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MX2018008159A - Un dispositivo de recuperacion de coagulos para eliminar coagulos oclusivos de un vaso sanguineo. - Google Patents

Un dispositivo de recuperacion de coagulos para eliminar coagulos oclusivos de un vaso sanguineo.

Info

Publication number
MX2018008159A
MX2018008159A MX2018008159A MX2018008159A MX2018008159A MX 2018008159 A MX2018008159 A MX 2018008159A MX 2018008159 A MX2018008159 A MX 2018008159A MX 2018008159 A MX2018008159 A MX 2018008159A MX 2018008159 A MX2018008159 A MX 2018008159A
Authority
MX
Mexico
Prior art keywords
clot
configuration
expandable structure
blood vessel
retrieval system
Prior art date
Application number
MX2018008159A
Other languages
English (en)
Inventor
Holian Maeve
Hardiman David
O'connor Grainne
Vale David
Casey Brendan
Original Assignee
Neuravi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuravi Ltd filed Critical Neuravi Ltd
Publication of MX2018008159A publication Critical patent/MX2018008159A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22031—Gripping instruments, e.g. forceps, for removing or smashing calculi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00477—Coupling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00526—Methods of manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00778—Operations on blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22031—Gripping instruments, e.g. forceps, for removing or smashing calculi
    • A61B2017/22034—Gripping instruments, e.g. forceps, for removing or smashing calculi for gripping the obstruction or the tissue part from inside
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22065—Functions of balloons
    • A61B2017/22067—Blocking; Occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22072—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22094—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for crossing total occlusions, i.e. piercing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A61B2017/2212—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having a closed distal end, e.g. a loop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A61B2017/2215—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having an open distal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3966—Radiopaque markers visible in an X-ray image

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Surgical Instruments (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Processing Of Meat And Fish (AREA)

Abstract

Un dispositivo de eliminación de coágulos para eliminar el coágulo de un vaso corporal que comprende una estructura dilatable y un miembro alargado; el miembro alargado puede tener un extremo proximal y un extremo distal, el miembro alargado que se conecta a la estructura dilatable en su extremo distal; la estructura dilatable puede tener una configuración de suministro restringida, una configuración desplegada de acoplamiento de coágulos expandida, y una configuración de pinzamiento de coágulos al menos parcialmente restringida; al menos una porción de la estructura dilatable puede configurarse para acoplarse al coágulo en la configuración desplegada expandida y para sujetar el coágulo al moverse desde la configuración desplegada a la configuración de pinzamiento de coágulos.
MX2018008159A 2017-06-28 2018-06-28 Un dispositivo de recuperacion de coagulos para eliminar coagulos oclusivos de un vaso sanguineo. MX2018008159A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762526005P 2017-06-28 2017-06-28

Publications (1)

Publication Number Publication Date
MX2018008159A true MX2018008159A (es) 2019-01-31

Family

ID=62791681

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018008159A MX2018008159A (es) 2017-06-28 2018-06-28 Un dispositivo de recuperacion de coagulos para eliminar coagulos oclusivos de un vaso sanguineo.

Country Status (13)

