[go: up one dir, main page]

MX2018013409A - Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido. - Google Patents

Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido.

Info

Publication number
MX2018013409A
MX2018013409A MX2018013409A MX2018013409A MX2018013409A MX 2018013409 A MX2018013409 A MX 2018013409A MX 2018013409 A MX2018013409 A MX 2018013409A MX 2018013409 A MX2018013409 A MX 2018013409A MX 2018013409 A MX2018013409 A MX 2018013409A
Authority
MX
Mexico
Prior art keywords
methods
devices
preparation
contrast agents
ultrasound contrast
Prior art date
Application number
MX2018013409A
Other languages
English (en)
Inventor
Lazewatsky Joel
Tuyet NGUYEN Nhung
C Onthank David
P Robinson Simon
Walker Carol
Original Assignee
Lantheus Medical Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lantheus Medical Imaging Inc filed Critical Lantheus Medical Imaging Inc
Publication of MX2018013409A publication Critical patent/MX2018013409A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/201—Holders therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2207—Use of data, i.e. barcodes, 3D codes or similar type of tagging information, as instruction or identification codes for controlling the computer programs, e.g. for manipulation, handling, production or compounding in mixing plants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/2201—Control or regulation characterised by the type of control technique used
    • B01F35/2209—Controlling the mixing process as a whole, i.e. involving a complete monitoring and controlling of the mixing process during the whole mixing cycle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B01J19/0066—Stirrers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13—Tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Acoustics & Sound (AREA)
  • Pathology (AREA)
  • Software Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Accessories For Mixers (AREA)

Abstract

En la presente se proporcionan métodos y dispositivos para identificar y/o distinguir formulaciones de UCA y específicamente activar esas formulaciones para producir un UCA adecuado para uso in vivo.
MX2018013409A 2016-05-04 2017-05-04 Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido. MX2018013409A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662331968P 2016-05-04 2016-05-04
US201662332462P 2016-05-05 2016-05-05
PCT/US2017/031150 WO2017192910A2 (en) 2016-05-04 2017-05-04 Methods and devices for preparation of ultrasound contrast agents

Publications (1)

Publication Number Publication Date
MX2018013409A true MX2018013409A (es) 2019-07-08

Family

ID=60203645

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018013409A MX2018013409A (es) 2016-05-04 2017-05-04 Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido.
MX2025002465A MX2025002465A (es) 2016-05-04 2018-11-01 Metodos y dispositivos para la preparacion de agentes de contraste de ultrasonido

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2025002465A MX2025002465A (es) 2016-05-04 2018-11-01 Metodos y dispositivos para la preparacion de agentes de contraste de ultrasonido

Country Status (13)

Country Link
US (4) US20170319718A1 (es)
EP (1) EP3452108A4 (es)
JP (2) JP2019515936A (es)
KR (3) KR102876914B1 (es)
CN (2) CN115531560B (es)
AU (2) AU2017260532B2 (es)
BR (1) BR112018072342A2 (es)
CA (1) CA3022698A1 (es)
IL (2) IL262647B2 (es)
MX (2) MX2018013409A (es)
TW (2) TWI832081B (es)
WO (1) WO2017192910A2 (es)
ZA (1) ZA201807591B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ733010A (en) 2014-12-31 2023-01-27 Lantheus Medical Imaging Inc Lipid-encapsulated gas microsphere compositions and related methods
BR112018072342A2 (pt) * 2016-05-04 2019-02-19 Lantheus Medical Imaging, Inc. métodos e dispositivos para preparação de agentes de contraste de ultrassom
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
IT201800006169A1 (it) * 2018-06-08 2019-12-08 Apparato e procedimento per il campionamento dello spazio di testa dotato di uno o più sensori
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
TW202222351A (zh) * 2020-08-04 2022-06-16 美商藍瑟斯醫學影像公司 用於製備超音波顯影劑之方法及裝置
JP7695052B2 (ja) 2022-12-01 2025-06-18 エルジー エナジー ソリューション リミテッド ゼリーロール型電極組立体およびこれを含む二次電池
WO2025038414A1 (en) * 2023-08-16 2025-02-20 Lantheus Medical Imaging, Inc. Therapeutic methods of use of gas bubble compositions

