MX2023012766A - Metodo para permitir la infiltracion de las celulas inmunitarias en los tumores. - Google Patents
Metodo para permitir la infiltracion de las celulas inmunitarias en los tumores.Info
- Publication number
- MX2023012766A MX2023012766A MX2023012766A MX2023012766A MX2023012766A MX 2023012766 A MX2023012766 A MX 2023012766A MX 2023012766 A MX2023012766 A MX 2023012766A MX 2023012766 A MX2023012766 A MX 2023012766A MX 2023012766 A MX2023012766 A MX 2023012766A
- Authority
- MX
- Mexico
- Prior art keywords
- tumors
- immune cells
- cells infiltration
- allowing immune
- present disclosure
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000008595 infiltration Effects 0.000 title abstract 2
- 238000001764 infiltration Methods 0.000 title abstract 2
- 210000002865 immune cell Anatomy 0.000 title 1
- 238000002648 combination therapy Methods 0.000 abstract 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960003668 docetaxel Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente divulgación se refiere en términos generales a un método para permitir la infiltración inmunitaria intratumoral y/o para el tratamiento de un sujeto que tiene un cáncer. El método de la presente divulgación se basa en la administración de un anticuerpo anti-clusterina o de un fragmento de enlace a los antígenos del mismo, ya sea como un solo agente o en una terapia de combinación con el docetaxel. También se proporcionan terapias de combinación, medicamentos y kits para tal uso.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CA2021/050572 WO2022226623A1 (en) | 2021-04-27 | 2021-04-27 | Method for allowing immune cells infiltration in tumors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023012766A true MX2023012766A (es) | 2024-02-23 |
Family
ID=83846453
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023012766A MX2023012766A (es) | 2021-04-27 | 2021-04-27 | Metodo para permitir la infiltracion de las celulas inmunitarias en los tumores. |
| MX2023012768A MX2023012768A (es) | 2021-04-27 | 2022-04-26 | Metodo para permitir la infiltracion de las celulas inmunitarias en los tumores. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023012768A MX2023012768A (es) | 2021-04-27 | 2022-04-26 | Metodo para permitir la infiltracion de las celulas inmunitarias en los tumores. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20240199758A1 (es) |
| EP (2) | EP4329801A4 (es) |
| JP (2) | JP2024516416A (es) |
| KR (2) | KR20240014052A (es) |
| CN (2) | CN117479955A (es) |
| AU (2) | AU2021442702A1 (es) |
| CA (2) | CA3173786A1 (es) |
| IL (2) | IL307954A (es) |
| MX (2) | MX2023012766A (es) |
| WO (2) | WO2022226623A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118914553B (zh) * | 2024-07-22 | 2025-03-18 | 西安医学院第一附属医院 | 一种结直肠腺瘤和结直肠癌早期筛查的生物标志物的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1882A (en) | 1872-12-11 | Angus. Campbell | A towel hanger | |
| ES2543341T3 (es) | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Métodos y composiciones para modular la actividad de células tumorales |
| HRP20191129T1 (hr) * | 2009-11-24 | 2019-09-20 | Alethia Biotherapeutics Inc. | Anti-klusterinska protutijela i ulomci koji vežu antigen i njihova uporaba za smanjivanje volumena tumora |
| EA201491568A1 (ru) * | 2012-02-22 | 2014-11-28 | Алетиа Байотерапьютикс Инк. | Совместное применение ингибитора кластерина и ингибитора egfr для лечения рака |
-
2021
- 2021-04-27 IL IL307954A patent/IL307954A/en unknown
- 2021-04-27 EP EP21938161.3A patent/EP4329801A4/en active Pending
- 2021-04-27 CN CN202180099369.0A patent/CN117479955A/zh active Pending
- 2021-04-27 JP JP2023566662A patent/JP2024516416A/ja active Pending
- 2021-04-27 CA CA3173786A patent/CA3173786A1/en active Pending
- 2021-04-27 AU AU2021442702A patent/AU2021442702A1/en active Pending
- 2021-04-27 KR KR1020237040576A patent/KR20240014052A/ko active Pending
- 2021-04-27 WO PCT/CA2021/050572 patent/WO2022226623A1/en not_active Ceased
- 2021-04-27 MX MX2023012766A patent/MX2023012766A/es unknown
- 2021-04-27 US US18/287,327 patent/US20240199758A1/en active Pending
-
2022
- 2022-04-26 CN CN202280042256.1A patent/CN117479956A/zh active Pending
- 2022-04-26 EP EP22794137.4A patent/EP4329802A4/en active Pending
- 2022-04-26 KR KR1020237040565A patent/KR20240013743A/ko active Pending
- 2022-04-26 CA CA3173797A patent/CA3173797A1/en active Pending
- 2022-04-26 US US18/287,331 patent/US20240317884A1/en active Pending
- 2022-04-26 JP JP2023565954A patent/JP2024516818A/ja active Pending
- 2022-04-26 IL IL307961A patent/IL307961A/en unknown
- 2022-04-26 MX MX2023012768A patent/MX2023012768A/es unknown
- 2022-04-26 AU AU2022266854A patent/AU2022266854A1/en active Pending
- 2022-04-26 WO PCT/CA2022/050632 patent/WO2022226637A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023012768A (es) | 2023-11-13 |
| JP2024516416A (ja) | 2024-04-15 |
| AU2022266854A1 (en) | 2023-11-30 |
| US20240199758A1 (en) | 2024-06-20 |
| AU2022266854A9 (en) | 2023-12-07 |
| EP4329801A1 (en) | 2024-03-06 |
| JP2024516818A (ja) | 2024-04-17 |
| CA3173786A1 (en) | 2022-10-27 |
| EP4329802A1 (en) | 2024-03-06 |
| IL307961A (en) | 2023-12-01 |
| CN117479956A (zh) | 2024-01-30 |
| US20240317884A1 (en) | 2024-09-26 |
| KR20240014052A (ko) | 2024-01-31 |
| IL307954A (en) | 2023-12-01 |
| EP4329802A4 (en) | 2025-09-03 |
| AU2021442702A1 (en) | 2023-11-30 |
| EP4329801A4 (en) | 2025-05-14 |
| CN117479955A (zh) | 2024-01-30 |
| WO2022226623A1 (en) | 2022-11-03 |
| KR20240013743A (ko) | 2024-01-30 |
| CA3173797A1 (en) | 2023-10-05 |
| WO2022226637A1 (en) | 2022-11-03 |
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