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MX2016004570A - Uso de inhibidores del bromodominio de cbp/ep300 para la inmunoterapia del cáncer. - Google Patents

Uso de inhibidores del bromodominio de cbp/ep300 para la inmunoterapia del cáncer.

Info

Publication number
MX2016004570A
MX2016004570A MX2016004570A MX2016004570A MX2016004570A MX 2016004570 A MX2016004570 A MX 2016004570A MX 2016004570 A MX2016004570 A MX 2016004570A MX 2016004570 A MX2016004570 A MX 2016004570A MX 2016004570 A MX2016004570 A MX 2016004570A
Authority
MX
Mexico
Prior art keywords
cbp
cancer immunotherapy
bromodomain inhibitors
bromodomain
inhibitors
Prior art date
Application number
MX2016004570A
Other languages
English (en)
Inventor
Steven Bellon
James Edmund Audia
Vickie Tsui
Andrea Cochran
Fauber Benjamin
crawford Terry
Magnuson Steven
Cote Alexandre
K Albrecht Brian
GHOSH Srimoyee
Christophe Harmange Jean-
Hatzivassiliou Georgia
JAYARAM Hariharan
Kim Jeong
M Lora Jose
Mellman Ira
Anthony Romero F
M Taylor Alexander
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2016004570A publication Critical patent/MX2016004570A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/475—Growth factors; Growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
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  • Oncology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

La presente invención se relaciona con el uso de inhibidores de bromodominio CBP/EP300 para el tratamiento del cáncer.
MX2016004570A 2013-10-11 2014-10-10 Uso de inhibidores del bromodominio de cbp/ep300 para la inmunoterapia del cáncer. MX2016004570A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361890041P 2013-10-11 2013-10-11
PCT/US2014/060147 WO2015054642A2 (en) 2013-10-11 2014-10-10 Use of cbp/ep300 bromodomain inhibitors for cancer immunotherapy

Publications (1)

Publication Number Publication Date
MX2016004570A true MX2016004570A (es) 2016-09-08

Family

ID=52813753

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016004570A MX2016004570A (es) 2013-10-11 2014-10-10 Uso de inhibidores del bromodominio de cbp/ep300 para la inmunoterapia del cáncer.

Country Status (13)

