MX2020006168A - Compuestos de 4-azaindol. - Google Patents
Compuestos de 4-azaindol.Info
- Publication number
- MX2020006168A MX2020006168A MX2020006168A MX2020006168A MX2020006168A MX 2020006168 A MX2020006168 A MX 2020006168A MX 2020006168 A MX2020006168 A MX 2020006168A MX 2020006168 A MX2020006168 A MX 2020006168A MX 2020006168 A MX2020006168 A MX 2020006168A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- sub
- azaindole compounds
- disclosed
- azaindole
- Prior art date
Links
- XWIYUCRMWCHYJR-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyridine Chemical class C1=CC=C2NC=CC2=N1 XWIYUCRMWCHYJR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 108010060825 Toll-Like Receptor 7 Proteins 0.000 abstract 1
- 108010060752 Toll-Like Receptor 8 Proteins 0.000 abstract 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 abstract 1
- 102100033110 Toll-like receptor 8 Human genes 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a compuestos de Fórmula (I) (VER FORMULA I) N-óxidos, o sus sales, donde G, A, R1, R5, y n se definen en la presente. También se describen métodos de uso de tales compuestos como inhibidores de señalización a través del receptor tipo Toll 7, o 8, o 9, y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles para tratar enfermedades inflamatorias y autoinmunes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762599875P | 2017-12-18 | 2017-12-18 | |
| PCT/US2018/065908 WO2019125977A1 (en) | 2017-12-18 | 2018-12-17 | 4-azaindole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020006168A true MX2020006168A (es) | 2020-08-13 |
Family
ID=65003548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020006168A MX2020006168A (es) | 2017-12-18 | 2018-12-17 | Compuestos de 4-azaindol. |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US10544143B2 (es) |
| EP (1) | EP3728252B1 (es) |
| JP (1) | JP7289301B2 (es) |
| KR (1) | KR102720550B1 (es) |
| CN (1) | CN111819176B (es) |
| AR (1) | AR113959A1 (es) |
| AU (1) | AU2018388464B2 (es) |
| BR (1) | BR112020011771A2 (es) |
| CA (1) | CA3085817A1 (es) |
| CL (1) | CL2020001546A1 (es) |
| DK (1) | DK3728252T3 (es) |
| EA (1) | EA202091484A1 (es) |
| ES (1) | ES2960411T3 (es) |
| FI (1) | FI3728252T3 (es) |
| HR (1) | HRP20231244T1 (es) |
| HU (1) | HUE064473T2 (es) |
| IL (1) | IL275344B2 (es) |
| LT (1) | LT3728252T (es) |
| MX (1) | MX2020006168A (es) |
| PE (1) | PE20210129A1 (es) |
| PL (1) | PL3728252T3 (es) |
| PT (1) | PT3728252T (es) |
| RS (1) | RS64728B1 (es) |
| SG (1) | SG11202005628RA (es) |
| SI (1) | SI3728252T1 (es) |
| SM (1) | SMT202300342T1 (es) |
| TW (1) | TWI689510B (es) |
| WO (1) | WO2019125977A1 (es) |
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| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| CN111819176B (zh) * | 2017-12-18 | 2023-12-15 | 百时美施贵宝公司 | 4-氮杂吲哚化合物 |
| ES2965182T3 (es) * | 2017-12-20 | 2024-04-11 | Bristol Myers Squibb Co | Compuestos de indol sustituidos con arilo y heteroarilo |
| BR112020012002A2 (pt) * | 2017-12-20 | 2020-11-17 | Bristol-Myers Squibb Company | compostos diazaindol |
| BR112020011984A2 (pt) * | 2017-12-20 | 2020-11-17 | Bristol-Myers Squibb Company | compostos de amino indol úteis como inibidores de tlr |
| EP3752505B1 (en) | 2018-02-12 | 2023-01-11 | F. Hoffmann-La Roche AG | Novel sulfone compounds and derivatives for the treatment and prophylaxis of virus infection |
| SG11202011137SA (en) | 2018-06-05 | 2020-12-30 | Hoffmann La Roche | Tetrahydro-1 h-pyrazino[2,1 -ajisoindolylquinoline compounds for the treatment of autoimmune disease |
