MX2022014965A - Sustituciones nucleotidicas predeterminadas. - Google Patents
Sustituciones nucleotidicas predeterminadas.Info
- Publication number
- MX2022014965A MX2022014965A MX2022014965A MX2022014965A MX2022014965A MX 2022014965 A MX2022014965 A MX 2022014965A MX 2022014965 A MX2022014965 A MX 2022014965A MX 2022014965 A MX2022014965 A MX 2022014965A MX 2022014965 A MX2022014965 A MX 2022014965A
- Authority
- MX
- Mexico
- Prior art keywords
- organisms
- genome
- finding
- dpcr
- pooling
- Prior art date
Links
- 238000013459 approach Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000011176 pooling Methods 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 4
- 125000003729 nucleotide group Chemical group 0.000 abstract 4
- 238000006467 substitution reaction Methods 0.000 abstract 3
- 238000007847 digital PCR Methods 0.000 abstract 1
- 238000002703 mutagenesis Methods 0.000 abstract 1
- 231100000350 mutagenesis Toxicity 0.000 abstract 1
- 238000003976 plant breeding Methods 0.000 abstract 1
- 238000003752 polymerase chain reaction Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
- A01H4/005—Methods for micropropagation; Vegetative plant propagation using cell or tissue culture techniques
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
- A01H6/46—Gramineae or Poaceae, e.g. ryegrass, rice, wheat or maize
- A01H6/4624—Hordeum vulgarus [barley]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/13—Plant traits
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Physiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
En los enfoques de mejoramiento de plantas tradicionales, puede utilizarse mutagénesis química para introducir sustituciones nucleotídicas aleatoriamente en el genoma de una planta, es decir sin posibilidades de controlar los sitios de los cambios nucleotídicos. A causa de las complejidades genómicas, la probabilidad estadística es extremadamente baja en cuanto a hallar una sustitución nucleotídica predeterminada. La presente invención, sin embargo, demuestra cómo se desarrolla un uso novedoso, alternativo, de la reacción en cadena de polimerasa digital (dPCR), preferiblemente dPCR en gotas (ddPCR), para explotar el hallazgo de sustituciones nucleotídicas específicas en genes mutados. La plataforma completa comprende un método de detección con una biblioteca de organismos mutagenizados, sistemas basados en PCR digital y una configuración para propagar y analizar organismos mutados identificados.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201670485 | 2016-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022014965A true MX2022014965A (es) | 2023-01-11 |
Family
ID=56681913
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018016110A MX2018016110A (es) | 2016-07-01 | 2017-06-23 | Sustituciones nucleotidicas predeterminadas. |
| MX2022014965A MX2022014965A (es) | 2016-07-01 | 2018-12-18 | Sustituciones nucleotidicas predeterminadas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018016110A MX2018016110A (es) | 2016-07-01 | 2017-06-23 | Sustituciones nucleotidicas predeterminadas. |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11884972B2 (es) |
| EP (3) | EP3693458A1 (es) |
| JP (2) | JP7208797B2 (es) |
| CN (2) | CN109477087B (es) |
| AR (1) | AR110103A1 (es) |
| AU (3) | AU2017288960B2 (es) |
| BR (1) | BR112018076429A2 (es) |
| CA (1) | CA3026016A1 (es) |
| CL (1) | CL2018003710A1 (es) |
| CO (1) | CO2019000828A2 (es) |
| CR (1) | CR20190040A (es) |
| CU (1) | CU20180158A7 (es) |
| DK (1) | DK3478832T3 (es) |
| EA (1) | EA201892809A1 (es) |
| ES (2) | ES3032697T3 (es) |
| IL (1) | IL263451B (es) |
| MA (3) | MA52594A (es) |
| MX (2) | MX2018016110A (es) |
| PE (1) | PE20190228A1 (es) |
| PL (2) | PL3478832T3 (es) |
| PT (1) | PT3478832T (es) |