Family Cites Families (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1490214A (en) 1923-03-05 1924-04-15 Alvin L Johnson Dental amalgam mixer
US2201428A (en) 1939-03-16 1940-05-21 Hugo J Chott Dental amalgamator
US2286600A (en) 1939-08-19 1942-06-16 Edward L Chott Dental amalgamator
US2334315A (en) 1942-06-03 1943-11-16 Edward L Chott Dental amalgamator
US3873564A (en) 1971-03-03 1975-03-25 Synvar Ass 2-Imidazolinyl-3-oxide-1-oxypropionic acid
CH588887A5 (es) 1974-07-19 1977-06-15 Battelle Memorial Institute
CH621479A5 (es) 1977-08-05 1981-02-13 Battelle Memorial Institute
CH624011A5 (es) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
AU545866B2 (en) 1980-11-17 1985-08-01 Schering Aktiengesellschaft Microbubble precursors and methods for their production and use
DE3141641A1 (de) 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4718433A (en) 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
SE463651B (sv) 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
DE3585967D1 (de) 1984-03-08 1992-06-11 Phares Pharma Holland Liposombildende zusammensetzung.
ES2054658T3 (es) 1986-01-24 1994-08-16 Childrens Hosp Medical Center Metodo para la preparacion de una emulsion fisiologicamente aceptable.
JPS6360943A (ja) 1986-09-01 1988-03-17 Green Cross Corp:The 超音波診断造影剤
FR2634375B3 (fr) 1988-06-30 1991-07-05 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles de lipide amphiphiles sous forme de liposomes submicroniques
FR2608942B1 (fr) 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5219538A (en) 1987-03-13 1993-06-15 Micro-Pak, Inc. Gas and oxygen carrying lipid vesicles
JPS63277618A (ja) 1987-03-31 1988-11-15 Noebia:Kk リポソ−ムの製造方法
CH672733A5 (es) 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
DE3803972A1 (de) 1988-02-05 1989-08-10 Schering Ag Ultraschallkontrastmittel
DE3812816A1 (de) 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung
US5171755A (en) 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US5045304A (en) 1988-08-31 1991-09-03 Wayne State University Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same
GB8824593D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Liposomes
US5114703A (en) 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
FR2649335B1 (fr) 1989-07-05 1991-09-20 Texinfine Sa Procede et dispositif de production directe de liposomes
US5843473A (en) 1989-10-20 1998-12-01 Sequus Pharmaceuticals, Inc. Method of treatment of infected tissues
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5705187A (en) 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5230882A (en) 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5088499A (en) 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5334381A (en) 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5209720A (en) 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5149319A (en) 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5352435A (en) 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5123414A (en) 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
IN172208B (es) 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5358702A (en) 1990-04-10 1994-10-25 Unger Evan C Methoxylated gel particle contrast media for improved diagnostic imaging
EP0693288B1 (en) 1990-04-10 1999-10-13 Imarx Pharmaceutical Corp. Polymers as contrast media for magnetic resonance
US5368840A (en) 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
IS1685B (is) 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US5184893A (en) 1991-03-25 1993-02-09 Kerr Manufacturing Company Automatic capsule mixing device
