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MX2019015068A - Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo ( bet ) y el uso de los mismos en el tratamiento de cancer. - Google Patents

Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo ( bet ) y el uso de los mismos en el tratamiento de cancer.

Info

Publication number
MX2019015068A
MX2019015068A MX2019015068A MX2019015068A MX2019015068A MX 2019015068 A MX2019015068 A MX 2019015068A MX 2019015068 A MX2019015068 A MX 2019015068A MX 2019015068 A MX2019015068 A MX 2019015068A MX 2019015068 A MX2019015068 A MX 2019015068A
Authority
MX
Mexico
Prior art keywords
bromodomain inhibitors
bet bromodomain
tetrahydroquinoline
compositions
tetrahydroquinoline compositions
Prior art date
Application number
MX2019015068A
Other languages
English (en)
Inventor
Herbertz Torsten
Stryker Kauffman Goss
J Kayser-Bricker Katherine
P Luke George
W Martin Matthew
S Millan David
E R Schiller Shawn
c talbot Adam
W Bair Kenneth
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MX2019015068A publication Critical patent/MX2019015068A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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Abstract

La presente invención se refiere a inhibidores de bromodominios de terminal extra y bromo (BET) que son útiles para el tratamiento de cáncer, enfermedades inflamatorias, diabetes, y obesidad, que tienen la fórmula (I): (ver Fórmula) en donde W, X, Y, Z, R1, R2, R5, y R8 son como se describe aquí.
MX2019015068A 2013-11-18 2016-05-17 Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo ( bet ) y el uso de los mismos en el tratamiento de cancer. MX2019015068A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361905639P 2013-11-18 2013-11-18
US201462054811P 2014-09-24 2014-09-24

Publications (1)

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MX2019015068A true MX2019015068A (es) 2020-02-13

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MX2016006438A MX370535B (es) 2013-11-18 2014-11-18 Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer.
MX2019015068A MX2019015068A (es) 2013-11-18 2016-05-17 Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo ( bet ) y el uso de los mismos en el tratamiento de cancer.

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MX2016006438A MX370535B (es) 2013-11-18 2014-11-18 Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer.

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