| SG (1) | SG11201811021YA (es) |
| UY (1) | UY37312A (es) |
| WO (1) | WO2018001884A1 (es) |
| ZA (3) | ZA201808218B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL263451B (en) * | 2016-07-01 | 2022-08-01 | Carlsberg As | A method to screen for a mutant within a population of organisms using a merge-and-split approach |
| JP7359768B2 (ja) | 2017-12-28 | 2023-10-11 | カールスバーグ アグシャセルスガーブ | 改善された細胞壁特性を有する穀類植物 |
| EP3821032A1 (en) * | 2018-07-13 | 2021-05-19 | HiFiBiO SAS | Use of droplet single cell epigenome profiling for patient stratification |
| US20210310063A1 (en) * | 2018-07-13 | 2021-10-07 | Hifibio Sas | Use of droplet single cell epigenome profiling for patient stratification |
| CN108913698B (zh) * | 2018-07-25 | 2021-10-26 | 安徽农业大学 | 一种与小麦穗发芽抗性/感性相关的caps标记及其应用 |
| CN110724741B (zh) * | 2019-07-24 | 2020-05-19 | 艾普拜生物科技(苏州)有限公司 | 一种检测微小残留白血病相关融合基因的引物、探针及其试剂盒 |
| CA3146189A1 (en) | 2019-08-16 | 2021-02-25 | Heineken Supply Chain B.V. | Production of an alcohol-free beverage |
| EP3785529A1 (en) | 2019-08-28 | 2021-03-03 | Carlsberg A/S | Barley plants with altered protein content in grains |
| EP4040946A1 (en) * | 2019-10-10 | 2022-08-17 | Carlsberg A/S | Methods for preparing mutant plants |
| US20240043911A1 (en) * | 2020-02-06 | 2024-02-08 | The Administrators Of The Tulane Educational Fund | Crispr-based assay for detecting tb in bodily fluids |
| BR112022015008A2 (pt) | 2020-03-02 | 2022-10-11 | Carlsberg As | Plantas de cevada com alto limite de atividade de dextrinase |
| EP4029935A1 (en) | 2021-01-14 | 2022-07-20 | Carlsberg A/S | S. eubayanus strain and hybrids thereof |
| US20230250467A1 (en) * | 2021-10-25 | 2023-08-10 | Gt Molecular, Inc. | Off-target blocking sequences to improve target discrimination by polymerase chain reaction |
| WO2023118136A1 (en) | 2021-12-22 | 2023-06-29 | BASF Agricultural Solutions Seed US LLC | Improved screening method for genome edited events |
| AU2023231447A1 (en) | 2022-03-11 | 2024-09-05 | Carlsberg A/S | Modulation of protein levels |
| CN120225050A (zh) | 2022-11-16 | 2025-06-27 | 哥本哈根大学 | 种子硫代葡萄糖苷含量低的植物 |
| WO2024133900A1 (en) | 2022-12-22 | 2024-06-27 | University Of Copenhagen | Improved (-)-sparteine production |
| AU2024265403A1 (en) | 2023-05-01 | 2025-10-16 | Carlsberg A/S | Barley with improved properties |
| WO2025108936A1 (en) * | 2023-11-20 | 2025-05-30 | Eth Zurich | Method for providing genetically-modified cells |
| CN117965576B (zh) * | 2024-02-01 | 2024-08-27 | 北京林业大学 | 一种王百合苷生物合成基因LlHCT1及其应用 |
| EP4644572A1 (en) * | 2024-04-29 | 2025-11-05 | KWS SAAT SE & Co. KGaA | Method for analysing trait purity in large seed bulks |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4351760A (en) | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
| US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| WO1998023759A2 (en) | 1996-11-26 | 1998-06-04 | Baylor College Of Medicine | Identification of inhibitors that prevent access of telomerase to chromosomal terminus |
| JP2002504820A (ja) | 1997-06-04 | 2002-02-12 | スミスクライン・ビーチャム・コーポレイション | 全長ｃＤＮＡの迅速クローニング法 |
| EP1068351A2 (en) | 1998-04-02 | 2001-01-17 | Tellus Genetic Resources, Inc. | A method for obtaining a plant with a genetic lesion in a gene sequence |
| GB9812768D0 (en) | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| WO2003000905A2 (en) * | 2001-06-22 | 2003-01-03 | Syngenta Participations Ag | Identification and characterization of plant genes |
| GB0127564D0 (en) | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
| US7420105B2 (en) | 2004-03-11 | 2008-09-02 | Carlsberg A/S | Barley for production of flavor-stable beverage |
| CA2738578C (en) | 2008-09-23 | 2021-05-04 | Quantalife, Inc. | Droplet-based assay system |
