MX2019007798A - Metodo para preparar acido 1,4,7,10-tetraazaciclododecano-1,4,7,10 -tetraacetico. - Google Patents
Metodo para preparar acido 1,4,7,10-tetraazaciclododecano-1,4,7,10 -tetraacetico.Info
- Publication number
- MX2019007798A MX2019007798A MX2019007798A MX2019007798A MX2019007798A MX 2019007798 A MX2019007798 A MX 2019007798A MX 2019007798 A MX2019007798 A MX 2019007798A MX 2019007798 A MX2019007798 A MX 2019007798A MX 2019007798 A MX2019007798 A MX 2019007798A
- Authority
- MX
- Mexico
- Prior art keywords
- dota
- preparing
- tetraazacyclododecane
- tetr
- formula
- Prior art date
Links
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- RRBYUSWBLVXTQN-UHFFFAOYSA-N tricyclene Chemical compound C12CC3CC2C1(C)C3(C)C RRBYUSWBLVXTQN-UHFFFAOYSA-N 0.000 abstract 1
- RRBYUSWBLVXTQN-VZCHMASFSA-N tricyclene Natural products C([C@@H]12)C3C[C@H]1C2(C)C3(C)C RRBYUSWBLVXTQN-VZCHMASFSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se divulga un método para preparar ácido 1,4,7,10-tetraazaciclodod ecano-1,4,7,10-tetraacético (DOTA) de fórmula (II), que comprende los siguientes pasos: llevar a cabo una reacción de alquilación en un cicleno de fórmula (I) y XCH2COOR en presencia de un agente de unión de ácidos en agua; ajustar un valor de pH para separar un producto crudo de DOTA y recristalizar. El método de preparación de la presente invención se puede aplicar a la producción industrial a gran escala de DOTA, el proceso total no requiere aplicar ninguna resina de intercambio iónico o modo de refrigeración a baja temperatura para la purificación, y la pureza y el rendimiento del producto son superiores. (ver fórmulas I y II).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611262335.6A CN108264491B (zh) | 2016-12-30 | 2016-12-30 | 1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的制备方法 |
| PCT/CN2017/102056 WO2018120923A1 (zh) | 2016-12-30 | 2017-09-18 | 1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019007798A true MX2019007798A (es) | 2019-08-29 |
| MX382285B MX382285B (es) | 2025-03-13 |
Family
ID=62710288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019007798A MX382285B (es) | 2016-12-30 | 2017-09-18 | Método para preparar ácido 1,4,7,10-tetraazaciclododecano-1,4,7,10-tetraacético. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11214553B2 (es) |
| EP (1) | EP3564218B1 (es) |
| JP (1) | JP2020504175A (es) |
| KR (1) | KR102265637B1 (es) |
| CN (2) | CN108264491B (es) |
| CA (1) | CA3048549C (es) |
| ES (1) | ES2865297T3 (es) |
| MX (1) | MX382285B (es) |
| WO (1) | WO2018120923A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108658882A (zh) * | 2017-03-28 | 2018-10-16 | 江苏恒瑞医药股份有限公司 | 一种1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的制备方法 |
| CN113087680A (zh) * | 2020-01-08 | 2021-07-09 | 威智医药有限公司 | Dota晶型及其制备方法 |
| KR20230022871A (ko) * | 2020-06-10 | 2023-02-16 | 후스테사 이마헨 에스.에이.유. | 고순도 테트라크세탄(dota)으로부터 가도테레이트 메글루민을 수득하기 위한 절차 및 주사제 생약 제형의 제조에서의 이의 용도 |
| CN113429362A (zh) * | 2021-06-01 | 2021-09-24 | 南昌大学 | 环胺高氯酸可逆相变材料及其制备方法 |
| CN113956262B (zh) * | 2021-10-18 | 2023-03-07 | 苏州百灵威超精细材料有限公司 | 一种四氮杂环烷类化合物及其中间体的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1293777B1 (it) | 1997-07-25 | 1999-03-10 | Bracco Spa | Processo per la preparazione di tetraazamacrocicli |
| CN103547290A (zh) * | 2011-04-20 | 2014-01-29 | Rf医疗公司 | 靶向造影剂及其用途 |
| CA2857014C (en) * | 2011-11-25 | 2018-08-14 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the purification of polyaminocarboxylates |
| CN102659702B (zh) * | 2012-04-09 | 2014-12-03 | 武汉工程大学 | 一种1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的纯化方法 |
| US9458117B2 (en) | 2013-01-28 | 2016-10-04 | Agfa Healthcare Nv | Process for producing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid and complexes thereof |
| CN104447598B (zh) * | 2013-09-18 | 2017-09-22 | 浙江大德药业集团有限公司 | Ca‑4的大环多胺衍生物及其抗肿瘤特性 |
| CN105939994B (zh) * | 2014-02-06 | 2018-05-29 | T2医药有限责任公司 | 纯化1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的方法 |
-
2016
- 2016-12-30 CN CN201611262335.6A patent/CN108264491B/zh active Active
-
2017
- 2017-09-18 MX MX2019007798A patent/MX382285B/es unknown
- 2017-09-18 US US16/473,242 patent/US11214553B2/en active Active
- 2017-09-18 JP JP2019556400A patent/JP2020504175A/ja active Pending
- 2017-09-18 CN CN201780080570.8A patent/CN110198931B/zh active Active
- 2017-09-18 WO PCT/CN2017/102056 patent/WO2018120923A1/zh not_active Ceased
- 2017-09-18 EP EP17889406.9A patent/EP3564218B1/en active Active
- 2017-09-18 KR KR1020197021751A patent/KR102265637B1/ko active Active
- 2017-09-18 ES ES17889406T patent/ES2865297T3/es active Active
- 2017-09-18 CA CA3048549A patent/CA3048549C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11214553B2 (en) | 2022-01-04 |
| CN110198931B (zh) | 2022-08-02 |
| EP3564218A4 (en) | 2019-12-18 |
| ES2865297T3 (es) | 2021-10-15 |
| EP3564218A1 (en) | 2019-11-06 |
| JP2020504175A (ja) | 2020-02-06 |
| US20200347023A1 (en) | 2020-11-05 |
| CN108264491A (zh) | 2018-07-10 |
| EP3564218B1 (en) | 2021-02-24 |
| KR20190098236A (ko) | 2019-08-21 |
| CA3048549A1 (en) | 2018-07-05 |
| MX382285B (es) | 2025-03-13 |
| CA3048549C (en) | 2023-11-21 |
| CN108264491B (zh) | 2022-09-16 |
| WO2018120923A1 (zh) | 2018-07-05 |
| KR102265637B1 (ko) | 2021-06-15 |
| CN110198931A (zh) | 2019-09-03 |
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