MX2023012427A - Proceso mejorado para la preparacion de derivados de 7-(morfolinil)-2-(n-piperazinil) metiltieno [2,3-c] piridina. - Google Patents
Proceso mejorado para la preparacion de derivados de 7-(morfolinil)-2-(n-piperazinil) metiltieno [2,3-c] piridina.Info
- Publication number
- MX2023012427A MX2023012427A MX2023012427A MX2023012427A MX2023012427A MX 2023012427 A MX2023012427 A MX 2023012427A MX 2023012427 A MX2023012427 A MX 2023012427A MX 2023012427 A MX2023012427 A MX 2023012427A MX 2023012427 A MX2023012427 A MX 2023012427A
- Authority
- MX
- Mexico
- Prior art keywords
- nrc
- methylthieno
- morpholinyl
- preparation
- methyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000003222 pyridines Chemical class 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- CQVKMVQRSNNAGO-UHFFFAOYSA-N 2-[4-formyl-3-methyl-n-(2-methylsulfonyloxyethyl)anilino]ethyl methanesulfonate Chemical compound CC1=CC(N(CCOS(C)(=O)=O)CCOS(C)(=O)=O)=CC=C1C=O CQVKMVQRSNNAGO-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- -1 4-methylsulfonylpiperazin-1-yl Chemical group 0.000 abstract 1
- 125000004938 5-pyridyl group Chemical group N1=CC=CC(=C1)* 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención describe un procedimiento mejorado de segunda generación para la síntesis de NRC-1111 (I, 5-[2-[[4-(metilsulfonil)-1-piperazinil]metil]-7-(4-morfolinil)tie no[2,3-c]piridin-5-il]-2-pirimidinamina) dimetano sulfonato y NRC-1109 (II, 5-[3-metil-2-([4-metilsulfonilpiperazin-1-il)metil]- 7-morfolino-tieno[2,3-c]piridin-5 il]pirimidin-2-amina) dimetanosulfonato. Este procedimiento es rentable, de alto rendimiento e industrialmente factible para la síntesis de compuestos de las fórmulas I y II con alta pureza. Fórmula (I) Fórmula (I): R = H para NRC-1111 y Fórmula (II): R = CH3 para NRC-1109.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202141018380 | 2021-04-21 | ||
| PCT/IN2022/050363 WO2022224267A1 (en) | 2021-04-21 | 2022-04-15 | Improved process for the preparation of 7-(morpholinyl)-2-(n-piperazinyl)methylthieno[2, 3-c]pyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023012427A true MX2023012427A (es) | 2024-02-09 |
Family
ID=83723591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023012427A MX2023012427A (es) | 2021-04-21 | 2022-04-15 | Proceso mejorado para la preparacion de derivados de 7-(morfolinil)-2-(n-piperazinil) metiltieno [2,3-c] piridina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240199637A1 (es) |
| EP (1) | EP4326276A4 (es) |
| JP (1) | JP2024517127A (es) |
| CN (1) | CN117529325A (es) |
| AU (1) | AU2022260846A1 (es) |
| BR (1) | BR112023021908A2 (es) |
| CA (1) | CA3216161A1 (es) |
| CO (1) | CO2023015302A2 (es) |
| IL (1) | IL307871A (es) |
| MX (1) | MX2023012427A (es) |
| WO (1) | WO2022224267A1 (es) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0710866A2 (pt) * | 2006-04-26 | 2012-08-14 | Hoffmann La Roche | compostos farmacÊuticos |
| AU2009270511B2 (en) * | 2008-07-15 | 2013-07-18 | Sanofi | Oxazolopyrimidines as Edg-1 receptor agonists |
| WO2011055770A1 (ja) * | 2009-11-06 | 2011-05-12 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| KR20140099556A (ko) * | 2010-12-16 | 2014-08-12 | 에프. 호프만-라 로슈 아게 | 트라이사이클릭 pi3k 억제제 화합물 및 이의 사용 방법 |
| MX364992B (es) * | 2012-05-09 | 2019-05-17 | Biogen Ma Inc | Moduladores del transporte nuclear y usos de los mismos. |
| US9487511B2 (en) * | 2014-04-11 | 2016-11-08 | Takeda Pharmaceutical Company Limited | Cyclopropanamine compound and use thereof |
| EP3928779B1 (en) * | 2014-09-12 | 2024-03-06 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical containing sodium-dependent phosphate transporter inhibitor and phosphorus adsorbent for use in the prevention, treatment or suppression of chronic kidney disease, arteriosclerosis associated with vascular calcification, or ectopic calcification. |
| RS59409B1 (sr) * | 2014-12-11 | 2019-11-29 | Natco Pharma Ltd | 7-(morfolinil)-2-(n-piperazinil) metil tieno [2, 3-c]piridinski derivati kao antikancerski lekovi |
-
2022
- 2022-04-15 EP EP22791275.5A patent/EP4326276A4/en active Pending
- 2022-04-15 WO PCT/IN2022/050363 patent/WO2022224267A1/en not_active Ceased
- 2022-04-15 BR BR112023021908A patent/BR112023021908A2/pt unknown
- 2022-04-15 AU AU2022260846A patent/AU2022260846A1/en active Pending
- 2022-04-15 JP JP2023565128A patent/JP2024517127A/ja active Pending
- 2022-04-15 MX MX2023012427A patent/MX2023012427A/es unknown
- 2022-04-15 US US18/556,389 patent/US20240199637A1/en active Pending
- 2022-04-15 CA CA3216161A patent/CA3216161A1/en active Pending
- 2022-04-15 IL IL307871A patent/IL307871A/en unknown
- 2022-04-15 CN CN202280043482.1A patent/CN117529325A/zh active Pending
-
2023
- 2023-11-14 CO CONC2023/0015302A patent/CO2023015302A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112023021908A2 (pt) | 2023-12-19 |
| CA3216161A1 (en) | 2022-10-27 |
| EP4326276A4 (en) | 2025-07-30 |
| CN117529325A (zh) | 2024-02-06 |
| US20240199637A1 (en) | 2024-06-20 |
| AU2022260846A1 (en) | 2023-11-16 |
| CO2023015302A2 (es) | 2023-11-20 |
| JP2024517127A (ja) | 2024-04-19 |
| EP4326276A1 (en) | 2024-02-28 |
| IL307871A (en) | 2023-12-01 |
| WO2022224267A1 (en) | 2022-10-27 |
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