Country Link
EP (3) EP4137071B1 (es)
JP (2) JP2019005587A (es)
KR (1) KR20190001935A (es)
CN (1) CN109124725A (es)
AU (1) AU2018204059A1 (es)
BR (1) BR102018013204A2 (es)
CA (1) CA3008899A1 (es)
CO (1) CO2018006688A1 (es)
ES (2) ES3006432T3 (es)
IL (1) IL259946A (es)
MX (1) MX2018008159A (es)
RU (1) RU2018123183A (es)
TW (1) TWI778088B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012052982A1 (en) 2010-10-22 2012-04-26 Neuravi Limited Clot engagement and removal system
EP4566553A3 (en) 2011-03-09 2025-08-06 Neuravi Limited A clot retrieval device for removing occlusive clot from a blood vessel
US12076037B2 (en) 2011-03-09 2024-09-03 Neuravi Limited Systems and methods to restore perfusion to a vessel
US9358021B2 (en) 2013-01-09 2016-06-07 Covidien Lp Connection of an endovascular intervention device to a manipulation member
TR201820525T4 (tr) 2013-03-14 2019-01-21 Neuravi Ltd Bir tıkayıcı pıhtının bir kan damarından çıkarılmasına yönelik bir pıhtı çıkarma cihazı.
ES2985753T3 (es) 2013-03-14 2024-11-07 Neuravi Ltd Dispositivos y métodos para la eliminación de obstrucciones agudas de los vasos sanguíneos
US10285720B2 (en) 2014-03-11 2019-05-14 Neuravi Limited Clot retrieval system for removing occlusive clot from a blood vessel
US10441301B2 (en) 2014-06-13 2019-10-15 Neuravi Limited Devices and methods for removal of acute blockages from blood vessels
US10265086B2 (en) 2014-06-30 2019-04-23 Neuravi Limited System for removing a clot from a blood vessel
US11253278B2 (en) 2014-11-26 2022-02-22 Neuravi Limited Clot retrieval system for removing occlusive clot from a blood vessel
US10617435B2 (en) 2014-11-26 2020-04-14 Neuravi Limited Clot retrieval device for removing clot from a blood vessel
EP3223723B1 (en) 2014-11-26 2020-01-08 Neuravi Limited A clot retrieval device for removing occlusive clot from a blood vessel
KR102457315B1 (ko) 2016-08-17 2022-10-24 뉴라비 리미티드 혈관으로부터 폐색 혈전을 제거하기 위한 혈전 회수 시스템
JP7046924B2 (ja) 2016-09-06 2022-04-04 ニューラヴィ・リミテッド 血管から閉塞性血塊を除去するための血塊回収装置
US11406416B2 (en) 2018-10-02 2022-08-09 Neuravi Limited Joint assembly for vasculature obstruction capture device
US12285182B2 (en) 2018-10-10 2025-04-29 Innova Vascular, Inc. Devices and methods for removing an embolus
EP4000540B1 (en) 2019-03-04 2024-02-14 Neuravi Limited Actuated clot retrieval catheter
US11109939B2 (en) * 2019-06-14 2021-09-07 DePuy Synthes Products, Inc. Intravascular devices with radiopaque body markers
US11266427B2 (en) * 2019-07-10 2022-03-08 Neuravi Limited Self-expanding intravascular medical device
ES2987037T3 (es) 2019-09-11 2024-11-13 Neuravi Ltd Catéter bucal expansible
JP7109413B2 (ja) 2019-09-18 2022-07-29 株式会社Biomedical Solutions ステントシステム
CN110729051B (zh) * 2019-10-10 2022-11-22 中国科学院深圳先进技术研究院 一种介入手术中的导丝力学分析方法、系统及电子设备
US11712231B2 (en) * 2019-10-29 2023-08-01 Neuravi Limited Proximal locking assembly design for dual stent mechanical thrombectomy device
US11779364B2 (en) 2019-11-27 2023-10-10 Neuravi Limited Actuated expandable mouth thrombectomy catheter
US11839725B2 (en) 2019-11-27 2023-12-12 Neuravi Limited Clot retrieval device with outer sheath and inner catheter
US11517340B2 (en) 2019-12-03 2022-12-06 Neuravi Limited Stentriever devices for removing an occlusive clot from a vessel and methods thereof
US11633198B2 (en) 2020-03-05 2023-04-25 Neuravi Limited Catheter proximal joint
US11944327B2 (en) 2020-03-05 2024-04-02 Neuravi Limited Expandable mouth aspirating clot retrieval catheter
US11883043B2 (en) 2020-03-31 2024-01-30 DePuy Synthes Products, Inc. Catheter funnel extension
JP7299191B2 (ja) * 2020-03-31 2023-06-27 大塚メディカルデバイス株式会社 ステント及びカテーテル・ステント・システム
US11759217B2 (en) 2020-04-07 2023-09-19 Neuravi Limited Catheter tubular support
US11730501B2 (en) 2020-04-17 2023-08-22 Neuravi Limited Floating clot retrieval device for removing clots from a blood vessel
US11871946B2 (en) 2020-04-17 2024-01-16 Neuravi Limited Clot retrieval device for removing clot from a blood vessel
US11717308B2 (en) 2020-04-17 2023-08-08 Neuravi Limited Clot retrieval device for removing heterogeneous clots from a blood vessel
US11738188B2 (en) * 2020-06-08 2023-08-29 Covidien Lp Connection of intravascular interventional elements and elongate manipulation members
US20210393277A1 (en) * 2020-06-18 2021-12-23 Neuravi Limited Catheter mouth designs
US11737771B2 (en) 2020-06-18 2023-08-29 Neuravi Limited Dual channel thrombectomy device
US11937836B2 (en) * 2020-06-22 2024-03-26 Neuravi Limited Clot retrieval system with expandable clot engaging framework
US11439418B2 (en) 2020-06-23 2022-09-13 Neuravi Limited Clot retrieval device for removing clot from a blood vessel
US11864781B2 (en) 2020-09-23 2024-01-09 Neuravi Limited Rotating frame thrombectomy device
US11937837B2 (en) 2020-12-29 2024-03-26 Neuravi Limited Fibrin rich / soft clot mechanical thrombectomy device
US12029442B2 (en) 2021-01-14 2024-07-09 Neuravi Limited Systems and methods for a dual elongated member clot retrieval apparatus
US11872354B2 (en) 2021-02-24 2024-01-16 Neuravi Limited Flexible catheter shaft frame with seam
US12064130B2 (en) 2021-03-18 2024-08-20 Neuravi Limited Vascular obstruction retrieval device having sliding cages pinch mechanism
US11974764B2 (en) 2021-06-04 2024-05-07 Neuravi Limited Self-orienting rotating stentriever pinching cells
US20230014731A1 (en) * 2021-07-14 2023-01-19 Neuravi Limited Clot retrieval device for removing clot from a blood vessel
US11937839B2 (en) 2021-09-28 2024-03-26 Neuravi Limited Catheter with electrically actuated expandable mouth
US12011186B2 (en) 2021-10-28 2024-06-18 Neuravi Limited Bevel tip expandable mouth catheter with reinforcing ring
US20240180571A1 (en) * 2022-12-01 2024-06-06 Neuravi Limited Small vasculature clot pinching