CA2062580A1 (en) 1991-03-25 1992-09-26 Charles E. Steele Mixing arm assembly for automatic capsule mixing device
GB9106673D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
EP0660714B1 (en) 1991-06-18 2003-07-02 ImaRx Pharmaceutical Corp. Novel liposomal drug delivery systems
JP3231768B2 (ja) 1991-09-17 2001-11-26 ソーナス ファーマシューティカルス，インコーポレイテッド 気体状超音波造影剤及び超音波造影剤として使用する気体の選定方法
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US5409688A (en) 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
WO1993006869A1 (en) 1991-10-04 1993-04-15 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
GB9200387D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
CN1068230C (zh) 1993-01-25 2001-07-11 索纳斯药品有限公司 用作超声造影剂的相转变胶体
US5558855A (en) 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
GB9305349D0 (en) 1993-03-16 1993-05-05 Nycomed Imaging As Improvements in or relating to contrast agents
GB9305351D0 (en) 1993-03-16 1993-05-05 Nycomed Imaging As Improvements in or relating to contrast agents
DE4313402A1 (de) 1993-04-23 1994-10-27 Hexal Pharma Gmbh Transdermale Wirkstoffzubereitung
US5853755A (en) 1993-07-28 1998-12-29 Pharmaderm Laboratories Ltd. Biphasic multilamellar lipid vesicles
DE69434119T3 (de) 1993-07-30 2011-05-05 Imcor Pharmaceutical Co., San Diego Stabilisierte mikrogasbläschen-zusammensetzungen für echographie
GB9318288D0 (en) 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
HUT74509A (en) 1993-09-09 1997-01-28 Schering Ag Active principles and gas containing microparticles, their use for realising active principles in ultrasonically controlled manner, and process for preparing them
ATE164515T1 (de) 1993-11-05 1998-04-15 Amgen Inc Herstellung von liposomen und verfahren zur substanzverkapselung
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
EP0682530B1 (en) 1993-12-15 2003-03-19 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media
NO940711D0 (no) 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5776488A (en) 1994-03-11 1998-07-07 Yoshitomi Pharmaceutical Industries, Ltd. Liposome preparation
AU2076895A (en) 1994-03-28 1995-10-17 Daiichi Pharmaceutical Co., Ltd. Liposomes
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US6066331A (en) 1994-07-08 2000-05-23 Barenholz; Yechezkel Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
US5562893A (en) 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
JPH08151335A (ja) 1994-09-27 1996-06-11 Otsuka Pharmaceut Co Ltd 超音波造影剤およびその製造方法
US5540909A (en) 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US5558092A (en) 1995-06-06 1996-09-24 Imarx Pharmaceutical Corp. Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
US5897851A (en) 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
CN1083280C (zh) 1995-06-07 2002-04-24 ImaRx药物公司 用于诊断和治疗的新的靶向组合物
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6120794A (en) 1995-09-26 2000-09-19 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells
DE69736981D1 (de) 1996-05-01 2007-01-04 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
US6214375B1 (en) 1996-07-16 2001-04-10 Generex Pharmaceuticals, Inc. Phospholipid formulations
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DK1323434T3 (da) 1996-09-11 2007-11-12 Bristol Myers Squibb Medical I Fremgangsmåde til diagnostisk billeddannelse af nyreregioner under anvendelse af et kontrastmiddel og en vasodilator
WO1998017324A2 (en) 1996-10-21 1998-04-30 Marsden, John, Christopher Improvements in or relating to contrast agents
JP2001511765A (ja) 1996-10-28 2001-08-14 ニユコメド・イメージング・アクシエセルカペト 改良された診断／治療用薬剤