Country Link
US (1) US20160317632A1 (es)
EP (1) EP3054966A4 (es)
JP (1) JP2016534044A (es)
KR (1) KR20160060765A (es)
CN (1) CN105979958A (es)
AU (1) AU2014331697A1 (es)
BR (1) BR112016007891A2 (es)
CA (1) CA2926946A1 (es)
IL (1) IL245016A0 (es)
MX (1) MX2016004570A (es)
RU (1) RU2016118008A (es)
SG (1) SG11201602815YA (es)
WO (1) WO2015054642A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX354217B (es) 2010-05-14 2018-02-19 Dana Farber Cancer Inst Inc Composiciones y metodos para el tratamiento de leucemia.
DK2571503T3 (en) 2010-05-14 2015-04-20 Dana Farber Cancer Inst Inc COMPOSITIONS AND THEIR USE IN THE TREATMENT OF NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS
CA2929652A1 (en) 2013-11-08 2015-05-14 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors
KR20160130778A (ko) 2014-02-28 2016-11-14 텐샤 세러퓨틱스 인코포레이티드 고인슐린혈증과 관련된 질환의 치료
AU2015339511B2 (en) 2014-10-27 2020-05-14 Tensha Therapeutics, Inc. Bromodomain inhibitors
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
JP6893608B2 (ja) * 2015-05-29 2021-06-23 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． がんの処置のためのＰＤ−１アンタゴニストとＣｐＧ−Ｃ型オリゴヌクレオチドの併用
PE20181068A1 (es) * 2015-10-02 2018-07-04 Dana Farber Cancer Inst Inc Terapia de combinacion de inhibidores de bromodominios y bloqueo de puntos de control
WO2017078049A1 (ja) * 2015-11-04 2017-05-11 アステラス製薬株式会社 ジアミノヘテロ環カルボキサミド化合物を有効成分とするがん免疫治療用、及び／又は、免疫活性化用医薬組成物
MX2019001001A (es) 2016-07-25 2019-10-15 Epizyme Inc Terapia contra el cáncer relacionada con crebbp.
WO2019161157A1 (en) * 2018-02-16 2019-08-22 Constellation Pharmceuticals, Inc. P300/cbp hat inhibitors
US11274090B2 (en) * 2018-02-16 2022-03-15 Constellation Pharmaceuticals, Inc. P300/CBP HAT inhibitors
TW202028222A (zh) * 2018-11-14 2020-08-01 美商Ionis製藥公司 Foxp3表現之調節劑
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
WO2020257278A2 (en) * 2019-06-18 2020-12-24 Dana-Farber Cancer Institute, Inc. Small molecule target bromo/acetyl proteins and uses thereof
CN110170052B (zh) * 2019-06-21 2020-07-10 复旦大学 Cbp-p300抑制剂在肠道损伤疾病中的应用
CN114761013A (zh) 2019-09-27 2022-07-15 迪斯克医药公司 治疗骨髓纤维化和相关病症的方法
CA3153456A1 (en) 2019-10-02 2021-04-08 Stefanie Fluckiger-Mangual Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer
CN110938630B (zh) * 2019-12-20 2023-07-28 中国人民解放军第四军医大学 人b3gnt5基因的用途及相关产品
JP2023528223A (ja) 2020-05-13 2023-07-04 ディスク・メディシン・インコーポレイテッド 骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体
WO2021260109A1 (en) * 2020-06-25 2021-12-30 Tolremo Therapeutics Ag A COMBINATION OF A CBP/p300 BROMODOMAIN INHIBITOR AND AN EGFR INHIBITOR FOR USE IN TREATING EGFR-MUTANT NSCLC
CA3184076A1 (en) 2020-06-25 2021-12-30 Stefanie Fluckiger-Mangual Combination of a cbp/p300 bromodomain inhibitor and a kras inhibitor for the treatment of cancer
WO2022184664A1 (en) 2021-03-02 2022-09-09 Boehringer Ingelheim International Gmbh Anticancer combination therapy

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US20120028912A1 (en) * 2000-02-22 2012-02-02 J.David Gladstone Institute Methods of modulating bromodomains
IN2014MN02330A (es) * 2007-06-21 2015-08-14 Wistar Inst
KR101600634B1 (ko) * 2007-12-28 2016-03-07 미쓰비시 타나베 파마 코퍼레이션 항암제
GB201020015D0 (en) * 2010-11-25 2011-01-12 Glaxo Group Ltd Method of treatment
WO2012116170A1 (en) * 2011-02-23 2012-08-30 Ming-Ming Zhou Inhibitors of bromodomains as modulators of gene expression
WO2013033420A1 (en) * 2011-08-30 2013-03-07 Whitehead Institute For Biomedical Research Methods of downregulating translocated oncogene expression using bromodomain inhibitors
US9763956B2 (en) * 2012-06-19 2017-09-19 The Broad Institute, Inc. Diagnostic and treatment methods in subjects having or at risk of developing resistance to cancer therapy
WO2016044694A1 (en) * 2014-09-19 2016-03-24 Genentech, Inc. Use of cbp/ep300 and bet inhibitors for treatment of cancer

Also Published As

Publication number Publication date
WO2015054642A2 (en) 2015-04-16
EP3054966A2 (en) 2016-08-17
US20160317632A1 (en) 2016-11-03
RU2016118008A3 (es) 2018-07-25
WO2015054642A3 (en) 2015-06-04
AU2014331697A9 (en) 2016-05-26
RU2016118008A (ru) 2017-11-16
KR20160060765A (ko) 2016-05-30
AU2014331697A1 (en) 2016-05-05
CA2926946A1 (en) 2015-04-16
SG11201602815YA (en) 2016-05-30
JP2016534044A (ja) 2016-11-04
CN105979958A (zh) 2016-09-28
WO2015054642A9 (en) 2016-04-28
BR112016007891A2 (pt) 2017-12-05
IL245016A0 (en) 2016-05-31
EP3054966A4 (en) 2017-04-19

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