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MX2021012041A - Metodos para promover la diferenciacion de celulas epiteliales timicas y progenitores de celulas epiteliales timicas de celulas madre pluripotentes, celulas resultantes y usos de estas. - Google Patents

Metodos para promover la diferenciacion de celulas epiteliales timicas y progenitores de celulas epiteliales timicas de celulas madre pluripotentes, celulas resultantes y usos de estas.

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Publication number
MX2021012041A
MX2021012041A MX2021012041A MX2021012041A MX2021012041A MX 2021012041 A MX2021012041 A MX 2021012041A MX 2021012041 A MX2021012041 A MX 2021012041A MX 2021012041 A MX2021012041 A MX 2021012041A MX 2021012041 A MX2021012041 A MX 2021012041A
Authority
MX
Mexico
Prior art keywords
thymic epithelial
epithelial cell
methods
pluripotent stem
stem cells
Prior art date
Application number
MX2021012041A
Other languages
English (en)
Inventor
Megan Sykes
Mohsen Khosravi-Maharlooei
Nichole Danzl
Pena Rafael Gras
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Publication of MX2021012041A publication Critical patent/MX2021012041A/es

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    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
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Abstract

La presente divulgación proporciona métodos para promover la diferenciación de células madre pluripotentes en células epiteliales tímicas o progenitores de células epiteliales tímicas, así como las células obtenidas de los métodos y soluciones, composiciones y composiciones farmacéuticas que comprenden dichas células. La presente divulgación también proporciona métodos de uso de células epiteliales tímicas o progenitores de células epiteliales tímicas para el tratamiento y prevención de enfermedades, órganos generadores, así como otros usos y kits.
MX2021012041A 2019-04-01 2020-03-31 Metodos para promover la diferenciacion de celulas epiteliales timicas y progenitores de celulas epiteliales timicas de celulas madre pluripotentes, celulas resultantes y usos de estas. MX2021012041A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962827383P 2019-04-01 2019-04-01
PCT/US2020/025955 WO2020205859A1 (en) 2019-04-01 2020-03-31 Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells

Publications (1)

Publication Number Publication Date
MX2021012041A true MX2021012041A (es) 2021-11-03

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ID=72667458

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MX2021012041A MX2021012041A (es) 2019-04-01 2020-03-31 Metodos para promover la diferenciacion de celulas epiteliales timicas y progenitores de celulas epiteliales timicas de celulas madre pluripotentes, celulas resultantes y usos de estas.

Country Status (11)

Country Link
US (1) US20220127569A1 (es)
EP (1) EP3947639A4 (es)
JP (2) JP7740706B2 (es)
KR (1) KR20210146297A (es)
CN (2) CN113646423B (es)
AU (1) AU2020253429A1 (es)
CA (1) CA3135377A1 (es)
IL (1) IL286936A (es)
MX (1) MX2021012041A (es)
SG (1) SG11202109279PA (es)
WO (1) WO2020205859A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023524213A (ja) * 2020-04-28 2023-06-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア インビトロで胸腺細胞を生成するための方法
EP4277977A4 (en) * 2021-01-15 2025-02-12 The Board of Trustees of the Leland Stanford Junior University PRODUCTION OF INDUCED HUMAN THYMIC EPITHELIAL CELLS AND THEIR APPLICATION IN CELL-BASED IMMUNOTHERAPIES
CN113215081B (zh) * 2021-06-01 2023-04-14 华中科技大学同济医学院附属同济医院 诱导干细胞分化为甲状旁腺细胞的方法及其组合物
CA3234507A1 (en) * 2021-10-15 2023-04-20 Bing Lim Thymic cells and methods of making
EP4293110A1 (en) 2022-06-17 2023-12-20 Nantes Université Process for obtaining functional lymphocytes cells
WO2025136749A1 (en) * 2023-12-19 2025-06-26 The Board Of Trustees Of The Leland Stanford Junior University Thymic epithelial cells and methods of producing and using the same
CN119614476A (zh) * 2024-11-13 2025-03-14 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） 胸腺类器官的构建方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040096971A1 (en) * 2000-12-22 2004-05-20 Blackburn Catherine Clare Thymic epithelial progenitor cells and uses thereof
WO2010143529A1 (ja) * 2009-06-09 2010-12-16 国立大学法人名古屋大学 多能性幹細胞を胸腺上皮へ分化誘導する方法
JP2013524836A (ja) * 2010-04-25 2013-06-20 マウント・シナイ・スクール・オブ・メディスン 多能性細胞からの前部前腸内胚葉の生成
CN102732479B (zh) * 2011-03-31 2014-08-27 北京大学 胸腺上皮前体细胞的制备方法及其专用培养基
WO2014058274A1 (ko) * 2012-10-12 2014-04-17 서강대학교 산학협력단 미분화 인간 유도만능줄기세포의 선택적 세포사멸 유도를 통한 테라토마 형성 억제 방법
CA3173076A1 (en) * 2013-02-27 2014-09-04 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
US11898166B2 (en) * 2017-09-20 2024-02-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services In vitro generation of thymic organoid from human pluripotent stem cells
EP3959304A4 (en) * 2019-04-26 2023-01-25 The Regents Of The University Of Colorado, A Body Corporate GENERATION OF FUNCTIONAL AND PATIENT-SPECIFIC THYMUS TISSUE IN VIVO FROM INDUCED PLURIPOTENTS STEM CELLS
JP2023502522A (ja) * 2019-11-25 2023-01-24 アレゲーニー シンガー リサーチ インスティテュート ヒト多能性幹細胞からバイオエンジニアリングされた胸腺オルガノイド

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CA3135377A1 (en) 2020-10-08
EP3947639A1 (en) 2022-02-09
IL286936A (en) 2021-10-31
SG11202109279PA (en) 2021-09-29
CN119351306A (zh) 2025-01-24
AU2020253429A1 (en) 2021-09-09
WO2020205859A1 (en) 2020-10-08
KR20210146297A (ko) 2021-12-03
CN113646423A (zh) 2021-11-12
JP2022527338A (ja) 2022-06-01
JP7740706B2 (ja) 2025-09-17
EP3947639A4 (en) 2023-01-25
CN113646423B (zh) 2024-10-01
JP2024153768A (ja) 2024-10-29
US20220127569A1 (en) 2022-04-28

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