MX2018013471A - Nuevos compuestos de tipo tetrahidropirimidodiazepina y dihidropiridodiazepina para tratar el dolor y afecciones relacionadas con el dolor. - Google Patents
Nuevos compuestos de tipo tetrahidropirimidodiazepina y dihidropiridodiazepina para tratar el dolor y afecciones relacionadas con el dolor.Info
- Publication number
- MX2018013471A MX2018013471A MX2018013471A MX2018013471A MX2018013471A MX 2018013471 A MX2018013471 A MX 2018013471A MX 2018013471 A MX2018013471 A MX 2018013471A MX 2018013471 A MX2018013471 A MX 2018013471A MX 2018013471 A MX2018013471 A MX 2018013471A
- Authority
- MX
- Mexico
- Prior art keywords
- pain
- new
- tetrahydropyrimidodiazepine
- dihydropyridodiazepine
- subunit
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- PGCLRYJVSIEXNI-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1H-pyrimido[5,4-c]diazepine Chemical compound N1NCCCC2=C1C=NC=N2 PGCLRYJVSIEXNI-UHFFFAOYSA-N 0.000 title 1
- 102000038650 voltage-gated calcium channel activity Human genes 0.000 abstract 5
- 108091023044 voltage-gated calcium channel activity Proteins 0.000 abstract 5
- 102000008092 Norepinephrine Plasma Membrane Transport Proteins Human genes 0.000 abstract 2
- 108010049586 Norepinephrine Plasma Membrane Transport Proteins Proteins 0.000 abstract 2
- 108090000312 Calcium Channels Proteins 0.000 abstract 1
- 102000003922 Calcium Channels Human genes 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a compuestos nuevos de fórmula general (I) que muestran una gran afinidad y actividad respecto a la subunidad a2d de los canales de calcio dependientes de voltaje (VGCC), especialmente la subunidad a2d-1 de los canales de calcio dependientes de voltaje, o una actividad dual respecto a la subunidad a2d de los canales de calcio dependientes de voltaje (VGCC), especialmente la subunidad a2d-1 de los canales de calcio dependientes de voltaje, y el transportador de noradrenalina (NET). La invención también se refiere al proceso para la preparación de dichos compuestos, así como también a las composiciones que los comprenden y su uso como medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382199 | 2016-05-06 | ||
| PCT/EP2017/060780 WO2017191304A1 (en) | 2016-05-06 | 2017-05-05 | Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018013471A true MX2018013471A (es) | 2019-06-06 |
| MX383520B MX383520B (es) | 2025-03-14 |
Family
ID=56024209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018013471A MX383520B (es) | 2016-05-06 | 2017-05-05 | Nuevos compuestos de tipo tetrahidropirimidodiazepina y dihidropiridodiazepina para tratar el dolor y afecciones relacionadas con el dolor |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US10590140B2 (es) |
| EP (1) | EP3452475B1 (es) |
| JP (1) | JP6926197B2 (es) |
| KR (1) | KR20190024876A (es) |
| CN (1) | CN109526220B (es) |
| AR (1) | AR108387A1 (es) |
| AU (1) | AU2017260305B2 (es) |
| BR (1) | BR112018072755A2 (es) |
| CA (1) | CA3023379A1 (es) |
| CO (1) | CO2018012002A2 (es) |
| CY (1) | CY1123231T1 (es) |
| DK (1) | DK3452475T3 (es) |
| ES (1) | ES2789676T3 (es) |
| HR (1) | HRP20200668T1 (es) |
| HU (1) | HUE051829T2 (es) |
| IL (1) | IL262825A (es) |
| LT (1) | LT3452475T (es) |
| ME (1) | ME03726B (es) |
| MX (1) | MX383520B (es) |
| MY (1) | MY196791A (es) |
| PH (1) | PH12018502337A1 (es) |
| PL (1) | PL3452475T3 (es) |
| PT (1) | PT3452475T (es) |
| RS (1) | RS60528B1 (es) |
| RU (1) | RU2018141084A (es) |
| SG (1) | SG11201809799WA (es) |
| SI (1) | SI3452475T1 (es) |
| SM (1) | SMT202000365T1 (es) |
| TN (1) | TN2018000372A1 (es) |
| TW (1) | TWI736619B (es) |
| UA (1) | UA123789C2 (es) |
| WO (1) | WO2017191304A1 (es) |
| ZA (1) | ZA201807653B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020536941A (ja) * | 2017-10-16 | 2020-12-17 | エステベ ファーマシューティカルズ, ソシエダッド アノニマEsteve Pharmaceuticals, S.A. | 疼痛及び疼痛に関連する状態を治療するためのプロパンアミン誘導体 |
| MX2020003575A (es) * | 2017-10-27 | 2020-07-22 | Esteve Pharmaceuticals Sa | Nuevos derivados de alcoxiamino para tratar dolor y estados relacionados con dolor. |
| AR113910A1 (es) * | 2017-12-04 | 2020-06-24 | Esteve Pharmaceuticals Sa | Derivados de o-fenoxi y o-benciloxipropilamino con actividad contra el dolor |
