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MX2018013372A - Metodo de microdilucion en caldo para evaluar y determinar la concentracion inhibitoria minima de polipeptidos antibacterianos. - Google Patents

Metodo de microdilucion en caldo para evaluar y determinar la concentracion inhibitoria minima de polipeptidos antibacterianos.

Info

Publication number
MX2018013372A
MX2018013372A MX2018013372A MX2018013372A MX2018013372A MX 2018013372 A MX2018013372 A MX 2018013372A MX 2018013372 A MX2018013372 A MX 2018013372A MX 2018013372 A MX2018013372 A MX 2018013372A MX 2018013372 A MX2018013372 A MX 2018013372A
Authority
MX
Mexico
Prior art keywords
inhibitory concentration
evaluating
minimal inhibitory
broth microdilution
polypeptides
Prior art date
Application number
MX2018013372A
Other languages
English (en)
Other versions
MX388569B (es
Inventor
Schuch Raymond
Original Assignee
Contrafect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contrafect Corp filed Critical Contrafect Corp
Publication of MX2018013372A publication Critical patent/MX2018013372A/es
Publication of MX388569B publication Critical patent/MX388569B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención proporciona componentes, ensayos y métodos para evaluar la efectividad antibacteriana y determinar la concentración inhibitoria mínima (MIC) de polipéptidos, incluyendo polipéptidos de lisina, que matan bacterias. Se proporcionan componentes y métodos de microdilución en caldo modificados, incluyendo suplementos para permitir la determinación MIC precisa que imita la actividad del polipéptido lisina en matrices humanas que incluyen suero y sangre.
MX2018013372A 2016-05-12 2017-05-12 Metodo de microdilucion en caldo para evaluar y determinar la concentracion inhibitoria minima de polipeptidos antibacterianos. MX388569B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662335129P 2016-05-12 2016-05-12
PCT/US2017/032344 WO2017197227A1 (en) 2016-05-12 2017-05-12 Broth microdilution method for evaluating and determining minimal inhibitory concentration of antibacterial polypeptides

Publications (2)

Publication Number Publication Date
MX2018013372A true MX2018013372A (es) 2019-05-09
MX388569B MX388569B (es) 2025-03-20

Family

ID=60266856

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018013372A MX388569B (es) 2016-05-12 2017-05-12 Metodo de microdilucion en caldo para evaluar y determinar la concentracion inhibitoria minima de polipeptidos antibacterianos.

Country Status (14)

Country Link
US (1) US10851401B2 (es)
EP (1) EP3454888B1 (es)
JP (1) JP6875756B2 (es)
KR (1) KR20190004799A (es)
CN (1) CN109152822B (es)
AU (1) AU2017263563A1 (es)
BR (1) BR112018073205A2 (es)
CA (1) CA3023730A1 (es)
DK (1) DK3454888T3 (es)
IL (1) IL262844B2 (es)
MX (1) MX388569B (es)
RU (1) RU2754667C2 (es)
WO (1) WO2017197227A1 (es)
ZA (1) ZA201806685B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106659748B (zh) * 2014-06-26 2021-08-31 洛克菲勒大学 不动杆菌属溶素
CN112118861A (zh) * 2018-02-26 2020-12-22 康特拉费克特公司 修饰的PlySs2溶素及其用途
EP3820605A4 (en) * 2018-07-11 2022-02-23 Selux Diagnostics Inc. ASSAYS AND REAGENTS FOR TESTING FOR ANTIBIOTIC SENSITIVITY
AU2020244764A1 (en) * 2019-03-22 2021-10-14 Contrafect Corporation Method of treating infective endocarditis
EP3980049A4 (en) * 2019-04-11 2023-07-19 Contrafect Corporation METHOD OF TREATMENT AND PREVENTION OF BONE AND JOINT INFECTIONS