WO1998018495A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
ES2264159T3 (es) 1996-10-28 2006-12-16 Amersham Health As Mejoras en/o relacionadas con agentes de diagnostico/terapeuticos.
WO1998018498A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
ES2244169T3 (es) 1998-02-09 2005-12-01 Bracco International B.V. Suministro direccionado de medios biologicamente activos.
US6572840B1 (en) 1999-07-28 2003-06-03 Bristol-Myers Squibb Pharma Company Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent
CA2437217C (en) 2001-02-02 2015-06-16 Bristol-Myers Squibb Pharma Company Apparatus and methods for on-line monitoring of fluorinated material in headspace of vial
US20030044354A1 (en) 2001-08-16 2003-03-06 Carpenter Alan P. Gas microsphere liposome composites for ultrasound imaging and ultrasound stimulated drug release
US20040062748A1 (en) 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
JP5513708B2 (ja) * 2003-12-22 2014-06-04 ブラッコ・シュイス・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
CN102600485B (zh) 2004-06-04 2014-10-22 阿库斯菲尔公司 超声对比剂剂量配方
EP1793919A4 (en) 2004-09-03 2009-12-23 Imarx Therapeutics Inc DEVICE AND METHOD FOR PRODUCING A MICROSPHERIC COMPOSITE COMPOSITION
CN101219087A (zh) 2005-04-06 2008-07-16 马林克罗特公司 管理有关医用液体及其容器的信息的系统与方法
EP1736113B1 (en) 2005-06-03 2009-08-05 3M Innovative Properties Company Dental material processing system and communication method
EP1834603A1 (en) 2006-03-10 2007-09-19 3M Innovative Properties Company Dispenser and method for dispensing dental material
US20080159066A1 (en) 2006-12-28 2008-07-03 Shu-Lung Wang Shock absorbing buffer structure for an amalgam mixer
CN101229382A (zh) 2008-02-04 2008-07-30 许川山 一种适用于多种成像模式的新型造影剂
US8459462B2 (en) * 2008-10-10 2013-06-11 Quest Diagnostics Investments Incorporated System and method for sorting specimen
US8784752B2 (en) * 2009-04-17 2014-07-22 Curiox Biosystems Pte Ltd Use of chemically patterned substrate for liquid handling, chemical and biological reactions
JP2012213475A (ja) * 2011-03-31 2012-11-08 Panasonic Corp 超音波造影剤注入装置
US9101895B2 (en) * 2011-04-15 2015-08-11 General Electric Company System for mixing and dispersing microbubble pharmaceuticals
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same
KR102076069B1 (ko) * 2011-08-24 2020-02-11 캘리포니아 인스티튜트 오브 테크놀로지 타기팅 미세버블
JP2015002752A (ja) * 2011-12-09 2015-01-08 パナソニック株式会社 薬剤容器
CN104661737B (zh) * 2012-07-18 2019-05-28 莱伯曼兹有限公司 自动化溶液分配器
JP6318177B2 (ja) * 2013-02-11 2018-04-25 アンドリュー イー． ブロック 非対称振動をもたらすための装置
EP2968825A4 (en) * 2013-03-15 2016-09-07 Childrens Medical Center Gas-filled stabilized particles and methods of use
EP3570040B1 (en) * 2013-04-05 2024-02-14 F. Hoffmann-La Roche AG Analysis method for a biological sample
TWI552761B (zh) 2013-05-03 2016-10-11 博信生物科技股份有限公司 一種脂質微／奈米氣泡、及其最佳化之製備方法及製備裝置
TWI504413B (zh) 2013-07-24 2015-10-21 Univ Nat Chiao Tung 奈米級複合高分子顯影劑及藥物載體
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
US9801959B2 (en) 2014-06-12 2017-10-31 Microvascuar Therapeutics Llc Phospholipid composition and microbubbles and emulsions formed using same
CN106999611A (zh) 2014-10-30 2017-08-01 蓝瑟斯医学影像公司 脂质封装的气体微球组合物和相关方法
NZ733010A (en) 2014-12-31 2023-01-27 Lantheus Medical Imaging Inc Lipid-encapsulated gas microsphere compositions and related methods
BR112018072342A2 (pt) 2016-05-04 2019-02-19 Lantheus Medical Imaging, Inc. métodos e dispositivos para preparação de agentes de contraste de ultrassom
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
TW202222351A (zh) 2020-08-04 2022-06-16 美商藍瑟斯醫學影像公司 用於製備超音波顯影劑之方法及裝置

