[go: up one dir, main page]

MX2018009938A - Profarmacos de hormona paratiroidea (pth). - Google Patents

Profarmacos de hormona paratiroidea (pth).

Info

Publication number
MX2018009938A
MX2018009938A MX2018009938A MX2018009938A MX2018009938A MX 2018009938 A MX2018009938 A MX 2018009938A MX 2018009938 A MX2018009938 A MX 2018009938A MX 2018009938 A MX2018009938 A MX 2018009938A MX 2018009938 A MX2018009938 A MX 2018009938A
Authority
MX
Mexico
Prior art keywords
pth prodrugs
pth
prodrugs
pharmaceutical compositions
relates
Prior art date
Application number
MX2018009938A
Other languages
English (en)
Inventor
Zettler Joachim
Maitro Guillaume
Wegge Thomas
Cleemann Felix
Sprogøe Kennett
Krusch Mathias
Original Assignee
Ascendis Pharma Bone Diseases As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ascendis Pharma Bone Diseases As filed Critical Ascendis Pharma Bone Diseases As
Publication of MX2018009938A publication Critical patent/MX2018009938A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Marine Sciences & Fisheries (AREA)

Abstract

La presente invención se refiere a profármacos de PTH, composiciones farmacéuticas que comprenden estos profármacos de PTH y sus usos.
MX2018009938A 2016-03-01 2017-02-28 Profarmacos de hormona paratiroidea (pth). MX2018009938A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16158048 2016-03-01
EP16179294 2016-07-13
EP16191484 2016-09-29
EP17155839 2017-02-13
PCT/EP2017/054550 WO2017148883A1 (en) 2016-03-01 2017-02-28 Pth prodrugs

Publications (1)

Publication Number Publication Date
MX2018009938A true MX2018009938A (es) 2019-03-14

Family

ID=58185540

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018009938A MX2018009938A (es) 2016-03-01 2017-02-28 Profarmacos de hormona paratiroidea (pth).
MX2022015755A MX2022015755A (es) 2016-03-01 2018-08-16 Profarmacos de hormona paratiroidea (pth).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022015755A MX2022015755A (es) 2016-03-01 2018-08-16 Profarmacos de hormona paratiroidea (pth).

Country Status (30)