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8108587A (en) 1986-10-08 1988-05-06 David Bernstein Method for exposing group a streptococcal antigens and an improved diagnostic test for the identification of group a streptococci
US5997862A (en) 1997-10-31 1999-12-07 New Horizons Diagnostics Corporation Therapeutic treatment of group A streptococcal infections
US6264945B1 (en) 1997-10-31 2001-07-24 Vincent A Fischetti Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
US6254866B1 (en) 1997-10-31 2001-07-03 New Horizons Diagnostics Corporation Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract
US6248324B1 (en) 1997-10-31 2001-06-19 Vincent Fischetti Bacterial phage associated lysing enzymes for treating dermatological infections
CA2366712A1 (en) 1999-02-25 2000-08-31 Vincent Fischetti A means for the prophylactic and therapeutic treatment of streptococcal infections
US6056955A (en) 1999-09-14 2000-05-02 Fischetti; Vincent Topical treatment of streptococcal infections
JP4381531B2 (ja) * 1999-12-08 2009-12-09 塩野義製薬株式会社 グリコペプチド誘導体
EP1501925A4 (en) 2002-05-17 2006-10-25 New Horizons Diagnostics Corp IDENTIFICATION OF A LYTIC ENZYME ASSOCIATED WITH A PHAGE TO DETECT AND ELIMINATE RAPIDLY AND SPECIFICALLY BACILLUS ANTHRACIS
US7569223B2 (en) 2004-03-22 2009-08-04 The Rockefeller University Phage-associated lytic enzymes for treatment of Streptococcus pneumoniae and related conditions
WO2005089527A2 (en) 2004-03-24 2005-09-29 The Rockefeller University Lytic enzymes and spore surface antigen for detection and treatment of bacillus anthracis bacteria and spores
WO2008018854A2 (en) 2005-06-06 2008-02-14 The Rockefeller University Bactiophage lysins for bacillus anthracis
US7582291B2 (en) 2005-06-30 2009-09-01 The Rockefeller University Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
ATE491026T1 (de) 2005-08-24 2010-12-15 Univ Rockefeller Ply-gbs-lysinmutanten
EP3263588A1 (en) 2008-07-03 2018-01-03 The Rockefeller University Isolated staphylococcus-specific soluble binding molecule
ES2546515T3 (es) * 2010-05-25 2015-09-24 Genome Pharmaceuticals Institute Co., Ltd. Nuevo compuesto péptido cíclico, método para producirlo, agente anti-infeccioso, fracción que contiene antibiótico, antibiótico, método para producir antibiótico, microorganismo productor de antibiótico y antibiótico producido mediante el mismo
JP5823733B2 (ja) * 2010-05-25 2015-11-25 株式会社ゲノム創薬研究所 抗生物質産生微生物及びそれが産生した抗生物質
DK2699253T3 (en) 2011-04-21 2018-07-16 Univ Rockefeller STREPTOCOCCUS BACTERYPHAGIC LYSINES FOR THE DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIES
KR102310387B1 (ko) * 2012-05-09 2021-10-13 콘트라펙트 코포레이션 그람 양성 박테리아에 대한 박테리오파지 리신과 항생제의 병용물

Also Published As

Publication number Publication date
EP3454888A1 (en) 2019-03-20
ZA201806685B (en) 2021-02-24
MX388569B (es) 2025-03-20
IL262844B2 (en) 2023-07-01
DK3454888T3 (da) 2021-04-26
CN109152822A (zh) 2019-01-04
CN109152822B (zh) 2023-12-05
IL262844A (en) 2018-12-31
IL262844B1 (en) 2023-03-01
JP2019514439A (ja) 2019-06-06
CA3023730A1 (en) 2017-11-16
JP6875756B2 (ja) 2021-05-26
WO2017197227A1 (en) 2017-11-16
BR112018073205A2 (pt) 2019-02-19
EP3454888B1 (en) 2021-02-24
US10851401B2 (en) 2020-12-01
AU2017263563A1 (en) 2018-10-18
RU2754667C2 (ru) 2021-09-06
US20190106724A1 (en) 2019-04-11
RU2018135238A3 (es) 2020-09-11
RU2018135238A (ru) 2020-06-15
KR20190004799A (ko) 2019-01-14
EP3454888A4 (en) 2019-12-11

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