2024004313A (es) | Codificador, decodificador, metodo de codificacion y metodo de decodificacion. | |
| ZA202000271B (en) | Short burst channel design and multiplexing |