MX2019008949A - Agente terapeutico para cardiomiopatia, infarto al miocardio antiguo e insuficiencia cardiaca cronica. - Google Patents
Agente terapeutico para cardiomiopatia, infarto al miocardio antiguo e insuficiencia cardiaca cronica.Info
- Publication number
- MX2019008949A MX2019008949A MX2019008949A MX2019008949A MX2019008949A MX 2019008949 A MX2019008949 A MX 2019008949A MX 2019008949 A MX2019008949 A MX 2019008949A MX 2019008949 A MX2019008949 A MX 2019008949A MX 2019008949 A MX2019008949 A MX 2019008949A
- Authority
- MX
- Mexico
- Prior art keywords
- prevent
- cardiomyopathy
- myocardial infarction
- fragment peptide
- heart failure
- Prior art date
Links
- 208000010125 myocardial infarction Diseases 0.000 title abstract 3
- 206010007558 Cardiac failure chronic Diseases 0.000 title abstract 2
- 208000031229 Cardiomyopathies Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 abstract 4
- 102000055207 HMGB1 Human genes 0.000 abstract 4
- 108700010013 HMGB1 Proteins 0.000 abstract 4
- 101150021904 HMGB1 gene Proteins 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010020880 Hypertrophy Diseases 0.000 abstract 3
- 206010028594 Myocardial fibrosis Diseases 0.000 abstract 3
- 238000010171 animal model Methods 0.000 abstract 3
- 210000004413 cardiac myocyte Anatomy 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 230000033115 angiogenesis Effects 0.000 abstract 2
- 206010056370 Congestive cardiomyopathy Diseases 0.000 abstract 1
- 201000010046 Dilated cardiomyopathy Diseases 0.000 abstract 1
- 206010058222 Hypertensive cardiomyopathy Diseases 0.000 abstract 1
- 206010048858 Ischaemic cardiomyopathy Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Los presentes inventores han encontrado que los péptidos de fragmento HMGB1 que tienen una secuencia de aminoácidos particular muestra los efectos de mejora de la función cardíaca, inhibición de la hipertrofia de cardiomiocitos, inhibición de fibrosis miocárdica, y promoción de angiogénesis en un modelo animal de cardiomiopatía dilatada, los péptidos de fragmento HMGB1 particulares también muestran los efectos de mejora de la función cardíaca, inhibición de cardiomegalia, inhibición de hipertrofia de cardiomiocitos, inhibición de fibrosis miocárdica, y promoción de angiogénesis en un modelo animal de cardiomiopatía isquémica provocada por infarto al miocardio antiguo, y que los péptidos de fragmento HMGB1 particular muestran los efectos de inhibición de hipertrofia de cardiomiocitos e inhibición de fibrosis miocárdica en un modelo animal de cardiomiopatía hipertensiva. Basadas en estos descubrimientos, las composiciones farmacéuticas se proporcionan para la prevención y/o tratamiento de cardiomiopatía e infarto al miocardio antiguo e insuficiencia cardíaca crónica que resulta de los mismos, que comprende un péptido de fragmento HMGB1 que tiene una secuencia de aminoácidos particular.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017013293 | 2017-01-27 | ||
| JP2017151788 | 2017-08-04 | ||
| PCT/JP2018/002373 WO2018139562A1 (ja) | 2017-01-27 | 2018-01-26 | 心筋症、陳旧性心筋梗塞および慢性心不全の治療薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019008949A true MX2019008949A (es) | 2019-10-07 |
Family
ID=62979422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019008949A MX2019008949A (es) | 2017-01-27 | 2018-01-26 | Agente terapeutico para cardiomiopatia, infarto al miocardio antiguo e insuficiencia cardiaca cronica. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11969459B2 (es) |