Also Published As

Publication number Publication date
US20200000943A1 (en) 2020-01-02
CN109641068A (zh) 2019-04-16
US10588988B2 (en) 2020-03-17
MX2025002465A (es) 2025-04-02
JP7565978B2 (ja) 2024-10-11
EP3452108A2 (en) 2019-03-13
BR112018072342A2 (pt) 2019-02-19
AU2017260532A1 (en) 2018-11-22
KR20220165808A (ko) 2022-12-15
WO2017192910A2 (en) 2017-11-09
IL296876B2 (en) 2025-05-01
CN115531560B (zh) 2024-05-17
IL296876A (en) 2022-12-01
US20200171177A1 (en) 2020-06-04
WO2017192910A3 (en) 2017-12-28
EP3452108A4 (en) 2019-12-25
TWI832081B (zh) 2024-02-11
US12097270B2 (en) 2024-09-24
CN115531560A (zh) 2022-12-30
US20170319718A1 (en) 2017-11-09
US20250121101A1 (en) 2025-04-17
KR102876914B1 (ko) 2025-10-28
AU2017260532B2 (en) 2024-08-22
KR20240121345A (ko) 2024-08-08
IL296876B1 (en) 2025-01-01
IL262647B2 (en) 2023-03-01
AU2024266778A1 (en) 2024-12-12
TW201800082A (zh) 2018-01-01
IL262647B (en) 2022-11-01
NZ747992A (en) 2024-11-29
ZA201807591B (en) 2025-04-30
JP2022163011A (ja) 2022-10-25
IL262647A (en) 2018-12-31
CN109641068B (zh) 2022-09-30
TW202222260A (zh) 2022-06-16
KR20180133527A (ko) 2018-12-14
TWI740937B (zh) 2021-10-01
JP2019515936A (ja) 2019-06-13
CA3022698A1 (en) 2017-11-09

Similar Documents

Publication Publication Date Title
MX2018013409A (es) Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido.
MX2016014247A (es) Conjugados de anticuerpo-farmaco anti-proteina tirosina quinasa 7 (anti-ptk7).
MX385845B (es) Usos y composiciones de la flagelina
MX2015003140A (es) Formulaciones de enzalutamida.
MX2015011445A (es) Compuestos y usos de estos para la modulacion de la hemoglobina.
BR112018005892A2 (pt) composições para higiene bucal e métodos de uso.
BR112016026378A2 (pt) formulações e métodos para tratamento com queratina
AU363796S (en) Nail care instruments
WO2018075692A3 (en) Antibody constructs
UY34395A (es) ?Tratamiento de Esclerosis Múltiple con la Combinación de Laquinimod y Fingolimod?.
BR112018005753A2 (pt) composições para higiene bucal e métodos de uso.
PL3381451T3 (pl) Kompozycja farmaceutyczna stosowana do redukcji zlokalizowanej tkanki tłuszczowej i zastosowanie kompozycji farmaceutycznej
PT3481846T (pt) 24-hidroxiesteroides 11-substituídos para utilização no tratamento de afeções relacionadas com nmda
EP3352771A4 (en) NAIL CHAIN COMPOSITIONS AND METHODS OF USE
AU363827S (en) Nail care instruments
EP3377069A4 (en) PHEROMONE COMPOSITION FOR STIMULATING REPRODUCTION OF FEMALE SUIDS AND METHOD FOR USE THEREOF
MX386055B (es) Uso de medicamentos para disminuir la evolución de la enfermedad de parkinson.
CO2020006907A2 (es) Péptidos antimicrobianos y métodos para usarlos
MX379359B (es) Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
MX391757B (es) Formulaciones de ácido 1-amino-1-ciclopropanocarboxílico.
MX392976B (es) Composiciones que comprenden cepas bacterianas.
EP3393459A4 (en) COMPOSITIONS OF A FLUORO CARBON NANOEMULSION, PROCESS FOR THE PREPARATION AND USE THEREOF
MX374378B (es) Mioinositol y probioticos, y uso de estos.
UY33662A (es) Combinaciones que comprenden inhibidores de dhodh e inhibidores de cox
MX2018012223A (es) Formulaciones liquidas de fosfaplatino.