Country Link
US (7) US20200276276A1 (es)
EP (2) EP3423103B1 (es)
JP (3) JP7059195B2 (es)
KR (4) KR102331820B1 (es)
CN (2) CN115025239B (es)
AU (4) AU2017227962C1 (es)
BR (1) BR112018017091A2 (es)
CA (1) CA3015585A1 (es)
DK (1) DK3423103T3 (es)
ES (1) ES2993932T3 (es)
FI (2) FI3423103T3 (es)
FR (1) FR24C1045I1 (es)
HR (1) HRP20241591T1 (es)
HU (2) HUE069445T2 (es)
IL (3) IL260756B2 (es)
LT (2) LT3423103T (es)
MA (2) MA45809B1 (es)
MX (2) MX2018009938A (es)
MY (2) MY196308A (es)
NL (1) NL301298I2 (es)
NO (1) NO2025005I1 (es)
NZ (1) NZ745318A (es)
PL (1) PL3423103T3 (es)
RS (1) RS66250B1 (es)
RU (1) RU2747316C2 (es)
SG (1) SG11201806092TA (es)
SI (1) SI3423103T1 (es)
SM (1) SMT202400423T1 (es)
WO (1) WO2017148883A1 (es)
ZA (1) ZA201805705B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016065042A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
MX2018009938A (es) 2016-03-01 2019-03-14 Ascendis Pharma Bone Diseases As Profarmacos de hormona paratiroidea (pth).
MX2019003181A (es) 2016-09-29 2019-08-05 Ascendis Pharma Bone Diseases As Regimen de dosificacion para un compuesto de hormona paratiroidea (pth) de liberacion controlada.
KR102531327B1 (ko) 2016-09-29 2023-05-11 아센디스 파마 그로우쓰 디스오더스 에이/에스 조절 방출 cnp 아고니스트를 사용한 병용 요법
KR20230170810A (ko) 2016-09-29 2023-12-19 아센디스 파마 본 디지즈 에이/에스 낮은 피크 대 트로프 비를 가진 pth 화합물
CN116059321A (zh) * 2016-09-29 2023-05-05 阿森迪斯药物骨疾病股份有限公司 控释pth的药物组合物
WO2019178462A1 (en) * 2018-03-16 2019-09-19 The General Hospital Corporation Parathyroid hormone polypeptide conjugates and methods of their use
BR112020019639A2 (pt) * 2018-03-28 2021-01-05 Ascendis Pharma Oncology Division A/S Conjugados de il-2
PT3793587T (pt) 2018-05-18 2025-07-25 Ascendis Pharma Bone Diseases As Dose inicial de conjugados de pth
US11634468B2 (en) 2019-01-29 2023-04-25 Shire-Nps Pharmaceuticals, Inc. Parathyroid hormone variants
BR112021014581A2 (pt) * 2019-02-11 2021-12-14 Ascendis Pharma Bone Diseases As Formulações farmacêuticas líquidas de conjugados de pth
EP4090357A1 (en) * 2020-01-13 2022-11-23 Ascendis Pharma Bone Diseases A/S Hypoparathyroidism treatment
JP2023527919A (ja) 2020-06-03 2023-06-30 アセンディス ファーマ オンコロジー ディヴィジョン エー／エス Ｉｌ－２配列及びその使用
TWI888383B (zh) * 2020-06-19 2025-07-01 丹麥商阿森迪斯藥物骨疾病股份有限公司 Ｐｔｈ綴合物的液體藥物製劑
WO2021263040A1 (en) * 2020-06-26 2021-12-30 Shire-Nps Pharmaceuticals, Inc. Stable peptibody formulations
AU2021319863A1 (en) 2020-08-05 2023-02-16 Ascendis Pharma A/S Conjugates comprising reversible linkers and uses thereof
IL319526A (en) 2022-09-30 2025-05-01 Extend Biosciences Inc Long-acting parathyroid hormone
AU2023374533A1 (en) 2022-11-02 2025-04-10 Ascendis Pharma Bone Diseases A/S Pth treatment regimen comprising two pth compounds
WO2025051711A1 (en) 2023-09-04 2025-03-13 Ascendis Pharma Bone Diseases A/S Pth treatment of chronic kidney disease
CN118638210B (zh) * 2024-08-14 2024-11-15 南方医科大学第三附属医院（广东省骨科研究院） 长效pth类似物的制备方法及应用