| WO2019115008A1 (en) * | 2017-12-12 | 2019-06-20 | Esteve Pharmaceuticals, S.A. | Dialkylaminoarylpiperidinyl-o-phenoxy and o-benzyloxypropylamino derivatives having multimodal activity against pain |
| WO2019149919A1 (en) * | 2018-02-05 | 2019-08-08 | Esteve Pharmaceuticals, S.A. | Aminopropoxypiperidinylamido derivatives having multimodal activity against pain |
| WO2020089263A1 (en) * | 2018-10-31 | 2020-05-07 | Esteve Pharmaceuticals, S.A. | Optionally nitrogenated isoquinolin-1(2h)-ones and 1h-isochromen- 1-ones for treating pain and pain related conditions |
| AR116972A1 (es) * | 2018-11-02 | 2021-06-30 | Esteve Pharmaceuticals Sa | Derivados de alcoxiaminopiridina para tratar dolor y estados relacionados con dolor |
| US20210395254A1 (en) * | 2018-11-02 | 2021-12-23 | Esteve Pharmaceuticals, S.A. | New tetrahydropyrimidodiazepin and tetrahydropyridodiazepin compounds for treating pain and pain related conditions |
| US12384763B2 (en) | 2019-02-28 | 2025-08-12 | Osaka University | Protein and/or peptide modification molecule |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL362048A1 (en) * | 2000-09-27 | 2004-10-18 | Ajinomoto Co, Inc. | Benzodiazepine derivative |
| EP1515709A2 (en) | 2002-06-27 | 2005-03-23 | Warner-Lambert Company LLC | Use of an alpha2delta ligand such as gabapentin or pregabalin for treating attention deficit hyperactivity disorder |
| US20070197510A1 (en) * | 2004-03-10 | 2007-08-23 | Kazuyuki Ohmoto | Nitriles and medicinal compositions containing the same as the active ingredient |
| ES2351367T3 (es) * | 2006-02-14 | 2011-02-03 | Vertex Pharmaceuticals Incorporated | Dihidrodiazepinas útiles como inhibidores de proteína quinasas. |
| TW200914457A (en) * | 2007-05-31 | 2009-04-01 | Kyowa Hakko Kogyo Kk | Pyrimidodiazepinone derivative |
| UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
-
2017
- 2017-05-05 DK DK17721680.1T patent/DK3452475T3/da active
- 2017-05-05 MX MX2018013471A patent/MX383520B/es unknown
- 2017-05-05 JP JP2019510471A patent/JP6926197B2/ja not_active Expired - Fee Related
- 2017-05-05 EP EP17721680.1A patent/EP3452475B1/en active Active
- 2017-05-05 RS RS20200595A patent/RS60528B1/sr unknown
- 2017-05-05 SG SG11201809799WA patent/SG11201809799WA/en unknown
- 2017-05-05 SM SM20200365T patent/SMT202000365T1/it unknown
- 2017-05-05 ES ES17721680T patent/ES2789676T3/es active Active
- 2017-05-05 ME MEP-2020-101A patent/ME03726B/me unknown
- 2017-05-05 KR KR1020187032195A patent/KR20190024876A/ko not_active Ceased
- 2017-05-05 PT PT177216801T patent/PT3452475T/pt unknown
- 2017-05-05 BR BR112018072755-5A patent/BR112018072755A2/pt not_active IP Right Cessation
- 2017-05-05 SI SI201730239T patent/SI3452475T1/sl unknown
- 2017-05-05 RU RU2018141084A patent/RU2018141084A/ru unknown
- 2017-05-05 HU HUE17721680A patent/HUE051829T2/hu unknown
- 2017-05-05 TW TW106114980A patent/TWI736619B/zh not_active IP Right Cessation
- 2017-05-05 WO PCT/EP2017/060780 patent/WO2017191304A1/en not_active Ceased
- 2017-05-05 HR HRP20200668TT patent/HRP20200668T1/hr unknown
- 2017-05-05 PL PL17721680T patent/PL3452475T3/pl unknown
- 2017-05-05 AU AU2017260305A patent/AU2017260305B2/en not_active Ceased
- 2017-05-05 CA CA3023379A patent/CA3023379A1/en not_active Abandoned
- 2017-05-05 CN CN201780042378.XA patent/CN109526220B/zh not_active Expired - Fee Related
- 2017-05-05 UA UAA201811326A patent/UA123789C2/uk unknown
- 2017-05-05 US US16/098,244 patent/US10590140B2/en active Active
- 2017-05-05 AR ARP170101172A patent/AR108387A1/es unknown
- 2017-05-05 TN TNP/2018/000372A patent/TN2018000372A1/en unknown
- 2017-05-05 MY MYPI2018704135A patent/MY196791A/en unknown
- 2017-05-05 LT LTEP17721680.1T patent/LT3452475T/lt unknown
-
2018
- 2018-11-06 PH PH12018502337A patent/PH12018502337A1/en unknown
- 2018-11-06 IL IL262825A patent/IL262825A/en unknown
- 2018-11-14 ZA ZA2018/07653A patent/ZA201807653B/en unknown
- 2018-11-29 CO CONC2018/0012002A patent/CO2018012002A2/es unknown
-
2020
- 2020-05-25 CY CY20201100472T patent/CY1123231T1/el unknown
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