| EP (1) | EP3556378B1 (es) |
| JP (1) | JP7182162B2 (es) |
| KR (1) | KR102559262B1 (es) |
| CN (1) | CN110494154B (es) |
| AU (1) | AU2018213671B2 (es) |
| BR (1) | BR112019014921A2 (es) |
| CA (1) | CA3051825A1 (es) |
| ES (1) | ES3018357T3 (es) |
| MX (1) | MX2019008949A (es) |
| PL (1) | PL3556378T3 (es) |
| TW (1) | TWI805565B (es) |
| WO (1) | WO2018139562A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009133943A1 (ja) | 2008-04-30 | 2009-11-05 | 株式会社ジェノミックス | 生体内機能的細胞の高効率採取法 |
| CN102711777B (zh) | 2009-10-28 | 2015-04-15 | 吉诺米克斯股份有限公司 | 利用骨髓间充质干细胞和/或多能干细胞的血中动员的组织再生促进剂 |
| BR112019014921A2 (pt) | 2017-01-27 | 2020-03-31 | StemRIM Inc. | Agente terapêutico para miocardiopatia, infarto antigo do miocárdio e insuficiência cardíaca crônica |
| CN110621331A (zh) * | 2017-04-07 | 2019-12-27 | 斯特姆里姆有限公司 | 纤维化疾病的治疗药物 |
| US11298403B2 (en) | 2017-12-01 | 2022-04-12 | StemRIM Inc. | Therapeutic agent for inflammatory bowel disease |
| EP3719117A4 (en) | 2017-12-01 | 2021-11-03 | Stemrim Inc. | EECTODERMAL MESENCHYMAL STEM CELLS AND METHOD FOR PRODUCING THEM |
| US20210024594A1 (en) | 2018-02-08 | 2021-01-28 | StemRIM Inc. | Therapeutic Agent for Psoriasis |
| WO2020071520A1 (ja) * | 2018-10-05 | 2020-04-09 | 株式会社ステムリム | 間葉系幹細胞の動員活性を有するペプチド |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| CN113423466B (zh) | 2018-10-25 | 2025-04-25 | 国立大学法人大阪大学 | 软骨病症的治疗剂 |
| JP7495075B2 (ja) * | 2019-12-25 | 2024-06-04 | ロート製薬株式会社 | 高血圧性心疾患治療剤 |
| CN113444692A (zh) * | 2021-06-29 | 2021-09-28 | 上海交通大学医学院附属第九人民医院 | 一种重组心肌细胞及其用途 |
| CN120329388B (zh) * | 2025-04-30 | 2025-09-26 | 中日友好医院(中日友好临床医学研究所) | 一种双靶点多肽及其在心衰治疗中的应用 |
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| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
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| US20220265787A1 (en) | 2019-07-31 | 2022-08-25 | StemRIM Inc. | Composition for promoting growth or suppressing decrease of mesenchymal stem cells |
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2018
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- 2018-01-26 US US16/477,878 patent/US11969459B2/en active Active
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- 2018-01-26 PL PL18745136.4T patent/PL3556378T3/pl unknown
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Also Published As
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| BR112019014921A2 (pt) | 2020-03-31 |
| CA3051825A1 (en) | 2018-08-02 |
| US20190343924A1 (en) | 2019-11-14 |
| TWI805565B (zh) | 2023-06-21 |
| ES3018357T3 (es) | 2025-05-16 |
| TW201832776A (zh) | 2018-09-16 |
| EP3556378C0 (en) | 2025-03-12 |
| WO2018139562A1 (ja) | 2018-08-02 |
| PL3556378T3 (pl) | 2025-06-09 |
| EP3556378A1 (en) | 2019-10-23 |
| CN110494154B (zh) | 2023-09-29 |
| KR102559262B1 (ko) | 2023-07-25 |
| KR20190122212A (ko) | 2019-10-29 |
| RU2019126796A (ru) | 2021-03-01 |
| CN110494154A (zh) | 2019-11-22 |
| EP3556378B1 (en) | 2025-03-12 |
| JPWO2018139562A1 (ja) | 2019-11-14 |
| AU2018213671A1 (en) | 2019-08-08 |
| US11969459B2 (en) | 2024-04-30 |
| AU2018213671B2 (en) | 2024-06-06 |
| JP7182162B2 (ja) | 2022-12-02 |
| EP3556378A4 (en) | 2020-11-18 |
| RU2019126796A3 (es) | 2021-05-26 |
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