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744444A (en) * 1989-10-27 1998-04-28 Haemopep Pharma Gmbh HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof
US5567439A (en) 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
MY120063A (en) 1997-12-09 2005-08-30 Lilly Co Eli Stabilized teriparatide solutions
US6624142B2 (en) 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US20050124537A1 (en) 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050148763A1 (en) * 2002-02-01 2005-07-07 Chugai Seiyaku Kabushiki Kaisha Peg-binding pth or peg-binding pth derivative
US6559293B1 (en) 2002-02-15 2003-05-06 Transform Pharmaceuticals, Inc. Topiramate sodium trihydrate
US7122189B2 (en) 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7332164B2 (en) 2003-03-21 2008-02-19 Enzon Pharmaceuticals, Inc. Heterobifunctional polymeric bioconjugates
EP1620118B1 (en) 2003-04-08 2014-06-18 Yeda Research And Development Co., Ltd. Reversible pegylated drugs
JP4133570B2 (ja) * 2003-05-15 2008-08-13 アルパイン株式会社 ナビゲーション装置
US7690003B2 (en) 2003-08-29 2010-03-30 Fuller Jeffrey C System and method for increasing data throughput using thread scheduling
BR122019021416A2 (es) 2003-09-19 2019-12-21
CN1657540A (zh) * 2004-02-18 2005-08-24 中国人民解放军军事医学科学院基础医学研究所 人甲状旁腺素（1－34）的聚乙二醇化衍生物，含有它们的药物组合物及用途
JP4950022B2 (ja) 2004-03-23 2012-06-13 コンプレックス バイオシステムズ ゲーエムベーハー 自壊性リンカーを有する高分子プロドラッグ
EP1750756A2 (en) 2004-05-10 2007-02-14 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of parathyroid hormone
US7968085B2 (en) 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
CN1597697A (zh) * 2004-07-19 2005-03-23 中国药科大学 一种人的甲状旁腺素1－34肽相关肽－Pro－Pro－[Arg11]]hPTH(1－34)－Pro－Pro
US20060069021A1 (en) 2004-08-13 2006-03-30 Nastech Pharmaceutical Company Inc. Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs
WO2006059237A1 (en) 2004-08-30 2006-06-08 Lunamed, Inc. 4-phenylbutyric acid controlled-release formulations for therapeutic use
GB2427360A (en) 2005-06-22 2006-12-27 Complex Biosystems Gmbh Aliphatic prodrug linker
CN1298386C (zh) 2005-08-31 2007-02-07 上海交通大学 甲状旁腺激素缓释微球的制备方法
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
WO2007106597A2 (en) 2006-03-15 2007-09-20 Alza Corporation Method for the transdermal delivery of parathyroid hormone agents for treating osteopenia
NO325064B1 (no) * 2006-07-06 2008-01-28 Tandberg Telecom As Kommunikasjonsklient
KR20090055623A (ko) 2006-09-15 2009-06-02 엔존 파마슈티컬즈, 인코포레이티드 올리고뉴클레오티드 전달을 위한 방해된 에스테르 기재 생분해성 링커
US7820179B2 (en) 2006-10-13 2010-10-26 Eli Lilly And Company Pegylated PTH as PTH receptor modulators and uses thereof
US8101729B2 (en) 2007-03-19 2012-01-24 Henry Joseph Niemczyk Pegylated amino acid derivatives and the process to synthesize the same
EP3091075B1 (en) 2007-04-09 2018-06-13 The Board of Trustees of The University of Arkansas Fusion proteins of collagen-binding domain and parathyroid hormone
KR101701080B1 (ko) 2007-06-21 2017-01-31 엑스엘-프로테인 게엠베하 증가된 생체내 및/또는 시험관내 안정성을 갖는 생물학적 활성 단백질
CA2693616A1 (en) 2007-07-11 2009-01-15 Enzon Pharmaceuticals, Inc. Polymeric drug delivery system containing a multi-substituted aromatic moiety
EP2052736A1 (en) 2007-10-26 2009-04-29 Nycomed Danmark ApS Parathyroid hormone formulations und uses thereof
EP3981761A3 (en) * 2008-02-01 2022-08-24 Ascendis Pharma A/S Intermediates for prodrugs
