MX2018009302A - Compuesto de piridina sustituida con azol. - Google Patents
Compuesto de piridina sustituida con azol.Info
- Publication number
- MX2018009302A MX2018009302A MX2018009302A MX2018009302A MX2018009302A MX 2018009302 A MX2018009302 A MX 2018009302A MX 2018009302 A MX2018009302 A MX 2018009302A MX 2018009302 A MX2018009302 A MX 2018009302A MX 2018009302 A MX2018009302 A MX 2018009302A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- formula
- atom
- azole
- membered
- Prior art date
Links
- -1 Azole-substituted pyridine compound Chemical class 0.000 title 1
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical class C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- NNDIXBJHNLFJJP-UHFFFAOYSA-N 20-Hydroxyeicosatetraenoic acid Chemical compound OCCCCCC=CCC=CCC=CCC=CCCCC(O)=O NNDIXBJHNLFJJP-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención proporciona un compuesto representado por formulas [I´] mostrada a continuación o una sal farmacéuticamente aceptable del mismo que tiene un efecto inhibidor sobre la enzima que produce 20-HETE, donde la estructura representada por la formula [III] mostrada abajo representa cualquiera de las estructuras representadas por el grupo de formula [IV] que se muestra a continuación, en donde R1 representa un atomo de hidrogeno, un atomo de fluor, metilo, etc.; R2, R3, y R4 representan cada uno independientemente un atomo de hidrogeno, un atomo de fluor o metilo; W representa un enlace simple, alcanodiilo de C1-3, o la formula -O-CH2CH2-; y el anillo A representa (a) cicloalquilo C4-6sustituido, (b) heterociclilo sustituido con nitrógeno, saturado, de 4 a 6 miembros, (c) fenilo sustituido, (d) piridilo sustituido, 2,3-dihidrobenzofurano sustituido, (f) heterocíclico saturado, que contiene oxígeno, de 4 a 6 miembros, etc. Ver formula 1 Ver formula 2 Ver formula 3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016025878 | 2016-02-15 | ||
| PCT/JP2017/005388 WO2017141927A1 (ja) | 2016-02-15 | 2017-02-14 | アゾールで置換されたピリジン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018009302A true MX2018009302A (es) | 2019-03-28 |
| MX377024B MX377024B (es) | 2025-03-07 |
Family
ID=59625084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018009302A MX377024B (es) | 2016-02-15 | 2017-02-14 | Compuesto de piridina sustituida con azol |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20210040062A1 (es) |
| EP (1) | EP3418276A4 (es) |
| JP (1) | JP6311845B2 (es) |
| KR (1) | KR20180109871A (es) |
| CN (1) | CN108602796A (es) |
| AU (1) | AU2017220454A1 (es) |
| BR (1) | BR112018015760A2 (es) |
| CA (1) | CA3012976A1 (es) |
| HK (1) | HK1256022A1 (es) |
| IL (1) | IL260776B (es) |
| MX (1) | MX377024B (es) |
| PH (1) | PH12018501627A1 (es) |
| RU (1) | RU2730498C2 (es) |
| SG (1) | SG11201806354SA (es) |
| TW (1) | TW201741294A (es) |
| WO (1) | WO2017141927A1 (es) |
| ZA (1) | ZA201805210B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017357333A1 (en) | 2016-11-14 | 2019-05-02 | Jiangsu Hengrui Medicine Co., Ltd. | 3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof |
| CA3072420A1 (en) * | 2017-08-10 | 2019-02-14 | Taisho Pharmaceutical Co., Ltd. | Pyridine compound substituted with azole |