| US9005565B2 (en) | 2010-06-24 | 2015-04-14 | Hamid-Reza Jahangiri-Famenini | Method and apparatus for forming graphene |
| WO2012122571A1 (en) * | 2011-03-10 | 2012-09-13 | Gen-Probe Incorporated | Methods and compositions for the selection and optimization of oligonucleotide tag sequences |
| ES2561885T3 (es) | 2011-04-11 | 2016-03-01 | F. Hoffmann-La Roche Ag | ADN polimerasas de actividad mejorada |
| ES2898460T3 (es) | 2014-02-27 | 2022-03-07 | Monsanto Technology Llc | Composiciones y procedimientos para la modificación genómica dirigida al sitio |
| GB201411603D0 (en) | 2014-06-30 | 2014-08-13 | Vela Operations Pte Ltd | Compositions for quantitative and/or semiquantitative mutation detection methods |
| IL263451B (en) * | 2016-07-01 | 2022-08-01 | Carlsberg As | A method to screen for a mutant within a population of organisms using a merge-and-split approach |
| EP4040946A1 (en) * | 2019-10-10 | 2022-08-17 | Carlsberg A/S | Methods for preparing mutant plants |
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2017
- 2017-06-23 IL IL263451A patent/IL263451B/en unknown
- 2017-06-23 MA MA052594A patent/MA52594A/fr unknown
- 2017-06-23 CN CN201780041101.5A patent/CN109477087B/zh active Active
- 2017-06-23 MX MX2018016110A patent/MX2018016110A/es unknown
- 2017-06-23 AU AU2017288960A patent/AU2017288960B2/en active Active
- 2017-06-23 CN CN202210633145.XA patent/CN114959098A/zh active Pending
- 2017-06-23 CR CR20190040A patent/CR20190040A/es unknown
- 2017-06-23 EA EA201892809A patent/EA201892809A1/ru unknown
- 2017-06-23 PT PT177338001T patent/PT3478832T/pt unknown
- 2017-06-23 JP JP2018569004A patent/JP7208797B2/ja active Active
- 2017-06-23 MA MA045531A patent/MA45531A/fr unknown
- 2017-06-23 CA CA3026016A patent/CA3026016A1/en active Pending
- 2017-06-23 ES ES20200115T patent/ES3032697T3/es active Active
- 2017-06-23 CU CU2018000158A patent/CU20180158A7/es unknown
- 2017-06-23 MA MA054568A patent/MA54568A/fr unknown
- 2017-06-23 US US16/311,450 patent/US11884972B2/en active Active
- 2017-06-23 EP EP20163553.9A patent/EP3693458A1/en active Pending
- 2017-06-23 SG SG11201811021YA patent/SG11201811021YA/en unknown
- 2017-06-23 PL PL17733800T patent/PL3478832T3/pl unknown
- 2017-06-23 PL PL20200115.2T patent/PL3792357T3/pl unknown
- 2017-06-23 DK DK17733800.1T patent/DK3478832T3/da active
- 2017-06-23 EP EP17733800.1A patent/EP3478832B1/en active Active
- 2017-06-23 EP EP20200115.2A patent/EP3792357B1/en active Active
- 2017-06-23 WO PCT/EP2017/065516 patent/WO2018001884A1/en not_active Ceased
- 2017-06-23 BR BR112018076429A patent/BR112018076429A2/pt active Search and Examination
- 2017-06-23 ES ES17733800T patent/ES2916221T3/es active Active
- 2017-06-23 PE PE2018003333A patent/PE20190228A1/es unknown
- 2017-06-30 AR ARP170101817A patent/AR110103A1/es unknown
- 2017-06-30 UY UY0001037312A patent/UY37312A/es not_active Application Discontinuation
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2018
- 2018-12-05 ZA ZA2018/08218A patent/ZA201808218B/en unknown
- 2018-12-18 MX MX2022014965A patent/MX2022014965A/es unknown
- 2018-12-20 CL CL2018003710A patent/CL2018003710A1/es unknown
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2019
- 2019-01-29 CO CONC2019/0000828A patent/CO2019000828A2/es unknown
- 2019-11-20 AU AU2019268103A patent/AU2019268103B2/en active Active
- 2019-11-20 AU AU2019268102A patent/AU2019268102B2/en active Active
- 2019-11-25 ZA ZA2019/07774A patent/ZA201907774B/en unknown
- 2019-11-25 ZA ZA2019/07775A patent/ZA201907775B/en unknown
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2022
- 2022-05-06 JP JP2022076471A patent/JP7539428B2/ja active Active
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2023
- 2023-12-12 US US18/536,784 patent/US12428678B2/en active Active
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