MX2023012170A - Metodos y materiales para detectar polipeptidos mal plegados. - Google Patents
Metodos y materiales para detectar polipeptidos mal plegados.Info
- Publication number
- MX2023012170A MX2023012170A MX2023012170A MX2023012170A MX2023012170A MX 2023012170 A MX2023012170 A MX 2023012170A MX 2023012170 A MX2023012170 A MX 2023012170A MX 2023012170 A MX2023012170 A MX 2023012170A MX 2023012170 A MX2023012170 A MX 2023012170A
- Authority
- MX
- Mexico
- Prior art keywords
- sample
- materials
- methods
- misfolded polypeptides
- absence
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 239000000463 material Substances 0.000 title abstract 4
- 239000000523 sample Substances 0.000 abstract 6
- 241000124008 Mammalia Species 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 abstract 1
- 239000000975 dye Substances 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract 1
- 239000010931 gold Substances 0.000 abstract 1
- 229910052737 gold Inorganic materials 0.000 abstract 1
- 239000002082 metal nanoparticle Substances 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Este documento se refiere a métodos y materiales para detectar la presencia o ausencia de polipéptidos mal plegados en una muestra. Por ejemplo, se proporcionan métodos y materiales para amplificar una muestra (por ejemplo, una muestra biológica o una muestra ambiental) de modo que los polipéptidos mal plegados presentes en la muestra puedan agregarse para formar fibrillas y/o agregados de polipéptidos globulares y poner en contacto la muestra amplificada con una solución que contiene nanopartículas metálicas (por ejemplo, nanopartículas de oro) o uno o más colorantes orgánicos (por ejemplo, rojo Congo) para detectar la presencia o ausencia de fibrillas y/o agregados de polipéptidos globulares. En algunos casos, se proporcionan métodos y materiales para determinar si un mamífero (por ejemplo, un ser humano) tiene una proteinopatía basada, al menos en parte, en la presencia o ausencia de polipéptidos mal plegados en una muestra obtenida del mamífero.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163176114P | 2021-04-16 | 2021-04-16 | |
| US202163277999P | 2021-11-10 | 2021-11-10 | |
| PCT/US2022/025059 WO2022221683A1 (en) | 2021-04-16 | 2022-04-15 | Methods and materials for detecting misfolded polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023012170A true MX2023012170A (es) | 2024-01-09 |
Family
ID=83640898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023012170A MX2023012170A (es) | 2021-04-16 | 2022-04-15 | Metodos y materiales para detectar polipeptidos mal plegados. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240192229A1 (es) |
| EP (1) | EP4323773A4 (es) |
| KR (1) | KR20230170958A (es) |
| CA (1) | CA3216826A1 (es) |
| MX (1) | MX2023012170A (es) |
| WO (1) | WO2022221683A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024220662A2 (en) * | 2023-04-18 | 2024-10-24 | Regents Of The University Of Minnesota | Nanoparticle enhanced methods and materials for detecting misfolded polypeptides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002001230A2 (en) * | 2000-06-23 | 2002-01-03 | Minerva Biotechnologies Corporation | Rapid and sensitive detection of protein aggregation |
| US8298793B2 (en) * | 2002-09-30 | 2012-10-30 | Auburn University | Methods for isolating proteons from plasma samples |
| EP2074222A4 (en) * | 2006-09-06 | 2010-03-03 | Univ Texas | METHOD AND COMPOSITIONS FOR DETECTING PROTEIN DISORDERING |
| WO2016123401A1 (en) * | 2015-01-28 | 2016-08-04 | University Of Delaware | Detection of disease-associated tau protein conformations and applications thereof |
-
2022
- 2022-04-15 KR KR1020237039341A patent/KR20230170958A/ko active Pending
- 2022-04-15 MX MX2023012170A patent/MX2023012170A/es unknown
- 2022-04-15 WO PCT/US2022/025059 patent/WO2022221683A1/en not_active Ceased
- 2022-04-15 CA CA3216826A patent/CA3216826A1/en active Pending
- 2022-04-15 US US18/286,682 patent/US20240192229A1/en active Pending
- 2022-04-15 EP EP22789028.2A patent/EP4323773A4/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022221683A1 (en) | 2022-10-20 |
| EP4323773A1 (en) | 2024-02-21 |
| KR20230170958A (ko) | 2023-12-19 |
| CA3216826A1 (en) | 2022-10-20 |
| US20240192229A1 (en) | 2024-06-13 |
| EP4323773A4 (en) | 2025-04-23 |
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