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006044831A1 (de) * 2006-09-20 2008-04-03 Phenox Gmbh Vorrichtung zur Entfernung von Thromben aus Blutgefäßen
US8529596B2 (en) * 2009-07-08 2013-09-10 Concentric Medical, Inc. Vascular and bodily duct treatment devices and methods
KR101680420B1 (ko) * 2011-02-04 2016-11-28 콘센트릭 메디칼, 인크. 혈관 및 신체 관 치료 장치 및 방법
EP4566553A3 (en) 2011-03-09 2025-08-06 Neuravi Limited A clot retrieval device for removing occlusive clot from a blood vessel
US9254205B2 (en) * 2012-09-27 2016-02-09 Covidien Lp Vascular stent with improved vessel wall apposition
TR201820525T4 (tr) * 2013-03-14 2019-01-21 Neuravi Ltd Bir tıkayıcı pıhtının bir kan damarından çıkarılmasına yönelik bir pıhtı çıkarma cihazı.
US9801644B2 (en) * 2014-01-03 2017-10-31 Legacy Ventures LLC Clot retrieval system
EP3145424B1 (en) * 2014-05-18 2018-06-27 Legacy Ventures LLC Clot retrieval system
EP3223723B1 (en) * 2014-11-26 2020-01-08 Neuravi Limited A clot retrieval device for removing occlusive clot from a blood vessel
RU2018122453A (ru) * 2015-11-25 2019-12-26 Ньюрави Лимитед Устройство извлечения тромба для удаления окклюзионного тромба из кровеносного сосуда
JP6666699B2 (ja) * 2015-11-25 2020-03-18 オリンパス株式会社 接続方法

Also Published As

Publication number Publication date
EP4137071C0 (en) 2024-11-20
EP4137071A1 (en) 2023-02-22
KR20190001935A (ko) 2019-01-07
BR102018013204A2 (pt) 2019-03-12
EP3593742A1 (en) 2020-01-15
IL259946A (en) 2018-07-31
TW201918228A (zh) 2019-05-16
EP3593742B1 (en) 2022-10-19
EP3420978A1 (en) 2019-01-02
ES3006432T3 (en) 2025-03-18
TWI778088B (zh) 2022-09-21
JP2022173487A (ja) 2022-11-18
EP4137071B1 (en) 2024-11-20
RU2018123183A (ru) 2020-01-10
JP7309991B2 (ja) 2023-07-18
CA3008899A1 (en) 2018-12-28
CO2018006688A1 (es) 2019-12-31
JP2019005587A (ja) 2019-01-17
ES2932031T3 (es) 2023-01-09
CN109124725A (zh) 2019-01-04
AU2018204059A1 (en) 2019-01-17

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