| KR102234399B1 (ko) | 2018-05-23 | 2021-04-05 | 아주대학교산학협력단 | 톨-유사 수용체 3/7/8/9 억제 기능이 있는 길항성 소분자 화합물 tac5 시리즈 |
| WO2019225920A1 (ko) * | 2018-05-23 | 2019-11-28 | 아주대학교산학협력단 | 톨-유사 수용체 3/7/8/9 억제 기능이 있는 길항성 소분자 화합물 tac5 시리즈 |
| TW202045494A (zh) * | 2019-02-08 | 2020-12-16 | 日商大正製藥股份有限公司 | 經雜芳基取代的吡啶化合物 |
| EP4219454B1 (en) * | 2022-01-28 | 2025-11-19 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Highly efficient process for the preparation of 4-fluoro-1h-pyrazole or salts thereof |
| CN120271573A (zh) * | 2024-04-08 | 2025-07-08 | 北京双鹤润创科技有限公司 | 杂环芳基或杂芳基-杂芳基衍生物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1177824C (zh) * | 2000-06-15 | 2004-12-01 | 大正制药株式会社 | 羟基甲脒衍生物及含有该衍生物的药物 |
| WO2003022821A1 (en) * | 2001-09-06 | 2003-03-20 | Taisho Pharmaceutical Co., Ltd. | Heterocycle derivative having 20-hete-producing enzyme inhibitory activity |
| JP2004262890A (ja) * | 2003-03-04 | 2004-09-24 | Taisho Pharmaceut Co Ltd | ２０−ｈｅｔｅ産生阻害作用を有するアゾール誘導体 |
| KR101331768B1 (ko) * | 2005-11-08 | 2013-11-22 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｐ 결합 카세트 수송체의 헤테로사이클릭 조정제 |
-
2017
- 2017-02-14 KR KR1020187019358A patent/KR20180109871A/ko not_active Withdrawn
- 2017-02-14 EP EP17753183.7A patent/EP3418276A4/en not_active Withdrawn
- 2017-02-14 BR BR112018015760A patent/BR112018015760A2/pt not_active IP Right Cessation
- 2017-02-14 HK HK18115072.9A patent/HK1256022A1/zh unknown
- 2017-02-14 MX MX2018009302A patent/MX377024B/es active IP Right Grant
- 2017-02-14 TW TW106104780A patent/TW201741294A/zh unknown
- 2017-02-14 SG SG11201806354SA patent/SG11201806354SA/en unknown
- 2017-02-14 WO PCT/JP2017/005388 patent/WO2017141927A1/ja not_active Ceased
- 2017-02-14 US US16/077,798 patent/US20210040062A1/en not_active Abandoned
- 2017-02-14 AU AU2017220454A patent/AU2017220454A1/en not_active Abandoned
- 2017-02-14 RU RU2018132726A patent/RU2730498C2/ru active
- 2017-02-14 JP JP2017538000A patent/JP6311845B2/ja not_active Expired - Fee Related
- 2017-02-14 CN CN201780011516.8A patent/CN108602796A/zh active Pending
- 2017-02-14 CA CA3012976A patent/CA3012976A1/en not_active Abandoned
-
2018
- 2018-07-25 IL IL260776A patent/IL260776B/en active IP Right Grant
- 2018-08-01 PH PH12018501627A patent/PH12018501627A1/en unknown
- 2018-08-02 ZA ZA201805210A patent/ZA201805210B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180109871A (ko) | 2018-10-08 |
| JPWO2017141927A1 (ja) | 2018-03-01 |
| AU2017220454A1 (en) | 2018-08-09 |
| EP3418276A4 (en) | 2019-07-31 |
| IL260776B (en) | 2020-06-30 |
| HK1256022A1 (zh) | 2019-09-13 |
| PH12018501627A1 (en) | 2019-06-03 |
| MX377024B (es) | 2025-03-07 |
| BR112018015760A2 (pt) | 2019-01-02 |
| TW201741294A (zh) | 2017-12-01 |
| CA3012976A1 (en) | 2017-08-24 |
| US20210040062A1 (en) | 2021-02-11 |
| RU2730498C2 (ru) | 2020-08-24 |
| ZA201805210B (en) | 2019-10-30 |
| RU2018132726A3 (es) | 2020-04-09 |
| RU2018132726A (ru) | 2020-03-17 |
| EP3418276A1 (en) | 2018-12-26 |
| SG11201806354SA (en) | 2018-08-30 |
| WO2017141927A1 (ja) | 2017-08-24 |
| CN108602796A (zh) | 2018-09-28 |
| JP6311845B2 (ja) | 2018-04-18 |
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