DK2279007T3 (en) 2008-04-29 2016-08-22 Ascendis Pharma Growth Disorders Div As Pegylated recombinant relations of human growth hormone
CA2723263A1 (en) 2008-05-23 2009-11-26 Enzon Pharmaceuticals, Inc. Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides
WO2009156481A1 (en) 2008-06-25 2009-12-30 Ascendis Pharma As Pegylated bnp
WO2010022171A1 (en) 2008-08-19 2010-02-25 Ferring International Center S.A. Peptidic pth receptor agonists
NZ593833A (en) 2009-02-03 2013-10-25 Amunix Operating Inc Extended recombinant polypeptides and compositions comprising same
CN102548583B (zh) 2009-07-31 2015-04-22 赛诺菲-安万特德国有限公司 包含胰岛素连接物缀合物的前药
US20120191039A1 (en) 2009-07-31 2012-07-26 Ascendis Pharma A/S Carrier linked pramipexole prodrugs
AU2010277560B2 (en) 2009-07-31 2014-12-11 Sanofi-Aventis Deutschland Gmbh Long acting insulin composition
US9173953B2 (en) 2009-07-31 2015-11-03 Ascendis Pharma As Prodrugs containing an aromatic amine connected by an amido bond to a linker
WO2011012723A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Injectable sustained release compositions comprising a pramipexole prodrug
HRP20201609T1 (hr) 2009-07-31 2021-01-08 Ascendis Pharma A/S Biorazgradivi hidrogelovi netopivi u vodi bazirani na polietilenglikolu
US20130053405A1 (en) 2009-10-06 2013-02-28 Ulrich Hersel Carrier linked paliperidone prodrugs
RU2012129674A (ru) * 2009-12-15 2014-01-27 Аспендис Фарма Ас Композиция гормона роста
WO2011082368A2 (en) 2009-12-31 2011-07-07 Enzon Pharmaceuticals, Inc Polymeric conjugates of aromatic amine containing compounds including releasable urea linker
WO2011089214A1 (en) 2010-01-22 2011-07-28 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
US20130030359A1 (en) 2010-01-22 2013-01-31 Ascendis Pharma A/S Dipeptide-based prodrug linkers for aromatic amine-containing drugs
WO2011089216A1 (en) 2010-01-22 2011-07-28 Ascendis Pharma As Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
US20110229580A1 (en) 2010-03-22 2011-09-22 Indian Institute of Technology Bombay, School of Biosciences and Bioengineering Compositions and methods for nano-in-micro particles
EP3372617B1 (en) 2010-04-02 2024-07-24 Amunix Pharmaceuticals, Inc. Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
WO2011140392A1 (en) 2010-05-05 2011-11-10 Prolynx Llc Controlled drug release from solid supports
DK2566335T3 (en) 2010-05-05 2016-10-03 Prolynx Llc Controlled release of active ingredients from macromolecular CONJUGATES
EP2569003B1 (en) 2010-05-13 2017-10-25 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
ES2691642T3 (es) 2010-05-21 2018-11-28 Xl-Protein Gmbh Polipéptidos de enrollamiento al azar de prolina/alanina biosintéticos y sus usos
US8865220B2 (en) 2010-06-14 2014-10-21 Kaohsiung Medical University Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres
JP5594791B2 (ja) 2010-06-30 2014-09-24 Ｎｅｃソリューションイノベータ株式会社 属性判定方法、属性判定装置、プログラム、記録媒体および属性判定システム
US20120040320A1 (en) 2010-08-13 2012-02-16 Nadeau Daniel A Injection Simulation Device and Methods Thereof
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
CN103857413A (zh) 2011-08-12 2014-06-11 阿森迪斯药物股份有限公司 载体连接的曲罗尼尔前药
EP2741778A1 (en) 2011-08-12 2014-06-18 Ascendis Pharma A/S Polymeric hyperbranched carrier-linked prodrugs
AU2012296951B2 (en) 2011-08-12 2016-09-15 Ascendis Pharma A/S Protein carrier-linked prodrugs
US9872864B2 (en) 2011-08-12 2018-01-23 Ascendis Pharma A/S Sustained release composition of prostacyclin