| JP7434186B2 (ja) | 2018-06-12 | 2024-02-20 | エフ． ホフマン－ラ ロシュ アーゲー | 自己免疫疾患の処置のための新規のヘテロアリールヘテロシクリル化合物 |
| CN112584903B (zh) | 2018-07-23 | 2025-12-23 | 豪夫迈·罗氏有限公司 | 用于自身免疫性疾病治疗的哌嗪化合物 |
| CN112638908A (zh) | 2018-09-04 | 2021-04-09 | 豪夫迈·罗氏有限公司 | 用于治疗自身免疫性疾病的苯并噻唑类化合物 |
| WO2020048596A1 (en) | 2018-09-06 | 2020-03-12 | F. Hoffmann-La Roche Ag | Novel pyrazolopyridine compounds for the treatment of autoimmune disease |
| CN112654618A (zh) | 2018-09-06 | 2021-04-13 | 豪夫迈·罗氏有限公司 | 用于治疗自身免疫性疾病的新型环脒化合物 |
| JP7629007B2 (ja) * | 2019-10-01 | 2025-02-12 | ブリストル－マイヤーズ スクイブ カンパニー | 置換二環ヘテロアリール化合物 |
| JP7545467B2 (ja) | 2019-10-04 | 2024-09-04 | ブリストル－マイヤーズ スクイブ カンパニー | 置換カルバゾール化合物 |
| EP4051387B1 (en) | 2019-10-31 | 2025-02-19 | F. Hoffmann-La Roche AG | Hydropyrazino[1,2-d][1,4]diazepine compounds for the treatment of autoimmune disease |
| US20230117470A1 (en) * | 2019-11-01 | 2023-04-20 | Bristol-Myers Squibb Company | Substituted pyrazole compounds as toll receptor inhibitors |
| WO2021099284A1 (en) | 2019-11-19 | 2021-05-27 | F. Hoffmann-La Roche Ag | Hydro-1h-pyrrolo[1,2-a]pyrazine compounds for the treatment of autoimmune disease |
| US12421252B2 (en) | 2019-11-20 | 2025-09-23 | Hoffmann-La Roche Inc. | Spiro (isobenzofuranazetidine) compounds for the treatment of autoimmune disease |
| KR20230053644A (ko) * | 2020-08-19 | 2023-04-21 | 브리스톨-마이어스 스큅 컴퍼니 | 섬유증의 치료를 위한 tlr9 억제제로서의 이미다조[1,2-a]피리딘 및 [1,2,4]트리아졸로[1,5-a]피리딘 유도체 |
| CA3189873A1 (en) | 2020-08-19 | 2022-02-24 | David S. Yoon | 1h-benzo[d]imidazole derivatives as tlr9 inhibitors for the treatment of fibrosis |
| IL300696A (en) * | 2020-08-19 | 2023-04-01 | Bristol Myers Squibb Co | ALTERNATIVE HETEROARYL COMPOUNDS ARE USEFUL AS TLR9 INHIBITORS |
| JP2023538608A (ja) * | 2020-08-19 | 2023-09-08 | ブリストル－マイヤーズ スクイブ カンパニー | 線維症の処置のためのｔｌｒ９阻害剤阻害剤としての１ｈ－ピロロ［３，２－ｃ］ピリジンおよび１ｈ－ピロロ［２，３－ｃ］ピリジン誘導体 |
| JP2023550793A (ja) * | 2020-11-26 | 2023-12-05 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | 縮合三環式化合物、その調製方法及びその医薬的応用 |
| CN116783202A (zh) * | 2021-02-09 | 2023-09-19 | 吉利德科学公司 | 噻吩并吡咯化合物 |
| TWI861488B (zh) | 2021-04-16 | 2024-11-11 | 美商基利科學股份有限公司 | 噻吩并吡咯化合物 |
| AU2022341114A1 (en) | 2021-09-10 | 2024-02-29 | Gilead Sciences, Inc. | Thienopyrrole compounds |
| CN114591339B (zh) * | 2022-05-10 | 2022-08-02 | 上海维申医药有限公司 | 一类Toll样受体抑制剂及其制备和应用 |
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-
2018
- 2018-12-17 CN CN201880080921.XA patent/CN111819176B/zh active Active
- 2018-12-17 WO PCT/US2018/065908 patent/WO2019125977A1/en not_active Ceased
- 2018-12-17 HR HRP20231244TT patent/HRP20231244T1/hr unknown
- 2018-12-17 JP JP2020533676A patent/JP7289301B2/ja active Active
- 2018-12-17 TW TW107145397A patent/TWI689510B/zh not_active IP Right Cessation
- 2018-12-17 EP EP18830648.4A patent/EP3728252B1/en active Active
- 2018-12-17 HU HUE18830648A patent/HUE064473T2/hu unknown
- 2018-12-17 US US16/222,145 patent/US10544143B2/en active Active
- 2018-12-17 SI SI201830990T patent/SI3728252T1/sl unknown
- 2018-12-17 SG SG11202005628RA patent/SG11202005628RA/en unknown
- 2018-12-17 DK DK18830648.4T patent/DK3728252T3/da active
- 2018-12-17 CA CA3085817A patent/CA3085817A1/en active Pending
- 2018-12-17 PT PT188306484T patent/PT3728252T/pt unknown
- 2018-12-17 RS RS20230961A patent/RS64728B1/sr unknown
- 2018-12-17 MX MX2020006168A patent/MX2020006168A/es unknown
- 2018-12-17 PL PL18830648.4T patent/PL3728252T3/pl unknown
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