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MX2022013599A - Métodos para el cultivo de células. - Google Patents

Métodos para el cultivo de células.

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Publication number
MX2022013599A
MX2022013599A MX2022013599A MX2022013599A MX2022013599A MX 2022013599 A MX2022013599 A MX 2022013599A MX 2022013599 A MX2022013599 A MX 2022013599A MX 2022013599 A MX2022013599 A MX 2022013599A MX 2022013599 A MX2022013599 A MX 2022013599A
Authority
MX
Mexico
Prior art keywords
cells
aspects
medium
methods
engineered
Prior art date
Application number
MX2022013599A
Other languages
English (en)
Inventor
Nicholas P Restifo
Suman Kumar Vodnala
Robert Langland Eil
Original Assignee
Lyell Immunopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyell Immunopharma Inc filed Critical Lyell Immunopharma Inc
Publication of MX2022013599A publication Critical patent/MX2022013599A/es

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4231—Cytokines
    • A61K40/4234—Interleukins [IL]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Virology (AREA)

Abstract

La presente descripción proporciona métodos para el cultivo de células, p. ej., células pluripotentes, células multipotentes, y/o células inmunitarias (p. ej., células T, células NK, y/o TIL) en un medio que comprende al menos aproximadamente 5 mM de ion de potasio, donde el medio no es hipertónico. En algunos aspectos, el medio es hipotónico. En algunos aspectos, los métodos descritos en la presente aumentan la cantidad de células menos diferenciadas en la población de células. En algunos aspectos, las células cultivadas se manipulan, por ejemplo, para comprender un receptor de antígeno quimérico o un receptor de células T manipulado. En algunos aspectos, las células se administran a un sujeto que lo necesita.
MX2022013599A 2020-04-28 2021-04-28 Métodos para el cultivo de células. MX2022013599A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063016907P 2020-04-28 2020-04-28
PCT/US2021/029762 WO2021222479A1 (en) 2020-04-28 2021-04-28 Methods for culturing cells

Publications (1)

Publication Number Publication Date
MX2022013599A true MX2022013599A (es) 2023-01-24

Family

ID=75954306

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022013599A MX2022013599A (es) 2020-04-28 2021-04-28 Métodos para el cultivo de células.

Country Status (11)

Country Link
US (1) US12365871B2 (es)
EP (1) EP4143300A1 (es)
JP (1) JP2023524047A (es)
KR (1) KR20230017786A (es)
CN (1) CN115768879A (es)
AU (1) AU2021265797A1 (es)
BR (1) BR112022021551A2 (es)
CA (1) CA3158133A1 (es)
IL (1) IL297751A (es)
MX (1) MX2022013599A (es)
WO (1) WO2021222479A1 (es)

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