EP2741744A1 (en) 2011-08-12 2014-06-18 Ascendis Pharma A/S Carrier-linked prodrugs having reversible carboxylic ester linkages
WO2013036857A1 (en) 2011-09-07 2013-03-14 Prolynx Llc Sulfone linkers
US20150010634A1 (en) 2011-10-12 2015-01-08 Ascendis Pharma Ophthamology Division A/S Prevention and treatment of ocular conditions
US8883862B2 (en) 2012-01-12 2014-11-11 Kaohsiung Medical University Method for controlled release of parathyroid hormone from cross-linked hyaluronic acid hydrogel
RU2014133818A (ru) 2012-01-20 2016-03-20 Люпин Лимитед Стабилизированный состав pth
HK1205697A1 (zh) 2012-04-25 2015-12-24 Ascendis Pharma A/S 含有羟基的药物的前药
US9457096B2 (en) 2012-07-06 2016-10-04 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery
CA2883707A1 (en) * 2012-08-28 2014-03-06 The Governors Of The University Of Alberta Parathyroid hormone, insulin, and related peptides conjugated to bone targeting moieties and methods of making and using thereof
US10980860B2 (en) * 2012-10-11 2021-04-20 Ascendis Pharma A/S Diagnosis, prevention and treatment of diseases of the joint
CA2883833C (en) 2012-10-11 2020-10-27 Ascendis Pharma A/S Hydrogel prodrugs
MY177912A (en) 2012-10-11 2020-09-25 Ascendis Pharma Ophthalmology Div A/S Vegf neutralizing prodrugs for the treatment of ocular conditions
US20150250882A1 (en) 2012-10-17 2015-09-10 Novo Nordisk Health Care Ag Fatty Acid Acylated Amino Acids for Growth Hormone Delivery
JP6290243B2 (ja) 2012-12-07 2018-03-07 アセンディス ファーマ エー／エス 担体連結プロスタノイドプロドラッグ
GB201303771D0 (en) 2013-03-04 2013-04-17 Midatech Ltd Nanoparticles peptide compositions
AU2014257745B2 (en) 2013-04-22 2018-10-04 Ascendis Pharma A/S Hydrogel-linked prodrugs releasing modified drugs
US20150065423A1 (en) 2013-08-30 2015-03-05 Perosphere, Inc. Rapid acting injectable formulations
WO2015052155A1 (en) 2013-10-08 2015-04-16 Ascendis Pharma A/S Protecting group comprising a purification tag
EP2868326A1 (en) 2013-11-04 2015-05-06 Université Pierre et Marie Curie (Paris 6) Peptide inhibitors of TEAD/YAP-TAZ interaction
US11633487B2 (en) 2014-08-06 2023-04-25 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
WO2016065042A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
MX2017008915A (es) 2015-01-09 2018-04-26 Ascendis Pharma Growth Disorders As Profarmacos de peptido natriuretico tipo c (cnp).
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
MX2018009938A (es) * 2016-03-01 2019-03-14 Ascendis Pharma Bone Diseases As Profarmacos de hormona paratiroidea (pth).
KR20230170810A (ko) 2016-09-29 2023-12-19 아센디스 파마 본 디지즈 에이/에스 낮은 피크 대 트로프 비를 가진 pth 화합물
MX2019003181A (es) 2016-09-29 2019-08-05 Ascendis Pharma Bone Diseases As Regimen de dosificacion para un compuesto de hormona paratiroidea (pth) de liberacion controlada.
KR102531327B1 (ko) * 2016-09-29 2023-05-11 아센디스 파마 그로우쓰 디스오더스 에이/에스 조절 방출 cnp 아고니스트를 사용한 병용 요법
CN116059321A (zh) * 2016-09-29 2023-05-05 阿森迪斯药物骨疾病股份有限公司 控释pth的药物组合物
AR110299A1 (es) 2016-12-02 2019-03-13 Sanofi Sa Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico
PT3793587T (pt) 2018-05-18 2025-07-25 Ascendis Pharma Bone Diseases As Dose inicial de conjugados de pth
BR112021014581A2 (pt) * 2019-02-11 2021-12-14 Ascendis Pharma Bone Diseases As Formulações farmacêuticas líquidas de conjugados de pth
EP4090357A1 (en) 2020-01-13 2022-11-23 Ascendis Pharma Bone Diseases A/S Hypoparathyroidism treatment

