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MX2018010923A - Analogos de nucleosidos sustituidos para su uso como inhibidores de prmt5. - Google Patents

Analogos de nucleosidos sustituidos para su uso como inhibidores de prmt5.

Info

Publication number
MX2018010923A
MX2018010923A MX2018010923A MX2018010923A MX2018010923A MX 2018010923 A MX2018010923 A MX 2018010923A MX 2018010923 A MX2018010923 A MX 2018010923A MX 2018010923 A MX2018010923 A MX 2018010923A MX 2018010923 A MX2018010923 A MX 2018010923A
Authority
MX
Mexico
Prior art keywords
nucleoside analogues
prmt5 inhibitors
substituted nucleoside
compounds
relates
Prior art date
Application number
MX2018010923A
Other languages
English (en)
Other versions
MX374813B (es
Inventor
Meerpoel Lieven
Arnodus Hendrika Joseph Gilissen Ronaldus
Bert Griet Schepens Wim
BREHMER Dirk
BEKE Lijs
Charles LAWSON Edward
Pande Vineet
Sun Weimei
Jean- Claude Berthelot Didier
Boeckx An
Stanislas Marcella Diels Gaston
Cornelis Bernardus Catharina Paradé Marcus
Christopher Shook Brian
Wilhelmus John F Thuring Johannes
Viellevoye Marcel
Wu Tongfei
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority claimed from PCT/EP2017/054324 external-priority patent/WO2017153186A1/en
Publication of MX2018010923A publication Critical patent/MX2018010923A/es
Publication of MX374813B publication Critical patent/MX374813B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invencion se refiere a nuevos analogos de nucleosidos sustituidos de Formula (I) (ver fórmula) en donde las variables tienen el significado definido en las reivindicaciones. Los compuestos de acuerdo con la presente invencion son utiles como inhibidores de PRMT5. La invencion se refiere ademas a composiciones farmaceuticas que comprenden dichos compuestos como principio activo, asi como tambien al uso de dichos compuestos como un medicamento.
MX2018010923A 2016-03-10 2017-02-24 Análogos de nucleósidos sustituidos para su uso como inhibidores de prmt5. MX374813B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662306222P 2016-03-10 2016-03-10
EP16162731 2016-03-30
PCT/EP2017/054324 WO2017153186A1 (en) 2016-03-10 2017-02-24 Substituted nucleoside analogues for use as prmt5 inhibitors

Publications (2)

Publication Number Publication Date
MX2018010923A true MX2018010923A (es) 2019-02-13
MX374813B MX374813B (es) 2025-03-06

Family

ID=65443152

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018010923A MX374813B (es) 2016-03-10 2017-02-24 Análogos de nucleósidos sustituidos para su uso como inhibidores de prmt5.

Country Status (11)

Country Link
US (1) US10898504B2 (es)
JP (1) JP6909799B2 (es)
BR (1) BR112018067789B1 (es)
EA (1) EA201892031A1 (es)
ES (1) ES2891320T3 (es)
MA (1) MA43671A (es)
MX (1) MX374813B (es)
PH (1) PH12018501895A1 (es)
TN (1) TN2018000310A1 (es)
UA (1) UA123637C2 (es)
ZA (1) ZA201806016B (es)

