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MX2018001268A - Combinacion de antagonista de pd-1 con un inhibidor de egfr. - Google Patents

Combinacion de antagonista de pd-1 con un inhibidor de egfr.

Info

Publication number
MX2018001268A
MX2018001268A MX2018001268A MX2018001268A MX2018001268A MX 2018001268 A MX2018001268 A MX 2018001268A MX 2018001268 A MX2018001268 A MX 2018001268A MX 2018001268 A MX2018001268 A MX 2018001268A MX 2018001268 A MX2018001268 A MX 2018001268A
Authority
MX
Mexico
Prior art keywords
combination
antagonist
egfr inhibitor
treatment
present
Prior art date
Application number
MX2018001268A
Other languages
English (en)
Inventor
Kasibhatla Shailaja
Cameron John
Jia Yong
Bilic Sanela
Howard Danny Jr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2018001268A publication Critical patent/MX2018001268A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a una composición farmacóutica que comprende un antagonista de PD-1 y un inhibidor de EGFR. La presente combinación se puede administrar en forma independiente o por separado, en una cantidad que es terapóuticamente eficaz conjuntamente para el tratamiento del cáncer. La invención también proporciona el uso de dicha combinación para la fabricación de un medicamento; el uso de dicha combinación como medicamento; un equipo de partes que comprende dicha combinación; y un método de tratamiento de dicha combinación.
MX2018001268A 2015-07-29 2016-07-27 Combinacion de antagonista de pd-1 con un inhibidor de egfr. MX2018001268A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562198390P 2015-07-29 2015-07-29
US201662331371P 2016-05-03 2016-05-03
PCT/IB2016/054488 WO2017017624A1 (en) 2015-07-29 2016-07-27 Combination of pd-1 antagonist with an egfr inhibitor

Publications (1)

Publication Number Publication Date
MX2018001268A true MX2018001268A (es) 2018-07-06

Family

ID=56682137

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018001268A MX2018001268A (es) 2015-07-29 2016-07-27 Combinacion de antagonista de pd-1 con un inhibidor de egfr.

Country Status (15)

Country Link
US (1) US20180177872A1 (es)
EP (1) EP3328407A1 (es)
JP (1) JP2018523652A (es)
KR (1) KR20180030911A (es)
CN (1) CN108235685A (es)
AU (1) AU2016298823A1 (es)
BR (1) BR112018001640A2 (es)
CA (1) CA2993908A1 (es)
CL (1) CL2018000223A1 (es)
HK (1) HK1247850A1 (es)
IL (1) IL256775A (es)
MX (1) MX2018001268A (es)
PH (1) PH12018500097A1 (es)
RU (1) RU2018105846A (es)
WO (1) WO2017017624A1 (es)

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Also Published As

Publication number Publication date
WO2017017624A1 (en) 2017-02-02
PH12018500097A1 (en) 2018-07-23
US20180177872A1 (en) 2018-06-28
IL256775A (en) 2018-03-29
CN108235685A (zh) 2018-06-29
KR20180030911A (ko) 2018-03-26
HK1247850A1 (zh) 2018-10-05
EP3328407A1 (en) 2018-06-06
CA2993908A1 (en) 2017-02-02
RU2018105846A (ru) 2019-08-28
BR112018001640A2 (pt) 2018-09-18
AU2016298823A1 (en) 2018-02-08
JP2018523652A (ja) 2018-08-23
CL2018000223A1 (es) 2018-07-13

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