Also Published As

Publication number Publication date
KR20210147085A (ko) 2021-12-06
AU2023285850B2 (en) 2025-09-18
CN115025239B (zh) 2025-03-21
IL301616B1 (en) 2025-01-01
MY208384A (en) 2025-05-05
WO2017148883A1 (en) 2017-09-08
FR24C1045I1 (fr) 2025-01-10
IL260756B1 (en) 2023-05-01
AU2022256158A1 (en) 2022-12-08
RU2018134135A3 (es) 2020-04-01
CA3015585A1 (en) 2017-09-08
KR20230015517A (ko) 2023-01-31
AU2022256158B2 (en) 2023-09-28
JP7059195B2 (ja) 2022-04-25
HRP20241591T1 (hr) 2025-02-28
AU2022256158A9 (en) 2023-09-28
NZ745318A (en) 2023-01-27
IL260756B2 (en) 2023-09-01
MA45277A (fr) 2019-01-09
US20250268988A1 (en) 2025-08-28
JP2025000652A (ja) 2025-01-07
JP2019513127A (ja) 2019-05-23
US20200276276A1 (en) 2020-09-03
KR20250044469A (ko) 2025-03-31
LTPA2025506I1 (es) 2025-02-25
IL317744A (en) 2025-02-01
US20240123038A1 (en) 2024-04-18
CN109069659A (zh) 2018-12-21
US20200360487A1 (en) 2020-11-19
AU2023285850A1 (en) 2024-01-18
EP4470613A3 (en) 2025-03-12
EP3423103A1 (en) 2019-01-09
MX2022015755A (es) 2023-01-19
US20220008516A1 (en) 2022-01-13
CN115025239A (zh) 2022-09-09
NZ785623A (en) 2024-10-25
CN109069659B (zh) 2022-04-19
IL301616A (en) 2023-05-01
MA45809A (fr) 2019-01-09
LT3423103T (lt) 2024-10-25
BR112018017091A2 (pt) 2019-01-02
AU2017227962B2 (en) 2020-11-12
AU2017227962C1 (en) 2021-05-13
JP7619973B2 (ja) 2025-01-22
PL3423103T3 (pl) 2025-02-10
SI3423103T1 (sl) 2024-12-31
ZA201805705B (en) 2019-06-26
EP4470613A2 (en) 2024-12-04
HUS2500009I1 (hu) 2025-02-28
ES2993932T3 (en) 2025-01-14
NL301298I2 (nl) 2024-12-11
KR102786270B1 (ko) 2025-03-24
HUE069445T2 (hu) 2025-03-28
AU2020286303A1 (en) 2021-02-04
FI3423103T3 (fi) 2024-11-20
KR20180118197A (ko) 2018-10-30
IL260756A (es) 2018-09-20
RU2018134135A (ru) 2020-04-01
FIC20250008I1 (fi) 2025-02-03
US20200376089A1 (en) 2020-12-03
NO2025005I1 (no) 2025-01-14
KR102524255B1 (ko) 2023-04-20
KR102331820B1 (ko) 2021-11-29
RU2747316C2 (ru) 2021-05-04
MY196308A (en) 2023-03-24
EP3423103B1 (en) 2024-09-11
AU2020286303C1 (en) 2023-03-02
AU2017227962A1 (en) 2018-08-09
US12214020B2 (en) 2025-02-04
US11793861B2 (en) 2023-10-24
SMT202400423T1 (it) 2024-11-15
IL301616B2 (en) 2025-05-01
DK3423103T3 (da) 2024-09-30
SG11201806092TA (en) 2018-08-30
JP2022068210A (ja) 2022-05-09
MA45809B1 (fr) 2024-12-31
AU2020286303B2 (en) 2022-07-21
US20230121525A1 (en) 2023-04-20
RS66250B1 (sr) 2024-12-31

Similar Documents

Publication Publication Date Title
MX2018009938A (es) Profarmacos de hormona paratiroidea (pth).
ECSP18040758A (es) Formulaciones subcutáneas de anticuerpos anti-cd38 y sus usos
BR112018006471A2 (pt) compostos úteis como moduladores de trpm8
SV2018005684A (es) Anticuerpos que se unen especificamente a pd-1 y sus usos
MX2019009361A (es) Composiciones y metodos para el tratamiento de hemoglobinopatias.
MX2018007987A (es) Composiciones y metodos para el tratamiento de hemoglobinopatias.
DOP2017000298A (es) Reguladores de nrf2
BR112019004785A2 (pt) variantes de alfa-glicosidase ácida e usos das mesmas
BR112018010118A2 (pt) inibidores de cxcr2
CL2016002772A1 (es) Composiciones de insulina de rápida acción
BR112017006137A2 (pt) formulação que contém biotensoativo
BR112019004783A2 (pt) variantes de alfa-glicosidase ácida e usos das mesmas
MX389001B (es) Moduladores de interacción de sestrina-gator2 y sus usos.
BR112018009120A2 (pt) métodos de formação de compostos contendo aromáticos
MX2018007390A (es) Composiciones que comprenden acido 15-hidroxi eicosapentaenoico (15-hepe) y metodos de uso del mismo.
DOP2017000260A (es) Piroglutamato de vortioxetina
GT201600252A (es) Derivados de naftiridinadiona
MX388186B (es) Granos de gluten reducido y composiciones de los mismos.
BR112016028192A2 (pt) gerritdina g. schoonus-gerritsma
ES1216222Y (es) Composicion que comprende cenizas de cremacion
CL2017000645A1 (es) Síntesis de ent-progesterona e intermediarios de la misma
CL2016003351A1 (es) Lipido que comprende ácido docosapentanoico
MX2021004581A (es) Composiciones acuosas que comprenden omega nitrooxi-1-alcanoles.
BR112017028361A2 (pt) 2,4,7-trimetiloct-6-en-1-ol como ingrediente de fragrância
BR112017000908A2 (pt) sal de tenofovir disoproxil