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224438A (en) 1970-07-14 1980-09-23 Boehringer Mannheim Gmbh Adenosine-5'-carboxylic acid amides
US6143749A (en) 1995-06-07 2000-11-07 Abbott Laboratories Heterocyclic substituted cyclopentane compounds
AU2002351077A1 (en) 2001-11-05 2003-05-19 Exiqon A/S Oligonucleotides modified with novel alpha-l-rna analogues
US7034147B2 (en) * 2001-11-29 2006-04-25 Irm Llc Nucleoside analog libraries
RU2317994C2 (ru) 2002-02-19 2008-02-27 Си Ви Терапьютикс, Инк. Частичные и полные агонисты аденозиновых рецепторов а1
US20040043959A1 (en) 2002-03-04 2004-03-04 Bloom Laura A. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
EP1694642A4 (en) 2003-12-19 2010-10-06 Koronis Pharmaceuticals Inc MUTAGENIC HETEROCYCLES
EP1844062A2 (en) 2005-01-21 2007-10-17 Methylgene, Inc. Inhibitors of dna methyltransferase
US20080132525A1 (en) 2006-12-04 2008-06-05 Methylgene Inc. Inhibitors of DNA Methyltransferase
AU2009298802A1 (en) 2008-09-23 2010-04-08 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
WO2011075665A2 (en) 2009-12-18 2011-06-23 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US9029343B2 (en) * 2010-12-03 2015-05-12 Epizyme, Inc. Modulators of histone methyltransferase, and methods of use thereof
BR112013013668A2 (pt) 2010-12-03 2016-09-06 Epizyme Inc moduladores 7-deazapurina de histona metiltransferase, e métodos de uso dos mesmos
CN103354808B (zh) 2010-12-16 2016-08-10 Abbvie公司 抗病毒化合物
WO2012138530A1 (en) 2011-04-04 2012-10-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 2'-o-aminooxymethyl nucleoside derivatives for use in the synthesis and modification of nucleosides, nucleotides and oligonucleotides
WO2013151975A1 (en) 2012-04-02 2013-10-10 Northeastern University Compositions and methods for the inhibition of methyltransferases
WO2014035140A2 (en) 2012-08-30 2014-03-06 Kainos Medicine, Inc. Compounds and compositions for modulating histone methyltransferase activity
US20140100184A1 (en) 2012-08-31 2014-04-10 Baylor College Of Medicine Selective inhibitors of histone methyltransferase dot1l
US8906900B2 (en) 2012-12-21 2014-12-09 Epizyme, Inc. PRMT5 inhibitors and uses thereof
EP2935243B1 (en) 2012-12-21 2018-03-14 Epizyme, Inc. Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
SI2935222T1 (sl) 2012-12-21 2019-02-28 Epizyme Inc. Inhibitorji PRMT5 in njihove uporabe
WO2015106025A1 (en) 2014-01-09 2015-07-16 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
EP3160477A4 (en) * 2014-06-25 2018-07-04 Epizyme, Inc. Prmt5 inhibitors and uses thereof
SG11201706050WA (en) 2015-02-24 2017-09-28 Pfizer Substituted nucleoside derivatives useful as anticancer agents
TWI791251B (zh) * 2015-08-26 2023-02-01 比利時商健生藥品公司 使用作為ｐｒｍｔ５抑制劑之新穎經６-６雙環芳香環取代之核苷類似物
US10685416B2 (en) 2015-12-10 2020-06-16 Uber Technologies, Inc. Suggested pickup location for ride services
WO2017153186A1 (en) 2016-03-10 2017-09-14 Janssen Pharmaceutica Nv Substituted nucleoside analogues for use as prmt5 inhibitors
WO2018065365A1 (en) 2016-10-03 2018-04-12 Janssen Pharmaceutica Nv Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors
PE20191359A1 (es) 2017-02-27 2019-10-01 Janssen Pharmaceutica Nv Uso de biomarcadores en la identificacion de pacientes con cancer que seran sensibles al tratamiento con un inhibidor de prmt5

Also Published As

Publication number Publication date
JP6909799B2 (ja) 2021-07-28
BR112018067789A2 (pt) 2019-04-30
NZ745827A (en) 2025-05-02
US10898504B2 (en) 2021-01-26
EA201892031A1 (ru) 2019-02-28
ZA201806016B (en) 2022-04-28
JP2019507778A (ja) 2019-03-22
MX374813B (es) 2025-03-06
TN2018000310A1 (en) 2020-01-16
ES2891320T3 (es) 2022-01-27
PH12018501895A1 (en) 2019-05-20
UA123637C2 (uk) 2021-05-05
US20200289539A1 (en) 2020-09-17
BR112018067789B1 (pt) 2023-12-12
MA43671A (fr) 2018-11-28

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